Case Report
Experience With Imatinib to Treat Pulmonary Arterial Hypertension
Francisco José García Hernández
, María Jesús Castillo Palma, Rocío González León, Rocío Garrido Rasco, Celia Ocaña Medina, Julio Sánchez Román
Corresponding author
fjgarciah@eresmas.com
Correspondence: Dr F.J. García Hernández Avda. de Andalucía, 72, bajo B 41700 Dos Hermanas, Sevilla, Spain
Correspondence: Dr F.J. García Hernández Avda. de Andalucía, 72, bajo B 41700 Dos Hermanas, Sevilla, Spain
Unidad de Colagenosis e Hipertensión Pulmonar, Servicio de Medicina Interna, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain
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Garrido Rasco, Celia Ocaña Medina, Julio Sánchez Román" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Francisco José" "apellidos" => "García Hernández" "email" => array:1 [ 0 => "fjgarciah@eresmas.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "María Jesús" "apellidos" => "Castillo Palma" ] 2 => array:2 [ "nombre" => "Rocío González" "apellidos" => "León" ] 3 => array:2 [ "nombre" => "Rocío Garrido" "apellidos" => "Rasco" ] 4 => array:2 [ "nombre" => "Celia Ocaña" "apellidos" => "Medina" ] 5 => array:2 [ "nombre" => "Julio Sánchez" "apellidos" => "Román" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Colagenosis e Hipertensión Pulmonar, Servicio de Medicina Interna, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr F.J. García Hernández Avda. de Andalucía, 72, bajo B 41700 Dos Hermanas, Sevilla, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-10-23" "fechaAceptado" => "2007-11-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155143" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Imatinib</span>" 1 => "<span class="elsevierStyleItalic">Pulmonary arterial hypertension</span>" 2 => "<span class="elsevierStyleItalic">Toxicity</span>" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155142" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Imatinib</span>" 1 => "<span class="elsevierStyleItalic">Hipertensión pulmonar</span>" 2 => "<span class="elsevierStyleItalic">Toxicidad</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Despite advances in the treatment of patients with pulmonary arterial hypertension (PAH), survival has not improved greatly. Imatinib, an antagonist of platelet-derived growth factor with antiproliferative activity, has been effective in experimental models and clinically in several published reports. We report the results of imatinib therapy in 4 patients with PAH (functional class IV) who were refractory to treatment with drug combinations for this condition. The final outcome was favorable in only 1 of the 4 cases. In this case, the patient was in functional class III and his hemodynamic parameters had improved significantly within 5 months after starting therapy. However, the patient died as a result of severe toxic hepatitis in which imatinib may have played a role. The present report adds to the few already in the literature (4 cases) and suggests that care should continue to be shown when using imatinib to treat PAH.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">A pesar de los avances en el tratamiento de los pacientes con hipertensión arterial pulmonar (HAP), su supervivencia sigue estando muy afectada. El imatinib, un antagonista del factor de crecimiento derivado de las plaquetas con acción antiproliferativa, ha sido eficaz en modelos experimentales y en algunos casos comunicados. Se describe el resultado del tratamiento con imatinib en 4 pacientes con HAP en clase funcional IV y refractarios al tratamiento con asociaciones de medicamentos para la HAP. La respuesta final fue favorable sólo en uno de los 4 casos, que 5 meses después de iniciado el tratamiento estaba en clase funcional III y con mejoría significativa de los parámetros hemodinámicos. Sin embargo, el paciente falleció por hepatitis tóxica grave en la que el imatinib pudo haber participado. Estos resultados se añaden a la escasa experiencia clínica comunicada (sólo otros 4 casos) e indican que debemos mantener la cautela sobre la utilidad del imatinib en el tratamiento de la HAP.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival in primary pulmonary hypertension. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 6 | 14 |
| 2024 October | 36 | 13 | 49 |
| 2024 September | 30 | 17 | 47 |
| 2024 August | 40 | 30 | 70 |
| 2024 July | 29 | 18 | 47 |
| 2024 June | 28 | 27 | 55 |
| 2024 May | 35 | 28 | 63 |
| 2024 April | 17 | 22 | 39 |
| 2024 March | 19 | 16 | 35 |
| 2024 February | 21 | 18 | 39 |
| 2023 March | 3 | 2 | 5 |
| 2023 February | 11 | 18 | 29 |
| 2023 January | 16 | 27 | 43 |
| 2022 December | 17 | 28 | 45 |
| 2022 November | 15 | 24 | 39 |
| 2022 October | 18 | 39 | 57 |
| 2022 September | 17 | 25 | 42 |
| 2022 August | 18 | 35 | 53 |
| 2022 July | 17 | 41 | 58 |
| 2022 June | 14 | 34 | 48 |
| 2022 May | 17 | 35 | 52 |
| 2022 April | 12 | 32 | 44 |
| 2022 March | 19 | 37 | 56 |
| 2022 February | 14 | 21 | 35 |
| 2022 January | 11 | 29 | 40 |
| 2021 December | 14 | 51 | 65 |
| 2021 November | 20 | 52 | 72 |
| 2021 October | 19 | 50 | 69 |
| 2021 September | 14 | 59 | 73 |
| 2021 August | 11 | 37 | 48 |
| 2021 July | 12 | 36 | 48 |
| 2021 June | 10 | 35 | 45 |
| 2021 May | 12 | 25 | 37 |
| 2021 April | 33 | 64 | 97 |
| 2021 March | 19 | 21 | 40 |
| 2021 February | 11 | 23 | 34 |
| 2021 January | 12 | 16 | 28 |
| 2020 December | 17 | 16 | 33 |
| 2020 November | 4 | 12 | 16 |
| 2020 October | 8 | 9 | 17 |
| 2020 September | 2 | 3 | 5 |
| 2020 August | 13 | 10 | 23 |
| 2020 July | 14 | 15 | 29 |
| 2020 June | 7 | 3 | 10 |
| 2020 May | 25 | 16 | 41 |
| 2020 April | 29 | 19 | 48 |
| 2020 March | 32 | 14 | 46 |
| 2020 February | 67 | 14 | 81 |
| 2020 January | 39 | 14 | 53 |
| 2019 December | 15 | 16 | 31 |
| 2019 November | 16 | 17 | 33 |
| 2019 October | 8 | 7 | 15 |
| 2019 September | 34 | 19 | 53 |
| 2019 August | 10 | 11 | 21 |
| 2019 July | 6 | 26 | 32 |
| 2019 June | 5 | 13 | 18 |
| 2019 May | 13 | 13 | 26 |
| 2019 April | 19 | 29 | 48 |
| 2019 March | 12 | 23 | 35 |
| 2019 February | 15 | 19 | 34 |
| 2019 January | 6 | 11 | 17 |
| 2018 December | 8 | 12 | 20 |
| 2018 November | 25 | 20 | 45 |
| 2018 October | 14 | 13 | 27 |
| 2018 September | 11 | 10 | 21 |
| 2018 May | 3 | 0 | 3 |
| 2018 April | 11 | 8 | 19 |
| 2018 March | 1 | 4 | 5 |
| 2018 February | 5 | 7 | 12 |
| 2018 January | 2 | 7 | 9 |
| 2017 December | 4 | 13 | 17 |
| 2017 November | 4 | 8 | 12 |
| 2017 October | 4 | 7 | 11 |
| 2017 September | 4 | 10 | 14 |
| 2017 August | 5 | 10 | 15 |
| 2017 July | 0 | 4 | 4 |
| 2017 June | 9 | 12 | 21 |
| 2017 May | 6 | 6 | 12 |
| 2017 April | 2 | 4 | 6 |
| 2017 March | 2 | 19 | 21 |
| 2017 February | 2 | 1 | 3 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 8 | 6 | 14 |
| 2016 November | 11 | 12 | 23 |
| 2016 October | 10 | 7 | 17 |
| 2016 September | 12 | 7 | 19 |
| 2016 August | 13 | 4 | 17 |
| 2016 July | 5 | 3 | 8 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 33 | 10 | 43 |
| 2015 September | 30 | 5 | 35 |
| 2015 August | 32 | 5 | 37 |
| 2015 July | 30 | 5 | 35 |
| 2015 June | 35 | 4 | 39 |
| 2015 May | 42 | 9 | 51 |
| 2015 April | 36 | 8 | 44 |
| 2015 March | 27 | 4 | 31 |
| 2015 February | 33 | 3 | 36 |
| 2015 January | 31 | 3 | 34 |
| 2014 December | 38 | 5 | 43 |
| 2014 November | 27 | 5 | 32 |
| 2014 October | 35 | 12 | 47 |
| 2014 September | 31 | 6 | 37 |
| 2014 August | 30 | 12 | 42 |
| 2014 July | 30 | 3 | 33 |
| 2014 June | 49 | 10 | 59 |
| 2014 May | 45 | 12 | 57 |
| 2014 April | 44 | 5 | 49 |
| 2014 March | 64 | 6 | 70 |
| 2014 February | 41 | 7 | 48 |
| 2014 January | 41 | 10 | 51 |
| 2013 December | 37 | 8 | 45 |
| 2013 November | 32 | 3 | 35 |
| 2013 October | 23 | 8 | 31 |
| 2013 September | 41 | 11 | 52 |
| 2013 August | 40 | 19 | 59 |
| 2013 July | 51 | 9 | 60 |
| 2013 June | 45 | 4 | 49 |
| 2013 May | 31 | 7 | 38 |
| 2013 April | 32 | 5 | 37 |
| 2013 March | 12 | 2 | 14 |
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