Original Articles
Differences in Clinical and Polysomnographic Variables Between Male and Female Patients With Sleep Apnea-Hypopnea Syndrome
Núria Rourea, Olga Medianoa, Joaquín Durán-Cantollab, Francisco García Ríoc, Mónica de la Peñad, Francisco Capotee, Joaquín Teránf, Juan Fernando Masag, David Gozalh, Ferran Barbéa,
Corresponding author
fbarbe@arnau.scs.es
Correspondence: Dr F. Barbé Servei de Pneumologia, Hospital Universitari Arnau de Vilanova Rovira Roure, 8025198 Lleida, Spain
Correspondence: Dr F. Barbé Servei de Pneumologia, Hospital Universitari Arnau de Vilanova Rovira Roure, 8025198 Lleida, Spain
a Servicio de Neumología, Hospital Universitario Arnau de Vilanova, IRBLLEIDA, Lleida, Spain
b Servicio de Neumología, Hospital de Txagorritxu, Vitoria, Álava, Spain
c Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain
d Servicio de Neumología, Hospital Universitario Son Dureta, Palma de Mallorca, Illes Balears, Spain
e Servicio de Neumología, Hospital Virgen del Rocío, Sevilla, Spain
f Servicio de Neumología, Hospital General Yagüe, Burgos, Spain
g Servicio de Neumología, Hospital San Pedro de Alcántara, Cáceres, Spain
h Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, United States
Read
4693
Timeswas read the article
2015
Total PDF
2678
Total HTML
Share statistics
array:23 [ "pii" => "S1579212909600070" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)60007-0" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60007" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:685-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2521 "formatos" => array:3 [ "EPUB" => 111 "HTML" => 1749 "PDF" => 661 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212909600082" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)60008-2" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60008" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2008;44:689-91" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2370 "formatos" => array:3 [ "EPUB" => 121 "HTML" => 1576 "PDF" => 673 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Experience With Imatinib to Treat Pulmonary Arterial Hypertension" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "689" "paginaFinal" => "691" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco José García Hernández, María Jesús Castillo Palma, Rocío González León, Rocío Garrido Rasco, Celia Ocaña Medina, Julio Sánchez Román" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Francisco José" "apellidos" => "García Hernández" ] 1 => array:2 [ "nombre" => "María Jesús" "apellidos" => "Castillo Palma" ] 2 => array:2 [ "nombre" => "Rocío González" "apellidos" => "León" ] 3 => array:2 [ "nombre" => "Rocío Garrido" "apellidos" => "Rasco" ] 4 => array:2 [ "nombre" => "Celia Ocaña" "apellidos" => "Medina" ] 5 => array:2 [ "nombre" => "Julio Sánchez" "apellidos" => "Román" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909600082?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000012/v1_201305150340/S1579212909600082/v1_201305150340/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212909600069" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)60006-9" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60006" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:679-84" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2546 "formatos" => array:3 [ "EPUB" => 118 "HTML" => 1831 "PDF" => 597 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Nontuberculous Mycobacterial Infection in Patients With Cystic Fibrosis: A Multicenter Prevalence Study" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "679" "paginaFinal" => "684" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rosa M. Girón, Luis Máiz, Isabel Barrio, M. Teresa Martínez, Antonio Salcedo, Concepción Prados" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Rosa M." "apellidos" => "Girón" ] 1 => array:2 [ "nombre" => "Luis" "apellidos" => "Máiz" ] 2 => array:2 [ "nombre" => "Isabel" "apellidos" => "Barrio" ] 3 => array:2 [ "nombre" => "M. Teresa" "apellidos" => "Martínez" ] 4 => array:2 [ "nombre" => "Antonio" "apellidos" => "Salcedo" ] 5 => array:2 [ "nombre" => "Concepción" "apellidos" => "Prados" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909600069?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000012/v1_201305150340/S1579212909600069/v1_201305150340/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Differences in Clinical and Polysomnographic Variables Between Male and Female Patients With Sleep Apnea-Hypopnea Syndrome" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "685" "paginaFinal" => "688" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Núria Roure, Olga Mediano, Joaquín Durán-Cantolla, Francisco García Río, Mónica de la Peña, Francisco Capote, Joaquín Terán, Juan Fernando Masa, David Gozal, Ferran Barbé" "autores" => array:10 [ 0 => array:3 [ "nombre" => "Núria" "apellidos" => "Roure" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "Olga" "apellidos" => "Mediano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Joaquín" "apellidos" => "Durán-Cantolla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Francisco García" "apellidos" => "Río" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Mónica" "apellidos" => "de la Peña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 5 => array:3 [ "nombre" => "Francisco" "apellidos" => "Capote" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] ] 6 => array:3 [ "nombre" => "Joaquín" "apellidos" => "Terán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] ] ] 7 => array:3 [ "nombre" => "Juan Fernando" "apellidos" => "Masa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff7" ] ] ] 8 => array:3 [ "nombre" => "David" "apellidos" => "Gozal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff8" ] ] ] 9 => array:4 [ "nombre" => "Ferran" "apellidos" => "Barbé" "email" => array:1 [ 0 => "fbarbe@arnau.scs.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:8 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Arnau de Vilanova, IRBLLEIDA, Lleida, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital de Txagorritxu, Vitoria, Álava, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Son Dureta, Palma de Mallorca, Illes Balears, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Virgen del Rocío, Sevilla, Spain" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] 5 => array:3 [ "entidad" => "Servicio de Neumología, Hospital General Yagüe, Burgos, Spain" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] 6 => array:3 [ "entidad" => "Servicio de Neumología, Hospital San Pedro de Alcántara, Cáceres, Spain" "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff7" ] 7 => array:3 [ "entidad" => "Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Kentucky, United States" "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff8" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr F. Barbé Servei de Pneumologia, Hospital Universitari Arnau de Vilanova Rovira Roure, 8025198 Lleida, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-04-17" "fechaAceptado" => "2008-05-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155139" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Sex</span>" 1 => "<span class="elsevierStyleItalic">Polysomnography</span>" 2 => "<span class="elsevierStyleItalic">Sleep apnea syndrome</span>" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155138" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Sexo</span>" 1 => "<span class="elsevierStyleItalic">Polisomnografía</span>" 2 => "<span class="elsevierStyleItalic">Síndrome de apneas del sueño</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to compare the clinical, anthropometric, and polysomnographic characteristics of a broad group of patients with sleep apnea-hypopnea syndrome according to sex.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study, conducted in 6 Spanish university hospitals, included consecutive patients attended from 2003 through 2005 with an apnea-hypopnea index greater than 5. Groups were formed according to sex and then stratified into age subgroups of younger (≤ 45 years) and older patients (>45 years) for further comparison.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 2464 men and 424 women. Women were older (mean [SD] age, 56 [12] years vs 51 [12] years), weighed more (body mass index, 31 [6] kg/m<span class="elsevierStyleSup">2</span> vs 30 [5] kg/m<span class="elsevierStyleSup">2</span>), and had a larger hip circumference (119 [15] cm vs 111 [12] cm) and smaller neck circumference (38 [3] cm vs 42 [9] cm) than men (<span class="elsevierStyleItalic">P</span><.001 in all cases). The degree of daytime sleepiness (Epworth scale) and the apnea-hypopnea index were similar in both groups, although women had a longer sleep latency (23[28] minutes vs 27 [32] minutes; <span class="elsevierStyleItalic">P</span><.004) and a higher mean oxygen saturation (92% [4%] vs 91% [5%]) and minimum oxygen saturation (78% [11%] vs 75% [12%]; <span class="elsevierStyleItalic">P</span><.0001) than men. On stratification by age, only weight differences between men and women were observed in the younger group whereas the older group also showed differences in oxygen saturation during sleep.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Women with sleep apnea-hypopnea are more overweight than men and tend to seek medical attention at an older age. The clinical and polysomnographic variables were generally similar for men and women—the only differences were that sleep latency was longer and hypoxemia during sleep was more accentuated in women.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Comparar, en una cohorte amplia de pacientes con síndrome de apneas-hipopneas durante el sueño, las características clínicas, antropométricas y polisomnográficas en función del sexo.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">En el estudio, realizado en 6 hospitales universitarios españoles, se incluyó a pacientes consecutivos con un índice de apneas-hipopneas del sueño mayor de 5 h<span class="elsevierStyleSup">−1</span>, que fueron evaluados entre 2003 y 2005. Se dividieron en función del sexo y, posteriormente, en función de la edad: pacientes jóvenes (≤ 45 años) y adultos (> 45 años).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha estudiado a 2.464 varones y 424 mujeres. Las mujeres eran mayores (edad media ± desviación estándar: 56 ± 12 frente a 51 ± 12 años; p < 0,0001), pesaban más (índice de masa corporal: 31 ± 6 frente a 30 ± 5 kg/m<span class="elsevierStyleSup">2</span>; p < 0,0001) y presentaban una mayor circunferencia de cadera (119 ± 15 frente a 111 ± 12 cm; p < 0,0001) y una menor circunferencia de cuello (38 ± 3 frente a 42 ± 9 cm; p < 0,0001) que los varones. El grado de somnolencia diurna (escala de Epworth) y el índice de apneas-hipopneas eran similares en ambos grupos, aunque el de mujeres presentaba una latencia de sueño más larga (23 ± 28 frente a 27 ± 32 min; p < 0,004) y una saturación de oxígeno media (un 92 ± 4 frente a un 91 ± 5%) y mínima menor (un 78 ± 11 frente a un 75 ± 12%; p < 0,0001) que los varones. Al diferenciar los grupos por edad, en el grupo de jóvenes sólo se mantenían las diferencias ponderales, mientras que entre los adultos reaparecían las diferencias en los valores de saturación nocturna.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Las mujeres con síndrome de apneas-hipopneas durante el sueño son más obesas que los varones y consultan a una edad más avanzada. Desde el punto de vista clínico y polisomnográfico, no hay grandes diferencias en función del sexo. Únicamente la latencia de sueño es superior y la hipoxemia nocturna más acentuada.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">Study financed by the Spanish Health Research Fund (Fondo de Investigaciones Sanitarias de España) (Grant 0300022*), the National Institute for Health (Grant HL65270), the Children's Foundation Endowment for Sleep Research, an award from the Commonwealth of Kentucky Challenge for Excellence Trust Fund to David Gozal, and the CIBER for Respiratory Diseases (CibeRes).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Documento de consenso nacional sobre el síndrome de apneas-hipopneas del sueño (SAHS)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Grupo Español de Sueño (GES)" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "numero" => "Suppl 4" "paginaInicial" => "12" "paginaFinal" => "29" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The occurrence of sleep-disordered breathing among middle-aged adults" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T Young" 1 => "M Palta" 2 => "J Dempsey" 3 => "J Skatrud" 4 => "S Weber" 5 => "S Badr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199304293281704" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1993" "volumen" => "328" "paginaInicial" => "1230" "paginaFinal" => "1235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8464434" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of sleep-disordered breathing in women – effects of gender" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "EO Bixler" 1 => "AN Vgontzas" 2 => "HM Lin" 3 => "T Ten Have" 4 => "J Rein" 5 => "A Vela-Bueno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.3.9911064" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "163" "paginaInicial" => "608" "paginaFinal" => "613" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254512" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstructive sleep apneahypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J Durán" 1 => "S Esnaola" 2 => "R Rubio" 3 => "A Iztueta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.3.2005065" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "163" "paginaInicial" => "685" "paginaFinal" => "689" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254524" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gender differences in sleep disordered breathing in a community-based sample" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S Redline" 1 => "K Kump" 2 => "PV Tishler" 3 => "I Browner" 4 => "V Ferrette" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.149.3.8118642" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1994" "volumen" => "149" "paginaInicial" => "722" "paginaFinal" => "726" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8118642" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep apnea, hypopnea and oxygen desaturation in normal subjects. A strong male predominance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "AJ Block" 1 => "PG Boysen" 2 => "JW Wynne" 3 => "LA Hunt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM197903083001001" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1979" "volumen" => "300" "paginaInicial" => "513" "paginaFinal" => "517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/216912" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "MR Shepertycky" 1 => "K Banno" 2 => "MH Kryger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep" "fecha" => "2005" "volumen" => "28" "paginaInicial" => "309" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16173651" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gender differences in obstructive sleep apnea syndrome: a clinical study of 1166 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E Quintana-Gallego" 1 => "C Carmona-Bernal" 2 => "F Capote" 3 => "A Sánchez-Armengol" 4 => "G Botebol-Benhamou" 5 => "J Polo-Padillo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2004" "volumen" => "98" "paginaInicial" => "984" "paginaFinal" => "989" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15481275" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A Rechtschaffen" 1 => "A Kales" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Manual of standardized terminology, techniques and scoring system for the sleep stages of human subjects" "fecha" => "1968" "editorial" => "US Government Printing Office" "editorialLocalizacion" => "Washington, DC" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EEG arousals: scoring rules and examples" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "ASDA Standards of Practice" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep" "fecha" => "1992" "volumen" => "15" "paginaInicial" => "173" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11032543" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validación de la versión española del test de somnolencia Epworth en pacientes con síndrome de apneas del sueño" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E Chiner" 1 => "JM Arriero" 2 => "J Signes-Costa" 3 => "J Marco" 4 => "I Fuentes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1999" "volumen" => "35" "paginaInicial" => "422" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10596338" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Daytime sleepiness, snoring, and obstructive sleep apnea; The Epworth Sleepiness Scale" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "MW Johns" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1993" "volumen" => "103" "paginaInicial" => "30" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8417909" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E Vagiakis" 1 => "F Kapsimalis" 2 => "I Lagogianni" 3 => "H Perraki" 4 => "A Minaritzoglou" 5 => "K Alexandropoulou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.sleep.2005.12.014" "Revista" => array:6 [ "tituloSerie" => "Sleep Med" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "424" "paginaFinal" => "430" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16740405" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gender differences in the expression of sleep-disordered breathing – role of upper airway dimensions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V Mohsenin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2001" "volumen" => "120" "paginaInicial" => "1442" "paginaFinal" => "1447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11713117" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gender differences in the polysomnographic features of obstructive sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C O'Connor" 1 => "KS Thornley" 2 => "PJ Hanly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.5.9904121" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "161" "paginaInicial" => "1465" "paginaFinal" => "1472" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10806140" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gender difference in sleep profile of severely obese patients with obstructive sleep apnea (OSA)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O Resta" 1 => "GE Carpanano" 2 => "D Lacedonia" 3 => "G DiGioia" 4 => "T Gilberti" 5 => "A Stefano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2005" "volumen" => "99" "paginaInicial" => "91" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15672855" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004400000012/v1_201305150340/S1579212909600070/v1_201305150340/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000012/v1_201305150340/S1579212909600070/v1_201305150340/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909600070?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 2 | 6 |
| 2024 October | 36 | 19 | 55 |
| 2024 September | 27 | 18 | 45 |
| 2024 August | 35 | 52 | 87 |
| 2024 July | 25 | 28 | 53 |
| 2024 June | 25 | 33 | 58 |
| 2024 May | 39 | 40 | 79 |
| 2024 April | 14 | 29 | 43 |
| 2024 March | 18 | 21 | 39 |
| 2024 February | 15 | 29 | 44 |
| 2023 March | 3 | 5 | 8 |
| 2023 February | 16 | 32 | 48 |
| 2023 January | 14 | 33 | 47 |
| 2022 December | 38 | 38 | 76 |
| 2022 November | 31 | 35 | 66 |
| 2022 October | 55 | 40 | 95 |
| 2022 September | 16 | 40 | 56 |
| 2022 August | 53 | 47 | 100 |
| 2022 July | 36 | 42 | 78 |
| 2022 June | 15 | 37 | 52 |
| 2022 May | 15 | 30 | 45 |
| 2022 April | 15 | 31 | 46 |
| 2022 March | 23 | 45 | 68 |
| 2022 February | 11 | 23 | 34 |
| 2022 January | 12 | 32 | 44 |
| 2021 December | 31 | 46 | 77 |
| 2021 November | 20 | 45 | 65 |
| 2021 October | 16 | 45 | 61 |
| 2021 September | 32 | 66 | 98 |
| 2021 August | 17 | 33 | 50 |
| 2021 July | 25 | 35 | 60 |
| 2021 June | 11 | 24 | 35 |
| 2021 May | 11 | 39 | 50 |
| 2021 April | 31 | 55 | 86 |
| 2021 March | 18 | 20 | 38 |
| 2021 February | 13 | 21 | 34 |
| 2021 January | 9 | 11 | 20 |
| 2020 December | 17 | 21 | 38 |
| 2020 November | 4 | 8 | 12 |
| 2020 October | 9 | 10 | 19 |
| 2020 September | 9 | 2 | 11 |
| 2020 August | 9 | 18 | 27 |
| 2020 July | 10 | 15 | 25 |
| 2020 June | 8 | 7 | 15 |
| 2020 May | 13 | 17 | 30 |
| 2020 April | 12 | 17 | 29 |
| 2020 March | 10 | 15 | 25 |
| 2020 February | 9 | 16 | 25 |
| 2020 January | 12 | 18 | 30 |
| 2019 December | 12 | 11 | 23 |
| 2019 November | 12 | 15 | 27 |
| 2019 October | 8 | 8 | 16 |
| 2019 September | 11 | 14 | 25 |
| 2019 August | 10 | 14 | 24 |
| 2019 July | 7 | 27 | 34 |
| 2019 June | 7 | 17 | 24 |
| 2019 May | 13 | 7 | 20 |
| 2019 April | 14 | 19 | 33 |
| 2019 March | 14 | 25 | 39 |
| 2019 February | 8 | 16 | 24 |
| 2019 January | 6 | 10 | 16 |
| 2018 December | 9 | 9 | 18 |
| 2018 November | 18 | 18 | 36 |
| 2018 October | 15 | 16 | 31 |
| 2018 September | 8 | 7 | 15 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 8 | 6 | 14 |
| 2018 March | 6 | 4 | 10 |
| 2018 February | 4 | 8 | 12 |
| 2018 January | 5 | 3 | 8 |
| 2017 December | 5 | 12 | 17 |
| 2017 November | 4 | 5 | 9 |
| 2017 October | 4 | 7 | 11 |
| 2017 September | 5 | 7 | 12 |
| 2017 August | 7 | 8 | 15 |
| 2017 June | 9 | 11 | 20 |
| 2017 May | 7 | 6 | 13 |
| 2017 April | 4 | 3 | 7 |
| 2017 March | 4 | 1 | 5 |
| 2017 February | 2 | 1 | 3 |
| 2017 January | 4 | 2 | 6 |
| 2016 December | 8 | 11 | 19 |
| 2016 November | 12 | 10 | 22 |
| 2016 October | 20 | 11 | 31 |
| 2016 September | 16 | 5 | 21 |
| 2016 August | 7 | 2 | 9 |
| 2016 July | 10 | 0 | 10 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 55 | 9 | 64 |
| 2015 September | 58 | 11 | 69 |
| 2015 August | 29 | 10 | 39 |
| 2015 July | 44 | 10 | 54 |
| 2015 June | 40 | 3 | 43 |
| 2015 May | 46 | 11 | 57 |
| 2015 April | 36 | 11 | 47 |
| 2015 March | 33 | 6 | 39 |
| 2015 February | 52 | 3 | 55 |
| 2015 January | 42 | 7 | 49 |
| 2014 December | 41 | 6 | 47 |
| 2014 November | 42 | 7 | 49 |
| 2014 October | 49 | 8 | 57 |
| 2014 September | 37 | 15 | 52 |
| 2014 August | 35 | 10 | 45 |
| 2014 July | 44 | 6 | 50 |
| 2014 June | 53 | 13 | 66 |
| 2014 May | 51 | 12 | 63 |
| 2014 April | 50 | 6 | 56 |
| 2014 March | 65 | 11 | 76 |
| 2014 February | 58 | 12 | 70 |
| 2014 January | 45 | 15 | 60 |
| 2013 December | 37 | 8 | 45 |
| 2013 November | 56 | 7 | 63 |
| 2013 October | 56 | 9 | 65 |
| 2013 September | 51 | 10 | 61 |
| 2013 August | 54 | 9 | 63 |
| 2013 July | 42 | 9 | 51 |
| 2013 June | 40 | 7 | 47 |
| 2013 May | 34 | 5 | 39 |
| 2013 April | 18 | 7 | 25 |
| 2013 March | 6 | 1 | 7 |
Show all
