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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of nontuberculous mycobacterial infection in patients with cystic fibrosis&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a prospective study in which patients with cystic fibrosis were followed for 2 years&#59; the patients were recruited from specialized units and were all over 6 years old&#46; Sputum samples collected every 6 months were stained with auramine-rhodamine and cultures were prepared with a liquid and a solid medium&#46; When stains or cultures were positive for nontuberculous mycobacteria&#44; 1 or 2 additional sputum samples were obtained from the patients&#44; who were monitored closely to assess the need for specific treatment&#46; We assessed the following clinical variables&#58; age&#44; sex&#44; presence of pancreatic insufficiency&#44; use of aerosol antibiotic therapy&#44; and long-term azithromycin and inhaled or oral corticosteroid therapies&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 220 patients &#40;119 women&#41; with a mean age of 22&#46;62 years &#40;range&#44; 6-74 years&#41; were enrolled&#59; of these23&#46;6&#37; were receiving azithromycin&#46; We prepared 1303 sputum samples for mycobacterial growth &#40;range per patient&#44; 4-68 samples&#41;&#59; 65 samples from a total of 17 patients&#40;7&#46;72&#37;&#41; were positive&#58; 17 by auramine-rhodamine staining and 48 by culture&#46; Eighty-eight culture samples were contaminated and <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> was not isolated in any of the cases&#46; The mycobacteria isolated were <span class="elsevierStyleItalic">avium complex</span> &#40;n&#61;10&#41;&#44; <span class="elsevierStyleItalic">abscessus</span> &#40;n&#61;6&#41;&#44; and <span class="elsevierStyleItalic">fortuitum</span> &#40;n&#61;1&#41;&#46; Two or more positive cultures were obtained in 9 patients&#44; 5 of whom experienced clinical deterioration and were prescribed specific treatment&#46; No significant differences in clinical variables were found between patients with nontuberculous mycobacteria and those without&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of nontuberculous mycobacterial infection in patients with cystic fibrosis was not very high &#40;7&#46;72&#37;&#41;&#44; perhaps because azithromycin interfered with the growth of these bacteria&#46; Patients with repeat isolations of mycobacteria should be monitored closely&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar la prevalencia de micobacterias ambientales &#40;MA&#41; en pacientes con fibrosis qu&#237;stica &#40;FQ&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospectivo de 2 a&#241;os de duraci&#243;n en pacientes con FQ mayores de 6 a&#241;os&#44; procedentes de 6 unidades monogr&#225;ficas&#46; En las muestras respiratorias&#44; recogidas cada 6 meses&#44; se efectu&#243; una tinci&#243;n de auramina-rodamina&#44; adem&#225;s de cultivos en medios s&#243;lido y l&#237;quido&#46; Si se detectaba una tinci&#243;n o cultivo positivo para MA&#44; se recog&#237;an 1 o 2 esputos m&#225;s y se hac&#237;a un seguimiento estricto para valorar la necesidad de tratamiento espec&#237;fico&#46; Se consideraron las siguientes variables cl&#237;nicas&#58; edad&#44; sexo&#44; insuficiencia pancre&#225;tica&#44; diabetes&#44; uso de aerosolterapia antibi&#243;tica y de azitromicina de forma continua&#44; tratamientos con corticoides inhalados o por v&#237;a oral de forma prolongada&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Participaron en el estudio 220 pacientes &#40;119 mujeres&#41;&#44; con una edad media de 22&#44;62 a&#241;os &#40;rango&#58; 6-74&#41;&#46; El 24&#37; recib&#237;a azitromicina&#46; Se cultivaron para la detecci&#243;n de micobacterias 1&#46;303 muestras de esputo &#40;rango por paciente&#58; 4-68&#41;&#44; de las que la tinci&#243;n de auramina fue positiva en 17 casos y el cultivo en 48&#44; correspondientes a 17 pacientes &#40;7&#44;72&#37;&#41;&#46; En 88 muestras el cultivo estaba contaminado&#46; En ning&#250;n caso se aisl&#243; <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#46; Las MA aisladas fueron&#58; <span class="elsevierStyleItalic">M&#46; avium complex</span> &#40;n &#61; 10&#41;<span class="elsevierStyleItalic">&#44; M&#46; abscessus</span> &#40;n &#61; 6&#41; y <span class="elsevierStyleItalic">M&#46; fortuitum</span> &#40;n &#61; 1&#41;&#46; Cinco de los 9 pacientes que presentaron m&#225;s de un aislamiento tuvieron deterioro cl&#237;nico y se les indic&#243; tratamiento espec&#237;fico&#46; No hubo diferencias entre las variables cl&#237;nicas de los pacientes con y sin aislamientos de MA&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de MA en pacientes con FQ no fue muy alta &#40;7&#44;72&#37;&#41;&#44; quiz&#225; debido a la interferencia de la azitromicina sobre el crecimiento de MA&#46; Hay que vigilar estrechamente a los pacientes con aislamientos repetidos&#46;</p>"
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Original Articles
Nontuberculous Mycobacterial Infection in Patients With Cystic Fibrosis: A Multicenter Prevalence Study
Rosa M. Giróna,
Corresponding author
med002861@nacom.es

Correspondence: Dr R.M. Girón Moreno Servicio de Neumología, Hospital de la Princesa Diego de León, 62, 28006 Madrid, Spain
, Luis Máizb, Isabel Barrioc, M. Teresa Martínezd, Antonio Salcedoe, Concepción Pradosc
a Unidad de Fibrosis Quística, Hospital de la Princesa, Madrid, Spain
b Unidad de Fibrosis Quística, Hospital Ramón y Cajal, Madrid, Spain
c Unidad de Fibrosis Quística, Hospital La Paz, Madrid, Spain
d Unidad de Fibrosis Quística, Hospital 12 de Octubre, Madrid, Spain
e Unidad de Fibrosis Quística, Hospital Materno-Infantil del Gregorio Marañón, Madrid, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of nontuberculous mycobacterial infection in patients with cystic fibrosis&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a prospective study in which patients with cystic fibrosis were followed for 2 years&#59; the patients were recruited from specialized units and were all over 6 years old&#46; Sputum samples collected every 6 months were stained with auramine-rhodamine and cultures were prepared with a liquid and a solid medium&#46; When stains or cultures were positive for nontuberculous mycobacteria&#44; 1 or 2 additional sputum samples were obtained from the patients&#44; who were monitored closely to assess the need for specific treatment&#46; We assessed the following clinical variables&#58; age&#44; sex&#44; presence of pancreatic insufficiency&#44; use of aerosol antibiotic therapy&#44; and long-term azithromycin and inhaled or oral corticosteroid therapies&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 220 patients &#40;119 women&#41; with a mean age of 22&#46;62 years &#40;range&#44; 6-74 years&#41; were enrolled&#59; of these23&#46;6&#37; were receiving azithromycin&#46; We prepared 1303 sputum samples for mycobacterial growth &#40;range per patient&#44; 4-68 samples&#41;&#59; 65 samples from a total of 17 patients&#40;7&#46;72&#37;&#41; were positive&#58; 17 by auramine-rhodamine staining and 48 by culture&#46; Eighty-eight culture samples were contaminated and <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> was not isolated in any of the cases&#46; The mycobacteria isolated were <span class="elsevierStyleItalic">avium complex</span> &#40;n&#61;10&#41;&#44; <span class="elsevierStyleItalic">abscessus</span> &#40;n&#61;6&#41;&#44; and <span class="elsevierStyleItalic">fortuitum</span> &#40;n&#61;1&#41;&#46; Two or more positive cultures were obtained in 9 patients&#44; 5 of whom experienced clinical deterioration and were prescribed specific treatment&#46; No significant differences in clinical variables were found between patients with nontuberculous mycobacteria and those without&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of nontuberculous mycobacterial infection in patients with cystic fibrosis was not very high &#40;7&#46;72&#37;&#41;&#44; perhaps because azithromycin interfered with the growth of these bacteria&#46; Patients with repeat isolations of mycobacteria should be monitored closely&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar la prevalencia de micobacterias ambientales &#40;MA&#41; en pacientes con fibrosis qu&#237;stica &#40;FQ&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospectivo de 2 a&#241;os de duraci&#243;n en pacientes con FQ mayores de 6 a&#241;os&#44; procedentes de 6 unidades monogr&#225;ficas&#46; En las muestras respiratorias&#44; recogidas cada 6 meses&#44; se efectu&#243; una tinci&#243;n de auramina-rodamina&#44; adem&#225;s de cultivos en medios s&#243;lido y l&#237;quido&#46; Si se detectaba una tinci&#243;n o cultivo positivo para MA&#44; se recog&#237;an 1 o 2 esputos m&#225;s y se hac&#237;a un seguimiento estricto para valorar la necesidad de tratamiento espec&#237;fico&#46; Se consideraron las siguientes variables cl&#237;nicas&#58; edad&#44; sexo&#44; insuficiencia pancre&#225;tica&#44; diabetes&#44; uso de aerosolterapia antibi&#243;tica y de azitromicina de forma continua&#44; tratamientos con corticoides inhalados o por v&#237;a oral de forma prolongada&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Participaron en el estudio 220 pacientes &#40;119 mujeres&#41;&#44; con una edad media de 22&#44;62 a&#241;os &#40;rango&#58; 6-74&#41;&#46; El 24&#37; recib&#237;a azitromicina&#46; Se cultivaron para la detecci&#243;n de micobacterias 1&#46;303 muestras de esputo &#40;rango por paciente&#58; 4-68&#41;&#44; de las que la tinci&#243;n de auramina fue positiva en 17 casos y el cultivo en 48&#44; correspondientes a 17 pacientes &#40;7&#44;72&#37;&#41;&#46; En 88 muestras el cultivo estaba contaminado&#46; En ning&#250;n caso se aisl&#243; <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#46; Las MA aisladas fueron&#58; <span class="elsevierStyleItalic">M&#46; avium complex</span> &#40;n &#61; 10&#41;<span class="elsevierStyleItalic">&#44; M&#46; abscessus</span> &#40;n &#61; 6&#41; y <span class="elsevierStyleItalic">M&#46; fortuitum</span> &#40;n &#61; 1&#41;&#46; Cinco de los 9 pacientes que presentaron m&#225;s de un aislamiento tuvieron deterioro cl&#237;nico y se les indic&#243; tratamiento espec&#237;fico&#46; No hubo diferencias entre las variables cl&#237;nicas de los pacientes con y sin aislamientos de MA&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La prevalencia de MA en pacientes con FQ no fue muy alta &#40;7&#44;72&#37;&#41;&#44; quiz&#225; debido a la interferencia de la azitromicina sobre el crecimiento de MA&#46; Hay que vigilar estrechamente a los pacientes con aislamientos repetidos&#46;</p>"
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