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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Thromboprophylaxis with fixed doses of low molecular weight heparin is recommended for hospitalized acutely ill medical patients&#46; The purpose of this study was to assess whether the anti-factor Xa &#40;anti-Xa&#41; activity of enoxaparin prescribed for venous thromboembolism prophylaxis depends on body mass index &#40;BMI&#41; in patients hospitalized for an acute respiratory disease&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">All patients admitted by the respiratory medicine department &#40;January-December 2006&#41; for an acute respiratory disease&#44; and for whom pharmacologic thromboprophylaxis was indicated&#44; were included in the study&#46; Anti-Xa activity was measured 4 hours after administration of enoxaparin on the third day of hospitalization&#46; The primary outcome was anti-Xa activity in relation to BMI&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">One hundred twelve patients were enrolled&#46; Mean anti-Xa activity decreased with each BMI quartile&#40;0&#46;28&#44; 0&#46;23&#44; 0&#46;15 and 0&#46;13 U&#47;mL for quartiles 1&#44; 2&#44; 3&#44; and 4&#44; respectively&#41;&#46; In the multivariate analysis&#44; BMI was the only predictor of inadequate anti-Xa activity &#40;odds ratio&#44; 1&#46;14&#59; 95&#37; confidence interval&#44; 10&#46;5-1&#46;24&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;002&#41; after adjustment for age&#44; sex&#44; and serum creatinine concentration&#46; Two episodes of symptomatic proximal deep vein thrombosis were observed in the month after hospitalization&#59; both were in patients who had inadequate anti-Xa activity&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Anti-Xa activity is dependent on BMI in hospitalized acute medical patients receiving enoxaparin for thromboprophylaxis&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Se recomienda la tromboprofilaxis con heparina de bajo peso molecular a dosis fijas en pacientes m&#233;dicos agudos que requieran ingreso hospitalario&#46; El objetivo de este estudio ha sido determinar si la actividad antifactor Xa de la enoxaparina depende del peso corporal cuando se administra a pacientes hospitalizados por un proceso respiratorio agudo como profilaxis de la enfermedad tromboemb&#243;lica venosa&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; prospectivamente en el estudio a todos los pacientes ingresados en el Servicio de Neumolog&#237;a entre enero y diciembre de 2006 por un proceso respiratorio agudo con indicaci&#243;n de tromboprofilaxis farmacol&#243;gica&#46; Se determin&#243; la actividad anti-Xa 4 h despu&#233;s de la administraci&#243;n de la enoxaparina&#44; en el tercer d&#237;a de ingreso hospitalario&#46; El criterio de evaluaci&#243;n principal fue la actividad anti-Xa en funci&#243;n del &#237;ndice de masa corporal &#40;IMC&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 112 pacientes en el estudio&#46; La actividad anti-Xa media disminuy&#243; a medida que aumentaban los cuartiles de IMC &#40;0&#44;28&#44; 0&#44;23&#44; 0&#44;15 y 0&#44;13 U&#47;ml para los cuartiles 1&#44; 2&#44; 3 y 4&#44; respectivamente&#41;&#46; En el an&#225;lisis multivariable&#44; el IMC fue la &#250;nica variable predictora de actividad anti-Xa insuficiente &#40;<span class="elsevierStyleItalic">odds ratio</span> &#61; 1&#44;14&#59; intervalo de confianza del 95&#37;&#44; 1&#44;05-1&#44;24&#59; p &#60; 0&#44;002&#41;&#44; despu&#233;s de ajustar por la edad&#44; el sexo y la creatinina s&#233;rica&#46; Hubo 2 episodios sintom&#225;ticos de trombosis venosa profunda proximal en el mes posterior al ingreso hospitalario&#44; ambos en pacientes con actividad anti-Xa insuficiente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La actividad anti-Xa de la enoxaparina depende del IMC en los pacientes que reciben tromboprofilaxis por un proceso m&#233;dico agudo que requiera hospitalizaci&#243;n&#46;</p>"
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Original Articles
Anti-factor Xa Activity of Enoxaparin for Thromboprophylaxis in Nonsurgical Patients Is Dependent on Body Mass
David Jiméneza,
Corresponding author
djc_69_98@yahoo.com

Correspondence: Dr D. Jiménez Servicio de Neumología, Hospital Ramón y Cajal Ctra de Colmenar, km 9.100 28034 Madrid, Spain
, Gema Díaza, Ana Iglesiasb, Jesús Césarb, Ángel García-Avellob, David Martíc, Carlos Escobarc, Rafael Vidala, Antonio Sueiroa
a Servicio de Neumología, Hospital Ramón y Cajal, Madrid, Spain
b Servicio de Hematología, Hospital Ramón y Cajal, Madrid, Spain
c Unidad de Ecocardiografía, Servicio de Cardiología, Hospital Ramón y Cajal, Madrid, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Thromboprophylaxis with fixed doses of low molecular weight heparin is recommended for hospitalized acutely ill medical patients&#46; The purpose of this study was to assess whether the anti-factor Xa &#40;anti-Xa&#41; activity of enoxaparin prescribed for venous thromboembolism prophylaxis depends on body mass index &#40;BMI&#41; in patients hospitalized for an acute respiratory disease&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">All patients admitted by the respiratory medicine department &#40;January-December 2006&#41; for an acute respiratory disease&#44; and for whom pharmacologic thromboprophylaxis was indicated&#44; were included in the study&#46; Anti-Xa activity was measured 4 hours after administration of enoxaparin on the third day of hospitalization&#46; The primary outcome was anti-Xa activity in relation to BMI&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">One hundred twelve patients were enrolled&#46; Mean anti-Xa activity decreased with each BMI quartile&#40;0&#46;28&#44; 0&#46;23&#44; 0&#46;15 and 0&#46;13 U&#47;mL for quartiles 1&#44; 2&#44; 3&#44; and 4&#44; respectively&#41;&#46; In the multivariate analysis&#44; BMI was the only predictor of inadequate anti-Xa activity &#40;odds ratio&#44; 1&#46;14&#59; 95&#37; confidence interval&#44; 10&#46;5-1&#46;24&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;002&#41; after adjustment for age&#44; sex&#44; and serum creatinine concentration&#46; Two episodes of symptomatic proximal deep vein thrombosis were observed in the month after hospitalization&#59; both were in patients who had inadequate anti-Xa activity&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Anti-Xa activity is dependent on BMI in hospitalized acute medical patients receiving enoxaparin for thromboprophylaxis&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Se recomienda la tromboprofilaxis con heparina de bajo peso molecular a dosis fijas en pacientes m&#233;dicos agudos que requieran ingreso hospitalario&#46; El objetivo de este estudio ha sido determinar si la actividad antifactor Xa de la enoxaparina depende del peso corporal cuando se administra a pacientes hospitalizados por un proceso respiratorio agudo como profilaxis de la enfermedad tromboemb&#243;lica venosa&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; prospectivamente en el estudio a todos los pacientes ingresados en el Servicio de Neumolog&#237;a entre enero y diciembre de 2006 por un proceso respiratorio agudo con indicaci&#243;n de tromboprofilaxis farmacol&#243;gica&#46; Se determin&#243; la actividad anti-Xa 4 h despu&#233;s de la administraci&#243;n de la enoxaparina&#44; en el tercer d&#237;a de ingreso hospitalario&#46; El criterio de evaluaci&#243;n principal fue la actividad anti-Xa en funci&#243;n del &#237;ndice de masa corporal &#40;IMC&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 112 pacientes en el estudio&#46; La actividad anti-Xa media disminuy&#243; a medida que aumentaban los cuartiles de IMC &#40;0&#44;28&#44; 0&#44;23&#44; 0&#44;15 y 0&#44;13 U&#47;ml para los cuartiles 1&#44; 2&#44; 3 y 4&#44; respectivamente&#41;&#46; En el an&#225;lisis multivariable&#44; el IMC fue la &#250;nica variable predictora de actividad anti-Xa insuficiente &#40;<span class="elsevierStyleItalic">odds ratio</span> &#61; 1&#44;14&#59; intervalo de confianza del 95&#37;&#44; 1&#44;05-1&#44;24&#59; p &#60; 0&#44;002&#41;&#44; despu&#233;s de ajustar por la edad&#44; el sexo y la creatinina s&#233;rica&#46; Hubo 2 episodios sintom&#225;ticos de trombosis venosa profunda proximal en el mes posterior al ingreso hospitalario&#44; ambos en pacientes con actividad anti-Xa insuficiente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La actividad anti-Xa de la enoxaparina depende del IMC en los pacientes que reciben tromboprofilaxis por un proceso m&#233;dico agudo que requiera hospitalizaci&#243;n&#46;</p>"
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ISSN: 15792129
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