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Case Reports
Hypersensitivity Pneumonitis Due to Venlafaxine
Luis Borderías Claua,
Corresponding author
lborderias@separ.es

Correspondence: Dr L. Borderías Clau Sección de Neumología, Hospital General San Jorge Avda. Martínez de Velasco, 36 22004 Huesca, Spain
, Miguel Ángel Marigil Gómezb, Pascual Val Adána, Mariano Marcén Letosaa, Rosa Biescas Lópeza, Francisco Garrapiz Lópeza
a Sección de Neumología, Hospital General San Jorge, Huesca, Spain
b Sección de Anatomía Patológica, Hospital General San Jorge, Huesca, Spain
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Venlafaxine is a selective serotonin&#44; noradrenalin&#44; and dopamine reuptake inhibitor&#46; Although side effects are rare&#44; venlafaxine has very occasionally been associated with hypersensitivity pneumonitis&#46; We report the case of a 61-year-old woman diagnosed with depressive disorder and treated with venlafaxine &#40;Dobupal&#41; at a dose of 150 mg&#47;d for 18 months&#46; When depression worsened&#44; the dose was increased to 255 mg&#47;d&#46; Three weeks later she complained of nonproductive cough&#44; shortness of breath with moderate effort&#44; and asthenia&#46; Clinical and radiologic findings&#44; lung function&#44; bronchoalveolar lavage&#44; and histology of lung biopsies all indicated a diagnosis of hypersensitivity pneumonitis&#46; Other causes were ruled out and venlafaxine was discontinued&#46; Clinical&#44; radiologic&#44; and lung function findings then resolved without the use of corticosteroids or nonsteroid immune modulators&#46; All findings were normal on follow-up after 3 months&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La venlafaxina es un antidepresivo que inhibe de forma selectiva la recaptaci&#243;n de serotonina&#44; noradrenalina y dopamina&#46; Los efectos secundarios son infrecuentes y excepcionalmente se ha asociado a neumonitis por hipersensibilidad&#46; Describimos el caso de una mujer de 61 a&#241;os diagnosticada de s&#237;ndrome depresivo y tratada con Dobupal&#174; &#40;venlafaxina&#41;&#44; a dosis de 150 mg&#47;24 h&#44; desde hac&#237;a 18 meses&#44; que present&#243; un deterioro de su enfermedad&#44; por lo que se increment&#243; la dosis de venlafaxina hasta 225 mg&#47;d&#237;a&#46; Tres semanas despu&#233;s desarroll&#243; s&#237;ntomas de tos no productiva&#44; disnea a esfuerzos moderados y astenia&#46; El cuadro clinicorradiol&#243;gico&#44; los hallazgos en la funci&#243;n pulmonar&#44; el lavado broncoalveolar y la histolog&#237;a de las biopsias pulmonares eran indicativos de neumonitis por hipersensibilidad&#46; Se descartaron otras etiolog&#237;as y se retir&#243; la venlafaxina sin utilizar corticoides ni otros inmunomoduladores&#44; con lo que desaparecieron tanto la cl&#237;nica como los hallazgos radiol&#243;gicos y funcionales&#44; que se normalizaron a los 3 meses&#46;</p>"
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ISSN: 15792129
Original language: English
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