Original Articles
Asthma Incidence in Huelva, Spain at 2 Stages of Life: Childhood and Young Adulthood
Read
4093
Timeswas read the article
1976
Total PDF
2117
Total HTML
Share statistics
array:23 [ "pii" => "S1579212908600841" "issn" => "15792129" "doi" => "10.1016/S1579-2129(08)60084-1" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60084" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:464-70" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2031 "formatos" => array:3 [ "EPUB" => 103 "HTML" => 1249 "PDF" => 679 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212908600853" "issn" => "15792129" "doi" => "10.1016/S1579-2129(08)60085-3" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60085" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:471-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2692 "formatos" => array:3 [ "EPUB" => 104 "HTML" => 1641 "PDF" => 947 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Incidence and Characteristics of Adult-Onset Asthma" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "471" "paginaFinal" => "477" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xavier Casas, Eduard Monsó, Xavier Orpella, Ramona Hervás, Josep Anton González, Elisabeth Arellano, Carlos Martínez, Gerardo Martínez, Àlex Ascosa, Jesús Comín, Rafael Ruiz, Berta Monsó, Irma Casas, Maria Esteve, Josep Morera" "autores" => array:15 [ 0 => array:2 [ "nombre" => "Xavier" "apellidos" => "Casas" ] 1 => array:2 [ "nombre" => "Eduard" "apellidos" => "Monsó" ] 2 => array:2 [ "nombre" => "Xavier" "apellidos" => "Orpella" ] 3 => array:2 [ "nombre" => "Ramona" "apellidos" => "Hervás" ] 4 => array:2 [ "nombre" => "Josep Anton" "apellidos" => "González" ] 5 => array:2 [ "nombre" => "Elisabeth" "apellidos" => "Arellano" ] 6 => array:2 [ "nombre" => "Carlos" "apellidos" => "Martínez" ] 7 => array:2 [ "nombre" => "Gerardo" "apellidos" => "Martínez" ] 8 => array:2 [ "nombre" => "Àlex" "apellidos" => "Ascosa" ] 9 => array:2 [ "nombre" => "Jesús" "apellidos" => "Comín" ] 10 => array:2 [ "nombre" => "Rafael" "apellidos" => "Ruiz" ] 11 => array:2 [ "nombre" => "Berta" "apellidos" => "Monsó" ] 12 => array:2 [ "nombre" => "Irma" "apellidos" => "Casas" ] 13 => array:2 [ "nombre" => "Maria" "apellidos" => "Esteve" ] 14 => array:2 [ "nombre" => "Josep" "apellidos" => "Morera" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600853?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000009/v1_201305150400/S1579212908600853/v1_201305150400/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S157921290860083X" "issn" => "15792129" "doi" => "10.1016/S1579-2129(08)60083-X" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60083" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:459-63" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2309 "formatos" => array:3 [ "EPUB" => 102 "HTML" => 1535 "PDF" => 672 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Perception of Dyspnea and Treatment Adherence in Asthmatic Patients" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "459" "paginaFinal" => "463" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Eva Martínez-Moragón, Miguel Perpiñá, Javier Fullana, Vicente Macián, Amparo Lloris, Amparo Belloch" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Eva" "apellidos" => "Martínez-Moragón" ] 1 => array:2 [ "nombre" => "Miguel" "apellidos" => "Perpiñá" ] 2 => array:2 [ "nombre" => "Javier" "apellidos" => "Fullana" ] 3 => array:2 [ "nombre" => "Vicente" "apellidos" => "Macián" ] 4 => array:2 [ "nombre" => "Amparo" "apellidos" => "Lloris" ] 5 => array:2 [ "nombre" => "Amparo" "apellidos" => "Belloch" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290860083X?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000009/v1_201305150400/S157921290860083X/v1_201305150400/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Asthma Incidence in Huelva, Spain at 2 Stages of Life: Childhood and Young Adulthood" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "464" "paginaFinal" => "470" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Antonio Pereira Vega, José Luis Sánchez Ramos, José Antonio Maldonado Pérez, Inmaculada Sánchez Rodríguez, Francisco Luis Gil Muñoz, Domingo García Jiménez" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Antonio Pereira" "apellidos" => "Vega" "email" => array:1 [ 0 => "apv01h@saludalia.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "José Luis" "apellidos" => "Sánchez Ramos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "José Antonio" "apellidos" => "Maldonado Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Inmaculada" "apellidos" => "Sánchez Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Francisco Luis" "apellidos" => "Gil Muñoz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "Domingo" "apellidos" => "García Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Sección de Neumología, Hospital Juan Ramón Jiménez, Huelva, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Enfermería, Universidad de Huelva, Huelva, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr A. Pereira Vega Puerto, 32, 7.º izqda 21001 Huelva, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-06-06" "fechaAceptado" => "2008-04-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155389" "palabras" => array:4 [ 0 => "Asthma" 1 => "Incidence" 2 => "Age" 3 => "Children and adults" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155388" "palabras" => array:4 [ 0 => "Asma" 1 => "Incidencia" 2 => "Edad" 3 => "Jóvenes y adultos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Few studies have evaluated the incidence of asthma in Spain. Although more children than adults develop asthma every year, no study to date has analyzed the differences in incidence by following 2 age cohorts in the same geographical area. The aim of this study was to determine changes in wheezing, bronchial hyperreactivity, and asthma (in terms of onset, persistence, and remission), changes in forced expiratory volume in 1 second (FEV<span class="elsevierStyleInf">1</span>), and asthma incidence in children (11–16 years) and young adults (20–44 years) in the city of Huelva, Spain.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed data from 2 groups studied for the first time between 1991 and 1993 and for the second time after an average of 9 years. In the first period, data came from the Study of Respiratory Diseases in Huelva (714 children) and the European Community Respiratory Health Survey conducted in the city (271 adults). Both groups answered a respiratory symptom questionnaire, underwent spirometry testing, and completed a nonspecific bronchial challenge test with methacholine.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In adults, onset was more common than remission for both wheezing (15.7% vs 6.9%, <span class="elsevierStyleItalic">P</span>=.011) and bronchial hyperreactivity (10.1% vs 3%, <span class="elsevierStyleItalic">P</span>=.017), and asthma incidence was 4.76 cases/1000 person-years. In children, there were more new cases than remissions for wheezing, (24.2% vs 4.3%, <span class="elsevierStyleItalic">P</span>=.001), bronchial hyperreactivity (13.9% vs 5.4%, <span class="elsevierStyleItalic">P</span>=.02), and asthma (9.3% vs 3%, <span class="elsevierStyleItalic">P</span>=.004). The incidence rate for asthma was 15.69 cases/1000 person-years in this age group. The annual decrease in lung function (FEV<span class="elsevierStyleInf">1</span>) was highest in adults with wheezing (34.3 mL) and asthma (54.8 mL).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">There were more new cases of wheezing and bronchial hyperreactivity than remissions in both children and young adults. Children had a 3.3-fold higher incidence of asthma than adults in Huelva.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Hay pocos estudios que valoren la incidencia de asma en nuestro país. Se sabe que es mayor en niños que en adultos, pero esta diferente incidencia no se ha comprobado mediante el seguimiento de 2 poblaciones de diferente edad en el mismo ámbito geográfico. El propósito de este trabajo ha sido determinar los cambios (aparición, persistencia y remisión) de sibilancias, hiperreactividad bronquial (HB) y asma, la evolución del volumen espiratorio forzado en el primer segundo y la incidencia anual de asma en niños (11–16 años) y adultos jóvenes (20–44 años) en la ciudad de Huelva.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado una segunda evaluación en el seguimiento de 2 grupos estudiados entre 1991 y 1993 (714 niños del Estudio de Enfermedades Respiratorias de Huelva y 271 adultos del Estudio Europeo de Enfermedades Respiratorias), con un promedio de tiempo de 9 años. Se pasó a ambos grupos un cuestionario sobre síntomas respiratorios, además de efectuar una espirometría y una prueba de provocación bronquial inespecífica con metacolina.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En los adultos se encontraron más nuevas apariciones (15,7%) que remisiones (6,9%) de sibilancias (p = 0,011) e HB (apariciones: 10,1%; remisiones: 3%; p = 0,017), con una incidencia anual de asma de 4,76 casos/1.000 personas-año. Los niños mostraron más nuevas apariciones (24,2%) que remisiones (4,3%) de sibilancias (p < 0,001), HB (un 13,9% de apariciones y un 5,4% de remisiones; p = 0,02) y asma (un 9,3% de apariciones y un 3% de remisiones; p = 0,004), con una incidencia anual de asma de 15,69 casos/1.000 personas-año. La pérdida anual de función pulmonar (volumen espiratorio forzado en el primer segundo) fue más elevada en los adultos en los que aparecieron sibilancias (34,3 ml) y asma (54,8 ml).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">En ambas poblaciones, hay más nuevos casos de sibilancias e HB que remisiones. La incidencia anual de asma es 3,3 veces mayor en niños que en adultos en la ciudad de Huelva.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">Study partially funded by Spanish Health Research grants FIS 99/0034 and FIS 99/0350.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The European Community Respiratory Health Survey" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "PGJ Burney" 1 => "C Luczynska" 2 => "S Chinn" 3 => "D Jarvis" 4 => "for the European Community Respiratory Health Survey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1994" "volumen" => "7" "paginaInicial" => "954" "paginaFinal" => "960" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8050554" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steering Committee. The European Community Respiratory Health Survey II" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "European Community Respiratory Health Survey II" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "1071" "paginaFinal" => "1079" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12449157" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Generational increase of selfreported first attack of asthma in fifteen industrialized countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J Sunyer" 1 => "JM Antó" 2 => "A Tobías" 3 => "P Burney" 4 => "for the European Community Respiratory Health Survey (ECRHS)" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1999" "volumen" => "14" "paginaInicial" => "885" "paginaFinal" => "891" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10573237" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of asthma and its determinants among adults in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "X Basagaña" 1 => "J Sunyer" 2 => "JP Zock" 3 => "M Kogevinas" 4 => "I Urrutia" 5 => "JA Maldonado" 6 => "Spanish Working Group of the European Community Respiratory Health Survey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.164.7.2012143" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "164" "paginaInicial" => "1133" "paginaFinal" => "1137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11673198" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El Estudio Europeo de asma. La prevalencia de síntomas relacionados con el asma en 5 regiones de España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Grupo Español del Estudio Europeo de asma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1995" "volumen" => "104" "paginaInicial" => "487" "paginaFinal" => "492" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Función pulmonar y síntomas respiratorios en niños de la ciudad de Huelva" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J Grávalos Guzmán" 1 => "A Pereira Vega" 2 => "JA Maldonado Pérez" 3 => "JL Ramos Sánchez" 4 => "G López Tierra" 5 => "E Pujol de la Llave" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1993" "volumen" => "39" "numero" => "Supl 55" "paginaInicial" => "86" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8291815" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Síntomas respiratorios en población infantil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A Pereira Vega" 1 => "JA Maldonado Pérez" 2 => "JL Sánchez Ramos" 3 => "J Grávalos Guzmán" 4 => "E Pujol de la Llave" 5 => "M Gómez Entrena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1995" "volumen" => "31" "paginaInicial" => "383" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7582428" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factores de riesgo relacionados con síntomas respiratorios, hiperreactividad bronquial y atopia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A Pereira Vega" 1 => "JA Maldonado Pérez" 2 => "JL Sánchez Ramos" 3 => "M Gómez Entrena" 4 => "J Grávalos Guzmán" 5 => "E Pujol de la Llave" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neumosur" "fecha" => "1995" "volumen" => "7" "paginaInicial" => "77" "paginaFinal" => "82" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren (ISAAC phases I and III) in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L García-Marcos" 1 => "AB Quirós" 2 => "GG Hernández" 3 => "F Guillén-Grima" 4 => "CG Díaz" 5 => "IC Urena" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2004.00562.x" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "1301" "paginaFinal" => "1307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio europeo del asma, prevalencia de hiperreactividad bronquial y asma en jóvenes en 5 regiones de España. Grupo Español del Estudio Europeo del Asma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Grupo Español del Estudio Europeo del Asma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1996" "volumen" => "106" "paginaInicial" => "761" "paginaFinal" => "767" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Towards a definition of asthma epidemiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B Toelle" 1 => "J Peat" 2 => "C Salome" 3 => "C Mellis" 4 => "A Woolcock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/146.3.633" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1992" "volumen" => "146" "paginaInicial" => "633" "paginaFinal" => "637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1519839" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuing the debate about measuring asthma in population studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J Peat" 1 => "B Toelle" 2 => "G Marks" 3 => "C Mellis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "406" "paginaFinal" => "411" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11312411" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "KJ Rothman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Epidemiología moderna" "fecha" => "1987" "editorial" => "Díaz de Santos" "editorialLocalizacion" => "Madrid" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in prevalence of asthma and allergies among children and adolescents in Italy: 1994–2002" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C Galassi" 1 => "M De Sario" 2 => "A Biggeri" 3 => "L Bisanti" 4 => "E Chellini" 5 => "G Ciccone" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2004-2709" "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2006" "volumen" => "117" "paginaInicial" => "34" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16396858" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S Chinn" 1 => "D Jarvis" 2 => "P Burney" 3 => "C Luczynska" 4 => "U Ackermann-Liebrich" 5 => "JM Antó" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2004.021642" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "646" "paginaFinal" => "651" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15282382" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective study of asthma incidence and its predictors: the RHINE study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "K Torén" 1 => "T Gislason" 2 => "E Omenaas" 3 => "R Jögi" 4 => "B Forsberg" 5 => "L Nystrom" 6 => "AC Olin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.04.00044804" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2004" "volumen" => "24" "paginaInicial" => "942" "paginaFinal" => "946" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15572536" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of asthma in adults – report from the Obstructive Lung Disease in Northern Sweden Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E Rönmark" 1 => "B Lundbäck" 2 => "E Jönson" 3 => "AC Jobsson" 4 => "M Lindström" 5 => "T Sandström" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1997" "volumen" => "52" "paginaInicial" => "1071" "paginaFinal" => "1078" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9404558" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Work is related to a substantial proportion of adult-onset asthma incidence in the Finnish population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A Karjalainen" 1 => "K Kurppa" 2 => "R Martikainen" 3 => "T Klaukka" 4 => "J Karjalainen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.164.4.2012146" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "164" "paginaInicial" => "565" "paginaFinal" => "568" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11520716" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R de Marco" 1 => "F Locatelli" 2 => "I Cerveri" 3 => "M Bugiani" 4 => "A Marinoni" 5 => "G Giammanco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Allergy Clinical Immunol" "fecha" => "2002" "volumen" => "110" "paginaInicial" => "228" "paginaFinal" => "235" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimating age incidence from survey data with adjustments for recall errors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W Stewart" 1 => "R Brookmeyer" 2 => "M Van Natta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Epidemiol" "fecha" => "1989" "volumen" => "42" "paginaInicial" => "869" "paginaFinal" => "875" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2789270" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breathing better or wheezing worse? The changing epidemiology of asthma morbility and mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "KB Weiss" 1 => "PJ Gergen" 2 => "DK Wagener" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Annu Rev Pub Health" "fecha" => "1993" "volumen" => "14" "paginaInicial" => "491" "paginaFinal" => "513" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The incidence of asthma in young adults" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "SF Thomsen" 1 => "CS Ulrik" 2 => "KO Kyvik" 3 => "K Larsen" 4 => "LR Skadhauge" 5 => "I Steffensen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.6.1928" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "1928" "paginaFinal" => "1934" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947304" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Smoking in the incidence of asthma during adolescence: results of a large cohort study in Germany" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Genuneit" 1 => "G Weinmayr" 2 => "K Radon" 3 => "H Dressel" 4 => "D Windstetter" 5 => "P Rzehak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "19" "paginaInicial" => "1040" "paginaFinal" => "1046" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12108854" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004400000009/v1_201305150400/S1579212908600841/v1_201305150400/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000009/v1_201305150400/S1579212908600841/v1_201305150400/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600841?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 4 | 7 |
| 2024 October | 33 | 23 | 56 |
| 2024 September | 31 | 20 | 51 |
| 2024 August | 47 | 31 | 78 |
| 2024 July | 25 | 29 | 54 |
| 2024 June | 37 | 30 | 67 |
| 2024 May | 39 | 36 | 75 |
| 2024 April | 13 | 25 | 38 |
| 2024 March | 19 | 14 | 33 |
| 2024 February | 18 | 16 | 34 |
| 2023 March | 1 | 3 | 4 |
| 2023 February | 12 | 18 | 30 |
| 2023 January | 16 | 26 | 42 |
| 2022 December | 16 | 25 | 41 |
| 2022 November | 16 | 22 | 38 |
| 2022 October | 20 | 30 | 50 |
| 2022 September | 15 | 28 | 43 |
| 2022 August | 17 | 40 | 57 |
| 2022 July | 19 | 44 | 63 |
| 2022 June | 13 | 30 | 43 |
| 2022 May | 15 | 28 | 43 |
| 2022 April | 18 | 28 | 46 |
| 2022 March | 18 | 43 | 61 |
| 2022 February | 18 | 35 | 53 |
| 2022 January | 14 | 40 | 54 |
| 2021 December | 22 | 70 | 92 |
| 2021 November | 16 | 53 | 69 |
| 2021 October | 57 | 52 | 109 |
| 2021 September | 32 | 63 | 95 |
| 2021 August | 22 | 32 | 54 |
| 2021 July | 14 | 32 | 46 |
| 2021 June | 10 | 32 | 42 |
| 2021 May | 9 | 30 | 39 |
| 2021 April | 20 | 74 | 94 |
| 2021 March | 19 | 26 | 45 |
| 2021 February | 15 | 20 | 35 |
| 2021 January | 12 | 16 | 28 |
| 2020 December | 17 | 18 | 35 |
| 2020 November | 21 | 18 | 39 |
| 2020 October | 11 | 8 | 19 |
| 2020 September | 4 | 4 | 8 |
| 2020 August | 12 | 14 | 26 |
| 2020 July | 10 | 13 | 23 |
| 2020 June | 6 | 4 | 10 |
| 2020 May | 11 | 17 | 28 |
| 2020 April | 14 | 18 | 32 |
| 2020 March | 14 | 10 | 24 |
| 2020 February | 17 | 16 | 33 |
| 2020 January | 5 | 21 | 26 |
| 2019 December | 18 | 19 | 37 |
| 2019 November | 9 | 13 | 22 |
| 2019 October | 11 | 7 | 18 |
| 2019 September | 12 | 15 | 27 |
| 2019 August | 18 | 24 | 42 |
| 2019 July | 15 | 18 | 33 |
| 2019 June | 7 | 10 | 17 |
| 2019 May | 14 | 15 | 29 |
| 2019 April | 13 | 47 | 60 |
| 2019 March | 7 | 14 | 21 |
| 2019 February | 14 | 11 | 25 |
| 2019 January | 3 | 12 | 15 |
| 2018 December | 7 | 10 | 17 |
| 2018 November | 25 | 20 | 45 |
| 2018 October | 29 | 17 | 46 |
| 2018 September | 12 | 8 | 20 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 8 | 6 | 14 |
| 2018 March | 4 | 3 | 7 |
| 2018 February | 6 | 6 | 12 |
| 2018 January | 5 | 3 | 8 |
| 2017 December | 3 | 7 | 10 |
| 2017 November | 3 | 4 | 7 |
| 2017 October | 6 | 14 | 20 |
| 2017 September | 6 | 15 | 21 |
| 2017 August | 6 | 11 | 17 |
| 2017 July | 7 | 10 | 17 |
| 2017 June | 6 | 18 | 24 |
| 2017 May | 4 | 8 | 12 |
| 2017 April | 5 | 9 | 14 |
| 2017 March | 4 | 2 | 6 |
| 2017 February | 2 | 6 | 8 |
| 2017 January | 3 | 4 | 7 |
| 2016 December | 7 | 6 | 13 |
| 2016 November | 10 | 5 | 15 |
| 2016 October | 10 | 10 | 20 |
| 2016 September | 16 | 13 | 29 |
| 2016 August | 12 | 4 | 16 |
| 2016 July | 8 | 6 | 14 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 29 | 8 | 37 |
| 2015 September | 25 | 4 | 29 |
| 2015 August | 24 | 9 | 33 |
| 2015 July | 21 | 6 | 27 |
| 2015 June | 24 | 3 | 27 |
| 2015 May | 45 | 4 | 49 |
| 2015 April | 28 | 7 | 35 |
| 2015 March | 28 | 4 | 32 |
| 2015 February | 30 | 3 | 33 |
| 2015 January | 17 | 6 | 23 |
| 2014 December | 14 | 5 | 19 |
| 2014 November | 16 | 3 | 19 |
| 2014 October | 24 | 6 | 30 |
| 2014 September | 17 | 4 | 21 |
| 2014 August | 21 | 10 | 31 |
| 2014 July | 16 | 5 | 21 |
| 2014 June | 36 | 10 | 46 |
| 2014 May | 26 | 9 | 35 |
| 2014 April | 34 | 2 | 36 |
| 2014 March | 34 | 11 | 45 |
| 2014 February | 36 | 9 | 45 |
| 2014 January | 33 | 5 | 38 |
| 2013 December | 29 | 10 | 39 |
| 2013 November | 24 | 10 | 34 |
| 2013 October | 26 | 10 | 36 |
| 2013 September | 32 | 11 | 43 |
| 2013 August | 27 | 6 | 33 |
| 2013 July | 50 | 13 | 63 |
| 2013 June | 36 | 7 | 43 |
| 2013 May | 47 | 8 | 55 |
| 2013 April | 12 | 8 | 20 |
| 2013 March | 9 | 1 | 10 |
Show all
