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Silent Heart Disease in Patients With Sleep Apnea-Hypopnea Syndrome: Usefulness of the Myocardial Performance Index
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Moro, Luis Almenar, Estrella Fernández-Fabrellas, Silvia Ponce, Rafael Blanquer, Antonio Salvador" "autores" => array:6 [ 0 => array:4 [ "nombre" => "José A." "apellidos" => "Moro" "email" => array:1 [ 0 => "moro@uv.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Luis" "apellidos" => "Almenar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Estrella" "apellidos" => "Fernández-Fabrellas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "Silvia" "apellidos" => "Ponce" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Rafael" "apellidos" => "Blanquer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 5 => array:3 [ "nombre" => "Antonio" "apellidos" => "Salvador" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Fundación para la Investigación, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Unidad de Insuficiencia Cardíaca y Trasplante, Servicio de Cardiología, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Dr. Peset, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr J. A. Moro Enebro, 4, puerta 5 46980 Paterna, Valencia, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-06-19" "fechaAceptado" => "2007-09-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155345" "palabras" => array:4 [ 0 => "Sleep apnea−hypopnea syndrome" 1 => "Doppler echocardiography" 2 => "Hypertrophy" 3 => "Left ventricular dysfunction" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155346" "palabras" => array:4 [ 0 => "Síndrome de apneas-hipopneas durante el sueño" 1 => "Ecocardiografía Doppler" 2 => "Hipertrofia" 3 => "Disfunción ventricular izquierda" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Sleep apnea-hypopnea syndrome (SAHS) is an emerging disease with considerable cardiovascular impact. The myocardial performance index (MPI) is an echocardiographic parameter that is useful in the assessment of global myocardial function. The purpose of this study was to identify any differences in the MPI between patients with and without SAHS.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 120 consecutive patients referred to our department for suspected SAHS. Following the overnight sleep study and after excluding all patients with hypertension, heart disease, or invalid recordings, 54 patients with SAHS and 13 patients without the disease matched for age and body mass were analyzed. A blinded cardiologist performed Doppler echocardiography, measuring parameters related to ventricular hypertrophy, systolic function, diastolic function, and the MPI. The data were compared by χ<span class="elsevierStyleSup">2</span> and analysis of variance.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Mean (SD) ventricular mass was greater in patients with SAHS (183.17 [40.5] g) than in those without that diagnosis (149 [26] g) (<span class="elsevierStyleItalic">P</span>=.005). No differences were observed in systolic function (78.5% [8.95%] vs 81.6% [7%]) (<span class="elsevierStyleItalic">P</span>=.2), although a higher percentage of patients with SAHS had abnormal diastolic function (71.2% vs 38.5%) (<span class="elsevierStyleItalic">P</span>=.049). The MPI was significantly higher in SAHS patients (0.54 [0.12] vs 0.46 [0.07]) (<span class="elsevierStyleItalic">P</span>=.028).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">On its own, SAHS leads to left ventricular hypertrophy. Diastolic involvement is common in these patients, although a large number of healthy individuals who are obese also present it. The MPI is higher in SAHS and could be a useful parameter to identify patients with silent heart disease before it progresses.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El síndrome de apneas-hipopneas durante el sueño (SAHS) es una enfermedad emergente con importante repercusión cardiovascular. El índice de rendimiento miocárdico (IRM) es un parámetro ecocardiográfico útil en la valoración de la función miocárdica global. El objetivo del estudio ha sido analizar si hay diferencias en el IRM entre pacientes con SAHS y un grupo control.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado a 120 pacientes consecutivos remitidos por sospecha de SAHS a nuestra unidad. Una vez realizado el estudio nocturno y excluidos los hipertensos, cardiópatas o registros inadecuados, analizamos a 54 pacientes y 13 controles de similar edad e índice de masa corporal. Un cardiólogo que desconocía la asignación les realizó un ecocardiograma Doppler. Se midieron parámetros de hipertrofia ventricular, función sistólica, función diastólica y el IRM. Los datos se compararon mediante el test de la χ<span class="elsevierStyleSup">2</span> y ANOVA.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes con SAHS presentaron mayor masa ventricular que el grupo control (media ± desviación estándar: 183,17 ± 40,5 frente a 149 ± 26 g; p = 0,005). No se apreciaron diferencias entre ambos grupos en la función sistólica (un 78,5 ± 8,95 frente al 81,6 ± 7%; p = 0,2), pero un mayor porcentaje de pacientes con SAHS tenía alterada la función diastólica (un 71,2 frente al 38,5%; p = 0,049). El IRM fue significativamente mayor en el grupo con SAHS (0,54 ± 0,12 frente a 0,46 ± 0,07; p = 0,028).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El SAHS por sí mismo produce hipertrofia ventricular izquierda. La afectación diastólica es importante en este grupo, pero también la presenta un número importante de personas sanas con obesidad. El IRM está incrementado en el SAHS y podría ser útil para identificar a los pacientes con disfunción miocárdica silente antes de su progresión.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The occurrence of sleep-disordered breathing among middle-aged adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T Young" 1 => "M Palta" 2 => "J Dempsey" 3 => "J Skatrud" 4 => "S Weber" 5 => "S Badr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199304293281704" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1993" "volumen" => "328" "paginaInicial" => "1230" "paginaFinal" => "1235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8464434" 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 1 | 4 |
| 2024 October | 29 | 14 | 43 |
| 2024 September | 31 | 9 | 40 |
| 2024 August | 36 | 29 | 65 |
| 2024 July | 27 | 24 | 51 |
| 2024 June | 36 | 25 | 61 |
| 2024 May | 35 | 27 | 62 |
| 2024 April | 24 | 25 | 49 |
| 2024 March | 19 | 19 | 38 |
| 2024 February | 16 | 20 | 36 |
| 2023 March | 1 | 5 | 6 |
| 2023 February | 19 | 20 | 39 |
| 2023 January | 27 | 25 | 52 |
| 2022 December | 20 | 29 | 49 |
| 2022 November | 18 | 24 | 42 |
| 2022 October | 32 | 30 | 62 |
| 2022 September | 18 | 25 | 43 |
| 2022 August | 18 | 42 | 60 |
| 2022 July | 27 | 45 | 72 |
| 2022 June | 21 | 32 | 53 |
| 2022 May | 15 | 33 | 48 |
| 2022 April | 21 | 29 | 50 |
| 2022 March | 26 | 38 | 64 |
| 2022 February | 16 | 26 | 42 |
| 2022 January | 25 | 34 | 59 |
| 2021 December | 22 | 47 | 69 |
| 2021 November | 24 | 46 | 70 |
| 2021 October | 28 | 49 | 77 |
| 2021 September | 17 | 59 | 76 |
| 2021 August | 12 | 31 | 43 |
| 2021 July | 16 | 29 | 45 |
| 2021 June | 18 | 41 | 59 |
| 2021 May | 21 | 28 | 49 |
| 2021 April | 47 | 63 | 110 |
| 2021 March | 34 | 27 | 61 |
| 2021 February | 15 | 22 | 37 |
| 2021 January | 15 | 12 | 27 |
| 2020 December | 17 | 29 | 46 |
| 2020 November | 12 | 11 | 23 |
| 2020 October | 14 | 12 | 26 |
| 2020 September | 8 | 7 | 15 |
| 2020 August | 12 | 15 | 27 |
| 2020 July | 12 | 21 | 33 |
| 2020 June | 10 | 10 | 20 |
| 2020 May | 12 | 12 | 24 |
| 2020 April | 26 | 22 | 48 |
| 2020 March | 27 | 15 | 42 |
| 2020 February | 23 | 18 | 41 |
| 2020 January | 18 | 15 | 33 |
| 2019 December | 22 | 16 | 38 |
| 2019 November | 17 | 13 | 30 |
| 2019 October | 6 | 6 | 12 |
| 2019 September | 9 | 11 | 20 |
| 2019 August | 19 | 13 | 32 |
| 2019 July | 18 | 18 | 36 |
| 2019 June | 16 | 7 | 23 |
| 2019 May | 10 | 7 | 17 |
| 2019 April | 39 | 11 | 50 |
| 2019 March | 11 | 14 | 25 |
| 2019 February | 13 | 15 | 28 |
| 2019 January | 10 | 15 | 25 |
| 2018 December | 8 | 15 | 23 |
| 2018 November | 22 | 18 | 40 |
| 2018 October | 14 | 11 | 25 |
| 2018 September | 15 | 7 | 22 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 6 | 6 | 12 |
| 2018 March | 16 | 2 | 18 |
| 2018 February | 5 | 6 | 11 |
| 2018 January | 10 | 8 | 18 |
| 2017 December | 8 | 5 | 13 |
| 2017 November | 8 | 2 | 10 |
| 2017 October | 7 | 8 | 15 |
| 2017 September | 3 | 9 | 12 |
| 2017 August | 5 | 5 | 10 |
| 2017 July | 11 | 8 | 19 |
| 2017 June | 10 | 6 | 16 |
| 2017 May | 6 | 5 | 11 |
| 2017 April | 2 | 3 | 5 |
| 2017 March | 9 | 6 | 15 |
| 2017 February | 5 | 6 | 11 |
| 2017 January | 4 | 5 | 9 |
| 2016 December | 7 | 9 | 16 |
| 2016 November | 11 | 4 | 15 |
| 2016 October | 21 | 17 | 38 |
| 2016 September | 11 | 10 | 21 |
| 2016 August | 16 | 3 | 19 |
| 2016 July | 16 | 3 | 19 |
| 2016 March | 4 | 0 | 4 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 59 | 12 | 71 |
| 2015 September | 74 | 12 | 86 |
| 2015 August | 42 | 8 | 50 |
| 2015 July | 70 | 6 | 76 |
| 2015 June | 44 | 2 | 46 |
| 2015 May | 76 | 6 | 82 |
| 2015 April | 55 | 7 | 62 |
| 2015 March | 49 | 6 | 55 |
| 2015 February | 39 | 4 | 43 |
| 2015 January | 49 | 4 | 53 |
| 2014 December | 41 | 7 | 48 |
| 2014 November | 73 | 7 | 80 |
| 2014 October | 83 | 15 | 98 |
| 2014 September | 60 | 6 | 66 |
| 2014 August | 47 | 14 | 61 |
| 2014 July | 62 | 9 | 71 |
| 2014 June | 71 | 10 | 81 |
| 2014 May | 60 | 7 | 67 |
| 2014 April | 63 | 5 | 68 |
| 2014 March | 77 | 8 | 85 |
| 2014 February | 73 | 8 | 81 |
| 2014 January | 63 | 9 | 72 |
| 2013 December | 63 | 10 | 73 |
| 2013 November | 46 | 3 | 49 |
| 2013 October | 41 | 7 | 48 |
| 2013 September | 48 | 9 | 57 |
| 2013 August | 52 | 8 | 60 |
| 2013 July | 72 | 18 | 90 |
| 2013 June | 51 | 10 | 61 |
| 2013 May | 47 | 6 | 53 |
| 2013 April | 46 | 4 | 50 |
| 2013 March | 12 | 2 | 14 |
Show all
