Case Reports
Organizing Pneumonia Associated With the Use of Pegylated Interferon Alfa
Joan-Carles Trullas Vila
, Demetrio-Roberto Padilla López, Vicenta Bisbe Company, Silvia Soler Simón, Pere Cortés Hausmann, Josep Bisbe Company
Corresponding author
jctrullas@hospiolot.com
Correspondence: Dr J.C. Trullas Vila Servei de Medicina Interna, Hospital Sant Jaume Mulleras, 15 17800 Olot, Girona, Spain
Correspondence: Dr J.C. Trullas Vila Servei de Medicina Interna, Hospital Sant Jaume Mulleras, 15 17800 Olot, Girona, Spain
Servicio de Medicina Interna, Hospital Sant Jaume, Olot, Girona, Spain
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] ] 1 => array:2 [ "nombre" => "Demetrio-Roberto" "apellidos" => "Padilla López" ] 2 => array:2 [ "nombre" => "Vicenta Bisbe" "apellidos" => "Company" ] 3 => array:2 [ "nombre" => "Silvia Soler" "apellidos" => "Simón" ] 4 => array:2 [ "nombre" => "Pere Cortés" "apellidos" => "Hausmann" ] 5 => array:1 [ "apellidos" => "Josep Bisbe Company" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Medicina Interna, Hospital Sant Jaume, Olot, Girona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr J.C. Trullas Vila Servei de Medicina Interna, Hospital Sant Jaume Mulleras, 15 17800 Olot, Girona, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-04-13" "fechaAceptado" => "2007-04-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155203" "palabras" => array:3 [ 0 => "Organizing pneumonia" 1 => "Interferon alfa-2b" 2 => "Hepatitis C" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155202" "palabras" => array:3 [ 0 => "Neumonía organizada" 1 => "Interferón α-2b" 2 => "Hepatitis C" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Organizing pneumonia is a well-differentiated clinical and histologic entity whose onset is usually subacute with respiratory symptoms and pulmonary infiltrates. Its origin may be unknown (cryptogenic) or it may be associated with various medical conditions, infectious diseases, or drugs. Diagnosis is confirmed by the presence of foci of organizing pneumonia in lung biopsy specimens. Our patient was a 49-year-old man infected with the hepatitis C virus who was receiving pegylated interferon alfa-2b. He presented with dry cough, fever, dyspnea, and ground glass pulmonary infiltrates. After an open lung biopsy, he was diagnosed with organizing pneumonia. When pegylated interferon was discontinued and corticosteroids started, the symptoms and pulmonary infiltrates disappeared. To our knowledge, this is the second report of organizing pneumonia related to pegylated interferon alfa-2b.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La neumonía organizada es una entidad clínico-histológica bien diferenciada, que suele presentarse de forma subaguda con síntomas respiratorios e infiltrados pulmonares. Puede ser de causa desconocida (criptogenética) o estar asociada a distintas enfermedades, infecciones o fármacos. El diagnóstico de seguridad requiere la demostración de focos de neumonía organizada en muestras de biopsia pulmonar. Presentamos el caso de un paciente de 49 años con infección por el virus de la hepatitis C en tratamiento con peginterferón α-2b que desarrolló un cuadro de tos seca, fiebre, disnea e infiltrados pulmonares en vidrio deslustrado, y a quien se diagnosticó por biopsia pulmonar abierta de neumonía organizada. Con la retirada del peginterferón y tratamiento con corticoides desaparecieron los síntomas y los infiltrados pulmonares. En nuestro conocimiento, éste es el segundo caso comunicado de neumonía organizada en relación con peginterferón α-2b.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnóstico y tratamiento de las enfermedades pulmonares intersticiales difusas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A Xaubet" 1 => "J Ancochea" 2 => "R Blanquer" 3 => "C Montero" 4 => "F Morell" 5 => "E Rodríguez Becerra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2003" "volumen" => "39" "paginaInicial" => "580" "paginaFinal" => "600" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14636495" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pneumotox" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P Foucher" 1 => "PH Camus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "http://www.pneumotox.com" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interferon-related bronchiolitis obliterans organizing pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K Ogata" 1 => "T Koga" 2 => "K Yagawa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1994" "volumen" => "106" "paginaInicial" => "612" "paginaFinal" => "613" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7774350" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Thoracic Society" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.165.2.ats01" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "165" "paginaInicial" => "277" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11790668" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced infiltrative lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "PH Camus" 1 => "P Foucher" 2 => "PH Bonniaud" 3 => "K Ask" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J Suppl" "fecha" => "2001" "volumen" => "32" "paginaInicial" => "93S" "paginaFinal" => "100S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11816828" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "MW Fried" 1 => "ML Shiffman" 2 => "KR Reddy" 3 => "C Smith" 4 => "G Marinos" 5 => "FL Goncales Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa020047" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2002" "volumen" => "347" "paginaInicial" => "975" "paginaFinal" => "982" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12324553" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis tras tratamiento con interferón y ribavirina. 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