Correspondence: Dr H. Píriz. Facultad de Medicina, Hospital de Clínicas Avda. Italia, s/n, piso 15 11600 Montevideo, Uruguay
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Martínez Francés, Miguel Perpiñá Tordera, Amparo Belloch Fuster, Eva M. Martínez Moragón, Luis Compte Torrero" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Manuela E." "apellidos" => "Martínez Francés" ] 1 => array:2 [ "nombre" => "Miguel Perpiñá" "apellidos" => "Tordera" ] 2 => array:2 [ "nombre" => "Amparo Belloch" "apellidos" => "Fuster" ] 3 => array:2 [ "nombre" => "Eva M." "apellidos" => "Martínez Moragón" ] 4 => array:2 [ "nombre" => "Luis Compte" "apellidos" => "Torrero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600269?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000003/v1_201305150345/S1579212908600269/v1_201305150345/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Salbutamol Improves Diaphragm Force Generation in Experimental Sepsis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "135" "paginaFinal" => "139" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Héctor Píriz, Nicolás Nin, José Boggia, Martín Angulo, Francisco Javier Hurtado" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Héctor" "apellidos" => "Píriz" "email" => array:1 [ 0 => "hpiriz@hc.edu.uy" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Nicolás" "apellidos" => "Nin" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Boggia" ] 3 => array:2 [ "nombre" => "Martín" "apellidos" => "Angulo" ] 4 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "Hurtado" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Fisiopatología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr H. Píriz. Facultad de Medicina, Hospital de Clínicas Avda. Italia, s/n, piso 15 11600 Montevideo, Uruguay" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-02-06" "fechaAceptado" => "2007-09-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155183" "palabras" => array:4 [ 0 => "Respiratory muscles" 1 => "Sepsis" 2 => "Diaphragmatic dysfunction" 3 => "β<span class="elsevierStyleInf">2</span>-adrenergic drugs" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155182" "palabras" => array:4 [ 0 => "Músculos respiratorios" 1 => "Sepsis" 2 => "Disfunción diafragmática" 3 => "Adrenérgicos β<span class="elsevierStyleInf">2</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">In a high percentage of cases, severe sepsis is accompanied by acute respiratory failure, in which weakness of the respiratory muscles plays an important role. Weakened respiratory muscles that are subjected to an increased mechanical load may develop muscle fatigue, with exacerbation of the respiratory failure. Because β<span class="elsevierStyleInf">2</span>-adrenergic drugs increase muscle contraction force, they may play a role in preventing and managing respiratory failure in septic patients. Our aim was to study the effects of salbutamol on diaphragm function in an animal model of peritoneal sepsis.</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 3 groups of animals: <span class="elsevierStyleItalic">a)</span> a control group (n=7), in which the animals underwent a median laparotomy without visceral manipulation; <span class="elsevierStyleItalic">b)</span> a septic group (n=10), in which peritoneal sepsis was induced by cecal ligation and puncture (CLP); and <span class="elsevierStyleItalic">c)</span> a salbutamol group (n=7), in which peritoneal sepsis (CLP) was treated with salbutamol. Hemodynamic parameters and blood gases were measured in vivo. Diaphragm function was evaluated in vitro.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Salbutamol increased aortic blood flow and heart rate while it reduced mean arterial pressure in the animals with peritoneal sepsis (<span class="elsevierStyleItalic">P</span><.05). Sepsis produced a significant drop in diaphragmatic force both before and after the application of a muscle-fatigue protocol. Treatment with salbutamol improved muscle contraction force before and after application of the protocol (<span class="elsevierStyleItalic">P</span><.05).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The use of β<span class="elsevierStyleInf">2</span>-adrenergic drugs such as salbutamol improves diaphragm function in experimental sepsis. The mechanisms that produce this improvement require further study.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La sepsis grave se acompaña en un alto porcentaje de casos de insuficiencia respiratoria aguda, donde la debilidad de los músculos respiratorios desempeña un papel importante. Los músculos respiratorios debilitados y sometidos a una carga mecánica aumentada pueden evolucionar a fatiga muscular con agravamiento de la insuficiencia respiratoria. Los fármacos adrenérgicos β<span class="elsevierStyleInf">2</span>, al mejorar la fuerza de contracción muscular, podrían ser de utilidad en la prevención y el manejo de la insuficiencia respiratoria de pacientes con sepsis. El objetivo de este trabajo ha sido estudiar los efectos del salbutamol en la función diafragmática en un modelo animal de sepsis peritoneal.</p> <span class="elsevierStyleSectionTitle">Material y Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 3 grupos de animales: <span class="elsevierStyleItalic">a)</span> grupo control (n = 7), al que se realizó laparotomía mediana sin abordaje visceral;<span class="elsevierStyleItalic">b)</span> grupo sepsis (n = 10), al que se indujo sepsis peritoneal por ligadura y punción cecal (LPC), y <span class="elsevierStyleItalic">c)</span> grupo salbutamol (n = 7), en el que la sepsis peritoneal se trató con salbutamol (LPC + salbutamol). Los parámetros hemodinámicos y los gases sanguíneos se midieron in vivo. La función diafragmática se evaluó in vitro.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El salbutamol aumentó el flujo aórtico y la frecuencia cardíaca a la vez que disminuyó la presión arterial media en la sepsis peritoneal (p < 0,05). La sepsis determinó una caída significativa de la fuerza diafragmática tanto antes como después de un protocolo de fatiga muscular. El tratamiento con salbutamol mejoró la fuerza de contracción muscular en ambos casos (p < 0,05).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El uso de agentes adrenérgicos β<span class="elsevierStyleInf">2</span> como el salbutamol mejora la función diafragmática durante la sepsis experimental. 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Year/Month | Html | Total | |
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2024 November | 5 | 5 | 10 |
2024 October | 36 | 16 | 52 |
2024 September | 40 | 11 | 51 |
2024 August | 51 | 30 | 81 |
2024 July | 25 | 22 | 47 |
2024 June | 43 | 31 | 74 |
2024 May | 41 | 28 | 69 |
2024 April | 24 | 22 | 46 |
2024 March | 21 | 15 | 36 |
2024 February | 20 | 21 | 41 |
2023 March | 0 | 2 | 2 |
2023 February | 25 | 15 | 40 |
2023 January | 29 | 36 | 65 |
2022 December | 35 | 26 | 61 |
2022 November | 19 | 24 | 43 |
2022 October | 25 | 34 | 59 |
2022 September | 16 | 23 | 39 |
2022 August | 21 | 36 | 57 |
2022 July | 30 | 43 | 73 |
2022 June | 12 | 37 | 49 |
2022 May | 22 | 39 | 61 |
2022 April | 18 | 37 | 55 |
2022 March | 19 | 32 | 51 |
2022 February | 18 | 29 | 47 |
2022 January | 21 | 36 | 57 |
2021 December | 15 | 48 | 63 |
2021 November | 20 | 44 | 64 |
2021 October | 20 | 41 | 61 |
2021 September | 19 | 57 | 76 |
2021 August | 13 | 34 | 47 |
2021 July | 23 | 34 | 57 |
2021 June | 16 | 41 | 57 |
2021 May | 22 | 22 | 44 |
2021 April | 56 | 48 | 104 |
2021 March | 64 | 31 | 95 |
2021 February | 11 | 10 | 21 |
2021 January | 17 | 13 | 30 |
2020 December | 12 | 10 | 22 |
2020 November | 14 | 14 | 28 |
2020 October | 14 | 3 | 17 |
2020 September | 12 | 3 | 15 |
2020 August | 23 | 12 | 35 |
2020 July | 20 | 14 | 34 |
2020 June | 13 | 5 | 18 |
2020 May | 12 | 15 | 27 |
2020 April | 27 | 18 | 45 |
2020 March | 16 | 8 | 24 |
2020 February | 24 | 20 | 44 |
2020 January | 12 | 14 | 26 |
2019 December | 32 | 13 | 45 |
2019 November | 15 | 8 | 23 |
2019 October | 11 | 8 | 19 |
2019 September | 6 | 14 | 20 |
2019 August | 17 | 8 | 25 |
2019 July | 15 | 14 | 29 |
2019 June | 6 | 9 | 15 |
2019 May | 14 | 7 | 21 |
2019 April | 15 | 47 | 62 |
2019 March | 10 | 15 | 25 |
2019 February | 9 | 8 | 17 |
2019 January | 9 | 6 | 15 |
2018 December | 16 | 15 | 31 |
2018 November | 14 | 7 | 21 |
2018 October | 16 | 12 | 28 |
2018 September | 14 | 16 | 30 |
2018 May | 5 | 1 | 6 |
2018 April | 8 | 6 | 14 |
2018 March | 4 | 3 | 7 |
2018 February | 10 | 6 | 16 |
2018 January | 6 | 9 | 15 |
2017 December | 7 | 8 | 15 |
2017 November | 5 | 4 | 9 |
2017 October | 5 | 9 | 14 |
2017 September | 1 | 9 | 10 |
2017 August | 10 | 8 | 18 |
2017 July | 14 | 8 | 22 |
2017 June | 10 | 17 | 27 |
2017 May | 6 | 4 | 10 |
2017 April | 5 | 8 | 13 |
2017 March | 3 | 9 | 12 |
2017 February | 4 | 3 | 7 |
2017 January | 2 | 3 | 5 |
2016 December | 8 | 7 | 15 |
2016 November | 10 | 8 | 18 |
2016 October | 14 | 7 | 21 |
2016 September | 14 | 7 | 21 |
2016 August | 13 | 4 | 17 |
2016 July | 14 | 3 | 17 |
2016 March | 2 | 0 | 2 |
2015 December | 2 | 0 | 2 |
2015 October | 30 | 7 | 37 |
2015 September | 34 | 3 | 37 |
2015 August | 37 | 10 | 47 |
2015 July | 37 | 5 | 42 |
2015 June | 31 | 3 | 34 |
2015 May | 39 | 10 | 49 |
2015 April | 36 | 8 | 44 |
2015 March | 29 | 5 | 34 |
2015 February | 29 | 4 | 33 |
2015 January | 32 | 7 | 39 |
2014 December | 38 | 4 | 42 |
2014 November | 34 | 8 | 42 |
2014 October | 52 | 11 | 63 |
2014 September | 33 | 12 | 45 |
2014 August | 29 | 12 | 41 |
2014 July | 27 | 10 | 37 |
2014 June | 40 | 13 | 53 |
2014 May | 58 | 14 | 72 |
2014 April | 49 | 9 | 58 |
2014 March | 52 | 13 | 65 |
2014 February | 52 | 11 | 63 |
2014 January | 44 | 5 | 49 |
2013 December | 35 | 13 | 48 |
2013 November | 39 | 11 | 50 |
2013 October | 39 | 18 | 57 |
2013 September | 41 | 14 | 55 |
2013 August | 45 | 15 | 60 |
2013 July | 57 | 16 | 73 |
2013 June | 36 | 14 | 50 |
2013 May | 31 | 12 | 43 |
2013 April | 23 | 6 | 29 |
2013 March | 9 | 3 | 12 |