Case Reports
Isolation of Nocardia Species in Patients With Cystic Fibrosis
M. Isabel Barrioa,
, M. Carmen Martíneza, Concepción Pradosb, Rosa M. Girónc, Luis Maizd, M. Teresa Martíneze, the Cystic Fibrosis Group of the Society of Pulmonology and Thoracic Surgery of Madrid (Neumomadrid)
Corresponding author
mbarrio.hulp@salud.madrid.org
Correspondence: Dra MI Barrio Sección de Neumología Pediátrica, Hospital Infantil La PazP.º de la Castellana, 261 28046 Madrid, Spain
Correspondence: Dra MI Barrio Sección de Neumología Pediátrica, Hospital Infantil La PazP.º de la Castellana, 261 28046 Madrid, Spain
a Sección de Neumología Pediátrica, Hospital Universitario La Paz, Madrid, Spain
b Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain
c Servicio de Neumología, Hospital Universitario de la Princesa, Madrid, Spain
d Servicio de Neumología, Hospital Ramón y Cajal, Madrid, Spain
e Servicio de Neumología, Hospital 12 de Octubre, Madrid, Spain
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From the sputum culture of a total of 387 patients with cystic fibrosis, <span class="elsevierStyleItalic">Nocardia</span> species was isolated in 9 cases (2%; 8 females and 1 male) with a mean (SD) age of 17 (7) years. Sixty-seven percent of the patients were asymptomatic and no relevant radiographic or analytical changes were detected. In only 3 patients was <span class="elsevierStyleItalic">Nocardia</span> species isolated again in successive samples. Two patients were not treated, 7 were treated with cotrimoxazole and 3 with minocycline; in 2 cases therapy was intravenous. After a mean follow-up of 48 (33) months, all patients had improved. Isolation of <span class="elsevierStyleItalic">Nocardia</span> species from the secretions of patients with cystic fibrosis does not necessarily imply infection and the need for treatment should be assessed on an individual basis.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El aislamiento de <span class="elsevierStyleItalic">Nocardia</span> spp. en las secreciones respiratorias de los pacientes con fibrosis quística (FQ) plantea problemas en cuanto a su trascendencia clínica. De un total de 387 pacientes con FQ, se aisló <span class="elsevierStyleItalic">Nocardia</span> spp. en el cultivo de esputo en 9 (2%; 8 mujeres y un varón), con una edad media (± desviación estándar) de 17 ± 7 años. El 67% de los casos se encontraba asintomático y en ningún paciente se detectaron cambios radiológicos ni analíticos de interés. En sólo 3 pacientes el aislamiento se repitió en muestras sucesiva. Dos pacientes no fueron tratados y en los restantes se empleó cotrimoxazol (7 casos), minociclina (3 casos) y tratamiento intravenoso (2 casos). Después de un seguimiento de 48 ± 33 meses, todos los pacientes presentaron una evolución clínica favorable. El aislamiento de <span class="elsevierStyleItalic">Nocardia</span> spp. en pacientes con FQ no implica necesariamente infección y la necesidad de tratamiento debe valorarse individualmente.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of the cystic fibrosis gene: genetic analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B Kerem" 1 => "JM Rommens" 2 => "JA Buchanan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1989" "volumen" => "245" "paginaInicial" => "1073" "paginaFinal" => "1080" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2570460" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 7 | 12 |
| 2024 October | 27 | 18 | 45 |
| 2024 September | 31 | 17 | 48 |
| 2024 August | 47 | 38 | 85 |
| 2024 July | 25 | 25 | 50 |
| 2024 June | 30 | 22 | 52 |
| 2024 May | 39 | 31 | 70 |
| 2024 April | 20 | 27 | 47 |
| 2024 March | 19 | 17 | 36 |
| 2024 February | 22 | 22 | 44 |
| 2023 March | 4 | 3 | 7 |
| 2023 February | 10 | 16 | 26 |
| 2023 January | 22 | 36 | 58 |
| 2022 December | 34 | 32 | 66 |
| 2022 November | 26 | 23 | 49 |
| 2022 October | 63 | 26 | 89 |
| 2022 September | 28 | 27 | 55 |
| 2022 August | 38 | 34 | 72 |
| 2022 July | 17 | 34 | 51 |
| 2022 June | 22 | 36 | 58 |
| 2022 May | 18 | 35 | 53 |
| 2022 April | 16 | 19 | 35 |
| 2022 March | 16 | 33 | 49 |
| 2022 February | 16 | 26 | 42 |
| 2022 January | 16 | 21 | 37 |
| 2021 December | 18 | 56 | 74 |
| 2021 November | 12 | 39 | 51 |
| 2021 October | 29 | 47 | 76 |
| 2021 September | 15 | 61 | 76 |
| 2021 August | 10 | 35 | 45 |
| 2021 July | 11 | 32 | 43 |
| 2021 June | 12 | 26 | 38 |
| 2021 May | 18 | 27 | 45 |
| 2021 April | 75 | 54 | 129 |
| 2021 March | 23 | 18 | 41 |
| 2021 February | 8 | 17 | 25 |
| 2021 January | 13 | 21 | 34 |
| 2020 December | 18 | 15 | 33 |
| 2020 November | 12 | 14 | 26 |
| 2020 October | 7 | 13 | 20 |
| 2020 September | 4 | 4 | 8 |
| 2020 August | 16 | 11 | 27 |
| 2020 July | 13 | 18 | 31 |
| 2020 June | 4 | 13 | 17 |
| 2020 May | 12 | 17 | 29 |
| 2020 April | 16 | 15 | 31 |
| 2020 March | 5 | 8 | 13 |
| 2020 February | 14 | 12 | 26 |
| 2020 January | 18 | 25 | 43 |
| 2019 December | 13 | 23 | 36 |
| 2019 November | 18 | 12 | 30 |
| 2019 October | 8 | 8 | 16 |
| 2019 September | 6 | 16 | 22 |
| 2019 August | 11 | 12 | 23 |
| 2019 July | 16 | 18 | 34 |
| 2019 June | 6 | 9 | 15 |
| 2019 May | 17 | 12 | 29 |
| 2019 April | 32 | 13 | 45 |
| 2019 March | 14 | 20 | 34 |
| 2019 February | 18 | 13 | 31 |
| 2019 January | 11 | 10 | 21 |
| 2018 December | 9 | 12 | 21 |
| 2018 November | 24 | 13 | 37 |
| 2018 October | 26 | 18 | 44 |
| 2018 September | 14 | 5 | 19 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 7 | 6 | 13 |
| 2018 March | 3 | 5 | 8 |
| 2018 February | 8 | 10 | 18 |
| 2018 January | 8 | 5 | 13 |
| 2017 December | 9 | 9 | 18 |
| 2017 November | 7 | 5 | 12 |
| 2017 October | 13 | 10 | 23 |
| 2017 September | 5 | 3 | 8 |
| 2017 August | 18 | 11 | 29 |
| 2017 July | 16 | 12 | 28 |
| 2017 June | 13 | 10 | 23 |
| 2017 May | 8 | 2 | 10 |
| 2017 April | 8 | 4 | 12 |
| 2017 March | 6 | 3 | 9 |
| 2017 February | 3 | 2 | 5 |
| 2017 January | 6 | 2 | 8 |
| 2016 December | 7 | 9 | 16 |
| 2016 November | 14 | 6 | 20 |
| 2016 October | 7 | 11 | 18 |
| 2016 September | 17 | 14 | 31 |
| 2016 August | 12 | 6 | 18 |
| 2016 July | 7 | 9 | 16 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 75 | 17 | 92 |
| 2015 September | 94 | 14 | 108 |
| 2015 August | 74 | 19 | 93 |
| 2015 July | 110 | 18 | 128 |
| 2015 June | 81 | 9 | 90 |
| 2015 May | 68 | 18 | 86 |
| 2015 April | 65 | 14 | 79 |
| 2015 March | 66 | 27 | 93 |
| 2015 February | 68 | 15 | 83 |
| 2015 January | 54 | 17 | 71 |
| 2014 December | 54 | 19 | 73 |
| 2014 November | 54 | 11 | 65 |
| 2014 October | 76 | 7 | 83 |
| 2014 September | 71 | 7 | 78 |
| 2014 August | 66 | 10 | 76 |
| 2014 July | 87 | 9 | 96 |
| 2014 June | 76 | 10 | 86 |
| 2014 May | 63 | 14 | 77 |
| 2014 April | 86 | 9 | 95 |
| 2014 March | 100 | 16 | 116 |
| 2014 February | 68 | 5 | 73 |
| 2014 January | 63 | 7 | 70 |
| 2013 December | 52 | 7 | 59 |
| 2013 November | 50 | 13 | 63 |
| 2013 October | 64 | 5 | 69 |
| 2013 September | 58 | 10 | 68 |
| 2013 August | 84 | 12 | 96 |
| 2013 July | 55 | 8 | 63 |
| 2013 June | 68 | 10 | 78 |
| 2013 May | 63 | 3 | 66 |
| 2013 April | 30 | 4 | 34 |
| 2013 March | 13 | 2 | 15 |
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