Correspondence: Dr MF Jiménez Servicio de Cirugía Torácica, Hospital Universitario de Salamanca P.° de San Vicente 58 37007 Salamanca, Spain
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"apellidos" => "López-Campos" ] 3 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Vigil" ] 4 => array:2 [ "nombre" => "Remedios" "apellidos" => "Otero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600129?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000002/v1_201305150342/S1579212908600129/v1_201305150342/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212908600166" "issn" => "15792129" "doi" => "10.1016/S1579-2129(08)60016-6" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60016" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:58-64" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2628 "formatos" => array:3 [ "EPUB" => 92 "HTML" => 1842 "PDF" => 694 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Treatment of Chronic Obstructive Pulmonary Disease in 5 Latin American Cities: The PLATINO Study" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "58" "paginaFinal" => "64" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Victorina López Varela, Adriana Muiño, Rogelio Pérez Padilla, José Roberto Jardim, Carlos Tálamo, María Montes de Oca, Gonzalo Valdivia, Julio Pertuzé, Ron Halbert, Ana María Menezes" "autores" => array:11 [ 0 => array:2 [ "nombre" => "María Victorina" "apellidos" => "López Varela" ] 1 => array:2 [ "nombre" => "Adriana" "apellidos" => "Muiño" ] 2 => array:2 [ "nombre" => "Rogelio Pérez" "apellidos" => "Padilla" ] 3 => array:2 [ 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"paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "65" "paginaFinal" => "69" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marcelo F. Jiménez, Gonzalo Varela, Nuria M. Novoa, José Luis Aranda" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Marcelo F." "apellidos" => "Jiménez" "email" => array:1 [ 0 => "mfjl@usal.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Gonzalo" "apellidos" => "Varela" ] 2 => array:2 [ "nombre" => "Nuria M." "apellidos" => "Novoa" ] 3 => array:2 [ "nombre" => "José Luis" "apellidos" => "Aranda" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Cirugía Torácica. Hospital Universitario de Salamanca. Salamanca. Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr MF Jiménez Servicio de Cirugía Torácica, Hospital Universitario de Salamanca P.° de San Vicente 58 37007 Salamanca, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-12-04" "fechaAceptado" => "2007-07-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155153" "palabras" => array:4 [ 0 => "Non-small cell cancer" 1 => "Lung resection" 2 => "Mediastinal metastases" 3 => "Prognosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155152" "palabras" => array:4 [ 0 => "Carcinoma no microcítico" 1 => "Resección pulmonar" 2 => "Metástasis mediastínicas" 3 => "Pronóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze survival in a group of patients with N2 involvement discovered during or after lung resection for non-small cell lung cancer and to evaluate the variables that affect survival.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included all patients with non-small cell lung cancer who underwent resection between January 1994 and October 2004 and in whom the definitive tumor classification was stage pIIIA due to N2 extension (n=74) detected during surgery. Patients with stage pIIIB who had undergone induction chemotherapy and patients for whom surgery was considered incomplete were excluded.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Mean survival times were significantly different (<span class="elsevierStyleItalic">P</span>=.002) between resection types: pneumonectomy, 18.1 months (95% confidence interval [CI], 6.9–29.2 months), and lobectomy, 42.4 months (95% CI, 28.7–56.1 months). The number of lymph-node stations affected did not have a significant effect on survival. However, when only 1 station was involved, mean survival was different for lobectomy and pneumonectomy (48.0 months [95% CI, 31–65 months] vs 14.8 months [95% CI, 4.8–24.7 months], respectively; <span class="elsevierStyleItalic">P</span>=.002) but no differences were found when N2 spread involved more than a single station. Adjuvant therapy was used in 50% of cases (n=35): chemotherapy in 6 cases; radiotherapy in 17 cases; and both in 12 cases. The mean survival rate for lobectomy patients with no adjuvant therapy was 31.6 months (95% CI, 15.6–47.5 months) and46.2 months (95% CI, 32.2–60.1 months) (<span class="elsevierStyleItalic">P</span>=.01) with adjuvant therapy, whereas there were no differences in the group of pneumonectomy patients.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Patients who undergo lobectomy clearly survive longer than those who undergo pneumonectomy when N2 lymph node involvement is found in only 1 station during surgery. Furthermore, adjuvant therapy may increase mean survival times for lobectomy patients.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Analizar la supervivencia de un grupo de pacientes con afectación N2 descubierta durante o tras la realización de la cirugía de resección pulmonar reglada por carcinoma de pulmón no microcítico, y valorar las variables que influyen en dicha supervivencia.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó en el estudio a todos los pacientes sometidos a resección pulmonar reglada con diagnóstico de carcinoma de pulmón no microcítico entre enero de 1994 y octubre de 2004, con extensión anatómica definitiva del tumor en el estadio qpIIIA por N2 (n = 74). Se excluyó a aquellos en estadio qpIIIB, con quimioterapia de inducción y aquellos en los que la cirugía se consideró incompleta.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La media de supervivencia según el tipo de resección mostró diferencias significativas (p = 0,002) entre la neumonectomía (18,1 meses; intervalo de confianza [IC] del 95%, 6,9–29,2) y la lobectomía (42,4 meses; IC del 95%, 28,7–56,1). El número de estaciones ganglionares no mostró una influencia significativa en la supervivencia. Sin embargo, cuando hubo afectación de una sola estación, las medias de supervivencia fueron diferentes entre la lobectomía (48,0 me-ses; IC del 95%, 31–65) y la neumonectomía (14,8 meses; IC del 95%, 4,8–24,7; p = 0,002), y no fueron distintas cuando había más de una estación N2. En el 50% de los casos (n = 35) se realizó tratamiento adyuvante (quimioterapia sólo en 6 casos; radioterapia en 17, y ambas en 12). En el grupo de pacientes de lobectomía, la media de supervivencia sin adyuvancia fue de 31,6 meses (IC del 95%, 15,6–47,5) y con adyuvancia de 46,2 meses (IC del 95%, 32,2–60,1) (p = 0,01), mientras que no hubo diferencias en el grupo de neumonectomía.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Cuando existe afectación N2 de una sola estación descubierta durante la cirugía, la lobectomía ofrece una supervivencia claramente superior a la neumonectomía; además, en este grupo de pacientes el tratamiento adyuvante puede aportar mayor supervivencia.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new international staging system for lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "CF Mountain" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1986" "volumen" => "89" "numero" => "Suppl 4" "paginaInicial" => "225" "paginaFinal" => "233" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The evolution of treatment outcomes for resected stage IIIA non-small cell lung cancer over 16 years at a single institution" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "LW Martin" 1 => "AM Correa" 2 => "W Hofstetter" 3 => "WK Hong" 4 => "R Komaki" 5 => "JB Putnam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jtcvs.2005.08.010" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2005" "volumen" => "130" "paginaInicial" => "1601" "paginaFinal" => "1610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16308005" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival of patients with resected N2 non-small-cell lung cancer: evidence for a subclassification and implications" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F André" 1 => "D Grunenwald" 2 => "JP Pignon" 3 => "A Dujon" 4 => "Jl Pujol" 5 => "PY Brichon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.2000.18.16.2981" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "2981" "paginaFinal" => "2989" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10944131" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Albain KS, Swann RS, Rusch VR, Turrisi AT, Shepherd FA, Smith CJ, et al. 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Year/Month | Html | Total | |
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2024 November | 7 | 3 | 10 |
2024 October | 28 | 11 | 39 |
2024 September | 29 | 18 | 47 |
2024 August | 46 | 30 | 76 |
2024 July | 20 | 18 | 38 |
2024 June | 34 | 22 | 56 |
2024 May | 40 | 31 | 71 |
2024 April | 13 | 27 | 40 |
2024 March | 26 | 15 | 41 |
2024 February | 21 | 19 | 40 |
2024 January | 0 | 1 | 1 |
2023 March | 3 | 3 | 6 |
2023 February | 15 | 12 | 27 |
2023 January | 15 | 28 | 43 |
2022 December | 19 | 31 | 50 |
2022 November | 29 | 21 | 50 |
2022 October | 27 | 34 | 61 |
2022 September | 15 | 23 | 38 |
2022 August | 25 | 34 | 59 |
2022 July | 22 | 34 | 56 |
2022 June | 16 | 31 | 47 |
2022 May | 24 | 27 | 51 |
2022 April | 23 | 33 | 56 |
2022 March | 25 | 36 | 61 |
2022 February | 14 | 22 | 36 |
2022 January | 19 | 34 | 53 |
2021 December | 17 | 55 | 72 |
2021 November | 17 | 56 | 73 |
2021 October | 28 | 48 | 76 |
2021 September | 27 | 58 | 85 |
2021 August | 10 | 26 | 36 |
2021 July | 13 | 28 | 41 |
2021 June | 11 | 21 | 32 |
2021 May | 20 | 19 | 39 |
2021 April | 56 | 55 | 111 |
2021 March | 28 | 13 | 41 |
2021 February | 18 | 8 | 26 |
2021 January | 21 | 14 | 35 |
2020 December | 5 | 7 | 12 |
2020 November | 20 | 11 | 31 |
2020 October | 12 | 5 | 17 |
2020 September | 4 | 4 | 8 |
2020 August | 14 | 10 | 24 |
2020 July | 18 | 15 | 33 |
2020 June | 8 | 0 | 8 |
2020 May | 11 | 16 | 27 |
2020 April | 22 | 15 | 37 |
2020 March | 13 | 8 | 21 |
2020 February | 19 | 13 | 32 |
2020 January | 17 | 15 | 32 |
2019 December | 18 | 25 | 43 |
2019 November | 9 | 11 | 20 |
2019 October | 1 | 13 | 14 |
2019 September | 8 | 11 | 19 |
2019 August | 6 | 12 | 18 |
2019 July | 16 | 16 | 32 |
2019 June | 7 | 6 | 13 |
2019 May | 8 | 13 | 21 |
2019 April | 9 | 42 | 51 |
2019 March | 6 | 19 | 25 |
2019 February | 8 | 20 | 28 |
2019 January | 1 | 16 | 17 |
2018 December | 7 | 16 | 23 |
2018 November | 12 | 19 | 31 |
2018 October | 17 | 20 | 37 |
2018 September | 15 | 12 | 27 |
2018 May | 3 | 0 | 3 |
2018 April | 9 | 7 | 16 |
2018 March | 4 | 3 | 7 |
2018 February | 8 | 11 | 19 |
2018 January | 8 | 7 | 15 |
2017 December | 5 | 9 | 14 |
2017 November | 4 | 12 | 16 |
2017 October | 5 | 9 | 14 |
2017 September | 6 | 11 | 17 |
2017 August | 10 | 12 | 22 |
2017 July | 17 | 21 | 38 |
2017 June | 10 | 13 | 23 |
2017 May | 4 | 9 | 13 |
2017 April | 5 | 22 | 27 |
2017 March | 4 | 9 | 13 |
2017 February | 3 | 8 | 11 |
2017 January | 5 | 4 | 9 |
2016 December | 5 | 5 | 10 |
2016 November | 12 | 7 | 19 |
2016 October | 11 | 10 | 21 |
2016 September | 16 | 6 | 22 |
2016 August | 15 | 8 | 23 |
2016 July | 13 | 3 | 16 |
2016 March | 1 | 0 | 1 |
2016 February | 1 | 0 | 1 |
2015 December | 2 | 0 | 2 |
2015 October | 45 | 15 | 60 |
2015 September | 40 | 5 | 45 |
2015 August | 26 | 11 | 37 |
2015 July | 44 | 11 | 55 |
2015 June | 34 | 9 | 43 |
2015 May | 40 | 9 | 49 |
2015 April | 35 | 9 | 44 |
2015 March | 27 | 10 | 37 |
2015 February | 32 | 7 | 39 |
2015 January | 24 | 12 | 36 |
2014 December | 24 | 6 | 30 |
2014 November | 28 | 5 | 33 |
2014 October | 43 | 11 | 54 |
2014 September | 35 | 5 | 40 |
2014 August | 41 | 9 | 50 |
2014 July | 32 | 17 | 49 |
2014 June | 43 | 14 | 57 |
2014 May | 39 | 13 | 52 |
2014 April | 41 | 3 | 44 |
2014 March | 52 | 9 | 61 |
2014 February | 46 | 7 | 53 |
2014 January | 37 | 7 | 44 |
2013 December | 34 | 5 | 39 |
2013 November | 22 | 8 | 30 |
2013 October | 37 | 10 | 47 |
2013 September | 39 | 11 | 50 |
2013 August | 44 | 9 | 53 |
2013 July | 37 | 9 | 46 |
2013 June | 26 | 8 | 34 |
2013 May | 33 | 4 | 37 |
2013 April | 18 | 3 | 21 |
2013 March | 8 | 2 | 10 |