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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to describe 5 microepidemics of tuberculosis occurring in schools&#44; establish the risk factors associated with the outbreaks&#44; assess how well a concentric circles strategy for contact tracing predicts infection&#44; and assess the usefulness of genotyping strains in the analysis of the outbreaks&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study assessed 5 epidemic outbreaks of tuberculosis using a standard contact tracing procedure&#46; The outbreaks occurred in 2 day nurseries and 2 high schools between 1998 and 2005&#46; Contacts were stratified using a concentric circle system based on level of exposure&#46; DNA fingerprints of the available strains were determined based on the restriction fragment length polymorphism &#40;RFLP&#41; IS6110 and compared with the contact study to interpret the transmission of the infection&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed 5 outbreaks&#46; Eighty-five contacts were analyzed in the first outbreak&#44; 519 in the second&#44; 116 in the third&#44; 655 in the fourth&#44; and 102 in the fifth&#46; The rate of infection was 31&#37;&#44; 29&#37;&#44; 66&#37;&#44; 37&#46;6&#37;&#44; and 32&#37;&#44; respectively&#46; Secondary cases of active disease were detected&#58; 9 in the first outbreak&#44; 16 in the second&#44; 5 in the third&#44; 6 in the fourth&#44; and 13 in the fifth&#46; RFLP analysis revealed that a single strain was involved in 3 of the outbreaks&#44; and in a fourth&#44; at least 2 strains were involved&#46; In outbreaks 2&#44; 3&#44; and 5&#44; there was a significant association between the degree of contact and the probability of infection &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; In all of the outbreaks&#44; the relative risk of developing the disease was associated with the level of exposure&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Analysis of contacts based on concentric circles of risk predicts the likelihood of infection&#46; RFLP facilitates analysis of complex transmission routes that are not detected using traditional methods of contact screening&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El prop&#243;sito del presente estudio ha sido describir 5 microepidemias de tuberculosis en centros escolares&#44; establecer los factores de riesgo relacionados con su aparici&#243;n&#44; valorar la predicci&#243;n de infecci&#243;n mediante la estrategia de c&#237;rculos conc&#233;ntricos y analizar la utilidad de la tipificaci&#243;n gen&#233;tica de cepa en su interpretaci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se presenta el estudio de 5 brotes de tuberculosis&#44; y su estudio convencional de contactos&#44; ocurridos en 2 guarder&#237;as y 2 institutos de ense&#241;anza media entre 1998 y 2005&#46; Los contactos se estratificaron seg&#250;n el grado de convivencia siguiendo el sistema de c&#237;rculos conc&#233;ntricos&#46; Se identificaron los perfiles gen&#233;ticos &#40;RFLP&#8211;polimorfismo de longitud de los fragmentos de restricci&#243;n&#8211;IS6110&#41; de las cepas disponibles y se cotejaron los resultados con el estudio de contactos para interpretar la transmisi&#243;n de la infecci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Analizamos 5 brotes&#46; En el primero estudiamos a 85 contactos&#59; en el segundo&#44; a 519&#59; en el tercero&#44; a 116&#59; en el cuarto&#44; a 655&#44; y 102 en el quinto&#46; La prevalencia de infecci&#243;n fue del 31&#44; el 29&#44; el 66&#44; el 37&#44;6 y el 32&#37;&#44; respectivamente&#46; Se detectaron casos secundarios de enfermedad activa&#58; 9 en el primero&#44; 16 en el segundo&#44; 5 en el tercero&#44; 6 en el cuarto y 13 en el quinto&#46; El an&#225;lisis mediante RFLP identific&#243; la coincidencia gen&#233;tica de todas las cepas en 3 brotes&#44; y en el cuarto evidenci&#243; la existencia de al menos 2 cepas implicadas en su desarrollo&#46; En los brotes 2&#44; 3 y 5 encontramos una asociaci&#243;n importante entre el grado de convivencia y las probabilidades de infectarse &#40;p &#60; 0&#44;05&#41;&#46; En todos los brotes el riesgo relativo de infectarse y enfermar se asoci&#243; con la intensidad de la exposici&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El estudio de contactos basado en c&#237;rculos de riesgo predice la probabilidad de infecci&#243;n&#46; La RFLP permite aclarar v&#237;as de transmisi&#243;n complejas que no son detectables mediante el estudio convencional de contactos&#46;</p>"
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Original Articles
The Importance of Genotyping of Strains for the Evaluation and Interpretation of 5 School-Based Epidemic Outbreaks of Tuberculosis
Pedro Jorge Marcos Rodrígueza,
Corresponding author
pedrojmarcos@canalejo.org

Correspondence: Dr. P.J. Marcos Rodríguez. Servicio de Neumología. Complejo Hospitalario Universitario Juan Canalejo. Xubias de Arriba, 84. 15006 A Coruña. España
, Daniel Díaz-Cabanelaa, María Isabel Ursua Díazb, María Fernández-Albalat Ruizb, Héctor Verea Hernandoa
a Servicio de Neumología, Complejo Hospitalario Universitario Juan Canalejo, A Coruña, Spain
b Servicio de Medicina Preventiva y Salud Pública, Complejo Hospitalario Universitario Juan Canalejo, A Coruña, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetive</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to describe 5 microepidemics of tuberculosis occurring in schools&#44; establish the risk factors associated with the outbreaks&#44; assess how well a concentric circles strategy for contact tracing predicts infection&#44; and assess the usefulness of genotyping strains in the analysis of the outbreaks&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study assessed 5 epidemic outbreaks of tuberculosis using a standard contact tracing procedure&#46; The outbreaks occurred in 2 day nurseries and 2 high schools between 1998 and 2005&#46; Contacts were stratified using a concentric circle system based on level of exposure&#46; DNA fingerprints of the available strains were determined based on the restriction fragment length polymorphism &#40;RFLP&#41; IS6110 and compared with the contact study to interpret the transmission of the infection&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed 5 outbreaks&#46; Eighty-five contacts were analyzed in the first outbreak&#44; 519 in the second&#44; 116 in the third&#44; 655 in the fourth&#44; and 102 in the fifth&#46; The rate of infection was 31&#37;&#44; 29&#37;&#44; 66&#37;&#44; 37&#46;6&#37;&#44; and 32&#37;&#44; respectively&#46; Secondary cases of active disease were detected&#58; 9 in the first outbreak&#44; 16 in the second&#44; 5 in the third&#44; 6 in the fourth&#44; and 13 in the fifth&#46; RFLP analysis revealed that a single strain was involved in 3 of the outbreaks&#44; and in a fourth&#44; at least 2 strains were involved&#46; In outbreaks 2&#44; 3&#44; and 5&#44; there was a significant association between the degree of contact and the probability of infection &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; In all of the outbreaks&#44; the relative risk of developing the disease was associated with the level of exposure&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Analysis of contacts based on concentric circles of risk predicts the likelihood of infection&#46; RFLP facilitates analysis of complex transmission routes that are not detected using traditional methods of contact screening&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El prop&#243;sito del presente estudio ha sido describir 5 microepidemias de tuberculosis en centros escolares&#44; establecer los factores de riesgo relacionados con su aparici&#243;n&#44; valorar la predicci&#243;n de infecci&#243;n mediante la estrategia de c&#237;rculos conc&#233;ntricos y analizar la utilidad de la tipificaci&#243;n gen&#233;tica de cepa en su interpretaci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se presenta el estudio de 5 brotes de tuberculosis&#44; y su estudio convencional de contactos&#44; ocurridos en 2 guarder&#237;as y 2 institutos de ense&#241;anza media entre 1998 y 2005&#46; Los contactos se estratificaron seg&#250;n el grado de convivencia siguiendo el sistema de c&#237;rculos conc&#233;ntricos&#46; Se identificaron los perfiles gen&#233;ticos &#40;RFLP&#8211;polimorfismo de longitud de los fragmentos de restricci&#243;n&#8211;IS6110&#41; de las cepas disponibles y se cotejaron los resultados con el estudio de contactos para interpretar la transmisi&#243;n de la infecci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Analizamos 5 brotes&#46; En el primero estudiamos a 85 contactos&#59; en el segundo&#44; a 519&#59; en el tercero&#44; a 116&#59; en el cuarto&#44; a 655&#44; y 102 en el quinto&#46; La prevalencia de infecci&#243;n fue del 31&#44; el 29&#44; el 66&#44; el 37&#44;6 y el 32&#37;&#44; respectivamente&#46; Se detectaron casos secundarios de enfermedad activa&#58; 9 en el primero&#44; 16 en el segundo&#44; 5 en el tercero&#44; 6 en el cuarto y 13 en el quinto&#46; El an&#225;lisis mediante RFLP identific&#243; la coincidencia gen&#233;tica de todas las cepas en 3 brotes&#44; y en el cuarto evidenci&#243; la existencia de al menos 2 cepas implicadas en su desarrollo&#46; En los brotes 2&#44; 3 y 5 encontramos una asociaci&#243;n importante entre el grado de convivencia y las probabilidades de infectarse &#40;p &#60; 0&#44;05&#41;&#46; En todos los brotes el riesgo relativo de infectarse y enfermar se asoci&#243; con la intensidad de la exposici&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El estudio de contactos basado en c&#237;rculos de riesgo predice la probabilidad de infecci&#243;n&#46; La RFLP permite aclarar v&#237;as de transmisi&#243;n complejas que no son detectables mediante el estudio convencional de contactos&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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