Correspondence: Dr. M. García-Yuste. Servicio de Cirugía Torácica. Hospital Clínico Universitario. Ramón y Cajal, 3. 47005 Valladolid. España
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Gayoso, Félix Heras, Marta Jiménez Prada, Andrés Alonso, Guillermo Ramos" "autores" => array:8 [ 0 => array:2 [ "nombre" => "José María" "apellidos" => "Matilla" ] 1 => array:2 [ "nombre" => "Mariano" "apellidos" => "García-Yuste" ] 2 => array:2 [ "nombre" => "Mariano Sánchez" "apellidos" => "Crespo" ] 3 => array:2 [ "nombre" => "Manuel J." "apellidos" => "Gayoso" ] 4 => array:2 [ "nombre" => "Félix" "apellidos" => "Heras" ] 5 => array:2 [ "nombre" => "Marta Jiménez" "apellidos" => "Prada" ] 6 => array:2 [ "nombre" => "Andrés" "apellidos" => "Alonso" ] 7 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Ramos" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907601256?idApp=UINPBA00003Z" "url" => "/15792129/0000004300000010/v1_201305150259/S1579212907601256/v1_201305150259/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Trends in Prognostic Factors for Neuroendocrine Lung Tumors" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "549" "paginaFinal" => "556" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mariano García-Yuste, Laureano Molins, José M. Matilla, Federico González-Aragoneses, Javier López-Pujol, Guillermo Ramos, Mercedes de la Torre" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Mariano" "apellidos" => "García-Yuste" "email" => array:1 [ 0 => "mgyuste2@wanadoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Laureano" "apellidos" => "Molins" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "José M." "apellidos" => "Matilla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Federico" "apellidos" => "González-Aragoneses" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Javier" "apellidos" => "López-Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 5 => array:3 [ "nombre" => "Guillermo" "apellidos" => "Ramos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 6 => array:3 [ "nombre" => "Mercedes" "apellidos" => "de la Torre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] ] 7 => array:2 [ "colaborador" => "members of the Spanish Multicenter Study of Neuroendocrine Lung Tumors of the Spanish Society of Pulmonology and Thoracic Surgery (EMETNE-SEPAR)" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital Clínico Universitario, Valladolid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital Sagrado Corazón, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital Gregorio Marañón, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital Reina Sofía, Córdoba, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital Juan Canalejo, A Coruña, Spain" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. M. García-Yuste. Servicio de Cirugía Torácica. Hospital Clínico Universitario. Ramón y Cajal, 3. 47005 Valladolid. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-10-05" "fechaAceptado" => "2007-11-22" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154626" "palabras" => array:3 [ 0 => "Neuroendocrine lung tumor" 1 => "Staging" 2 => "Mediastinal lymph node excision" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154625" "palabras" => array:3 [ 0 => "Tumor pulmonar neuroendocrino" 1 => "Estadificación" 2 => "Disección ganglionar mediastínica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to analyze trends in a variety of prognostic factors for neuroendocrine lung carcinomas through analysis of 2 groups of surgically treated patients.</p> <span class="elsevierStyleSectionTitle">PATIENTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">Group A contained the first 361 patients, treated between 1980 and 1997. That group was analyzed retrospectively and contained 261 patients with typical carcinoid tumors, 43 with atypical carcinoid tumors, 22 with large-cell neuroendocrine carcinoma, and 35 with small-cell neuroendocrine carcinoma. Group B contained 404 patients enrolled prospectively between 1998 and 2002: 308 with typical carcinoid tumors, 49 with atypical carcinoid tumors, 18 with large-cell neuroendocrine carcinoma, and 29 with small-cell neuroendocrine carcinoma. The following clinical variables were considered: sex, mean age, tumor site, tumor size, lymph node involvement, stage, metastasis, and local recurrence. The 1997 TNM classification was used for staging of lung cancer and survival analysis was performed along with assessment of factors influencing survival. Statistical analysis of the data involved univariate and multivariate analysis.</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">In both groups, significant differences were observed between patients with typical and atypical carcinoid tumors in terms of mean age, tumor size, node involvement, and recurrence. In group A, female sex, node involvement, and recurrence differed between patients with atypical carcinoid tumors and those with large-cell neuroendocrine carcinoma; the same was true for group B, with the exception of lymph node involvement. Node involvement differed between patients with small-cell versus large-cell neuroendocrine carcinoma in group A but not group B.</p><p class="elsevierStyleSimplePara elsevierViewall">Both groups displayed significant differences in overall survival and survival of patients with lymph node involvement between patients with typical and atypical carcinoid tumors and between patients with atypical carcinoid tumors and those with large- cell neuroendocrine carcinoma; no differences were observed between patients with large-cell versus small-cell neuroendocrine carcinoma. Histological type and lymph node involvement had the greatest influence on prognosis in the multivariate analysis.</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">A well-defined trend is observed in prognostic factors for neuroendocrine lung tumors. Histological type and lymph node involvement show the greatest influence on survival.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Este estudio tiene como objetivo determinar la tendencia de distintos factores pronósticos en carcinomas neuroendocrinos del pulmón a través del análisis de 2 grupos de pacientes tratados quirúrgicamente.</p> <span class="elsevierStyleSectionTitle">PACIENTES Y MÉTODOS</span><p class="elsevierStyleSimplePara elsevierViewall">En el grupo A se incluyeron los primeros 361 casos, tratados entre 1980 y 1997 —261 carcinoides típicos (CT), 43 carcinoides atípicos (CA), 22 carcinomas neuroendocrinos de células grandes (CNECG) y 35 carcinomas neuroendocrinos de células pequeñas (CNECP)—, que se estudiaron retrospectivamente. El grupo B estuvo compuesto por 404 casos, recogidos desde 1998 a 2002 —308 CT, 49 CA, 18 CNECG y 29 CNECP—, que se estudiaron prospectivamente. Las variables clínicas consideradas fueron: sexo, edad media, localización tumoral, tamaño tumoral, afectación ganglionar, estadio, metástasis y recurrencia local. Se utilizó la clasificación TNM del carcinoma broncogénico de 1997 y se practicó un estudio de supervivencia y de factores que influyen en ella. Se realizó un análisis estadístico uni y multivariante con los datos obtenidos.</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Por lo que se refiere al CT y al CA, se observaron diferencias significativas en los 2 grupos de pacientes en cuanto a la edad media, el tamaño tumoral, la afectación ganglionar y la recurrencia. Entre CA y CNECG, el sexo, la afectación ganglionar y la recurrencia difirieron en el grupo A; lo mismo ocurrió en el grupo B, con la excepción de la afectación ganglionar. Entre CNECG y CNECP, la diferencia en la afectación ganglionar observada en el grupo A no estuvo presente en los pacientes del grupo B. Respecto a la supervivencia, global y por afectación ganglionar, se observaron diferencias significativas en ambos grupos al comparar CT frente a CA y CA frente a CNECG; no se encontraron diferencias entre CNECG y CNECP. El tipo histológico y la afectación ganglionar mostraron la mayor influencia pronóstica en análisis multivariante.</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">En los carcinomas neuroendocrinos de pulmón se observa una tendencia definida en sus factores pronósticos. El tipo histológico y la detección de afectación ganglionar se muestran como los factores con mayor influencia en la supervivencia.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">The names of the EMETNE-SEPAR members are provided at the end of the article.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "WD Travis" 1 => "W Rush" 2 => "DB Flieder" 3 => "R Falk" 4 => "M Fleming" 5 => "A Gal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "1998" "volumen" => "22" "paginaInicial" => "934" "paginaFinal" => "944" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9706973" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchial carcinoid tumors: surgical management and longterm outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PL Filosso" 1 => "O Rena" 2 => "G Donati" 3 => "C Casadio" 4 => "E Ruffini" 5 => "E Papalia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2002" "volumen" => "123" "paginaInicial" => "303" "paginaFinal" => "309" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11828290" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of outcomes in typical and atypical carcinoids according to latest WHO classification" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Mezzetti" 1 => "F Raveglia" 2 => "T Panigalli" 3 => "L Giuliani" 4 => "F lo Giudice" 5 => "S Meda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2003" "volumen" => "76" "paginaInicial" => "1838" "paginaFinal" => "1842" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14667595" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroendocrine tumors of the bronchopulmonary tract. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 3 | 6 |
2024 October | 30 | 24 | 54 |
2024 September | 28 | 14 | 42 |
2024 August | 52 | 38 | 90 |
2024 July | 23 | 20 | 43 |
2024 June | 27 | 23 | 50 |
2024 May | 38 | 21 | 59 |
2024 April | 18 | 30 | 48 |
2024 March | 20 | 14 | 34 |
2024 February | 19 | 17 | 36 |
2023 March | 1 | 0 | 1 |
2023 February | 14 | 21 | 35 |
2023 January | 18 | 30 | 48 |
2022 December | 26 | 34 | 60 |
2022 November | 13 | 19 | 32 |
2022 October | 22 | 23 | 45 |
2022 September | 22 | 26 | 48 |
2022 August | 17 | 29 | 46 |
2022 July | 24 | 41 | 65 |
2022 June | 20 | 33 | 53 |
2022 May | 14 | 31 | 45 |
2022 April | 19 | 26 | 45 |
2022 March | 20 | 39 | 59 |
2022 February | 13 | 21 | 34 |
2022 January | 21 | 36 | 57 |
2021 December | 54 | 57 | 111 |
2021 November | 26 | 42 | 68 |
2021 October | 35 | 44 | 79 |
2021 September | 14 | 62 | 76 |
2021 August | 24 | 29 | 53 |
2021 July | 50 | 26 | 76 |
2021 June | 13 | 19 | 32 |
2021 May | 17 | 29 | 46 |
2021 April | 15 | 36 | 51 |
2021 March | 21 | 17 | 38 |
2021 February | 15 | 11 | 26 |
2021 January | 14 | 19 | 33 |
2020 December | 12 | 13 | 25 |
2020 November | 10 | 10 | 20 |
2020 October | 11 | 12 | 23 |
2020 September | 8 | 0 | 8 |
2020 August | 40 | 6 | 46 |
2020 July | 30 | 24 | 54 |
2020 June | 18 | 1 | 19 |
2020 May | 34 | 13 | 47 |
2020 April | 47 | 13 | 60 |
2020 March | 8 | 15 | 23 |
2020 February | 14 | 8 | 22 |
2020 January | 50 | 15 | 65 |
2019 December | 22 | 11 | 33 |
2019 November | 13 | 7 | 20 |
2019 October | 3 | 4 | 7 |
2019 September | 4 | 10 | 14 |
2019 August | 8 | 4 | 12 |
2019 July | 13 | 16 | 29 |
2019 June | 5 | 7 | 12 |
2019 May | 6 | 8 | 14 |
2019 April | 15 | 24 | 39 |
2019 March | 3 | 16 | 19 |
2019 February | 6 | 10 | 16 |
2019 January | 5 | 7 | 12 |
2018 December | 6 | 15 | 21 |
2018 November | 10 | 17 | 27 |
2018 October | 25 | 24 | 49 |
2018 September | 9 | 6 | 15 |
2018 May | 4 | 0 | 4 |
2018 April | 7 | 7 | 14 |
2018 March | 7 | 3 | 10 |
2018 February | 4 | 8 | 12 |
2018 January | 4 | 5 | 9 |
2017 December | 2 | 6 | 8 |
2017 November | 3 | 4 | 7 |
2017 October | 4 | 7 | 11 |
2017 September | 4 | 10 | 14 |
2017 August | 6 | 9 | 15 |
2017 July | 4 | 9 | 13 |
2017 June | 10 | 12 | 22 |
2017 May | 4 | 4 | 8 |
2017 April | 4 | 5 | 9 |
2017 March | 1 | 4 | 5 |
2017 February | 1 | 2 | 3 |
2017 January | 1 | 1 | 2 |
2016 December | 2 | 6 | 8 |
2016 November | 5 | 6 | 11 |
2016 October | 6 | 5 | 11 |
2016 September | 4 | 1 | 5 |
2016 August | 6 | 4 | 10 |
2016 July | 1 | 3 | 4 |
2016 March | 1 | 0 | 1 |
2016 February | 1 | 0 | 1 |
2015 December | 2 | 0 | 2 |
2015 October | 46 | 17 | 63 |
2015 September | 62 | 11 | 73 |
2015 August | 42 | 19 | 61 |
2015 July | 55 | 10 | 65 |
2015 June | 40 | 7 | 47 |
2015 May | 48 | 16 | 64 |
2015 April | 31 | 13 | 44 |
2015 March | 46 | 3 | 49 |
2015 February | 28 | 5 | 33 |
2015 January | 31 | 4 | 35 |
2014 December | 47 | 7 | 54 |
2014 November | 52 | 6 | 58 |
2014 October | 64 | 8 | 72 |
2014 September | 38 | 12 | 50 |
2014 August | 45 | 11 | 56 |
2014 July | 41 | 6 | 47 |
2014 June | 46 | 12 | 58 |
2014 May | 48 | 14 | 62 |
2014 April | 46 | 4 | 50 |
2014 March | 49 | 13 | 62 |
2014 February | 43 | 7 | 50 |
2014 January | 48 | 9 | 57 |
2013 December | 46 | 11 | 57 |
2013 November | 50 | 2 | 52 |
2013 October | 44 | 9 | 53 |
2013 September | 47 | 13 | 60 |
2013 August | 39 | 5 | 44 |
2013 July | 57 | 14 | 71 |
2013 June | 28 | 5 | 33 |
2013 May | 44 | 5 | 49 |
2013 April | 21 | 6 | 27 |
2013 March | 8 | 1 | 9 |