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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Local cytokine production is a pathogenic factor in ischemia-reperfusion injury in early graft dysfunction&#46; This study analyzed interleukin 8 &#40;IL-8&#41; messenger RNA &#40;mRNA&#41; expression in lung tissue and the association between IL-8 mRNA levels and interstitial lung changes in an experimental model of warm lung ischemia-reperfusion&#46;</p> <span class="elsevierStyleSectionTitle">MATERIAL AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 16 New Zealand rabbits divided into 3 groups&#58; control&#44; ischemia &#40;tissue taken from right lower lobe after 1&#44; 2&#44; or 3 hours of ischemia&#41;&#44; and reperfusion &#40;tissue taken from right upper and middle lobes after 1 hour of ischemia and 1&#44; 2&#44; or 3 hours of reperfusion&#41;&#46; Expression of IL-8 mRNA was determined by reverse transcription and polymerase chain reaction&#46; Interstitial infiltration by polymorphonuclear neutrophils was determined&#46; The Mann-Whitney U-test was used for statistical comparisons&#44; with <span class="elsevierStyleItalic">P</span>&#60;&#46;05 considered to indicate a significant result&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">During ischemia&#44; IL-8 mRNA levels were elevated at the end of hour 1 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;009&#41; with respect to the control group&#44; but not thereafter&#46; Interstitial changes were minimal&#46; IL-8 mRNA levels during reperfusion were similar to those observed during ischemia&#44; with a slight increase at the end of hour 2&#46; There were no significant differences between hours 1&#44; 2&#44; and 3&#46; Polymorphonuclear neutrophil recruitment occurred at the beginning of reperfusion &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;014&#41;&#44; but no significant differences were observed at hours 2 or 3&#46; Progressive thickening of alveolar septa and edema was documented&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">Changes in IL-8 mRNA expression during ischemia precede interstitial infiltration by polymorphonuclear neutrophils during reperfusion&#44; suggesting that the 2 processes are related&#46; Quantification of IL-8 mRNA expression could facilitate early diagnosis of graft dysfunction&#46;</p>"
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      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La generaci&#243;n local de citocinas es un factor patog&#233;nico en el da&#241;o por isquemia-reperfusi&#243;n en la disfunci&#243;n precoz del injerto&#46; Este estudio analiza la expresi&#243;n en tejido pulmonar de ARN mensajero de interleucina-8 &#40;ARNm de IL-8&#41; y su relaci&#243;n con los cambios intersticiales pulmonares en un modelo experimental de isquemia-reperfusi&#243;n pulmonar normot&#233;rmica&#46;</p> <span class="elsevierStyleSectionTitle">MATERIAL Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 16 conejos de la raza Nueva Zelanda en 3 grupos de estudio&#58; a&#41; basal&#59; b&#41; isquemia &#40;l&#243;bulo inferior derecho tras isquemia de 1&#44; 2 o 3 h&#41;&#44; y c&#41; reperfusi&#243;n &#40;l&#243;bulos superior y medio derechos tras 1 h de isquemia y 1&#44; 2 o 3 h de reperfusi&#243;n&#41;&#46; Se deter- min&#243; la expresi&#243;n del ARNm de IL-8 mediante transcripci&#243;n inversa y reacci&#243;n en cadena de la polimerasa y estudi&#243; la infiltraci&#243;n intersticial por polimorfonucleares &#40;PMN&#41;&#46; Para el an&#225;lisis estad&#237;stico se emple&#243; el test de la U de Mann-Whitney aceptando como significativo un valor de p &#60; 0&#44;05&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Durante el per&#237;odo de isquemia se observ&#243; respecto al basal elevaci&#243;n del ARNm de IL-8 al final de la primera hora &#40;p &#61; 0&#44;009&#41;&#44; pero no durante el resto del per&#237;odo isqu&#233;mico&#46; Los cambios intersticiales fueron m&#237;nimos&#46; Durante la reperfusi&#243;n los valores de ARNm de IL-8 fueron semejantes a los observados durante la isquemia&#44; con una ligera elevaci&#243;n al final de segunda hora&#59; no hubo diferencias significativas entre la primera&#44; segunda y tercera horas&#46; Hubo reclutamiento de PMN al inicio de la reperfusi&#243;n &#40;p &#61; 0&#44;014&#41;&#44; sin observarse diferencias significativas en la segunda y tercera horas&#46; Se objetiv&#243; un engrosamiento progresivo de los tabiques interalveolares y edema&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">Los cambios en la expresi&#243;n del ARNm de IL-8 durante la isquemia preceden a la infiltraci&#243;n intersticial de PMN durante la reperfusi&#243;n&#44; lo que se&#241;ala una relaci&#243;n entre ambos procesos&#46; La cuantificaci&#243;n del ARNm de IL-8 podr&#237;a ser un procedimiento para el seguimiento diagn&#243;stico de la disfunci&#243;n precoz del injerto&#46;</p>"
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Original Articles
Interleukin-8 Expression in Lung Tissue During Ischemia-Reperfusion
José María Matillaa,
Corresponding author
jmmatilla17@hotmail.com

Correspondence: Dr. J.M. Matilla González. Servicio de Cirugía Torácica. Hospital Clínico Universitario de Valladolid. Ramón y Cajal, 3. 47005 Valladolid. España
, Mariano García-Yustea, Mariano Sánchez Crespob, Manuel J. Gayoso, Félix Herasa, Marta Jiménez Pradaa, Andrés Alonsob, Guillermo Ramosa
a Unidad de Cirugía Torácica Experimental, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain
b Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid-CSIC, Valladolid, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Local cytokine production is a pathogenic factor in ischemia-reperfusion injury in early graft dysfunction&#46; This study analyzed interleukin 8 &#40;IL-8&#41; messenger RNA &#40;mRNA&#41; expression in lung tissue and the association between IL-8 mRNA levels and interstitial lung changes in an experimental model of warm lung ischemia-reperfusion&#46;</p> <span class="elsevierStyleSectionTitle">MATERIAL AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 16 New Zealand rabbits divided into 3 groups&#58; control&#44; ischemia &#40;tissue taken from right lower lobe after 1&#44; 2&#44; or 3 hours of ischemia&#41;&#44; and reperfusion &#40;tissue taken from right upper and middle lobes after 1 hour of ischemia and 1&#44; 2&#44; or 3 hours of reperfusion&#41;&#46; Expression of IL-8 mRNA was determined by reverse transcription and polymerase chain reaction&#46; Interstitial infiltration by polymorphonuclear neutrophils was determined&#46; The Mann-Whitney U-test was used for statistical comparisons&#44; with <span class="elsevierStyleItalic">P</span>&#60;&#46;05 considered to indicate a significant result&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">During ischemia&#44; IL-8 mRNA levels were elevated at the end of hour 1 &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;009&#41; with respect to the control group&#44; but not thereafter&#46; Interstitial changes were minimal&#46; IL-8 mRNA levels during reperfusion were similar to those observed during ischemia&#44; with a slight increase at the end of hour 2&#46; There were no significant differences between hours 1&#44; 2&#44; and 3&#46; Polymorphonuclear neutrophil recruitment occurred at the beginning of reperfusion &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;014&#41;&#44; but no significant differences were observed at hours 2 or 3&#46; Progressive thickening of alveolar septa and edema was documented&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">Changes in IL-8 mRNA expression during ischemia precede interstitial infiltration by polymorphonuclear neutrophils during reperfusion&#44; suggesting that the 2 processes are related&#46; Quantification of IL-8 mRNA expression could facilitate early diagnosis of graft dysfunction&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La generaci&#243;n local de citocinas es un factor patog&#233;nico en el da&#241;o por isquemia-reperfusi&#243;n en la disfunci&#243;n precoz del injerto&#46; Este estudio analiza la expresi&#243;n en tejido pulmonar de ARN mensajero de interleucina-8 &#40;ARNm de IL-8&#41; y su relaci&#243;n con los cambios intersticiales pulmonares en un modelo experimental de isquemia-reperfusi&#243;n pulmonar normot&#233;rmica&#46;</p> <span class="elsevierStyleSectionTitle">MATERIAL Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 16 conejos de la raza Nueva Zelanda en 3 grupos de estudio&#58; a&#41; basal&#59; b&#41; isquemia &#40;l&#243;bulo inferior derecho tras isquemia de 1&#44; 2 o 3 h&#41;&#44; y c&#41; reperfusi&#243;n &#40;l&#243;bulos superior y medio derechos tras 1 h de isquemia y 1&#44; 2 o 3 h de reperfusi&#243;n&#41;&#46; Se deter- min&#243; la expresi&#243;n del ARNm de IL-8 mediante transcripci&#243;n inversa y reacci&#243;n en cadena de la polimerasa y estudi&#243; la infiltraci&#243;n intersticial por polimorfonucleares &#40;PMN&#41;&#46; Para el an&#225;lisis estad&#237;stico se emple&#243; el test de la U de Mann-Whitney aceptando como significativo un valor de p &#60; 0&#44;05&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Durante el per&#237;odo de isquemia se observ&#243; respecto al basal elevaci&#243;n del ARNm de IL-8 al final de la primera hora &#40;p &#61; 0&#44;009&#41;&#44; pero no durante el resto del per&#237;odo isqu&#233;mico&#46; Los cambios intersticiales fueron m&#237;nimos&#46; Durante la reperfusi&#243;n los valores de ARNm de IL-8 fueron semejantes a los observados durante la isquemia&#44; con una ligera elevaci&#243;n al final de segunda hora&#59; no hubo diferencias significativas entre la primera&#44; segunda y tercera horas&#46; Hubo reclutamiento de PMN al inicio de la reperfusi&#243;n &#40;p &#61; 0&#44;014&#41;&#44; sin observarse diferencias significativas en la segunda y tercera horas&#46; Se objetiv&#243; un engrosamiento progresivo de los tabiques interalveolares y edema&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">Los cambios en la expresi&#243;n del ARNm de IL-8 durante la isquemia preceden a la infiltraci&#243;n intersticial de PMN durante la reperfusi&#243;n&#44; lo que se&#241;ala una relaci&#243;n entre ambos procesos&#46; La cuantificaci&#243;n del ARNm de IL-8 podr&#237;a ser un procedimiento para el seguimiento diagn&#243;stico de la disfunci&#243;n precoz del injerto&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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2015 August 14 20 34
2015 July 36 12 48
2015 June 26 8 34
2015 May 35 20 55
2015 April 17 13 30
2015 March 25 10 35
2015 February 39 6 45
2015 January 24 5 29
2014 December 22 4 26
2014 November 23 5 28
2014 October 30 10 40
2014 September 24 8 32
2014 August 33 10 43
2014 July 22 6 28
2014 June 34 8 42
2014 May 42 10 52
2014 April 39 2 41
2014 March 49 12 61
2014 February 42 6 48
2014 January 34 6 40
2013 December 48 10 58
2013 November 42 2 44
2013 October 36 8 44
2013 September 26 9 35
2013 August 42 4 46
2013 July 51 14 65
2013 June 27 6 33
2013 May 41 6 47
2013 April 11 4 15
2013 March 6 1 7
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