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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine whether variability in peak expiratory flow &#40;PEF&#41; could be used to classify the level of severity of asthma in children&#46;</p> <span class="elsevierStyleSectionTitle">PATIENTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 387 boys and girls diagnosed with asthma and classified severity according to clinical criteria &#40;Spanish Society of Pediatric Pneumology&#41;&#46; PEF variability was determined using a portable mini- Wright peak flow meter &#40;Clement Clarke International&#44; London&#44; UK&#59; range&#44; 50 L&#47;min&#8211;800 L&#47;min&#41; over a 14-day period&#44; with no changes in normal treatment&#46; The following indices were used to calculate PEF variability&#58; <span class="elsevierStyleItalic">1&#41;</span> difference between morning PEF and nighttime PEF&#44; expressed as a percentage of the mean value of the PEF measurements taken on that day&#59; <span class="elsevierStyleItalic">2&#41;</span> minimum PEF rate during a week&#44; expressed as a percentage of the highest value recorded during that week&#59; <span class="elsevierStyleItalic">3&#41;</span> difference between the highest and the lowest PEF values&#44; expressed as a percentage of the highest value&#59; and <span class="elsevierStyleItalic">4&#41;</span> the 10th percentile of PEF values recorded during a week&#44; expressed as a percentage of the highest value recorded during that week&#46; We assessed agreement between clinical classification and PEF variability using the weighted &#91;&#46;kappa&#93; coefficient&#46; We also analyzed the sensitivity and specificity of PEF variability indices for episodic and persistent asthma&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">The analysis of levels of agreement between clinical classification of asthma and formulas 1&#44; 2&#44; 3&#44; and 4 gave quadratic weighted &#954; coefficients of 0&#46;494&#44; 0&#44; 0&#46;488&#44; and 0&#46;346&#44; respectively&#46; The results were similar when patients were grouped and analyzed by type of asthma &#40;episodic or persistent asthma&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The monitoring of PEF variability&#44; a recommendation common in national and international guidelines on the management of asthma in children&#44; is not valid for classifying severity of asthma in children&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio ha sido estudiar si la variabilidad del flujo espiratorio m&#225;ximo &#40;FEM&#41; permite clasificar el asma en ni&#241;os por niveles de gravedad&#46;</p> <span class="elsevierStyleSectionTitle">PACIENTES Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha estudiado a 387 ni&#241;os y ni&#241;as diagnosticados de asma&#44; cuya gravedad se clasific&#243; atendiendo a criterios cl&#237;nicos &#40;Sociedad Espa&#241;ola de Neumolog&#237;a Pedi&#225;trica&#41;&#46; Se determin&#243; la variabilidad del FEM con un medidor port&#225;til &#40;Mini Wright Peak Flow Meter Clement&#44; Clarke International Ltd&#46;&#44; Londres&#44; Reino Unido&#59; escala 50-800 l&#47;min&#41; en los 14 d&#237;as siguientes&#44; sin modificar los tratamientos habituales&#44; seg&#250;n los &#237;ndices de variabilidad del FEM&#58; <span class="elsevierStyleItalic">1&#41;</span> diferencia entre el FEM de la ma&#241;ana y el de la noche&#44; expresado como porcentaje del valor medio de las medidas del FEM durante el d&#237;a&#59; <span class="elsevierStyleItalic">2&#41;</span> m&#237;nimo valor del FEM durante una semana&#44; expresado como porcentaje del mejor FEM durante esa semana&#59; <span class="elsevierStyleItalic">3&#41;</span> diferencia del mejor sobre el peor FEM&#44; como porcentaje sobre el mejor&#44; y <span class="elsevierStyleItalic">4&#41;</span> percentil 10 de los valores del FEM durante una semana&#44; expresado como porcentaje del mejor FEM durante esa semana&#46; Se analiz&#243; el grado de acuerdo entre la clasificaci&#243;n cl&#237;nica y la variabilidad del FEM mediante el estudio de la concordancia &#40;&#237;ndice kappa ponderado&#41;&#46; Tambi&#233;n se efectu&#243; un an&#225;lisis de sensibilidad y especificidad para el asma epis&#243;dica y el asma persistente en relaci&#243;n con la variabilidad del FEM&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Los niveles de acuerdo entre la clasificaci&#243;n cl&#237;nica del asma y las f&#243;rmulas 1&#44; 2&#44; 3 y 4 mostraron &#237;ndices kappa ponderados bicuadrados de 0&#44;494&#44; 0&#44; 0&#44;488 y 0&#44;346&#44; respectivamente&#46; Los resultados fueron similares cuando los pacientes se agruparon en asma epis&#243;dica y asma persistente&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">La medida de la variabilidad del FEM&#44; recomendaci&#243;n com&#250;n de las gu&#237;as nacionales e internacionales para el manejo del asma en ni&#241;os&#44; no es v&#225;lida para clasificar el asma en ni&#241;os por niveles de gravedad&#46;</p>"
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                  "referenciaCompleta" => "Global Initiative for asthma&#46; Global strategy for asthma management and prevention&#46; NHLBI&#47;WHO Workshop Report&#46; Bethesda&#58; National Heart&#44; Lung and Blood Institute&#46; National Institutes of Health&#59; 2005&#46; Available from&#58; http&#58;&#47;www&#46;ginasthma&#46;org&#46; Accessed September 19&#44; 2006&#46;"
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                  "referenciaCompleta" => "The British Thoracic Society and the Scottish Intercollegiate Guidelines Network&#46; British guideline on the management of asthma&#46; A national clinical guideline&#44; 2005&#46; Available from&#58; http&#58;&#47;www&#46;sing&#46;ac&#46;uk&#47; guideline&#47;fulltext&#47;63&#47;index&#46;html&#46; Accessed September 19&#44; 2006&#46;"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "RM Busquets Monge"
                            1 => "A Escribano Montaner"
                            2 => "M Fern&#225;ndez Benitez"
                            3 => "L Garc&#237;a-Marcos"
                            4 => "J Garde Garde"
                            5 => "M Ibero Iborra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2006"
                        "volumen" => "64"
                        "paginaInicial" => "365"
                        "paginaFinal" => "378"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a de pr&#225;ctica cl&#237;nica sobre asma &#40;1&#46;&#170; parte&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Merino"
                            1 => "J Aranguren"
                            2 => "M Call&#233;n"
                            3 => "J Elorz"
                            4 => "A Etxeberr&#237;a"
                            5 => "JB Galdiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2006"
                        "volumen" => "64"
                        "paginaInicial" => "557"
                        "paginaFinal" => "572"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a de pr&#225;ctica cl&#237;nica sobre asma &#40;2&#46;&#170; parte&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Merino"
                            1 => "J Aranguren"
                            2 => "M Call&#233;n"
                            3 => "J Elorz"
                            4 => "A Etxeberr&#237;a"
                            5 => "JB Galdiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2006"
                        "volumen" => "65"
                        "paginaInicial" => "51"
                        "paginaFinal" => "66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Global Strategy for Asthma Management and Prevention&#46; Revised 2006&#46; Available from&#58; http&#58;&#47;www&#46;ginasthma&#46;org&#46; Accessed November 30&#44; 2006&#46;"
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The distribution of peak expiratory flow variability in a population sample"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B Higgins"
                            1 => "JR Britton"
                            2 => "S Chinn"
                            3 => "TD Jones"
                            4 => "D Jenkinson"
                            5 => "PG Buerney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/140.5.1368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "140"
                        "paginaInicial" => "1368"
                        "paginaFinal" => "1372"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2817599"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peak flow variation in childhood asthma&#58; a three year analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "JE Gern"
                            1 => "PA Eggleston"
                            2 => "KC Schuberth"
                            3 => "ND Eney"
                            4 => "EO Goldstein"
                            5 => "ME Weiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1994"
                        "volumen" => "93"
                        "paginaInicial" => "706"
                        "paginaFinal" => "716"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8163780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of peak expiratory flow variability in an adolescent population sample&#58; the Odense schoolchild study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "HC Siersted"
                            1 => "HS Hansen"
                            2 => "NCG Hansen"
                            3 => "N Hyldebrandt"
                            4 => "G Mostgaard"
                            5 => "H Oxhoy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.149.3.8118624"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1994"
                        "volumen" => "149"
                        "paginaInicial" => "598"
                        "paginaFinal" => "603"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8118624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Which index of peak expiratory flow is most useful in the management of stable asthma&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "HK Reddel"
                            1 => "CM Salome"
                            2 => "JK Peat"
                            3 => "AJ Woolcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.151.5.7735580"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "151"
                        "paginaInicial" => "1320"
                        "paginaFinal" => "1325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7735580"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "JL Fleiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Statistical methods for rates and proportions"
                        "paginaInicial" => "38"
                        "paginaFinal" => "48"
                        "edicion" => "2nd ed&#46;"
                        "serieFecha" => "1981"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G Polgar"
                            1 => "V Promadhat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Pulmonary function testing in children&#58; techniques and standards"
                        "fecha" => "1971"
                        "editorial" => "Saunders"
                        "editorialLocalizacion" => "Philadelphia"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ATS&#47;ERS Task Force&#58; standardisation of lung function testing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Standardisation of Spirometry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00034805"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "319"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spirometric reference values for white European children and adolescents&#58; Polgar revisited"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "PH Quanjer"
                            1 => "GJ Borsboom"
                            2 => "B Brunekreff"
                            3 => "M Zach"
                            4 => "G Forche"
                            5 => "JE Cotes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "1995"
                        "volumen" => "19"
                        "paginaInicial" => "135"
                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7659469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "DG Altman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Practical statistics for medical research"
                        "fecha" => "1991"
                        "editorial" => "Chapman and Hall"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Home peak expiratory flow rate monitoring in patients with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "TCJ Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0025-6196(11)63916-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1995"
                        "volumen" => "70"
                        "paginaInicial" => "649"
                        "paginaFinal" => "656"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7791387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variability of peak expiratory flow rate in children&#58; short and long term reproducibility"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T Frischer"
                            1 => "R Meinert"
                            2 => "R Urbanek"
                            3 => "J Kuehr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1995"
                        "volumen" => "50"
                        "paginaInicial" => "35"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7886646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acceptability&#44; reproducibility&#44; and sensitivity of forced expiratory volumes and peak expiratory flow during bronchial challenge testing in asthmatic children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "LP Malmberg"
                            1 => "K Nikander"
                            2 => "AS Pelkonen"
                            3 => "P Syv&#228;nen"
                            4 => "T Koljonen"
                            5 => "T Haahtela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "120"
                        "paginaInicial" => "1843"
                        "paginaFinal" => "1849"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11742911"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persisting airway obstruction in asymptomatic children with asthma with normal peak expiratory flow rates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "AC Ferguson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1988"
                        "volumen" => "82"
                        "paginaInicial" => "19"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3392366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of mini peak flow meters in indicating changes in lung function in children with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "PD Sly"
                            1 => "P Cahill"
                            2 => "K Willet"
                            3 => "P Burton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1994"
                        "volumen" => "308"
                        "paginaInicial" => "572"
                        "paginaFinal" => "574"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8148680"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Can peak expiratory flow predict airflow obstruction in children with asthma&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N Eid"
                            1 => "B Yandell"
                            2 => "L Howell"
                            3 => "M Heddy"
                            4 => "S Sheikh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2000"
                        "volumen" => "105"
                        "paginaInicial" => "354"
                        "paginaFinal" => "358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10654955"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0014256512000501"
                          "estado" => "S300"
                          "issn" => "00142565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of atopy on the natural history of symptoms&#44; peak expiratory flow&#44; and bronchial responsiveness in 7 and 8 year old children with cough and wheeze"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JB Clough"
                            1 => "JD Williams"
                            2 => "ST Holgate"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/143.4_Pt_1.755"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1991"
                        "volumen" => "143"
                        "paginaInicial" => "755"
                        "paginaFinal" => "760"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2008988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of 22 months of treatment with inhaled corticosteroids and&#47;or beta-2-agonists on lung function&#44; airway responsiveness&#44; and symptoms in children with asthma&#46; The Dutch Chronic Non-specific Lung Disease Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "EEM van Essen-Zandvliet"
                            1 => "MD Hugues"
                            2 => "HJ Waalkens"
                            3 => "EG Duiverman"
                            4 => "SJ Pocock"
                            5 => "KF Kerrebijn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/148.3.818"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1993"
                        "volumen" => "148"
                        "paginaInicial" => "818"
                        "paginaFinal" => "893"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8368655"
                            "web" => "Medline"
                          ]
                        ]
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                          "pii" => "S014067360416769X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                          "etal" => false
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                    ]
                  ]
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                        "paginaInicial" => "220"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                  ]
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              ]
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              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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                          "autores" => array:6 [
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                            1 => "GMW Reijnen"
                            2 => "WJHM van den Bosch"
                            3 => "CP van Schayck"
                            4 => "J Molema"
                            5 => "C van Weel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Gen Pract"
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                        "paginaInicial" => "487"
                        "paginaFinal" => "492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9302787"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Comparisons of peak diurnal expiratory flow variation&#44; postbronchodilator FEV<span class="elsevierStyleInf">1</span> responses&#44; and methacholine inhalation challenges in the evaluation of suspected asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "MF Goldstein"
                            1 => "BA Veza"
                            2 => "EH Dunsky"
                            3 => "DJ Dvorin"
                            4 => "GA Belecanech"
                            5 => "IC Haralabatos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "119"
                        "paginaInicial" => "1001"
                        "paginaFinal" => "1010"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11296161"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peak flow variation in childhood asthma&#58; relationship to symptoms&#44; atopy&#44; airways obstruction and hyperresponsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "PLP Brand"
                            1 => "EJ Duiverman"
                            2 => "DS Postma"
                            3 => "HJ Waalkens"
                            4 => "KF Kerrebijn"
                            5 => "EEM van Essen-Zandvliet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1997"
                        "volumen" => "10"
                        "paginaInicial" => "1242"
                        "paginaFinal" => "1247"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9192923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
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              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of asthma severity&#58; should the international guidelines be changed&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G Sawyer"
                            1 => "J Miles"
                            2 => "S Lewis"
                            3 => "P Fitzharris"
                            4 => "N Pearce"
                            5 => "R Beasley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Allergy"
                        "fecha" => "1998"
                        "volumen" => "28"
                        "paginaInicial" => "1565"
                        "paginaFinal" => "1570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10024229"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Underestimation of the peak flow variability in asthmatic children&#58; evaluation of a new formula"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "MH Vargas"
                            1 => "HH Ruiz-Guti&#233;rrez"
                            2 => "C Espinosa-Seraf&#237;n"
                            3 => "G Zu&#241;iga-V&#225;zquez"
                            4 => "ME Furuya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ppul.20196"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Pulmonol"
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                        "paginaInicial" => "325"
                        "paginaFinal" => "331"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15704185"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "AL Fuhlbrigge"
                            1 => "ST Weiss"
                            2 => "KM Kuntz"
                            3 => "AD Paltiel"
                            4 => "for the CAMP Research Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
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              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classifying asthma severity in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "LB Bacharier"
                            1 => "RC Strunk"
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                            3 => "D White"
                            4 => "RF Lemanske Jr"
                            5 => "CA Sorkness"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200308-1178OC"
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                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2004"
                        "volumen" => "170"
                        "paginaInicial" => "426"
                        "paginaFinal" => "432"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15172893"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of monitoring lung function in asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "PLP Brand"
                            1 => "RJ Roorda"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "2003"
                        "volumen" => "88"
                        "paginaInicial" => "1021"
                        "paginaFinal" => "1025"
                        "link" => array:1 [
                          0 => array:2 [
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Original Articles
Variability in Peak Expiratory Flow Does Not Classify Asthma According to Severity
Eduardo G. Pérez-Yarzaa,
Corresponding author
perezyar@chdo.osakidetza.net

Correspondence: Eduardo G. Pérez-Yarza. Unidad de Neumología. Servicio de Pediatría. Hospital Donostia. P.º Dr. Beguiristain, s/n. 20014 San Sebastián. Guipúzcoa. España
, Nicolás Cobosb, Juan José de la Cruzc, on behalf of the Asthma Working Group of the Spanish Society of Pediatric Pneumology *
a Unidad de Neumología, Servicio de Pediatría, Hospital Donostia, San Sebastián, Guipúzcoa, Spain
b Unidad de Neumología Infantil y Fibrosis Quística, Hospital Materno-Infantil Vall d'Hebron, Barcelona, Spain
c Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid, Madrid, Spain
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    "titulo" => "Variability in Peak Expiratory Flow Does Not Classify Asthma According to Severity"
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        "autoresLista" => "Eduardo G&#46; P&#233;rez-Yarza, Nicol&#225;s Cobos, Juan Jos&#233; de la Cruz"
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            "correspondencia" => "Correspondence&#58; Eduardo G&#46; P&#233;rez-Yarza&#46; Unidad de Neumolog&#237;a&#46; Servicio de Pediatr&#237;a&#46; Hospital Donostia&#46; P&#46;&#186; Dr&#46; Beguiristain&#44; s&#47;n&#46; 20014 San Sebasti&#225;n&#46; Guip&#250;zcoa&#46; Espa&#241;a"
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    "fechaRecibido" => "2006-12-23"
    "fechaAceptado" => "2007-02-20"
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            0 => "Asthma"
            1 => "Classification"
            2 => "Severity"
            3 => "Peak expiratory flow"
            4 => "Variability"
            5 => "Children"
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          "palabras" => array:6 [
            0 => "Asma"
            1 => "Clasificaci&#243;n"
            2 => "Gravedad"
            3 => "Flujo espiratorio m&#225;ximo"
            4 => "Variabilidad"
            5 => "Ni&#241;os"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine whether variability in peak expiratory flow &#40;PEF&#41; could be used to classify the level of severity of asthma in children&#46;</p> <span class="elsevierStyleSectionTitle">PATIENTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 387 boys and girls diagnosed with asthma and classified severity according to clinical criteria &#40;Spanish Society of Pediatric Pneumology&#41;&#46; PEF variability was determined using a portable mini- Wright peak flow meter &#40;Clement Clarke International&#44; London&#44; UK&#59; range&#44; 50 L&#47;min&#8211;800 L&#47;min&#41; over a 14-day period&#44; with no changes in normal treatment&#46; The following indices were used to calculate PEF variability&#58; <span class="elsevierStyleItalic">1&#41;</span> difference between morning PEF and nighttime PEF&#44; expressed as a percentage of the mean value of the PEF measurements taken on that day&#59; <span class="elsevierStyleItalic">2&#41;</span> minimum PEF rate during a week&#44; expressed as a percentage of the highest value recorded during that week&#59; <span class="elsevierStyleItalic">3&#41;</span> difference between the highest and the lowest PEF values&#44; expressed as a percentage of the highest value&#59; and <span class="elsevierStyleItalic">4&#41;</span> the 10th percentile of PEF values recorded during a week&#44; expressed as a percentage of the highest value recorded during that week&#46; We assessed agreement between clinical classification and PEF variability using the weighted &#91;&#46;kappa&#93; coefficient&#46; We also analyzed the sensitivity and specificity of PEF variability indices for episodic and persistent asthma&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">The analysis of levels of agreement between clinical classification of asthma and formulas 1&#44; 2&#44; 3&#44; and 4 gave quadratic weighted &#954; coefficients of 0&#46;494&#44; 0&#44; 0&#46;488&#44; and 0&#46;346&#44; respectively&#46; The results were similar when patients were grouped and analyzed by type of asthma &#40;episodic or persistent asthma&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The monitoring of PEF variability&#44; a recommendation common in national and international guidelines on the management of asthma in children&#44; is not valid for classifying severity of asthma in children&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio ha sido estudiar si la variabilidad del flujo espiratorio m&#225;ximo &#40;FEM&#41; permite clasificar el asma en ni&#241;os por niveles de gravedad&#46;</p> <span class="elsevierStyleSectionTitle">PACIENTES Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha estudiado a 387 ni&#241;os y ni&#241;as diagnosticados de asma&#44; cuya gravedad se clasific&#243; atendiendo a criterios cl&#237;nicos &#40;Sociedad Espa&#241;ola de Neumolog&#237;a Pedi&#225;trica&#41;&#46; Se determin&#243; la variabilidad del FEM con un medidor port&#225;til &#40;Mini Wright Peak Flow Meter Clement&#44; Clarke International Ltd&#46;&#44; Londres&#44; Reino Unido&#59; escala 50-800 l&#47;min&#41; en los 14 d&#237;as siguientes&#44; sin modificar los tratamientos habituales&#44; seg&#250;n los &#237;ndices de variabilidad del FEM&#58; <span class="elsevierStyleItalic">1&#41;</span> diferencia entre el FEM de la ma&#241;ana y el de la noche&#44; expresado como porcentaje del valor medio de las medidas del FEM durante el d&#237;a&#59; <span class="elsevierStyleItalic">2&#41;</span> m&#237;nimo valor del FEM durante una semana&#44; expresado como porcentaje del mejor FEM durante esa semana&#59; <span class="elsevierStyleItalic">3&#41;</span> diferencia del mejor sobre el peor FEM&#44; como porcentaje sobre el mejor&#44; y <span class="elsevierStyleItalic">4&#41;</span> percentil 10 de los valores del FEM durante una semana&#44; expresado como porcentaje del mejor FEM durante esa semana&#46; Se analiz&#243; el grado de acuerdo entre la clasificaci&#243;n cl&#237;nica y la variabilidad del FEM mediante el estudio de la concordancia &#40;&#237;ndice kappa ponderado&#41;&#46; Tambi&#233;n se efectu&#243; un an&#225;lisis de sensibilidad y especificidad para el asma epis&#243;dica y el asma persistente en relaci&#243;n con la variabilidad del FEM&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Los niveles de acuerdo entre la clasificaci&#243;n cl&#237;nica del asma y las f&#243;rmulas 1&#44; 2&#44; 3 y 4 mostraron &#237;ndices kappa ponderados bicuadrados de 0&#44;494&#44; 0&#44; 0&#44;488 y 0&#44;346&#44; respectivamente&#46; Los resultados fueron similares cuando los pacientes se agruparon en asma epis&#243;dica y asma persistente&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">La medida de la variabilidad del FEM&#44; recomendaci&#243;n com&#250;n de las gu&#237;as nacionales e internacionales para el manejo del asma en ni&#241;os&#44; no es v&#225;lida para clasificar el asma en ni&#241;os por niveles de gravedad&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">This study was partially funded by a GlaxoSmithKline &#40;GSK&#41; Spain research grant to the Asthma Working Group of the Spanish Society of Pediatric Pneumology &#40;SENP&#41;&#46; GSK Spain did not participate in the design of the study&#44; data analysis&#44; results&#44; or conclusions&#46; The data are the property of the Asthma Working Group of the SENP&#46;</p>"
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            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "National Asthma Education and Prevention Program&#46; Expert Panel Report&#46; Guidelines for the Diagnosis and Management of Asthma&#46; National Institutes of Health&#46; National Heart&#44; Lung and Blood Institute&#46; Update on selected topics 2002&#46; NIH Publication n&#46;&#186; 025074&#44; 2003&#46; Available from&#58; http&#58;&#47;www&#46; nhlbi&#46;nih&#46;gov&#47;guidelines&#47;asthma&#47; index&#46;htm&#46; Accessed September19&#44; 2006"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fisiopatolog&#237;a&#44; diagn&#243;stico y evaluaci&#243;n del paciente asm&#225;tico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J Sirvent G&#243;mez"
                            1 => "E Gonz&#225;lez P&#233;rez-Yarza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Tratado de Neumolog&#237;a Infantil"
                        "paginaInicial" => "577"
                        "paginaFinal" => "598"
                        "serieFecha" => "2003"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Grupo de Respiratorio de Atenci&#243;n Primaria&#44; Sociedad Espa&#241;ola de Medicina Rural y Generalista&#44; Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica&#44; Sociedad Espa&#241;ola de Neumolog&#237;a Pedi&#225;trica y Associaci&#243; Asmatol&#243;gica Catalana&#46; Gu&#237;a Espa&#241;ola para el Manejo del Asma &#40;GEMA&#41;&#46;Available from&#58; www&#46;gemesama&#46;com&#46; Accessed September19&#44; 2006"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "National Heart&#44; Lung&#44; and Blood Institute&#44; National Institutes of Health&#46; International consensus report on diagnosis and treatment of asthma&#46; Bethesda&#58; NHLBI&#47;NIH&#59; 1992 &#91;publication 92-3091&#93;&#46;"
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "National Asthma Education and Preventing Program&#46; Expert Panel Report&#46; Guidelines for the diagnosis and management of asthma&#46; National Institutes of Health&#46; National Heart&#44; Lung and Blood Institute&#46; NIH Publication No&#46; 97-4051&#44; 1997&#46; Available from&#58; http&#58;&#47;www&#46;nhlbi&#46;nih&#46;gov&#47;guidelines&#47;asthma&#47;index&#46;htm&#46; Accessed September 19&#44; 2006&#46;"
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Global Initiative for asthma&#46; Global strategy for asthma management and prevention&#46; NHLBI&#47;WHO Workshop Report&#46; Bethesda&#58; National Heart&#44; Lung and Blood Institute&#46; National Institutes of Health&#59; 2005&#46; Available from&#58; http&#58;&#47;www&#46;ginasthma&#46;org&#46; Accessed September 19&#44; 2006&#46;"
                ]
              ]
            ]
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              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "The British Thoracic Society and the Scottish Intercollegiate Guidelines Network&#46; British guideline on the management of asthma&#46; A national clinical guideline&#44; 2005&#46; Available from&#58; http&#58;&#47;www&#46;sing&#46;ac&#46;uk&#47; guideline&#47;fulltext&#47;63&#47;index&#46;html&#46; Accessed September 19&#44; 2006&#46;"
                ]
              ]
            ]
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              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consenso sobre tratamiento del asma en Pediatr&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "RM Busquets Monge"
                            1 => "A Escribano Montaner"
                            2 => "M Fern&#225;ndez Benitez"
                            3 => "L Garc&#237;a-Marcos"
                            4 => "J Garde Garde"
                            5 => "M Ibero Iborra"
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                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
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                        "volumen" => "64"
                        "paginaInicial" => "365"
                        "paginaFinal" => "378"
                      ]
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              "etiqueta" => "9"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Gu&#237;a de pr&#225;ctica cl&#237;nica sobre asma &#40;1&#46;&#170; parte&#41;"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Merino"
                            1 => "J Aranguren"
                            2 => "M Call&#233;n"
                            3 => "J Elorz"
                            4 => "A Etxeberr&#237;a"
                            5 => "JB Galdiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
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                        "volumen" => "64"
                        "paginaInicial" => "557"
                        "paginaFinal" => "572"
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              ]
            ]
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              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a de pr&#225;ctica cl&#237;nica sobre asma &#40;2&#46;&#170; parte&#41;"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "J Aranguren"
                            2 => "M Call&#233;n"
                            3 => "J Elorz"
                            4 => "A Etxeberr&#237;a"
                            5 => "JB Galdiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
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                        "volumen" => "65"
                        "paginaInicial" => "51"
                        "paginaFinal" => "66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Global Strategy for Asthma Management and Prevention&#46; Revised 2006&#46; Available from&#58; http&#58;&#47;www&#46;ginasthma&#46;org&#46; Accessed November 30&#44; 2006&#46;"
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The distribution of peak expiratory flow variability in a population sample"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B Higgins"
                            1 => "JR Britton"
                            2 => "S Chinn"
                            3 => "TD Jones"
                            4 => "D Jenkinson"
                            5 => "PG Buerney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/140.5.1368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "140"
                        "paginaInicial" => "1368"
                        "paginaFinal" => "1372"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2817599"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peak flow variation in childhood asthma&#58; a three year analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "JE Gern"
                            1 => "PA Eggleston"
                            2 => "KC Schuberth"
                            3 => "ND Eney"
                            4 => "EO Goldstein"
                            5 => "ME Weiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1994"
                        "volumen" => "93"
                        "paginaInicial" => "706"
                        "paginaFinal" => "716"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8163780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of peak expiratory flow variability in an adolescent population sample&#58; the Odense schoolchild study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "HC Siersted"
                            1 => "HS Hansen"
                            2 => "NCG Hansen"
                            3 => "N Hyldebrandt"
                            4 => "G Mostgaard"
                            5 => "H Oxhoy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.149.3.8118624"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1994"
                        "volumen" => "149"
                        "paginaInicial" => "598"
                        "paginaFinal" => "603"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8118624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Which index of peak expiratory flow is most useful in the management of stable asthma&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "HK Reddel"
                            1 => "CM Salome"
                            2 => "JK Peat"
                            3 => "AJ Woolcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.151.5.7735580"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "151"
                        "paginaInicial" => "1320"
                        "paginaFinal" => "1325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7735580"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "JL Fleiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Statistical methods for rates and proportions"
                        "paginaInicial" => "38"
                        "paginaFinal" => "48"
                        "edicion" => "2nd ed&#46;"
                        "serieFecha" => "1981"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G Polgar"
                            1 => "V Promadhat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Pulmonary function testing in children&#58; techniques and standards"
                        "fecha" => "1971"
                        "editorial" => "Saunders"
                        "editorialLocalizacion" => "Philadelphia"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ATS&#47;ERS Task Force&#58; standardisation of lung function testing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Standardisation of Spirometry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00034805"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "319"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spirometric reference values for white European children and adolescents&#58; Polgar revisited"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "PH Quanjer"
                            1 => "GJ Borsboom"
                            2 => "B Brunekreff"
                            3 => "M Zach"
                            4 => "G Forche"
                            5 => "JE Cotes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "1995"
                        "volumen" => "19"
                        "paginaInicial" => "135"
                        "paginaFinal" => "142"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7659469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "DG Altman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Practical statistics for medical research"
                        "fecha" => "1991"
                        "editorial" => "Chapman and Hall"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Home peak expiratory flow rate monitoring in patients with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "TCJ Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0025-6196(11)63916-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1995"
                        "volumen" => "70"
                        "paginaInicial" => "649"
                        "paginaFinal" => "656"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7791387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variability of peak expiratory flow rate in children&#58; short and long term reproducibility"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T Frischer"
                            1 => "R Meinert"
                            2 => "R Urbanek"
                            3 => "J Kuehr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1995"
                        "volumen" => "50"
                        "paginaInicial" => "35"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7886646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acceptability&#44; reproducibility&#44; and sensitivity of forced expiratory volumes and peak expiratory flow during bronchial challenge testing in asthmatic children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "LP Malmberg"
                            1 => "K Nikander"
                            2 => "AS Pelkonen"
                            3 => "P Syv&#228;nen"
                            4 => "T Koljonen"
                            5 => "T Haahtela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "120"
                        "paginaInicial" => "1843"
                        "paginaFinal" => "1849"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11742911"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persisting airway obstruction in asymptomatic children with asthma with normal peak expiratory flow rates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "AC Ferguson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1988"
                        "volumen" => "82"
                        "paginaInicial" => "19"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3392366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of mini peak flow meters in indicating changes in lung function in children with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "PD Sly"
                            1 => "P Cahill"
                            2 => "K Willet"
                            3 => "P Burton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1994"
                        "volumen" => "308"
                        "paginaInicial" => "572"
                        "paginaFinal" => "574"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8148680"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Can peak expiratory flow predict airflow obstruction in children with asthma&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N Eid"
                            1 => "B Yandell"
                            2 => "L Howell"
                            3 => "M Heddy"
                            4 => "S Sheikh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2000"
                        "volumen" => "105"
                        "paginaInicial" => "354"
                        "paginaFinal" => "358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10654955"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0014256512000501"
                          "estado" => "S300"
                          "issn" => "00142565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of atopy on the natural history of symptoms&#44; peak expiratory flow&#44; and bronchial responsiveness in 7 and 8 year old children with cough and wheeze"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JB Clough"
                            1 => "JD Williams"
                            2 => "ST Holgate"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/143.4_Pt_1.755"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1991"
                        "volumen" => "143"
                        "paginaInicial" => "755"
                        "paginaFinal" => "760"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2008988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of 22 months of treatment with inhaled corticosteroids and&#47;or beta-2-agonists on lung function&#44; airway responsiveness&#44; and symptoms in children with asthma&#46; The Dutch Chronic Non-specific Lung Disease Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "EEM van Essen-Zandvliet"
                            1 => "MD Hugues"
                            2 => "HJ Waalkens"
                            3 => "EG Duiverman"
                            4 => "SJ Pocock"
                            5 => "KF Kerrebijn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/148.3.818"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1993"
                        "volumen" => "148"
                        "paginaInicial" => "818"
                        "paginaFinal" => "893"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8368655"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S014067360416769X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of treatment on peak expiratory flow and its relation to airway hyperresponsiveness and symptoms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "HAM Kerstjens"
                            1 => "PLP Brnad"
                            2 => "PM de Jong"
                            3 => "GH K&#246;eter"
                            4 => "DS Postma"
                            5 => "Dutch CNSLD Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1994"
                        "volumen" => "49"
                        "paginaInicial" => "1109"
                        "paginaFinal" => "1115"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7831626"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchial responsiveness to histamine&#58; relationship to diurnal variation of peak flow rate&#44; improvement after bronchodilator&#44; and airway calibre"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G Ryan"
                            1 => "KM Latimer"
                            2 => "J Dolovich"
                            3 => "FE Hargreave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1982"
                        "volumen" => "37"
                        "paginaInicial" => "423"
                        "paginaFinal" => "429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6890243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in peak expiratory flow indices as a proxy for changes in bronchial hyperresponsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "WR Douma"
                            1 => "HAM Kerstjens"
                            2 => "CM Roos"
                            3 => "GH Ko&#235;ter"
                            4 => "DS Postma"
                            5 => "Dutch Chronic Non-specific Lung Disease study group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2000"
                        "volumen" => "16"
                        "paginaInicial" => "220"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10968495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Testing bronchial hyper-responsiveness&#58; provocation or peak expiratory flow variability&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "JJ den Otter"
                            1 => "GMW Reijnen"
                            2 => "WJHM van den Bosch"
                            3 => "CP van Schayck"
                            4 => "J Molema"
                            5 => "C van Weel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Gen Pract"
                        "fecha" => "1997"
                        "volumen" => "47"
                        "paginaInicial" => "487"
                        "paginaFinal" => "492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9302787"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparisons of peak diurnal expiratory flow variation&#44; postbronchodilator FEV<span class="elsevierStyleInf">1</span> responses&#44; and methacholine inhalation challenges in the evaluation of suspected asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "MF Goldstein"
                            1 => "BA Veza"
                            2 => "EH Dunsky"
                            3 => "DJ Dvorin"
                            4 => "GA Belecanech"
                            5 => "IC Haralabatos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "119"
                        "paginaInicial" => "1001"
                        "paginaFinal" => "1010"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11296161"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peak flow variation in childhood asthma&#58; relationship to symptoms&#44; atopy&#44; airways obstruction and hyperresponsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "PLP Brand"
                            1 => "EJ Duiverman"
                            2 => "DS Postma"
                            3 => "HJ Waalkens"
                            4 => "KF Kerrebijn"
                            5 => "EEM van Essen-Zandvliet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1997"
                        "volumen" => "10"
                        "paginaInicial" => "1242"
                        "paginaFinal" => "1247"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9192923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of asthma severity&#58; should the international guidelines be changed&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G Sawyer"
                            1 => "J Miles"
                            2 => "S Lewis"
                            3 => "P Fitzharris"
                            4 => "N Pearce"
                            5 => "R Beasley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Allergy"
                        "fecha" => "1998"
                        "volumen" => "28"
                        "paginaInicial" => "1565"
                        "paginaFinal" => "1570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10024229"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
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              ]
            ]
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              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Underestimation of the peak flow variability in asthmatic children&#58; evaluation of a new formula"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "MH Vargas"
                            1 => "HH Ruiz-Guti&#233;rrez"
                            2 => "C Espinosa-Seraf&#237;n"
                            3 => "G Zu&#241;iga-V&#225;zquez"
                            4 => "ME Furuya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ppul.20196"
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                        "tituloSerie" => "Pediatr Pulmonol"
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                        "paginaInicial" => "325"
                        "paginaFinal" => "331"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15704185"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
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              "etiqueta" => "37"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
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                        0 => array:2 [
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                          "autores" => array:5 [
                            0 => "AL Fuhlbrigge"
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                            2 => "KM Kuntz"
                            3 => "AD Paltiel"
                            4 => "for the CAMP Research Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatrics"
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                        "paginaInicial" => "247"
                        "paginaFinal" => "355"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classifying asthma severity in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "LB Bacharier"
                            1 => "RC Strunk"
                            2 => "D Mauger"
                            3 => "D White"
                            4 => "RF Lemanske Jr"
                            5 => "CA Sorkness"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200308-1178OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2004"
                        "volumen" => "170"
                        "paginaInicial" => "426"
                        "paginaFinal" => "432"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15172893"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of monitoring lung function in asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "PLP Brand"
                            1 => "RJ Roorda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "2003"
                        "volumen" => "88"
                        "paginaInicial" => "1021"
                        "paginaFinal" => "1025"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14612375"
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ISSN: 15792129
Original language: English
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