array:23 [
  "pii" => "S1579212907601232"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60123-2"
  "estado" => "S300"
  "fechaPublicacion" => "2007-01-01"
  "aid" => "60123"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2007"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2007;43:530-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3131
    "formatos" => array:3 [
      "EPUB" => 95
      "HTML" => 2325
      "PDF" => 711
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907601244"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60124-4"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60124"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:535-41"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4126
      "formatos" => array:3 [
        "EPUB" => 86
        "HTML" => 3263
        "PDF" => 777
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Variability in Peak Expiratory Flow Does Not Classify Asthma According to Severity"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "535"
          "paginaFinal" => "541"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eduardo G&#46; P&#233;rez-Yarza, Nicol&#225;s Cobos, Juan Jos&#233; de la Cruz"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Eduardo G&#46;"
              "apellidos" => "P&#233;rez-Yarza"
            ]
            1 => array:2 [
              "nombre" => "Nicol&#225;s"
              "apellidos" => "Cobos"
            ]
            2 => array:2 [
              "nombre" => "Juan Jos&#233;"
              "apellidos" => "de la Cruz"
            ]
            3 => array:1 [
              "colaborador" => "on behalf of the Asthma Working Group of the Spanish Society of Pediatric Pneumology"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907601244?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000010/v1_201305150259/S1579212907601244/v1_201305150259/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212907601220"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60122-0"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60122"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "edi"
    "cita" => "Arch Bronconeumol. 2007;43:527-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2147
      "formatos" => array:3 [
        "EPUB" => 84
        "HTML" => 1355
        "PDF" => 708
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "Health Case Support for Home Machanical Ventilation&#58; Networking Versus Centralization"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "527"
          "paginaFinal" => "529"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Joan Escarrabill"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Joan"
              "apellidos" => "Escarrabill"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907601220?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000010/v1_201305150259/S1579212907601220/v1_201305150259/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Spirometry Reference Values After Inhalation of 200 &#956;g of Salbutamol"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "530"
        "paginaFinal" => "534"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Rogelio P&#233;rez-Padilla, Luis Torre Bouscoulet, Juan Carlos V&#225;zquez-Garc&#237;a, Adriana Mui&#241;o, Mar&#237;a M&#225;rquez, Mar&#237;a Victorina L&#243;pez, Mar&#237;a Montes de Oca, Carlos T&#225;lamo, Gonzalo Valdivia, Julio Pertuze, Jos&#233; Jardim, Ana Mar&#237;a B&#46; Menezes"
        "autores" => array:13 [
          0 => array:4 [
            "nombre" => "Rogelio"
            "apellidos" => "P&#233;rez-Padilla"
            "email" => array:1 [
              0 => "perezpad&#64;servidor&#46;unam&#46;mx"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Luis Torre"
            "apellidos" => "Bouscoulet"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Juan Carlos"
            "apellidos" => "V&#225;zquez-Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Adriana"
            "apellidos" => "Mui&#241;o"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;a"
            "apellidos" => "M&#225;rquez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Mar&#237;a Victorina"
            "apellidos" => "L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Mar&#237;a Montes"
            "apellidos" => "de Oca"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Carlos"
            "apellidos" => "T&#225;lamo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Gonzalo"
            "apellidos" => "Valdivia"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff4"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Julio"
            "apellidos" => "Pertuze"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff4"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Jardim"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff5"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "Ana Mar&#237;a B&#46;"
            "apellidos" => "Menezes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff6"
              ]
            ]
          ]
          12 => array:2 [
            "colaborador" => "on behalf of the PLATINO group"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "fn1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:6 [
          0 => array:3 [
            "entidad" => "Instituto Nacional de Enfermedades Respiratorias&#44; Mexico City&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Divisi&#243;n Pulmonar&#44; Hospital Universitario de Caracas&#44; Universidad Central de Venezuela&#44; Caracas&#44; Venezuela"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
          3 => array:3 [
            "entidad" => "Pontificia Universidad Cat&#243;lica de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff4"
          ]
          4 => array:3 [
            "entidad" => "Universidad Federal de S&#227;o Paulo&#44; S&#227;o Paulo&#44; Brazil"
            "etiqueta" => "<span class="elsevierStyleSup">e</span>"
            "identificador" => "aff5"
          ]
          5 => array:3 [
            "entidad" => "Universidad Federal de Pelotas&#44; Pelotas&#44; Brazil"
            "etiqueta" => "<span class="elsevierStyleSup">f</span>"
            "identificador" => "aff6"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; R&#46; P&#233;rez-Padilla&#46; Instituto Nacional de Enfermedades Respiratorias&#46; Tlalpan&#44; 4502&#46; 14080 Mexico City&#44; Mexico"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-09-03"
    "fechaAceptado" => "2006-09-19"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154612"
          "palabras" => array:7 [
            0 => "Chronic obstructive pulmonary disease &#40;COPD&#41;"
            1 => "Bronchodilator response"
            2 => "Reference values"
            3 => "Spirometry"
            4 => "Cross- sectional study"
            5 => "Latin America"
            6 => "PLATINO"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec154611"
          "palabras" => array:7 [
            0 => "EPOC"
            1 => "Respuesta al broncodilatador"
            2 => "Valores de referencia"
            3 => "Espirometr&#237;a"
            4 => "Estudio transversal"
            5 => "Latinoam&#233;rica"
            6 => "PLATINO"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The criteria for disease severity established by the Global Initiative for Chronic Obstructive Lung Disease are based on forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; expressed as a percentage of the predicted value after application of a bronchodilator&#46; This study aims to determine postbronchodilator spirometry reference values&#46;</p> <span class="elsevierStyleSectionTitle">SUBJECTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">A cluster sample of subjects aged 40 years or over was chosen to be representative of the metropolitan areas of 5 Latin American cities &#40;S&#227;o Paulo&#44; Mexico City&#44; Montevideo&#44; Santiago&#44; and Caracas&#41;&#46; Spirometry was performed on 5183 subjects following the recommendations of the American Thoracic Society before and after inhalation of 200 &#956;g of salbutamol&#46; Multiple linear regression equations were fitted for the postbronchodilator spirometric values&#8211;FEV<span class="elsevierStyleInf">1</span>&#44; forced expiratory volume in 6 seconds &#40;FEV<span class="elsevierStyleInf">6</span>&#41;&#44; peak expiratory flow rate&#44; forced vital capacity &#40;FVC&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC and forced expiratory flow between 25&#37; and 75&#37; of vital capacity &#40;FEF<span class="elsevierStyleInf">25-75</span>&#41;&#46; These were adjusted for sex&#44; age&#44; and height in 887 asymptomatic subjects with no history of lung disease&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">The postbronchodilator reference values for FEV<span class="elsevierStyleInf">1</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#44; and FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span> were on average 3&#37; higher than those obtained before bronchodilation&#46; This apparently small difference caused an upward shift in the 5th percentile &#40;lower limit of normal&#41; of the predicted values&#46; When prebronchodilation instead of postbronchodilation reference values were used&#44; 3&#46;2&#37; of the results for airflow obstruction in our population of over-40-year-olds were false negatives&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The reported reference values are more appropriate for postbronchodilator spirometry and make it possible to reduce the number of misclassifications&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La clasificaci&#243;n de la gravedad de la enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; se basa&#44; de acuerdo con la iniciativa GOLD&#44; en el volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41; despu&#233;s de usar broncodilatador&#44; expresado como porcentaje del esperado&#46; El prop&#243;sito de este trabajo ha sido determinar los valores de referencia para la espirometr&#237;a despu&#233;s de la administraci&#243;n de broncodilatador&#46;</p> <span class="elsevierStyleSectionTitle">SUJETOS Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un muestreo por conglomerados de sujetos de 40 a&#241;os o m&#225;s&#44; representativos de las zonas metropolitanas de S&#227;o Paulo&#44; Ciudad de M&#233;xico&#44; Montevideo&#44; Santiago y Caracas&#46; Se realiz&#243; una espirometr&#237;a a 5&#46;183 sujetos de acuerdo con las recomendaciones de la American Thoracic Society&#44; antes y despu&#233;s de la inhalaci&#243;n de 200 &#956;g de salbutamol&#46; Se efectuaron regresiones lineales m&#250;ltiples para los valores espirom&#233;tricos &#8211;FEV<span class="elsevierStyleInf">1</span>&#44; volumen espiratorio forzado en 6 s &#40;FEV<span class="elsevierStyleInf">6</span>&#41;&#44; &#237;ndice de flujo espiratorio m&#225;ximo&#44; capacidad vital forzada &#40;FVC&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC y flujo mesoespiratorio forzado&#8211; despu&#233;s del uso del broncodilatador&#44; ajustando por sexo&#44; edad y altura&#44; en 887 sujetos sin evidencia de enfermedad pulmonar previa&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Los valores de referencia tras broncodilatador para FEV<span class="elsevierStyleInf">1</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC y FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span> fueron en promedio un 3&#37; mayores que los obtenidos con la espirometr&#237;a realizada antes de la inhalaci&#243;n del broncodilatador&#46; Esta diferencia&#44; que parece peque&#241;a&#44; causa un desplazamiento hacia arriba en el percentil 5 &#40;l&#237;mite inferior de la normalidad&#41; de los valores esperados&#46; Si se utiliza el valor de referencia prebroncodilatador&#44; en lugar del posbroncodilatador&#44; se genera un 3&#44;2&#37; de falsos negativos para obstrucci&#243;n al flujo a&#233;reo en el total de la poblaci&#243;n de 40 o m&#225;s a&#241;os de edad&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">Los valores de referencia indicados son m&#225;s apropiados para espirometr&#237;as realizadas despu&#233;s de la inhalaci&#243;n del broncodilatador y permiten minimizar los errores de clasificaci&#243;n&#46;</p>"
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#42;"
        "nota" => "<p class="elsevierStyleNotepara">The remaining members of the PLATINO group are listed at the end of the article&#46;</p>"
      ]
      1 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">This study was financed by a Boehringer-Ingelheim research grant&#46; The company played no role in the data analysis or preparation of the manuscript&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standards for the diagnosis and treatment of patients with COPD&#58; a summary of the ATS&#47;ERS position paper"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "BR Celli"
                            1 => "W MacNee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2004"
                        "volumen" => "23"
                        "paginaInicial" => "932"
                        "paginaFinal" => "946"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15219010"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Workshop report&#44; global strategy for diagnosis&#44; management and prevention of COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "GOLD"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Available from&#58; http&#58;&#47;&#47;www&#46;gold-copd&#46;com&#47;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interpretative strategies for lung function tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R Pellegrino"
                            1 => "G Viegi"
                            2 => "V Brusasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00035205"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "948"
                        "paginaFinal" => "968"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16264058"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-bronchodilator spirometry reference values in adults and implications for disease management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A Johannessen"
                            1 => "S Lehmann"
                            2 => "ER Omenaas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200601-023OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "173"
                        "paginaInicial" => "1316"
                        "paginaFinal" => "1325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16556696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The PLATINO project&#58; methodology of a multicenter prevalence survey of chronic obstructive pulmonary disease in major Latin American cities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "AM Menezes"
                            1 => "CG Victora"
                            2 => "R P&#233;rez-Padilla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2288-4-15"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Med Res Methodol"
                        "fecha" => "2004"
                        "volumen" => "4"
                        "paginaInicial" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15202950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease in five Latin American cities &#40;the PLATINO study&#41;&#58; a prevalence study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "AM Menezes"
                            1 => "R P&#233;rez-Padilla"
                            2 => "JR Jardim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)67632-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2005"
                        "volumen" => "366"
                        "paginaInicial" => "1875"
                        "paginaFinal" => "1881"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16310554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Valores de referencia espirom&#233;trica en 5 grandes ciudades de Latinoam&#233;rica para sujetos de 40 o m&#225;s a&#241;os de edad"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J P&#233;rez Padilla"
                            1 => "G Valdivia"
                            2 => "A Mui&#241;o"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2006"
                        "volumen" => "42"
                        "paginaInicial" => "317"
                        "paginaFinal" => "325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16945261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The long-term stability of portable spirometers used in a multinational study of COPD prevalence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R P&#233;rez-Padilla"
                            1 => "J V&#225;zquez-Garc&#237;a"
                            2 => "M M&#225;rquez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Care"
                        "fecha" => "2006"
                        "volumen" => "51"
                        "paginaInicial" => "1167"
                        "paginaFinal" => "1171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17005063"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardisation of spirometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "MR Miller"
                            1 => "J Hankinson"
                            2 => "V Brusasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00034805"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "319"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung function testing&#58; selection of reference values and interpretative strategies&#46; American Thoracic Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/144.5.1202"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1991"
                        "volumen" => "144"
                        "paginaInicial" => "1202"
                        "paginaFinal" => "1218"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1952453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spirometric reference values from a sample of the general U&#46;S&#46; population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JL Hankinson"
                            1 => "JR Odencrantz"
                            2 => "KB Fedan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.159.1.9712108"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "179"
                        "paginaFinal" => "187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872837"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "StataCorp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Stata Statistical Software&#58; release 9&#46;0"
                        "fecha" => "2005"
                        "editorial" => "Stata Corporation"
                        "editorialLocalizacion" => "College Station&#44; TX"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardization of spirometry&#44; 1994 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.3.7663792"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "1107"
                        "paginaFinal" => "1136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7663792"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessing the reversibility of airway obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R Pellegrino"
                            1 => "JR Rodarte"
                            2 => "V Brusasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
                        "volumen" => "114"
                        "paginaInicial" => "1607"
                        "paginaFinal" => "1612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872196"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short term variability in FEV1 and bronchodilator responsiveness in patients with obstructive ventilatory defects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "PM Tweeddale"
                            1 => "F Alexander"
                            2 => "GJ McHardy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "487"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3438892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004300000010/v1_201305150259/S1579212907601232/v1_201305150259/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004300000010/v1_201305150259/S1579212907601232/v1_201305150259/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907601232?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original Articles
Spirometry Reference Values After Inhalation of 200 μg of Salbutamol
Rogelio Pérez-Padillaa,
Corresponding author
perezpad@servidor.unam.mx

Correspondence: Dr. R. Pérez-Padilla. Instituto Nacional de Enfermedades Respiratorias. Tlalpan, 4502. 14080 Mexico City, Mexico
, Luis Torre Bouscouleta, Juan Carlos Vázquez-Garcíaa, Adriana Muiñob, María Márquezb, María Victorina Lópezb, María Montes de Ocac, Carlos Tálamoc, Gonzalo Valdiviad, Julio Pertuzed, José Jardime, Ana María B. Menezesf, on behalf of the PLATINO group *
a Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
b Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
c División Pulmonar, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela
d Pontificia Universidad Católica de Chile, Santiago, Chile
e Universidad Federal de São Paulo, São Paulo, Brazil
f Universidad Federal de Pelotas, Pelotas, Brazil
Read
5413
Times
was read the article
2103
Total PDF
3310
Total HTML
Share statistics
 array:23 [
  "pii" => "S1579212907601232"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60123-2"
  "estado" => "S300"
  "fechaPublicacion" => "2007-01-01"
  "aid" => "60123"
  "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
  "copyrightAnyo" => "2007"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2007;43:530-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3131
    "formatos" => array:3 [
      "EPUB" => 95
      "HTML" => 2325
      "PDF" => 711
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907601244"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60124-4"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60124"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:535-41"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 4126
      "formatos" => array:3 [
        "EPUB" => 86
        "HTML" => 3263
        "PDF" => 777
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Variability in Peak Expiratory Flow Does Not Classify Asthma According to Severity"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "535"
          "paginaFinal" => "541"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Eduardo G&#46; P&#233;rez-Yarza, Nicol&#225;s Cobos, Juan Jos&#233; de la Cruz"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Eduardo G&#46;"
              "apellidos" => "P&#233;rez-Yarza"
            ]
            1 => array:2 [
              "nombre" => "Nicol&#225;s"
              "apellidos" => "Cobos"
            ]
            2 => array:2 [
              "nombre" => "Juan Jos&#233;"
              "apellidos" => "de la Cruz"
            ]
            3 => array:1 [
              "colaborador" => "on behalf of the Asthma Working Group of the Spanish Society of Pediatric Pneumology"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907601244?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000010/v1_201305150259/S1579212907601244/v1_201305150259/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212907601220"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60122-0"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60122"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "edi"
    "cita" => "Arch Bronconeumol. 2007;43:527-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2147
      "formatos" => array:3 [
        "EPUB" => 84
        "HTML" => 1355
        "PDF" => 708
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "Health Case Support for Home Machanical Ventilation&#58; Networking Versus Centralization"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "527"
          "paginaFinal" => "529"
        ]
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Joan Escarrabill"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Joan"
              "apellidos" => "Escarrabill"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907601220?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000010/v1_201305150259/S1579212907601220/v1_201305150259/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Spirometry Reference Values After Inhalation of 200 &#956;g of Salbutamol"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "530"
        "paginaFinal" => "534"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Rogelio P&#233;rez-Padilla, Luis Torre Bouscoulet, Juan Carlos V&#225;zquez-Garc&#237;a, Adriana Mui&#241;o, Mar&#237;a M&#225;rquez, Mar&#237;a Victorina L&#243;pez, Mar&#237;a Montes de Oca, Carlos T&#225;lamo, Gonzalo Valdivia, Julio Pertuze, Jos&#233; Jardim, Ana Mar&#237;a B&#46; Menezes"
        "autores" => array:13 [
          0 => array:4 [
            "nombre" => "Rogelio"
            "apellidos" => "P&#233;rez-Padilla"
            "email" => array:1 [
              0 => "perezpad&#64;servidor&#46;unam&#46;mx"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Luis Torre"
            "apellidos" => "Bouscoulet"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Juan Carlos"
            "apellidos" => "V&#225;zquez-Garc&#237;a"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Adriana"
            "apellidos" => "Mui&#241;o"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;a"
            "apellidos" => "M&#225;rquez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Mar&#237;a Victorina"
            "apellidos" => "L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Mar&#237;a Montes"
            "apellidos" => "de Oca"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Carlos"
            "apellidos" => "T&#225;lamo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Gonzalo"
            "apellidos" => "Valdivia"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff4"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Julio"
            "apellidos" => "Pertuze"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff4"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Jardim"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff5"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "Ana Mar&#237;a B&#46;"
            "apellidos" => "Menezes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff6"
              ]
            ]
          ]
          12 => array:2 [
            "colaborador" => "on behalf of the PLATINO group"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "fn1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:6 [
          0 => array:3 [
            "entidad" => "Instituto Nacional de Enfermedades Respiratorias&#44; Mexico City&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Divisi&#243;n Pulmonar&#44; Hospital Universitario de Caracas&#44; Universidad Central de Venezuela&#44; Caracas&#44; Venezuela"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
          3 => array:3 [
            "entidad" => "Pontificia Universidad Cat&#243;lica de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff4"
          ]
          4 => array:3 [
            "entidad" => "Universidad Federal de S&#227;o Paulo&#44; S&#227;o Paulo&#44; Brazil"
            "etiqueta" => "<span class="elsevierStyleSup">e</span>"
            "identificador" => "aff5"
          ]
          5 => array:3 [
            "entidad" => "Universidad Federal de Pelotas&#44; Pelotas&#44; Brazil"
            "etiqueta" => "<span class="elsevierStyleSup">f</span>"
            "identificador" => "aff6"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; R&#46; P&#233;rez-Padilla&#46; Instituto Nacional de Enfermedades Respiratorias&#46; Tlalpan&#44; 4502&#46; 14080 Mexico City&#44; Mexico"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-09-03"
    "fechaAceptado" => "2006-09-19"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154612"
          "palabras" => array:7 [
            0 => "Chronic obstructive pulmonary disease &#40;COPD&#41;"
            1 => "Bronchodilator response"
            2 => "Reference values"
            3 => "Spirometry"
            4 => "Cross- sectional study"
            5 => "Latin America"
            6 => "PLATINO"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec154611"
          "palabras" => array:7 [
            0 => "EPOC"
            1 => "Respuesta al broncodilatador"
            2 => "Valores de referencia"
            3 => "Espirometr&#237;a"
            4 => "Estudio transversal"
            5 => "Latinoam&#233;rica"
            6 => "PLATINO"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The criteria for disease severity established by the Global Initiative for Chronic Obstructive Lung Disease are based on forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; expressed as a percentage of the predicted value after application of a bronchodilator&#46; This study aims to determine postbronchodilator spirometry reference values&#46;</p> <span class="elsevierStyleSectionTitle">SUBJECTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">A cluster sample of subjects aged 40 years or over was chosen to be representative of the metropolitan areas of 5 Latin American cities &#40;S&#227;o Paulo&#44; Mexico City&#44; Montevideo&#44; Santiago&#44; and Caracas&#41;&#46; Spirometry was performed on 5183 subjects following the recommendations of the American Thoracic Society before and after inhalation of 200 &#956;g of salbutamol&#46; Multiple linear regression equations were fitted for the postbronchodilator spirometric values&#8211;FEV<span class="elsevierStyleInf">1</span>&#44; forced expiratory volume in 6 seconds &#40;FEV<span class="elsevierStyleInf">6</span>&#41;&#44; peak expiratory flow rate&#44; forced vital capacity &#40;FVC&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC and forced expiratory flow between 25&#37; and 75&#37; of vital capacity &#40;FEF<span class="elsevierStyleInf">25-75</span>&#41;&#46; These were adjusted for sex&#44; age&#44; and height in 887 asymptomatic subjects with no history of lung disease&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">The postbronchodilator reference values for FEV<span class="elsevierStyleInf">1</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#44; and FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span> were on average 3&#37; higher than those obtained before bronchodilation&#46; This apparently small difference caused an upward shift in the 5th percentile &#40;lower limit of normal&#41; of the predicted values&#46; When prebronchodilation instead of postbronchodilation reference values were used&#44; 3&#46;2&#37; of the results for airflow obstruction in our population of over-40-year-olds were false negatives&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The reported reference values are more appropriate for postbronchodilator spirometry and make it possible to reduce the number of misclassifications&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La clasificaci&#243;n de la gravedad de la enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; se basa&#44; de acuerdo con la iniciativa GOLD&#44; en el volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41; despu&#233;s de usar broncodilatador&#44; expresado como porcentaje del esperado&#46; El prop&#243;sito de este trabajo ha sido determinar los valores de referencia para la espirometr&#237;a despu&#233;s de la administraci&#243;n de broncodilatador&#46;</p> <span class="elsevierStyleSectionTitle">SUJETOS Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un muestreo por conglomerados de sujetos de 40 a&#241;os o m&#225;s&#44; representativos de las zonas metropolitanas de S&#227;o Paulo&#44; Ciudad de M&#233;xico&#44; Montevideo&#44; Santiago y Caracas&#46; Se realiz&#243; una espirometr&#237;a a 5&#46;183 sujetos de acuerdo con las recomendaciones de la American Thoracic Society&#44; antes y despu&#233;s de la inhalaci&#243;n de 200 &#956;g de salbutamol&#46; Se efectuaron regresiones lineales m&#250;ltiples para los valores espirom&#233;tricos &#8211;FEV<span class="elsevierStyleInf">1</span>&#44; volumen espiratorio forzado en 6 s &#40;FEV<span class="elsevierStyleInf">6</span>&#41;&#44; &#237;ndice de flujo espiratorio m&#225;ximo&#44; capacidad vital forzada &#40;FVC&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC y flujo mesoespiratorio forzado&#8211; despu&#233;s del uso del broncodilatador&#44; ajustando por sexo&#44; edad y altura&#44; en 887 sujetos sin evidencia de enfermedad pulmonar previa&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Los valores de referencia tras broncodilatador para FEV<span class="elsevierStyleInf">1</span>&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC y FEV<span class="elsevierStyleInf">1</span>&#47;FEV<span class="elsevierStyleInf">6</span> fueron en promedio un 3&#37; mayores que los obtenidos con la espirometr&#237;a realizada antes de la inhalaci&#243;n del broncodilatador&#46; Esta diferencia&#44; que parece peque&#241;a&#44; causa un desplazamiento hacia arriba en el percentil 5 &#40;l&#237;mite inferior de la normalidad&#41; de los valores esperados&#46; Si se utiliza el valor de referencia prebroncodilatador&#44; en lugar del posbroncodilatador&#44; se genera un 3&#44;2&#37; de falsos negativos para obstrucci&#243;n al flujo a&#233;reo en el total de la poblaci&#243;n de 40 o m&#225;s a&#241;os de edad&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">Los valores de referencia indicados son m&#225;s apropiados para espirometr&#237;as realizadas despu&#233;s de la inhalaci&#243;n del broncodilatador y permiten minimizar los errores de clasificaci&#243;n&#46;</p>"
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#42;"
        "nota" => "<p class="elsevierStyleNotepara">The remaining members of the PLATINO group are listed at the end of the article&#46;</p>"
      ]
      1 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">This study was financed by a Boehringer-Ingelheim research grant&#46; The company played no role in the data analysis or preparation of the manuscript&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standards for the diagnosis and treatment of patients with COPD&#58; a summary of the ATS&#47;ERS position paper"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "BR Celli"
                            1 => "W MacNee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2004"
                        "volumen" => "23"
                        "paginaInicial" => "932"
                        "paginaFinal" => "946"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15219010"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Workshop report&#44; global strategy for diagnosis&#44; management and prevention of COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "GOLD"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Available from&#58; http&#58;&#47;&#47;www&#46;gold-copd&#46;com&#47;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interpretative strategies for lung function tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R Pellegrino"
                            1 => "G Viegi"
                            2 => "V Brusasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00035205"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "948"
                        "paginaFinal" => "968"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16264058"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-bronchodilator spirometry reference values in adults and implications for disease management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A Johannessen"
                            1 => "S Lehmann"
                            2 => "ER Omenaas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200601-023OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "173"
                        "paginaInicial" => "1316"
                        "paginaFinal" => "1325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16556696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The PLATINO project&#58; methodology of a multicenter prevalence survey of chronic obstructive pulmonary disease in major Latin American cities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "AM Menezes"
                            1 => "CG Victora"
                            2 => "R P&#233;rez-Padilla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2288-4-15"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Med Res Methodol"
                        "fecha" => "2004"
                        "volumen" => "4"
                        "paginaInicial" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15202950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease in five Latin American cities &#40;the PLATINO study&#41;&#58; a prevalence study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "AM Menezes"
                            1 => "R P&#233;rez-Padilla"
                            2 => "JR Jardim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(05)67632-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2005"
                        "volumen" => "366"
                        "paginaInicial" => "1875"
                        "paginaFinal" => "1881"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16310554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Valores de referencia espirom&#233;trica en 5 grandes ciudades de Latinoam&#233;rica para sujetos de 40 o m&#225;s a&#241;os de edad"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J P&#233;rez Padilla"
                            1 => "G Valdivia"
                            2 => "A Mui&#241;o"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2006"
                        "volumen" => "42"
                        "paginaInicial" => "317"
                        "paginaFinal" => "325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16945261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The long-term stability of portable spirometers used in a multinational study of COPD prevalence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R P&#233;rez-Padilla"
                            1 => "J V&#225;zquez-Garc&#237;a"
                            2 => "M M&#225;rquez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Care"
                        "fecha" => "2006"
                        "volumen" => "51"
                        "paginaInicial" => "1167"
                        "paginaFinal" => "1171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17005063"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardisation of spirometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "MR Miller"
                            1 => "J Hankinson"
                            2 => "V Brusasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00034805"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "319"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung function testing&#58; selection of reference values and interpretative strategies&#46; American Thoracic Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/144.5.1202"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1991"
                        "volumen" => "144"
                        "paginaInicial" => "1202"
                        "paginaFinal" => "1218"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1952453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spirometric reference values from a sample of the general U&#46;S&#46; population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JL Hankinson"
                            1 => "JR Odencrantz"
                            2 => "KB Fedan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.159.1.9712108"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "179"
                        "paginaFinal" => "187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872837"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "StataCorp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Stata Statistical Software&#58; release 9&#46;0"
                        "fecha" => "2005"
                        "editorial" => "Stata Corporation"
                        "editorialLocalizacion" => "College Station&#44; TX"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardization of spirometry&#44; 1994 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.3.7663792"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "1107"
                        "paginaFinal" => "1136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7663792"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessing the reversibility of airway obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R Pellegrino"
                            1 => "JR Rodarte"
                            2 => "V Brusasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
                        "volumen" => "114"
                        "paginaInicial" => "1607"
                        "paginaFinal" => "1612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872196"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short term variability in FEV1 and bronchodilator responsiveness in patients with obstructive ventilatory defects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "PM Tweeddale"
                            1 => "F Alexander"
                            2 => "GJ McHardy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "487"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3438892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004300000010/v1_201305150259/S1579212907601232/v1_201305150259/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004300000010/v1_201305150259/S1579212907601232/v1_201305150259/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907601232?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 7 7 14
2024 October 33 31 64
2024 September 35 24 59
2024 August 63 50 113
2024 July 22 18 40
2024 June 48 28 76
2024 May 42 25 67
2024 April 26 31 57
2024 March 32 19 51
2024 February 25 23 48
2023 March 4 4 8
2023 February 20 18 38
2023 January 20 32 52
2022 December 20 34 54
2022 November 31 26 57
2022 October 38 50 88
2022 September 22 48 70
2022 August 28 42 70
2022 July 33 42 75
2022 June 25 48 73
2022 May 28 43 71
2022 April 28 42 70
2022 March 32 59 91
2022 February 21 50 71
2022 January 14 28 42
2021 December 14 57 71
2021 November 16 47 63
2021 October 19 49 68
2021 September 14 64 78
2021 August 16 26 42
2021 July 23 34 57
2021 June 11 24 35
2021 May 17 36 53
2021 April 33 66 99
2021 March 13 15 28
2021 February 10 15 25
2021 January 9 13 22
2020 December 10 12 22
2020 November 11 14 25
2020 October 8 12 20
2020 September 7 5 12
2020 August 10 8 18
2020 July 10 19 29
2020 June 3 9 12
2020 May 9 12 21
2020 April 10 19 29
2020 March 10 14 24
2020 February 11 6 17
2020 January 9 15 24
2019 December 18 16 34
2019 November 9 10 19
2019 October 9 5 14
2019 September 17 14 31
2019 August 14 5 19
2019 July 9 14 23
2019 June 6 3 9
2019 May 10 6 16
2019 April 20 21 41
2019 March 7 18 25
2019 February 10 12 22
2019 January 18 10 28
2018 December 11 15 26
2018 November 15 10 25
2018 October 28 16 44
2018 September 20 10 30
2018 May 4 0 4
2018 April 6 11 17
2018 March 9 3 12
2018 February 4 8 12
2018 January 3 5 8
2017 December 3 7 10
2017 November 2 6 8
2017 October 3 14 17
2017 September 4 14 18
2017 August 5 22 27
2017 July 6 23 29
2017 June 8 9 17
2017 May 10 7 17
2017 April 10 8 18
2017 March 33 38 71
2017 February 4 1 5
2017 January 5 0 5
2016 December 8 6 14
2016 November 10 7 17
2016 October 10 5 15
2016 September 7 5 12
2016 August 5 3 8
2016 July 2 3 5
2016 April 2 0 2
2016 March 1 0 1
2016 February 1 0 1
2015 December 2 0 2
2015 October 75 18 93
2015 September 87 10 97
2015 August 69 17 86
2015 July 85 10 95
2015 June 63 10 73
2015 May 65 10 75
2015 April 47 5 52
2015 March 66 7 73
2015 February 43 4 47
2015 January 52 4 56
2014 December 67 11 78
2014 November 62 4 66
2014 October 78 10 88
2014 September 75 10 85
2014 August 56 9 65
2014 July 87 11 98
2014 June 84 5 89
2014 May 88 12 100
2014 April 81 5 86
2014 March 69 13 82
2014 February 52 14 66
2014 January 37 13 50
2013 December 65 7 72
2013 November 49 5 54
2013 October 49 9 58
2013 September 46 9 55
2013 August 35 17 52
2013 July 53 14 67
2013 June 47 7 54
2013 May 56 8 64
2013 April 21 11 32
2013 March 13 1 14
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?