Correspondence: Dr. N. Santana Rodríguez, Unidad de Cirugía Torácica, Unidad de Investigación, Hospital Universitario Insular de Gran Canaria, Dr. Negrín Marítima del Sur, s/n. 35010 Las Palmas de Gran Canarias. Las Palmas. España
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[ 0 => array:4 [ "autoresLista" => "Norberto Santana Rodríguez, José Luis Martín Barrasa, Miguel Ángel Ponce González, Ana López García, José Antonio Ruiz Caballero, Antonio Torres García, Jorge Freixinet Gilart" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Norberto Santana" "apellidos" => "Rodríguez" "email" => array:1 [ 0 => "norbesr@terra.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "José Luis Martín" "apellidos" => "Barrasa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Miguel Ángel Ponce" "apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "Ana López" "apellidos" => "García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 4 => array:3 [ "nombre" => "José Antonio Ruiz" "apellidos" => "Caballero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] ] 5 => array:3 [ "nombre" => "Antonio Torres" "apellidos" => "García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] ] ] 6 => array:3 [ "nombre" => "Jorge Freixinet" "apellidos" => "Gilart" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Unidad de Cirugía Torácica, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria Dr. Negrín, Las Palmas, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Unidad de Cirugía Experimental and Unidad de Investigación, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Unidad de Hospitalización Domiciliaria, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Clínica Puerta de Hierro, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Departamento de Ciencias Clínicas, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] 5 => array:3 [ "entidad" => "Unidad de Cirugía Torácica and Trasplante Pulmonar de Donante en Asistolia, Hospital Clínico San Carlos, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. N. Santana Rodríguez, Unidad de Cirugía Torácica, Unidad de Investigación, Hospital Universitario Insular de Gran Canaria, Dr. Negrín Marítima del Sur, s/n. 35010 Las Palmas de Gran Canarias. Las Palmas. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-04-24" "fechaAceptado" => "2006-09-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154925" "palabras" => array:3 [ 0 => "Lung transplantation" 1 => "Ischemic time" 2 => "Experimental surgery" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154926" "palabras" => array:3 [ 0 => "Trasplante pulmonar" 1 => "Tiempo de isquemia" 2 => "Cirugía experimental" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">OBJECTIVE</span><p class="elsevierStyleSimplePara elsevierViewall">To assess ischemia–reperfusion injury and early acute rejection of the lung subjected to ischemia for 10 hours.</p> <span class="elsevierStyleSectionTitle">MATERIAL AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">Fifteen of 30 Sprague–Dawley rats underwent transplantation of a left lung that had been subjected to ischemic times of 4 (n=5), 6 (n=5), or 10 hours (n=5). The cardiopulmonary block was removed from the donor, the left lung was dissected, and the transplant was carried out using the cuff technique. The cardiopulmonary block was extracted after 48 hours. We assessed postoperative progress, ischemia–reperfusion injury and acute rejection of the transplanted and contralateral lungs. Statistical probabilities were analyzed using the χ<span class="elsevierStyleSup">2</span> and Fisher exact tests.</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">Clinical course was not worse after an ischemic time of 10 hours (=.711). No significant differences were observed in histological markers of ischemia–reperfusion injury and acute rejection or in clinical course in relation to the different ischemic times; nor was clinical course related to the presence or severity of lesions or rejection. Similarly, acute rejection was unrelated to ischemia–reperfusion injury (>.05).</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">In this study, a prolonged ischemic time of 10 hours was not associated with ischemia–reperfusion injuries, with more severe acute rejection, or with a worse clinical course. Acute rejection was also unrelated to the presence or severity of ischemia–reperfusion injury.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la lesión de isquemia-reperfusión y el rechazo agudo precoz del pulmón sometido a un tiempo de isquemia de 10 h.</p> <span class="elsevierStyleSectionTitle">MATERIAL Y MÉTODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se han utilizado 30 ratas Sprague-Dawley, en 15 de las cuales se realizó un trasplante pulmonar izquierdo con tiempos de isquemia de 4 h (n = 5), 6 h (n = 5) y 10 h (n = 5). Del donante se extrajo el bloque cardiopulmonar, se disecó el pulmón izquierdo y se efectuó el implante con la técnica de manguitos <span class="elsevierStyleItalic">(cuffs)</span>. A las 48 h se extrajo el bloque cardiopulmonar. Se valoraron la evolución postoperatoria, la lesión de isquemia-reperfusión y el rechazo agudo del χ<span class="elsevierStyleSup">2</span> pulmón trasplantado y del contralateral. El análisis estadístico se realizó con el test de la χ<span class="elsevierStyleSup">2</span> y el test exacto de Fisher para el cálculo de probabilidades.</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">Los animales trasplantados con un tiempo de isquemia de 10 h no tuvieron peor evolución clínica (p = 0,711). No se observaron diferencias significativas entre los parámetros histológicos de lesión de isquemia-reperfusión y de rechazo agudo con los distintos tiempos de isquemia, ni en la evolución clínica por la presencia y gravedad de éstos. Tampoco se observó que el rechazo agudo se relacionara con la lesión de isquemia-reperfusión (p > 0,05).</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">En nuestro estudio, el tiempo de isquemia pulmonar prolongado de 10 h no se asocia ni a lesiones de isquemia-reperfusión y rechazo agudo más graves ni a una peor evolución clínica. El rechazo agudo no se relaciona con la presencia ni con la gravedad de la lesión de isquemiareperfusión.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This project was funded by the Spanish Health Research Fund (Fondo de Investigación Sanitaria Español, or FIS), the Canary Island Research Foundation (Fundación Canaria de Investigación y Salud, or FUNCIS, project 1104), the Canary Island Cancer Research Institute (Instituto Canario de Investigación del Cáncer, ICIC) and the Madrid MMA Foundation (Fundación MMA).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary allograft ischemic time: an important predictor of survival after lung transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 4 | 3 | 7 |
2024 October | 29 | 18 | 47 |
2024 September | 33 | 18 | 51 |
2024 August | 45 | 35 | 80 |
2024 July | 28 | 22 | 50 |
2024 June | 33 | 23 | 56 |
2024 May | 34 | 29 | 63 |
2024 April | 14 | 22 | 36 |
2024 March | 20 | 15 | 35 |
2024 February | 22 | 20 | 42 |
2023 March | 2 | 2 | 4 |
2023 February | 23 | 29 | 52 |
2023 January | 15 | 20 | 35 |
2022 December | 25 | 23 | 48 |
2022 November | 22 | 28 | 50 |
2022 October | 18 | 21 | 39 |
2022 September | 20 | 23 | 43 |
2022 August | 19 | 35 | 54 |
2022 July | 19 | 31 | 50 |
2022 June | 23 | 39 | 62 |
2022 May | 18 | 35 | 53 |
2022 April | 15 | 47 | 62 |
2022 March | 28 | 47 | 75 |
2022 February | 30 | 24 | 54 |
2022 January | 13 | 38 | 51 |
2021 December | 14 | 38 | 52 |
2021 November | 17 | 45 | 62 |
2021 October | 18 | 37 | 55 |
2021 September | 16 | 62 | 78 |
2021 August | 12 | 30 | 42 |
2021 July | 18 | 33 | 51 |
2021 June | 18 | 36 | 54 |
2021 May | 10 | 22 | 32 |
2021 April | 28 | 85 | 113 |
2021 March | 16 | 14 | 30 |
2021 February | 17 | 13 | 30 |
2021 January | 16 | 12 | 28 |
2020 December | 8 | 16 | 24 |
2020 November | 11 | 7 | 18 |
2020 October | 20 | 11 | 31 |
2020 September | 2 | 1 | 3 |
2020 August | 11 | 8 | 19 |
2020 July | 16 | 16 | 32 |
2020 June | 11 | 6 | 17 |
2020 May | 14 | 8 | 22 |
2020 April | 9 | 18 | 27 |
2020 March | 22 | 13 | 35 |
2020 February | 14 | 16 | 30 |
2020 January | 17 | 26 | 43 |
2019 December | 9 | 9 | 18 |
2019 November | 8 | 12 | 20 |
2019 October | 4 | 17 | 21 |
2019 September | 13 | 9 | 22 |
2019 August | 10 | 4 | 14 |
2019 July | 29 | 20 | 49 |
2019 June | 54 | 12 | 66 |
2019 May | 29 | 13 | 42 |
2019 April | 27 | 10 | 37 |
2019 March | 11 | 13 | 24 |
2019 February | 3 | 9 | 12 |
2019 January | 4 | 6 | 10 |
2018 December | 5 | 14 | 19 |
2018 November | 19 | 6 | 25 |
2018 October | 30 | 18 | 48 |
2018 September | 15 | 9 | 24 |
2018 May | 5 | 1 | 6 |
2018 April | 8 | 6 | 14 |
2018 March | 10 | 3 | 13 |
2018 February | 5 | 8 | 13 |
2018 January | 7 | 7 | 14 |
2017 December | 6 | 7 | 13 |
2017 November | 3 | 6 | 9 |
2017 October | 5 | 10 | 15 |
2017 September | 6 | 4 | 10 |
2017 August | 4 | 8 | 12 |
2017 July | 2 | 1 | 3 |
2017 June | 11 | 8 | 19 |
2017 May | 4 | 7 | 11 |
2017 April | 7 | 3 | 10 |
2017 March | 37 | 3 | 40 |
2017 February | 6 | 5 | 11 |
2017 January | 2 | 4 | 6 |
2016 December | 2 | 4 | 6 |
2016 November | 7 | 7 | 14 |
2016 October | 8 | 3 | 11 |
2016 September | 5 | 5 | 10 |
2016 August | 8 | 6 | 14 |
2016 July | 3 | 5 | 8 |
2016 March | 2 | 0 | 2 |
2015 December | 2 | 0 | 2 |
2015 October | 47 | 4 | 51 |
2015 September | 48 | 6 | 54 |
2015 August | 47 | 9 | 56 |
2015 July | 37 | 6 | 43 |
2015 June | 34 | 4 | 38 |
2015 May | 46 | 4 | 50 |
2015 April | 38 | 15 | 53 |
2015 March | 40 | 6 | 46 |
2015 February | 28 | 2 | 30 |
2015 January | 25 | 7 | 32 |
2014 December | 33 | 7 | 40 |
2014 November | 56 | 5 | 61 |
2014 October | 54 | 12 | 66 |
2014 September | 38 | 7 | 45 |
2014 August | 43 | 10 | 53 |
2014 July | 33 | 9 | 42 |
2014 June | 56 | 5 | 61 |
2014 May | 70 | 7 | 77 |
2014 April | 57 | 7 | 64 |
2014 March | 61 | 11 | 72 |
2014 February | 53 | 7 | 60 |
2014 January | 39 | 5 | 44 |
2013 December | 55 | 10 | 65 |
2013 November | 54 | 5 | 59 |
2013 October | 52 | 9 | 61 |
2013 September | 45 | 8 | 53 |
2013 August | 35 | 6 | 41 |
2013 July | 52 | 11 | 63 |
2013 June | 36 | 8 | 44 |
2013 May | 37 | 3 | 40 |
2013 April | 16 | 5 | 21 |
2013 March | 8 | 2 | 10 |