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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJECTIVE</span><p class="elsevierStyleSimplePara elsevierViewall">To investigate the incidence of tuberculosis &#40;TB&#41; in a cohort of contacts and to analyze the variables associated with the disease&#46;</p> <span class="elsevierStyleSectionTitle">METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective analysis was undertaken of all the contact investigations carried out in a health district in the Basque Country in northern Spain between January 1&#44; 1995 and December 31&#44; 2004&#46; The dependent variable was the number of cases of TB detected among the contacts&#46; Independent variables were age&#44; sex&#44; tuberculin skin test result&#44; and the degree of contact&#46; In index cases&#44; additional variables were the site of the disease and smear test result&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">Analysis of 5444 contacts of 596 patients with TB yielded 66 secondary cases of TB &#40;40 at the time of the contact investigation and 26 at a later stage&#41;&#59; the majority &#40;73&#37;&#41; developed the disease within 12 months&#46; Multivariate analysis revealed a significant relationship between the detection of secondary cases and the following variables&#58; close contact &#40;odds ratio &#91;OR&#93;&#44; 3&#46;05&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;75-5&#46;31&#41;&#44; positive smear test &#40;OR&#44; 8&#46;54&#59; 95&#37; CI&#44; 2&#46;06-35&#46;43&#41;&#44; induration of 10 mm or larger &#40;OR&#44; 10&#46;18&#59; 95&#37; CI&#44; 4&#46;27-24&#46;26&#41;&#44; and age under 30 years &#40;OR&#44; 3&#46;35&#59; 95&#37; CI&#44; 1&#46;88-5&#46;98&#41;&#46; The final predictive model constructed on the basis of these 3 variables had a sensitivity of 77&#46;4&#37;&#44; a specificity of 80&#46;3&#37;&#44; and an area under the curve of 0&#46;83 &#40;95&#37; CI&#44; 0&#46;78-0&#46;88&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The contact investigation is a valid strategy for the detection of new cases of TB&#46; Prophylactic treatment should be implemented at an early stage&#44; and priority should be given to young contacts of smear-positive patients using an induration size of 10 mm or more as a reference&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer la incidencia de tuberculosis &#40;TB&#41; en una cohorte de contactos y analizar las variables asociadas a la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha efectuado un an&#225;lisis prospectivo de los estudios de contactos &#40;EC&#41; realizados en un &#225;rea sanitaria del Pa&#237;s Vasco del 1 de enero de 1995 al 31 de diciembre de 2004&#46; La variable dependiente fue el n&#250;mero de casos de TB detectados entre los contactos&#46; Las variables independientes fueron la edad&#44; el sexo&#44; la prueba de la tuberculina &#40;PT&#41; y el grado de contacto&#44; y en los casos &#237;ndice&#44; la localizaci&#243;n de la TB y la baciloscopia del esputo&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">De los 5&#46;444 contactos de 596 pacientes con TB que se estudiaron&#44; se encontraron 66 casos secundarios de TB &#40;40 en el momento del EC y 26 en el per&#237;odo posterior&#41;&#44; la mayor&#237;a de ellos &#40;73&#37;&#41; durante el primer a&#241;o&#46; El an&#225;lisis multivariante demostr&#243; una relaci&#243;n significativa entre la detecci&#243;n de casos secundarios y las siguientes variables&#58; contacto &#237;ntimo &#40;<span class="elsevierStyleItalic">odds ratio</span> &#91;OR&#93; &#61; 3&#44;05&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 1&#44;75-5&#44;31&#41;&#44; baciloscopia positiva &#40;OR &#61; 8&#44;54&#59; IC del 95&#37;&#44; 2&#44;06-35&#44;43&#41;&#44; PT de 10 mm o mayor &#40;OR &#61; 10&#44;18&#59; IC del 95&#37;&#44; 4&#44;27-24&#44;26&#41; y edad inferior a 30 a&#241;os &#40;OR &#61; 3&#44;35&#59; IC del 95&#37;&#44; 1&#44;88-5&#44;98&#41;&#46; El modelo predictivo final que se obtuvo utilizando estas 3 variables alcanz&#243; una sensibilidad del 77&#44;4&#37;&#44; una especificidad del 80&#44;3&#37; y un &#225;rea bajo la curva de 0&#44;83 &#40;IC del 95&#37;&#44; 0&#44;78-0&#44;88&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">El EC es una estrategia v&#225;lida para la detecci&#243;n de nuevos casos de TB&#46; La intervenci&#243;n profil&#225;ctica deber&#237;a realizarse de forma precoz y dirigirse prioritariamente a los contactos j&#243;venes de pacientes bacil&#237;feros&#44; utilizando como referencia una PT de 10 mm o mayor&#46;</p>"
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Original Articles
Longitudinal Incidence of Tuberculosis in a Cohort of Contacts: Factors Associated With the Disease
Carlos Salinasa,
Corresponding author
csalinas@hgda.osakidetza.net

Correspondence: Dr. C. Salinas, Servicio de Neumología. Hospital de Galdakao. B.° Labeaga, s/n, 48960 Galdakao. Bizkaia. España
, Alberto Capelasteguia, Lander Altubea, Pedro Pablo Españaa, Rosa Díeza, Mikel Oribea, Isabel Urrutiaa, Urko Aguirreb
a Servicio de Neumología, Hospital de Galdakao, Galdakao, Bizkaia, Spain
b Unidad de Investigación, Hospital de Galdakao, Galdakao, Bizkaia, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJECTIVE</span><p class="elsevierStyleSimplePara elsevierViewall">To investigate the incidence of tuberculosis &#40;TB&#41; in a cohort of contacts and to analyze the variables associated with the disease&#46;</p> <span class="elsevierStyleSectionTitle">METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective analysis was undertaken of all the contact investigations carried out in a health district in the Basque Country in northern Spain between January 1&#44; 1995 and December 31&#44; 2004&#46; The dependent variable was the number of cases of TB detected among the contacts&#46; Independent variables were age&#44; sex&#44; tuberculin skin test result&#44; and the degree of contact&#46; In index cases&#44; additional variables were the site of the disease and smear test result&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">Analysis of 5444 contacts of 596 patients with TB yielded 66 secondary cases of TB &#40;40 at the time of the contact investigation and 26 at a later stage&#41;&#59; the majority &#40;73&#37;&#41; developed the disease within 12 months&#46; Multivariate analysis revealed a significant relationship between the detection of secondary cases and the following variables&#58; close contact &#40;odds ratio &#91;OR&#93;&#44; 3&#46;05&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;75-5&#46;31&#41;&#44; positive smear test &#40;OR&#44; 8&#46;54&#59; 95&#37; CI&#44; 2&#46;06-35&#46;43&#41;&#44; induration of 10 mm or larger &#40;OR&#44; 10&#46;18&#59; 95&#37; CI&#44; 4&#46;27-24&#46;26&#41;&#44; and age under 30 years &#40;OR&#44; 3&#46;35&#59; 95&#37; CI&#44; 1&#46;88-5&#46;98&#41;&#46; The final predictive model constructed on the basis of these 3 variables had a sensitivity of 77&#46;4&#37;&#44; a specificity of 80&#46;3&#37;&#44; and an area under the curve of 0&#46;83 &#40;95&#37; CI&#44; 0&#46;78-0&#46;88&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The contact investigation is a valid strategy for the detection of new cases of TB&#46; Prophylactic treatment should be implemented at an early stage&#44; and priority should be given to young contacts of smear-positive patients using an induration size of 10 mm or more as a reference&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer la incidencia de tuberculosis &#40;TB&#41; en una cohorte de contactos y analizar las variables asociadas a la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha efectuado un an&#225;lisis prospectivo de los estudios de contactos &#40;EC&#41; realizados en un &#225;rea sanitaria del Pa&#237;s Vasco del 1 de enero de 1995 al 31 de diciembre de 2004&#46; La variable dependiente fue el n&#250;mero de casos de TB detectados entre los contactos&#46; Las variables independientes fueron la edad&#44; el sexo&#44; la prueba de la tuberculina &#40;PT&#41; y el grado de contacto&#44; y en los casos &#237;ndice&#44; la localizaci&#243;n de la TB y la baciloscopia del esputo&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">De los 5&#46;444 contactos de 596 pacientes con TB que se estudiaron&#44; se encontraron 66 casos secundarios de TB &#40;40 en el momento del EC y 26 en el per&#237;odo posterior&#41;&#44; la mayor&#237;a de ellos &#40;73&#37;&#41; durante el primer a&#241;o&#46; El an&#225;lisis multivariante demostr&#243; una relaci&#243;n significativa entre la detecci&#243;n de casos secundarios y las siguientes variables&#58; contacto &#237;ntimo &#40;<span class="elsevierStyleItalic">odds ratio</span> &#91;OR&#93; &#61; 3&#44;05&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 1&#44;75-5&#44;31&#41;&#44; baciloscopia positiva &#40;OR &#61; 8&#44;54&#59; IC del 95&#37;&#44; 2&#44;06-35&#44;43&#41;&#44; PT de 10 mm o mayor &#40;OR &#61; 10&#44;18&#59; IC del 95&#37;&#44; 4&#44;27-24&#44;26&#41; y edad inferior a 30 a&#241;os &#40;OR &#61; 3&#44;35&#59; IC del 95&#37;&#44; 1&#44;88-5&#44;98&#41;&#46; El modelo predictivo final que se obtuvo utilizando estas 3 variables alcanz&#243; una sensibilidad del 77&#44;4&#37;&#44; una especificidad del 80&#44;3&#37; y un &#225;rea bajo la curva de 0&#44;83 &#40;IC del 95&#37;&#44; 0&#44;78-0&#44;88&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">El EC es una estrategia v&#225;lida para la detecci&#243;n de nuevos casos de TB&#46; La intervenci&#243;n profil&#225;ctica deber&#237;a realizarse de forma precoz y dirigirse prioritariamente a los contactos j&#243;venes de pacientes bacil&#237;feros&#44; utilizando como referencia una PT de 10 mm o mayor&#46;</p>"
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