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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJECTIVE</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze prognostic factors associated with survival in a group of patients who underwent resection of pulmonary metastases from colorectal cancer&#46;</p> <span class="elsevierStyleSectionTitle">PATIENTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">A retrospective review was performed for 55 consecutive patients who had undergone resection of pulmonary metastases from colorectal adenocarcinoma between January 1993 and June 2004&#46; Univariate and multivariate analyses were performed to assess the effect of the recorded variables on overall survival&#46;</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">Median overall survival was 32&#46;9 months and the probability of survival at 1&#44; 3&#44; and 5 years was 79&#37;&#44; 44&#37;&#44; and 22&#37;&#44; respectively&#46; Survival was lower in patients in whom the largest metastasis was at least 4 cm &#40;8&#46;6 vs 34&#46;5 months&#44; <span class="elsevierStyleItalic">P</span> &#61;&#46;0085&#41; and in patients with elevated levels of carcinoembryonic antigen &#40;24&#46;5 vs 41&#46;4 months&#44; <span class="elsevierStyleItalic">P</span> &#61;&#46;05&#41;&#46; Significantly longer survival was observed in patients who received adjuvant chemotherapy after surgery &#40;49&#46;8 vs 30&#46;9 months&#44; <span class="elsevierStyleItalic">P</span> &#61;&#46;0058&#41;&#46; Preoperative positron emission tomography &#40;PET&#41; and the absence of previous or synchronous liver metastases were associated with a nonsignificant trend toward increased survival&#46; In the multivariate analysis&#44; only size of the largest pulmonary metastasis influenced overall survival &#40;<span class="elsevierStyleItalic">P</span> &#61;&#46;036&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The preoperative variables that best predicted survival in our patients were size of the largest pulmonary metastasis and the level of carcinoembryonic antigen&#46; Prospective studies are needed to determine the usefulness of PET for tumor staging prior to resection of pulmonary metastases&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar los factores pron&#243;sticos de supervivencia en una serie de pacientes con met&#225;stasis pulmonares resecadas de c&#225;ncer colorrectal&#46;</p> <span class="elsevierStyleSectionTitle">PACIENTES Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se revisaron retrospectivamente los casos de 55 pacientes consecutivos a quienes entre enero de 1993 y junio de 2004 se hab&#237;a practicado una metastasectom&#237;a pulmonar de adenocarcinoma colorrectal&#46; Se realiz&#243; un an&#225;lisis univariante y multivariante para la supervivencia global con las variables recogidas&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">La mediana de la supervivencia global fue de 32&#44;9 meses&#44; con una probabilidad de supervivencia a 1&#44; 3 y 5 a&#241;os del 79&#44; el 44 y el 22&#37;&#44; respectivamente&#46; La supervivencia fue inferior &#40;p &#61; 0&#44;0085&#41; en los pacientes en que la met&#225;stasis mayor era de 4 cm o m&#225;s respecto a aquellos en que era menor de 4 cm &#40;8&#44;6 frente a 34&#44;5 meses&#41;&#44; y en los pacientes con t&#237;tulos elevados de ant&#237;geno carcinoembrionario frente a aqu&#233;llos con valores normales &#40;24&#44;5 frente a 41&#44;4 meses&#59; p &#61; 0&#44;05&#41;&#46; Quienes recibieron quimioterapia adyuvante tras la cirug&#237;a vivieron significativamente m&#225;s &#40;49&#44;8 frente a 30&#44;9 meses&#59; p &#61; 0&#44;0058&#41;&#46; La realizaci&#243;n de una tomograf&#237;a por emisi&#243;n de positrones preoperatoria y la ausencia de met&#225;stasis hep&#225;ticas previas o sincr&#243;nicas se asociaron a una tendencia no significativa hacia una mejor supervivencia&#46; En el an&#225;lisis multivariante s&#243;lo el tama&#241;o de la met&#225;stasis pulmonar mayor influy&#243; en la supervivencia global &#40;p &#61; 0&#44;036&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">El tama&#241;o de la met&#225;stasis mayor y el valor del ant&#237;geno carcinoembrionario fueron las variables preoperatorias que mejor predijeron la supervivencia de nuestros pacientes&#46; Se necesitan estudios prospectivos que valoren el papel de la tomograf&#237;a por emisi&#243;n de positrones como estudio de extensi&#243;n previo a metastasectom&#237;as pulmonares&#46;</p>"
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Original Articles
Prognostic Factors Associated With Resectable Pulmonary Metastases From Colorectal Cancer
Alberto Muñoz Llarenaa,
Corresponding author
amunoz@hcru.osakidetza.net

Correspondence: Dr. A. Muñoz Llarena. Servicio de Oncología Médica. Hospital de Cruces. Pza. de Cruces, s/n. 48903 Barakaldo. Bizkaia. España
, Sergio Carrera Revillaa, Aitziber Gil-Negrete Labordaa, Joaquín Pac Ferrerb, Ramón Barceló Galíndeza, Guillermo López Vivancoa
a Servicio de Oncología Médica, Hospital de Cruces, Osakidetza-Servicio Vasco de Salud, Barakaldo, Bizkaia, Spain
b Servicio de Cirugía Torácica, Hospital de Cruces, Osakidetza-Servicio Vasco de Salud, Barakaldo, Bizkaia, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar los factores pron&#243;sticos de supervivencia en una serie de pacientes con met&#225;stasis pulmonares resecadas de c&#225;ncer colorrectal&#46;</p> <span class="elsevierStyleSectionTitle">PACIENTES Y M&#201;TODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se revisaron retrospectivamente los casos de 55 pacientes consecutivos a quienes entre enero de 1993 y junio de 2004 se hab&#237;a practicado una metastasectom&#237;a pulmonar de adenocarcinoma colorrectal&#46; Se realiz&#243; un an&#225;lisis univariante y multivariante para la supervivencia global con las variables recogidas&#46;</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">La mediana de la supervivencia global fue de 32&#44;9 meses&#44; con una probabilidad de supervivencia a 1&#44; 3 y 5 a&#241;os del 79&#44; el 44 y el 22&#37;&#44; respectivamente&#46; La supervivencia fue inferior &#40;p &#61; 0&#44;0085&#41; en los pacientes en que la met&#225;stasis mayor era de 4 cm o m&#225;s respecto a aquellos en que era menor de 4 cm &#40;8&#44;6 frente a 34&#44;5 meses&#41;&#44; y en los pacientes con t&#237;tulos elevados de ant&#237;geno carcinoembrionario frente a aqu&#233;llos con valores normales &#40;24&#44;5 frente a 41&#44;4 meses&#59; p &#61; 0&#44;05&#41;&#46; Quienes recibieron quimioterapia adyuvante tras la cirug&#237;a vivieron significativamente m&#225;s &#40;49&#44;8 frente a 30&#44;9 meses&#59; p &#61; 0&#44;0058&#41;&#46; La realizaci&#243;n de una tomograf&#237;a por emisi&#243;n de positrones preoperatoria y la ausencia de met&#225;stasis hep&#225;ticas previas o sincr&#243;nicas se asociaron a una tendencia no significativa hacia una mejor supervivencia&#46; En el an&#225;lisis multivariante s&#243;lo el tama&#241;o de la met&#225;stasis pulmonar mayor influy&#243; en la supervivencia global &#40;p &#61; 0&#44;036&#41;&#46;</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">El tama&#241;o de la met&#225;stasis mayor y el valor del ant&#237;geno carcinoembrionario fueron las variables preoperatorias que mejor predijeron la supervivencia de nuestros pacientes&#46; Se necesitan estudios prospectivos que valoren el papel de la tomograf&#237;a por emisi&#243;n de positrones como estudio de extensi&#243;n previo a metastasectom&#237;as pulmonares&#46;</p>"
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    ]
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