Correspondence: Dr. A. Muñoz Llarena. Servicio de Oncología Médica. Hospital de Cruces. Pza. de Cruces, s/n. 48903 Barakaldo. Bizkaia. España
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"Alberto Muñoz Llarena, Sergio Carrera Revilla, Aitziber Gil-Negrete Laborda, Joaquín Pac Ferrer, Ramón Barceló Galíndez, Guillermo López Vivanco" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Alberto Muñoz" "apellidos" => "Llarena" "email" => array:1 [ 0 => "amunoz@hcru.osakidetza.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Sergio Carrera" "apellidos" => "Revilla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Aitziber Gil-Negrete" "apellidos" => "Laborda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Joaquín Pac" "apellidos" => "Ferrer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "Ramón Barceló" "apellidos" => "Galíndez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "Guillermo López" "apellidos" => "Vivanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Oncología Médica, Hospital de Cruces, Osakidetza-Servicio Vasco de Salud, Barakaldo, Bizkaia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital de Cruces, Osakidetza-Servicio Vasco de Salud, Barakaldo, Bizkaia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. A. Muñoz Llarena. Servicio de Oncología Médica. Hospital de Cruces. Pza. de Cruces, s/n. 48903 Barakaldo. Bizkaia. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-02-07" "fechaAceptado" => "2006-06-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154895" "palabras" => array:4 [ 0 => "Colorectal cancer" 1 => "Pulmonary metastases" 2 => "Surgical resection" 3 => "Adjuvant chemotherapy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154894" "palabras" => array:4 [ 0 => "Cáncer colorrectal" 1 => "Metástasis pulmonares" 2 => "Resección quirúrgica" 3 => "Quimioterapia adyuvante" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">OBJECTIVE</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze prognostic factors associated with survival in a group of patients who underwent resection of pulmonary metastases from colorectal cancer.</p> <span class="elsevierStyleSectionTitle">PATIENTS AND METHODS</span><p class="elsevierStyleSimplePara elsevierViewall">A retrospective review was performed for 55 consecutive patients who had undergone resection of pulmonary metastases from colorectal adenocarcinoma between January 1993 and June 2004. Univariate and multivariate analyses were performed to assess the effect of the recorded variables on overall survival.</p> <span class="elsevierStyleSectionTitle">RESULTS</span><p class="elsevierStyleSimplePara elsevierViewall">Median overall survival was 32.9 months and the probability of survival at 1, 3, and 5 years was 79%, 44%, and 22%, respectively. Survival was lower in patients in whom the largest metastasis was at least 4 cm (8.6 vs 34.5 months, <span class="elsevierStyleItalic">P</span> =.0085) and in patients with elevated levels of carcinoembryonic antigen (24.5 vs 41.4 months, <span class="elsevierStyleItalic">P</span> =.05). Significantly longer survival was observed in patients who received adjuvant chemotherapy after surgery (49.8 vs 30.9 months, <span class="elsevierStyleItalic">P</span> =.0058). Preoperative positron emission tomography (PET) and the absence of previous or synchronous liver metastases were associated with a nonsignificant trend toward increased survival. In the multivariate analysis, only size of the largest pulmonary metastasis influenced overall survival (<span class="elsevierStyleItalic">P</span> =.036).</p> <span class="elsevierStyleSectionTitle">CONCLUSIONS</span><p class="elsevierStyleSimplePara elsevierViewall">The preoperative variables that best predicted survival in our patients were size of the largest pulmonary metastasis and the level of carcinoembryonic antigen. Prospective studies are needed to determine the usefulness of PET for tumor staging prior to resection of pulmonary metastases.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">OBJETIVO</span><p class="elsevierStyleSimplePara elsevierViewall">Estudiar los factores pronósticos de supervivencia en una serie de pacientes con metástasis pulmonares resecadas de cáncer colorrectal.</p> <span class="elsevierStyleSectionTitle">PACIENTES Y MÉTODOS</span><p class="elsevierStyleSimplePara elsevierViewall">Se revisaron retrospectivamente los casos de 55 pacientes consecutivos a quienes entre enero de 1993 y junio de 2004 se había practicado una metastasectomía pulmonar de adenocarcinoma colorrectal. Se realizó un análisis univariante y multivariante para la supervivencia global con las variables recogidas.</p> <span class="elsevierStyleSectionTitle">RESULTADOS</span><p class="elsevierStyleSimplePara elsevierViewall">La mediana de la supervivencia global fue de 32,9 meses, con una probabilidad de supervivencia a 1, 3 y 5 años del 79, el 44 y el 22%, respectivamente. La supervivencia fue inferior (p = 0,0085) en los pacientes en que la metástasis mayor era de 4 cm o más respecto a aquellos en que era menor de 4 cm (8,6 frente a 34,5 meses), y en los pacientes con títulos elevados de antígeno carcinoembrionario frente a aquéllos con valores normales (24,5 frente a 41,4 meses; p = 0,05). Quienes recibieron quimioterapia adyuvante tras la cirugía vivieron significativamente más (49,8 frente a 30,9 meses; p = 0,0058). La realización de una tomografía por emisión de positrones preoperatoria y la ausencia de metástasis hepáticas previas o sincrónicas se asociaron a una tendencia no significativa hacia una mejor supervivencia. En el análisis multivariante sólo el tamaño de la metástasis pulmonar mayor influyó en la supervivencia global (p = 0,036).</p> <span class="elsevierStyleSectionTitle">CONCLUSIONES</span><p class="elsevierStyleSimplePara elsevierViewall">El tamaño de la metástasis mayor y el valor del antígeno carcinoembrionario fueron las variables preoperatorias que mejor predijeron la supervivencia de nuestros pacientes. Se necesitan estudios prospectivos que valoren el papel de la tomografía por emisión de positrones como estudio de extensión previo a metastasectomías pulmonares.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer statistics, 2006" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A Jemal" 1 => "R Siegel" 2 => "E Ward" 3 => "T Murray" 4 => "J Xu" 5 => "C Smigal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CA Cancer J Clin" "fecha" => "2006" "volumen" => "56" "paginaInicial" => "106" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16514137" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 8 | 6 | 14 |
2024 October | 29 | 11 | 40 |
2024 September | 24 | 13 | 37 |
2024 August | 41 | 46 | 87 |
2024 July | 29 | 18 | 47 |
2024 June | 29 | 17 | 46 |
2024 May | 30 | 25 | 55 |
2024 April | 17 | 21 | 38 |
2024 March | 22 | 15 | 37 |
2024 February | 16 | 19 | 35 |
2023 March | 3 | 5 | 8 |
2023 February | 15 | 15 | 30 |
2023 January | 17 | 30 | 47 |
2022 December | 21 | 29 | 50 |
2022 November | 15 | 19 | 34 |
2022 October | 21 | 23 | 44 |
2022 September | 19 | 23 | 42 |
2022 August | 18 | 39 | 57 |
2022 July | 19 | 43 | 62 |
2022 June | 16 | 34 | 50 |
2022 May | 17 | 28 | 45 |
2022 April | 16 | 25 | 41 |
2022 March | 19 | 32 | 51 |
2022 February | 16 | 31 | 47 |
2022 January | 12 | 30 | 42 |
2021 December | 20 | 41 | 61 |
2021 November | 15 | 46 | 61 |
2021 October | 14 | 36 | 50 |
2021 September | 11 | 60 | 71 |
2021 August | 11 | 29 | 40 |
2021 July | 9 | 18 | 27 |
2021 June | 14 | 23 | 37 |
2021 May | 12 | 23 | 35 |
2021 April | 27 | 35 | 62 |
2021 March | 19 | 13 | 32 |
2021 February | 12 | 15 | 27 |
2021 January | 12 | 13 | 25 |
2020 December | 9 | 9 | 18 |
2020 November | 12 | 14 | 26 |
2020 October | 6 | 1 | 7 |
2020 September | 8 | 0 | 8 |
2020 August | 6 | 10 | 16 |
2020 July | 14 | 10 | 24 |
2020 June | 11 | 2 | 13 |
2020 May | 17 | 10 | 27 |
2020 April | 18 | 13 | 31 |
2020 March | 10 | 4 | 14 |
2020 February | 17 | 14 | 31 |
2020 January | 12 | 9 | 21 |
2019 December | 14 | 13 | 27 |
2019 November | 14 | 17 | 31 |
2019 October | 12 | 7 | 19 |
2019 September | 22 | 16 | 38 |
2019 August | 11 | 8 | 19 |
2019 July | 12 | 25 | 37 |
2019 June | 5 | 13 | 18 |
2019 May | 12 | 10 | 22 |
2019 April | 11 | 50 | 61 |
2019 March | 14 | 19 | 33 |
2019 February | 6 | 7 | 13 |
2019 January | 5 | 6 | 11 |
2018 December | 8 | 9 | 17 |
2018 November | 8 | 6 | 14 |
2018 October | 27 | 16 | 43 |
2018 September | 11 | 8 | 19 |
2018 May | 4 | 0 | 4 |
2018 April | 7 | 7 | 14 |
2018 March | 4 | 4 | 8 |
2018 February | 6 | 4 | 10 |
2018 January | 1 | 3 | 4 |
2017 December | 5 | 6 | 11 |
2017 November | 2 | 5 | 7 |
2017 October | 8 | 11 | 19 |
2017 September | 8 | 7 | 15 |
2017 August | 3 | 9 | 12 |
2017 July | 8 | 11 | 19 |
2017 June | 8 | 39 | 47 |
2017 May | 11 | 7 | 18 |
2017 April | 4 | 5 | 9 |
2017 March | 8 | 14 | 22 |
2017 February | 1 | 3 | 4 |
2017 January | 1 | 0 | 1 |
2016 December | 7 | 7 | 14 |
2016 November | 6 | 5 | 11 |
2016 October | 7 | 3 | 10 |
2016 September | 4 | 6 | 10 |
2016 August | 4 | 2 | 6 |
2016 July | 1 | 3 | 4 |
2016 March | 2 | 0 | 2 |
2015 December | 3 | 0 | 3 |
2015 October | 28 | 15 | 43 |
2015 September | 32 | 15 | 47 |
2015 August | 34 | 9 | 43 |
2015 July | 46 | 10 | 56 |
2015 June | 30 | 8 | 38 |
2015 May | 38 | 13 | 51 |
2015 April | 29 | 14 | 43 |
2015 March | 45 | 9 | 54 |
2015 February | 36 | 16 | 52 |
2015 January | 37 | 9 | 46 |
2014 December | 29 | 6 | 35 |
2014 November | 31 | 10 | 41 |
2014 October | 43 | 17 | 60 |
2014 September | 30 | 15 | 45 |
2014 August | 32 | 15 | 47 |
2014 July | 37 | 14 | 51 |
2014 June | 59 | 8 | 67 |
2014 May | 50 | 20 | 70 |
2014 April | 53 | 13 | 66 |
2014 March | 55 | 11 | 66 |
2014 February | 51 | 11 | 62 |
2014 January | 43 | 10 | 53 |
2013 December | 48 | 8 | 56 |
2013 November | 33 | 10 | 43 |
2013 October | 39 | 8 | 47 |
2013 September | 42 | 12 | 54 |
2013 August | 49 | 17 | 66 |
2013 July | 60 | 14 | 74 |
2013 June | 47 | 11 | 58 |
2013 May | 43 | 8 | 51 |
2013 April | 32 | 8 | 40 |
2013 March | 12 | 2 | 14 |