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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the influence of thoracentesis and pleural biopsy on biochemical parameters and cytology of pleural fluid from patients with lymphocytic exudate&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective&#44; descriptive study was performed in 72 patients with pleural effusion who had lymphocytic exudate and in whom biopsy was indicated&#46; Biochemical variables and cytology of pleural fluid were analyzed at baseline&#44; 48 hours later &#40;immediately prior to biopsy&#41;&#44; and 48 hours after biopsy&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The patients had a mean &#40;SD&#41; age of 63 &#40;17&#41; years&#44; 57&#37; were smokers&#44; and 61&#37; were men&#46; Effusion was right-sided in 36&#37; of patients&#44; unilateral in 80&#37;&#44; and massive in 21&#37;&#46; The etiology was benign in 43 cases and neoplastic in 29 &#40;40&#37;&#41;&#46; Pleural lactate dehydrogenase &#40;LDH&#41; was found to be increased following biopsy&#46; This effect was significant in the overall population of 72 patients &#40;649 &#91;481&#93; U&#47;L just prior to biopsy and 736 &#91;536&#93; U&#47;L 48 hours after biopsy&#59; mean increase&#44; 86 U&#47;L&#59; 95&#37; confidence interval&#44; 45-128 U&#47;L&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; in patients with pleural tumors &#40;799 &#91;529&#93; U&#47;L prior to biopsy and 957 &#91;571&#93; U&#47;L 48 hours later&#44; P&#60;&#46;001&#41;&#44; and in those with LDH concentration greater than 266 U&#47;L&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of our study show that a single thoracentesis procedure does not alter biochemical parameters or pleural cytology after 48 hours in lymphocytic exudates&#46; Pleural needle biopsy leads to a significant increase in the concentration of LDH in patients with pleural tumors or higher baseline concentrations of LDH&#46; Thoracentesis&#44; pleural biopsy&#44; or a combination of the two do not lead to significant changes in the number of eosinophils in pleural fluid&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la influencia de la toracocentesis y la biopsia pleural en la bioqu&#237;mica y la citolog&#237;a del l&#237;quido en los pacientes con un exudado linfocitario&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospec-tivo y descriptivo de 72 pacientes con derrame pleural que te-n&#237;an un exudado linfocitario e indicaci&#243;n de biopsia&#46; Se anali-zaron y compararon la bioqu&#237;mica y citolog&#237;a del l&#237;quido pleural al inicio&#44; a las 48 h de la punci&#243;n &#40;antes de la biopsia&#41; y a las 48 h de la biopsia pleural&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes ten&#237;an una edad media &#177; desviaci&#243;n est&#225;ndar de 63 &#177; 17 a&#241;os&#44; el 57&#37; eran fumadores y el 61&#37;&#44; va-rones&#46; El derrame era derecho en un 36&#37;&#44; unilateral en un 80&#37; y masivo en el 21&#37;&#46; La etiolog&#237;a era benigna en 43 casos y neopl&#225;sica en 29 &#40;40&#37;&#41;&#46; La lactatodeshidrogenasa &#40;LDH&#41; pleu-ral aument&#243; despu&#233;s de la biopsia en el an&#225;lisis de todos los pa-cientes &#40;649 &#177; 481 U&#47;l antes de &#233;sta y 736 &#177; 536 U&#47;l a las 48 h&#59; aument&#243; en promedio 86 U&#47;l&#59; intervalo de confianza del 95&#37;&#44; 45-128 U&#47;l&#59; p &#60; 0&#44;001&#41;&#44; en los pacientes con neoplasia pleural &#40;799 &#177; 529 U&#47;l de LDH antes de la biopsia y 957 &#177; 571 U&#47;l a las 48 h&#59; p &#60; 0&#44;001&#41; o valores de LDH superiores a 266 U&#47;l&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio demuestra que una &#250;nica toracocentesis no modifica los valores de la bioqu&#237;mica o la citolog&#237;a pleural a las 48 h en los exudados linfocitarios&#46; La biopsia pleural transparietal aumenta de forma significativa los valores de la LDH en los pacientes con neoplasia pleural o valores iniciales de LDH m&#225;s elevados&#46; La realizaci&#243;n de la toracocentesis&#44; la biopsia pleural o ambas t&#233;cnicas no mo-difica de forma significativa el n&#250;mero de eosin&#243;filos del l&#237;-quido pleural&#46;</p>"
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Original Articles
Influence of Thoracentesis and Pleural Biopsy on Biochemical Parameters and Cytology of Pleural Fluid
Haro-Estarriol Manuela,
Corresponding author
mip.mharo@htrueta.scs.es

Correspondence: Dr. M. Haro-Estarriol. Servicio de Neumología (planta 4.a B). Hospital Universitario de Girona Dr. Josep Trueta. Avda. de Francia, s/n. 17007 Girona. España
, Alberto Álvarez-Castillo Luisa, Baldó-Padró Xavierb, Manuel Ramírez-Malagón Joséc, Rubio-Goday Manuela, Sendra-Salillas Salvib
a Servicio de Neumología, Hospital Universitario de Girona Dr. Josep Trueta, Girona, Spain
b Servicio de Cirugía Torácica, Hospital Universitario de Girona Dr. Josep Trueta, Girona, Spain
c Laboratori Clínic, Hospital Universitario de Girona Dr. Josep Trueta, Girona, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the influence of thoracentesis and pleural biopsy on biochemical parameters and cytology of pleural fluid from patients with lymphocytic exudate&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective&#44; descriptive study was performed in 72 patients with pleural effusion who had lymphocytic exudate and in whom biopsy was indicated&#46; Biochemical variables and cytology of pleural fluid were analyzed at baseline&#44; 48 hours later &#40;immediately prior to biopsy&#41;&#44; and 48 hours after biopsy&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The patients had a mean &#40;SD&#41; age of 63 &#40;17&#41; years&#44; 57&#37; were smokers&#44; and 61&#37; were men&#46; Effusion was right-sided in 36&#37; of patients&#44; unilateral in 80&#37;&#44; and massive in 21&#37;&#46; The etiology was benign in 43 cases and neoplastic in 29 &#40;40&#37;&#41;&#46; Pleural lactate dehydrogenase &#40;LDH&#41; was found to be increased following biopsy&#46; This effect was significant in the overall population of 72 patients &#40;649 &#91;481&#93; U&#47;L just prior to biopsy and 736 &#91;536&#93; U&#47;L 48 hours after biopsy&#59; mean increase&#44; 86 U&#47;L&#59; 95&#37; confidence interval&#44; 45-128 U&#47;L&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; in patients with pleural tumors &#40;799 &#91;529&#93; U&#47;L prior to biopsy and 957 &#91;571&#93; U&#47;L 48 hours later&#44; P&#60;&#46;001&#41;&#44; and in those with LDH concentration greater than 266 U&#47;L&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of our study show that a single thoracentesis procedure does not alter biochemical parameters or pleural cytology after 48 hours in lymphocytic exudates&#46; Pleural needle biopsy leads to a significant increase in the concentration of LDH in patients with pleural tumors or higher baseline concentrations of LDH&#46; Thoracentesis&#44; pleural biopsy&#44; or a combination of the two do not lead to significant changes in the number of eosinophils in pleural fluid&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la influencia de la toracocentesis y la biopsia pleural en la bioqu&#237;mica y la citolog&#237;a del l&#237;quido en los pacientes con un exudado linfocitario&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospec-tivo y descriptivo de 72 pacientes con derrame pleural que te-n&#237;an un exudado linfocitario e indicaci&#243;n de biopsia&#46; Se anali-zaron y compararon la bioqu&#237;mica y citolog&#237;a del l&#237;quido pleural al inicio&#44; a las 48 h de la punci&#243;n &#40;antes de la biopsia&#41; y a las 48 h de la biopsia pleural&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes ten&#237;an una edad media &#177; desviaci&#243;n est&#225;ndar de 63 &#177; 17 a&#241;os&#44; el 57&#37; eran fumadores y el 61&#37;&#44; va-rones&#46; El derrame era derecho en un 36&#37;&#44; unilateral en un 80&#37; y masivo en el 21&#37;&#46; La etiolog&#237;a era benigna en 43 casos y neopl&#225;sica en 29 &#40;40&#37;&#41;&#46; La lactatodeshidrogenasa &#40;LDH&#41; pleu-ral aument&#243; despu&#233;s de la biopsia en el an&#225;lisis de todos los pa-cientes &#40;649 &#177; 481 U&#47;l antes de &#233;sta y 736 &#177; 536 U&#47;l a las 48 h&#59; aument&#243; en promedio 86 U&#47;l&#59; intervalo de confianza del 95&#37;&#44; 45-128 U&#47;l&#59; p &#60; 0&#44;001&#41;&#44; en los pacientes con neoplasia pleural &#40;799 &#177; 529 U&#47;l de LDH antes de la biopsia y 957 &#177; 571 U&#47;l a las 48 h&#59; p &#60; 0&#44;001&#41; o valores de LDH superiores a 266 U&#47;l&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio demuestra que una &#250;nica toracocentesis no modifica los valores de la bioqu&#237;mica o la citolog&#237;a pleural a las 48 h en los exudados linfocitarios&#46; La biopsia pleural transparietal aumenta de forma significativa los valores de la LDH en los pacientes con neoplasia pleural o valores iniciales de LDH m&#225;s elevados&#46; La realizaci&#243;n de la toracocentesis&#44; la biopsia pleural o ambas t&#233;cnicas no mo-difica de forma significativa el n&#250;mero de eosin&#243;filos del l&#237;-quido pleural&#46;</p>"
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ISSN: 15792129
Original language: English
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