Original Articles
Influence of Thoracentesis and Pleural Biopsy on Biochemical Parameters and Cytology of Pleural Fluid
Haro-Estarriol Manuela,
, Alberto Álvarez-Castillo Luisa, Baldó-Padró Xavierb, Manuel Ramírez-Malagón Joséc, Rubio-Goday Manuela, Sendra-Salillas Salvib
Corresponding author
mip.mharo@htrueta.scs.es
Correspondence: Dr. M. Haro-Estarriol. Servicio de Neumología (planta 4.a B). Hospital Universitario de Girona Dr. Josep Trueta. Avda. de Francia, s/n. 17007 Girona. España
Correspondence: Dr. M. Haro-Estarriol. Servicio de Neumología (planta 4.a B). Hospital Universitario de Girona Dr. Josep Trueta. Avda. de Francia, s/n. 17007 Girona. España
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"url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600664/v1_201305150317/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Influence of Thoracentesis and Pleural Biopsy on Biochemical Parameters and Cytology of Pleural Fluid" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "277" "paginaFinal" => "282" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Haro-Estarriol Manuel, Alberto Álvarez-Castillo Luis, Baldó-Padró Xavier, Manuel Ramírez-Malagón José, Rubio-Goday Manuel, Sendra-Salillas Salvi" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Haro-Estarriol" "apellidos" => "Manuel" "email" => array:1 [ 0 => "mip.mharo@htrueta.scs.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Alberto Álvarez-Castillo" "apellidos" => "Luis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Baldó-Padró" "apellidos" => "Xavier" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Manuel Ramírez-Malagón" "apellidos" => "José" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Rubio-Goday" "apellidos" => "Manuel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "Sendra-Salillas" "apellidos" => "Salvi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario de Girona Dr. Josep Trueta, Girona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Torácica, Hospital Universitario de Girona Dr. Josep Trueta, Girona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Laboratori Clínic, Hospital Universitario de Girona Dr. Josep Trueta, Girona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. M. Haro-Estarriol. Servicio de Neumología (planta 4.<span class="elsevierStyleSup">a</span> B). Hospital Universitario de Girona Dr. Josep Trueta. Avda. de Francia, s/n. 17007 Girona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-03-20" "fechaAceptado" => "2006-10-31" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154872" "palabras" => array:4 [ 0 => "Pleural fluid" 1 => "Thoracentesis" 2 => "Pleural biopsy" 3 => "Eosinophilia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154873" "palabras" => array:4 [ 0 => "Líquido pleural" 1 => "Toracocentesis" 2 => "Biopsia pleural" 3 => "Eosinofilia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the influence of thoracentesis and pleural biopsy on biochemical parameters and cytology of pleural fluid from patients with lymphocytic exudate.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective, descriptive study was performed in 72 patients with pleural effusion who had lymphocytic exudate and in whom biopsy was indicated. Biochemical variables and cytology of pleural fluid were analyzed at baseline, 48 hours later (immediately prior to biopsy), and 48 hours after biopsy.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The patients had a mean (SD) age of 63 (17) years, 57% were smokers, and 61% were men. Effusion was right-sided in 36% of patients, unilateral in 80%, and massive in 21%. The etiology was benign in 43 cases and neoplastic in 29 (40%). Pleural lactate dehydrogenase (LDH) was found to be increased following biopsy. This effect was significant in the overall population of 72 patients (649 [481] U/L just prior to biopsy and 736 [536] U/L 48 hours after biopsy; mean increase, 86 U/L; 95% confidence interval, 45-128 U/L; <span class="elsevierStyleItalic">P</span><.001), in patients with pleural tumors (799 [529] U/L prior to biopsy and 957 [571] U/L 48 hours later, P<.001), and in those with LDH concentration greater than 266 U/L.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of our study show that a single thoracentesis procedure does not alter biochemical parameters or pleural cytology after 48 hours in lymphocytic exudates. Pleural needle biopsy leads to a significant increase in the concentration of LDH in patients with pleural tumors or higher baseline concentrations of LDH. Thoracentesis, pleural biopsy, or a combination of the two do not lead to significant changes in the number of eosinophils in pleural fluid.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la influencia de la toracocentesis y la biopsia pleural en la bioquímica y la citología del líquido en los pacientes con un exudado linfocitario.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospec-tivo y descriptivo de 72 pacientes con derrame pleural que te-nían un exudado linfocitario e indicación de biopsia. Se anali-zaron y compararon la bioquímica y citología del líquido pleural al inicio, a las 48 h de la punción (antes de la biopsia) y a las 48 h de la biopsia pleural.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes tenían una edad media ± desviación estándar de 63 ± 17 años, el 57% eran fumadores y el 61%, va-rones. El derrame era derecho en un 36%, unilateral en un 80% y masivo en el 21%. La etiología era benigna en 43 casos y neoplásica en 29 (40%). La lactatodeshidrogenasa (LDH) pleu-ral aumentó después de la biopsia en el análisis de todos los pa-cientes (649 ± 481 U/l antes de ésta y 736 ± 536 U/l a las 48 h; aumentó en promedio 86 U/l; intervalo de confianza del 95%, 45-128 U/l; p < 0,001), en los pacientes con neoplasia pleural (799 ± 529 U/l de LDH antes de la biopsia y 957 ± 571 U/l a las 48 h; p < 0,001) o valores de LDH superiores a 266 U/l.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio demuestra que una única toracocentesis no modifica los valores de la bioquímica o la citología pleural a las 48 h en los exudados linfocitarios. La biopsia pleural transparietal aumenta de forma significativa los valores de la LDH en los pacientes con neoplasia pleural o valores iniciales de LDH más elevados. La realización de la toracocentesis, la biopsia pleural o ambas técnicas no mo-difica de forma significativa el número de eosinófilos del lí-quido pleural.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pleural effusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "RW Light" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2002" "volumen" => "25" "paginaInicial" => "1971" "paginaFinal" => "1977" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Villena V" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "¿De qué nos informa el líquido pleural? 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 8 | 12 |
| 2024 October | 26 | 37 | 63 |
| 2024 September | 24 | 34 | 58 |
| 2024 August | 40 | 47 | 87 |
| 2024 July | 21 | 28 | 49 |
| 2024 June | 34 | 30 | 64 |
| 2024 May | 27 | 25 | 52 |
| 2024 April | 17 | 21 | 38 |
| 2024 March | 29 | 14 | 43 |
| 2024 February | 17 | 24 | 41 |
| 2023 September | 3 | 0 | 3 |
| 2023 March | 3 | 3 | 6 |
| 2023 February | 11 | 20 | 31 |
| 2023 January | 13 | 32 | 45 |
| 2022 December | 20 | 26 | 46 |
| 2022 November | 21 | 29 | 50 |
| 2022 October | 20 | 24 | 44 |
| 2022 September | 16 | 22 | 38 |
| 2022 August | 19 | 30 | 49 |
| 2022 July | 23 | 36 | 59 |
| 2022 June | 11 | 32 | 43 |
| 2022 May | 14 | 29 | 43 |
| 2022 April | 24 | 25 | 49 |
| 2022 March | 17 | 34 | 51 |
| 2022 February | 22 | 36 | 58 |
| 2022 January | 16 | 29 | 45 |
| 2021 December | 14 | 52 | 66 |
| 2021 November | 16 | 41 | 57 |
| 2021 October | 10 | 36 | 46 |
| 2021 September | 13 | 53 | 66 |
| 2021 August | 11 | 47 | 58 |
| 2021 July | 18 | 18 | 36 |
| 2021 June | 9 | 25 | 34 |
| 2021 May | 19 | 22 | 41 |
| 2021 April | 30 | 33 | 63 |
| 2021 March | 30 | 16 | 46 |
| 2021 February | 10 | 13 | 23 |
| 2021 January | 7 | 13 | 20 |
| 2020 December | 10 | 8 | 18 |
| 2020 November | 5 | 11 | 16 |
| 2020 October | 10 | 3 | 13 |
| 2020 September | 1 | 3 | 4 |
| 2020 August | 6 | 8 | 14 |
| 2020 July | 10 | 11 | 21 |
| 2020 June | 7 | 5 | 12 |
| 2020 May | 16 | 8 | 24 |
| 2020 April | 3 | 11 | 14 |
| 2020 March | 12 | 10 | 22 |
| 2020 February | 10 | 8 | 18 |
| 2020 January | 10 | 11 | 21 |
| 2019 December | 11 | 19 | 30 |
| 2019 November | 3 | 7 | 10 |
| 2019 October | 3 | 6 | 9 |
| 2019 September | 15 | 9 | 24 |
| 2019 August | 5 | 3 | 8 |
| 2019 July | 8 | 23 | 31 |
| 2019 June | 9 | 11 | 20 |
| 2019 May | 14 | 11 | 25 |
| 2019 April | 48 | 16 | 64 |
| 2019 March | 13 | 19 | 32 |
| 2019 February | 6 | 12 | 18 |
| 2019 January | 7 | 6 | 13 |
| 2018 December | 6 | 8 | 14 |
| 2018 November | 13 | 7 | 20 |
| 2018 October | 30 | 17 | 47 |
| 2018 September | 12 | 10 | 22 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 4 | 6 | 10 |
| 2018 March | 8 | 4 | 12 |
| 2018 February | 5 | 8 | 13 |
| 2018 January | 3 | 12 | 15 |
| 2017 December | 4 | 5 | 9 |
| 2017 November | 5 | 5 | 10 |
| 2017 October | 9 | 11 | 20 |
| 2017 September | 6 | 20 | 26 |
| 2017 August | 7 | 13 | 20 |
| 2017 July | 4 | 8 | 12 |
| 2017 June | 9 | 17 | 26 |
| 2017 May | 4 | 14 | 18 |
| 2017 April | 2 | 14 | 16 |
| 2017 March | 3 | 7 | 10 |
| 2017 February | 1 | 5 | 6 |
| 2017 January | 2 | 6 | 8 |
| 2016 December | 9 | 6 | 15 |
| 2016 November | 11 | 5 | 16 |
| 2016 October | 9 | 5 | 14 |
| 2016 September | 5 | 6 | 11 |
| 2016 August | 5 | 4 | 9 |
| 2016 May | 1 | 0 | 1 |
| 2016 March | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 60 | 9 | 69 |
| 2015 September | 61 | 7 | 68 |
| 2015 August | 65 | 7 | 72 |
| 2015 July | 79 | 6 | 85 |
| 2015 June | 40 | 3 | 43 |
| 2015 May | 66 | 8 | 74 |
| 2015 April | 48 | 6 | 54 |
| 2015 March | 96 | 4 | 100 |
| 2015 February | 58 | 6 | 64 |
| 2015 January | 41 | 6 | 47 |
| 2014 December | 61 | 9 | 70 |
| 2014 November | 60 | 8 | 68 |
| 2014 October | 84 | 6 | 90 |
| 2014 September | 73 | 4 | 77 |
| 2014 August | 63 | 8 | 71 |
| 2014 July | 56 | 7 | 63 |
| 2014 June | 54 | 15 | 69 |
| 2014 May | 64 | 6 | 70 |
| 2014 April | 47 | 7 | 54 |
| 2014 March | 60 | 10 | 70 |
| 2014 February | 58 | 11 | 69 |
| 2014 January | 46 | 6 | 52 |
| 2013 December | 55 | 9 | 64 |
| 2013 November | 37 | 6 | 43 |
| 2013 October | 58 | 13 | 71 |
| 2013 September | 34 | 9 | 43 |
| 2013 August | 45 | 6 | 51 |
| 2013 July | 51 | 12 | 63 |
| 2013 June | 38 | 7 | 45 |
| 2013 May | 40 | 4 | 44 |
| 2013 April | 24 | 4 | 28 |
| 2013 March | 7 | 1 | 8 |
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