Correspondence: Dra. I. Otero González. Servicio de Neumología. Complexo Hospitalario Universitario Juan Canalejo. Xubias de Arriba, 84. 15006 A Coruña. España
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"nombre" => "Alberto Álvarez-Castillo" "apellidos" => "Luis" ] 2 => array:2 [ "nombre" => "Baldó-Padró" "apellidos" => "Xavier" ] 3 => array:2 [ "nombre" => "Manuel Ramírez-Malagón" "apellidos" => "José" ] 4 => array:2 [ "nombre" => "Rubio-Goday" "apellidos" => "Manuel" ] 5 => array:2 [ "nombre" => "Sendra-Salillas" "apellidos" => "Salvi" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600676?idApp=UINPBA00003Z" "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600676/v1_201305150317/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212907600652" "issn" => "15792129" "doi" => "10.1016/S1579-2129(07)60065-2" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "60065" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2007;43:267-71" "abierto" => array:3 [ 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] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600652?idApp=UINPBA00003Z" "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600652/v1_201305150317/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Clinical Efficacy of Sildenafil in Patients With Pulmonary Hypertension in Functional Class II or III" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "272" "paginaFinal" => "276" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Isabel Otero González, Marina Blanco Aparicio, Ana Souto Alonso, Inés Raposo Sonnenfeld, Héctor Verea Hernando" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Isabel Otero" "apellidos" => "González" "email" => array:1 [ 0 => "iotero@canalejo.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Marina Blanco" "apellidos" => "Aparicio" ] 2 => array:2 [ "nombre" => "Ana Souto" "apellidos" => "Alonso" ] 3 => array:2 [ "nombre" => "Inés Raposo" "apellidos" => "Sonnenfeld" ] 4 => array:2 [ "nombre" => "Héctor Verea" "apellidos" => "Hernando" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología, Complexo Hospitalario Universitario Juan Canalejo, A Coruña, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra. I. Otero González. Servicio de Neumología. Complexo Hospitalario Universitario Juan Canalejo. Xubias de Arriba, 84. 15006 A Coruña. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-02-06" "fechaAceptado" => "2006-11-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154869" "palabras" => array:4 [ 0 => "Pulmonary hypertension" 1 => "Inoperable chronic thromboembolic pulmonary hypertension" 2 => "Sildenafil" 3 => "Clinical efficacy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154868" "palabras" => array:4 [ 0 => "Hipertensión pulmonar" 1 => "Hipertensión pulmonar tromboembólica crónica y no quirúrgica" 2 => "Sildenafilo" 3 => "Eficacia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the efficacy of treatment with sildenafil monotherapy in patients with pulmonary hypertension.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">An observational study was undertaken in 11 patients with pulmonary hypertension in functional class II or III who received treatment with sildenafil (150 mg/day). Seven of the patients had inoperable chronic thromboembolic pulmonary hypertension and 4 had pulmonary arterial hypertension. To assess treatment response, the following parameters were assessed during follow-up at 3, 6, and 12 months: exercise tolerance in the 6-minute walk test, change in functional class, and systolic pulmonary arterial pressure measured by echocardiography.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We observed a significant improvement in exercise tolerance, as shown by increased 6-minute walk distance after 3, 6, and 12 months of treatment (increases of 20, 67, and 95 m, respectively). All patients showed an improvement in functional class. The results of echocardiography did not reveal statistically significant differences in systolic pulmonary arterial pressure between baseline and 6 or 12 months of treatment. No significant adverse effects were observed, although sildenafil treatment was suspended in 1 patient due to persistent headache.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of this study confirm that sildenafil is an effective drug for the management of pulmonary arterial hypertension and inoperable chronic thromboembolic pulmonary hypertension both in the short term and medium to long term, and that the drug is well tolerated and shows few side effects.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la eficacia del tratamiento con sildena-filo en monoterapia en pacientes con hipertensión pulmonar (HP).</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio obser-vacional de 11 pacientes con HP en clases funcionales II y III, a quienes se administró tratamiento con sildenafilo (150 mg/día). Siete presentaban HP tromboembólica crónica y no quirúrgica y 4, hipertensión arterial pulmonar. Para valo-rar la respuesta analizamos a los 3, 6 y 12 meses los siguien-tes parámetros: tolerancia al esfuerzo mediante el test de la marcha de 6 min, cambio de clase funcional y ecocardiogra-ma para valorar la presión sistólica en la arteria pulmonar.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Encontramos una mejoría significativa de la tolerancia al esfuerzo, con un incremento de la distancia ca-minada en 6 min, a los 3, 6 y 12 meses de tratamiento (+20, +67 y +95 m, respectivamente). Todos los pacientes mejora-ron de clase funcional. El seguimiento ecocardiográfico no mostró diferencias estadísticamente significativas entre los valores basal y a los 6 y 12 meses de tratamiento de la pre-sión sistólica en la arteria pulmonar. No observamos efectos adversos significativos, aun cuando se retiró el tratamiento con sildenafilo en un paciente por cefalea persistente.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los hallazgos de este estudio confirman que el sildenafilo es un fármaco eficaz para el manejo de la hipertensión arterial pulmonar y la HP tromboembólica crónica y no quirúrgica, tanto a corto como a medio-largo plazo, con buena tolerancia y escasos efectos secundarios.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Introduction. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 5 | 3 | 8 |
2024 October | 49 | 16 | 65 |
2024 September | 34 | 17 | 51 |
2024 August | 59 | 38 | 97 |
2024 July | 33 | 17 | 50 |
2024 June | 46 | 24 | 70 |
2024 May | 42 | 25 | 67 |
2024 April | 25 | 24 | 49 |
2024 March | 26 | 20 | 46 |
2024 February | 24 | 24 | 48 |
2023 March | 4 | 3 | 7 |
2023 February | 17 | 20 | 37 |
2023 January | 18 | 27 | 45 |
2022 December | 19 | 22 | 41 |
2022 November | 23 | 22 | 45 |
2022 October | 29 | 29 | 58 |
2022 September | 55 | 33 | 88 |
2022 August | 31 | 33 | 64 |
2022 July | 24 | 41 | 65 |
2022 June | 13 | 27 | 40 |
2022 May | 20 | 23 | 43 |
2022 April | 19 | 27 | 46 |
2022 March | 18 | 36 | 54 |
2022 February | 21 | 35 | 56 |
2022 January | 22 | 32 | 54 |
2021 December | 14 | 44 | 58 |
2021 November | 15 | 58 | 73 |
2021 October | 11 | 36 | 47 |
2021 September | 22 | 65 | 87 |
2021 August | 19 | 37 | 56 |
2021 July | 17 | 17 | 34 |
2021 June | 18 | 34 | 52 |
2021 May | 16 | 28 | 44 |
2021 April | 43 | 41 | 84 |
2021 March | 14 | 15 | 29 |
2021 February | 7 | 20 | 27 |
2021 January | 11 | 9 | 20 |
2020 December | 8 | 11 | 19 |
2020 November | 7 | 5 | 12 |
2020 October | 10 | 5 | 15 |
2020 September | 4 | 2 | 6 |
2020 August | 18 | 7 | 25 |
2020 July | 9 | 13 | 22 |
2020 June | 13 | 5 | 18 |
2020 May | 15 | 6 | 21 |
2020 April | 10 | 11 | 21 |
2020 March | 16 | 8 | 24 |
2020 February | 11 | 11 | 22 |
2020 January | 11 | 12 | 23 |
2019 December | 16 | 9 | 25 |
2019 November | 5 | 7 | 12 |
2019 October | 9 | 7 | 16 |
2019 September | 5 | 13 | 18 |
2019 August | 11 | 7 | 18 |
2019 July | 9 | 14 | 23 |
2019 June | 4 | 4 | 8 |
2019 May | 10 | 9 | 19 |
2019 April | 23 | 14 | 37 |
2019 March | 7 | 9 | 16 |
2019 February | 12 | 10 | 22 |
2019 January | 11 | 4 | 15 |
2018 December | 15 | 12 | 27 |
2018 November | 13 | 5 | 18 |
2018 October | 39 | 12 | 51 |
2018 September | 8 | 9 | 17 |
2018 May | 9 | 0 | 9 |
2018 April | 13 | 5 | 18 |
2018 March | 4 | 5 | 9 |
2018 February | 4 | 5 | 9 |
2018 January | 3 | 6 | 9 |
2017 December | 3 | 5 | 8 |
2017 November | 3 | 5 | 8 |
2017 October | 6 | 11 | 17 |
2017 September | 5 | 10 | 15 |
2017 August | 9 | 8 | 17 |
2017 July | 4 | 8 | 12 |
2017 June | 6 | 13 | 19 |
2017 May | 4 | 5 | 9 |
2017 April | 3 | 6 | 9 |
2017 March | 2 | 2 | 4 |
2017 February | 1 | 1 | 2 |
2017 January | 1 | 4 | 5 |
2016 December | 8 | 6 | 14 |
2016 November | 11 | 6 | 17 |
2016 October | 22 | 8 | 30 |
2016 September | 6 | 11 | 17 |
2016 August | 13 | 5 | 18 |
2016 July | 8 | 4 | 12 |
2016 March | 1 | 0 | 1 |
2016 February | 1 | 0 | 1 |
2016 January | 1 | 0 | 1 |
2015 December | 2 | 0 | 2 |
2015 October | 56 | 6 | 62 |
2015 September | 69 | 10 | 79 |
2015 August | 28 | 7 | 35 |
2015 July | 43 | 5 | 48 |
2015 June | 40 | 3 | 43 |
2015 May | 53 | 13 | 66 |
2015 April | 62 | 7 | 69 |
2015 March | 68 | 7 | 75 |
2015 February | 48 | 7 | 55 |
2015 January | 71 | 7 | 78 |
2014 December | 70 | 4 | 74 |
2014 November | 48 | 6 | 54 |
2014 October | 57 | 9 | 66 |
2014 September | 54 | 4 | 58 |
2014 August | 42 | 7 | 49 |
2014 July | 63 | 8 | 71 |
2014 June | 49 | 8 | 57 |
2014 May | 37 | 11 | 48 |
2014 April | 71 | 6 | 77 |
2014 March | 76 | 3 | 79 |
2014 February | 292 | 11 | 303 |
2014 January | 265 | 5 | 270 |
2013 December | 165 | 8 | 173 |
2013 November | 186 | 4 | 190 |
2013 October | 48 | 12 | 60 |
2013 September | 41 | 4 | 45 |
2013 August | 35 | 5 | 40 |
2013 July | 68 | 12 | 80 |
2013 June | 38 | 7 | 45 |
2013 May | 44 | 5 | 49 |
2013 April | 25 | 7 | 32 |
2013 March | 7 | 1 | 8 |