array:23 [
  "pii" => "S1579212907600664"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60066-4"
  "estado" => "S300"
  "fechaPublicacion" => "2007-01-01"
  "aid" => "60066"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2007"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2007;43:272-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3291
    "formatos" => array:3 [
      "EPUB" => 78
      "HTML" => 2689
      "PDF" => 524
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907600676"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60067-6"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60067"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:277-82"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2766
      "formatos" => array:3 [
        "EPUB" => 82
        "HTML" => 2071
        "PDF" => 613
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Influence of Thoracentesis and Pleural Biopsy on Biochemical Parameters and Cytology of Pleural Fluid"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "277"
          "paginaFinal" => "282"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Haro-Estarriol Manuel, Alberto &#193;lvarez-Castillo Luis, Bald&#243;-Padr&#243; Xavier, Manuel Ram&#237;rez-Malag&#243;n Jos&#233;, Rubio-Goday Manuel, Sendra-Salillas Salvi"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Haro-Estarriol"
              "apellidos" => "Manuel"
            ]
            1 => array:2 [
              "nombre" => "Alberto &#193;lvarez-Castillo"
              "apellidos" => "Luis"
            ]
            2 => array:2 [
              "nombre" => "Bald&#243;-Padr&#243;"
              "apellidos" => "Xavier"
            ]
            3 => array:2 [
              "nombre" => "Manuel Ram&#237;rez-Malag&#243;n"
              "apellidos" => "Jos&#233;"
            ]
            4 => array:2 [
              "nombre" => "Rubio-Goday"
              "apellidos" => "Manuel"
            ]
            5 => array:2 [
              "nombre" => "Sendra-Salillas"
              "apellidos" => "Salvi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600676?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600676/v1_201305150317/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212907600652"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60065-2"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60065"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:267-71"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2132
      "formatos" => array:3 [
        "EPUB" => 92
        "HTML" => 1457
        "PDF" => 583
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Noninvasive&#44; Indirect Measurement of Pulmonary Artery Pressure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "267"
          "paginaFinal" => "271"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Isabel Blanco Vich, Jos&#233; Belda Ram&#237;rez, Pere Casan Clar&#224;"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Isabel Blanco"
              "apellidos" => "Vich"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Belda"
              "apellidos" => "Ram&#237;rez"
            ]
            2 => array:2 [
              "nombre" => "Pere Casan"
              "apellidos" => "Clar&#224;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600652?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600652/v1_201305150317/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Clinical Efficacy of Sildenafil in Patients With Pulmonary Hypertension in Functional Class II or III"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "272"
        "paginaFinal" => "276"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Isabel Otero Gonz&#225;lez, Marina Blanco Aparicio, Ana Souto Alonso, In&#233;s Raposo Sonnenfeld, H&#233;ctor Verea Hernando"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Isabel Otero"
            "apellidos" => "Gonz&#225;lez"
            "email" => array:1 [
              0 => "iotero&#64;canalejo&#46;org"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Marina Blanco"
            "apellidos" => "Aparicio"
          ]
          2 => array:2 [
            "nombre" => "Ana Souto"
            "apellidos" => "Alonso"
          ]
          3 => array:2 [
            "nombre" => "In&#233;s Raposo"
            "apellidos" => "Sonnenfeld"
          ]
          4 => array:2 [
            "nombre" => "H&#233;ctor Verea"
            "apellidos" => "Hernando"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Complexo Hospitalario Universitario Juan Canalejo&#44; A Coru&#241;a&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dra&#46; I&#46; Otero Gonz&#225;lez&#46; Servicio de Neumolog&#237;a&#46; Complexo Hospitalario Universitario Juan Canalejo&#46; Xubias de Arriba&#44; 84&#46; 15006 A Coru&#241;a&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-02-06"
    "fechaAceptado" => "2006-11-07"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154869"
          "palabras" => array:4 [
            0 => "Pulmonary hypertension"
            1 => "Inoperable chronic thromboembolic pulmonary hypertension"
            2 => "Sildenafil"
            3 => "Clinical efficacy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec154868"
          "palabras" => array:4 [
            0 => "Hipertensi&#243;n pulmonar"
            1 => "Hipertensi&#243;n pulmonar tromboemb&#243;lica cr&#243;nica y no quir&#250;rgica"
            2 => "Sildenafilo"
            3 => "Eficacia"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the efficacy of treatment with sildenafil monotherapy in patients with pulmonary hypertension&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">An observational study was undertaken in 11 patients with pulmonary hypertension in functional class II or III who received treatment with sildenafil &#40;150 mg&#47;day&#41;&#46; Seven of the patients had inoperable chronic thromboembolic pulmonary hypertension and 4 had pulmonary arterial hypertension&#46; To assess treatment response&#44; the following parameters were assessed during follow-up at 3&#44; 6&#44; and 12 months&#58; exercise tolerance in the 6-minute walk test&#44; change in functional class&#44; and systolic pulmonary arterial pressure measured by echocardiography&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We observed a significant improvement in exercise tolerance&#44; as shown by increased 6-minute walk distance after 3&#44; 6&#44; and 12 months of treatment &#40;increases of 20&#44; 67&#44; and 95 m&#44; respectively&#41;&#46; All patients showed an improvement in functional class&#46; The results of echocardiography did not reveal statistically significant differences in systolic pulmonary arterial pressure between baseline and 6 or 12 months of treatment&#46; No significant adverse effects were observed&#44; although sildenafil treatment was suspended in 1 patient due to persistent headache&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of this study confirm that sildenafil is an effective drug for the management of pulmonary arterial hypertension and inoperable chronic thromboembolic pulmonary hypertension both in the short term and medium to long term&#44; and that the drug is well tolerated and shows few side effects&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la eficacia del tratamiento con sildena-filo en monoterapia en pacientes con hipertensi&#243;n pulmonar &#40;HP&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio obser-vacional de 11 pacientes con HP en clases funcionales II y III&#44; a quienes se administr&#243; tratamiento con sildenafilo &#40;150 mg&#47;d&#237;a&#41;&#46; Siete presentaban HP tromboemb&#243;lica cr&#243;nica y no quir&#250;rgica y 4&#44; hipertensi&#243;n arterial pulmonar&#46; Para valo-rar la respuesta analizamos a los 3&#44; 6 y 12 meses los siguien-tes par&#225;metros&#58; tolerancia al esfuerzo mediante el test de la marcha de 6 min&#44; cambio de clase funcional y ecocardiogra-ma para valorar la presi&#243;n sist&#243;lica en la arteria pulmonar&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Encontramos una mejor&#237;a significativa de la tolerancia al esfuerzo&#44; con un incremento de la distancia ca-minada en 6 min&#44; a los 3&#44; 6 y 12 meses de tratamiento &#40;&#43;20&#44; &#43;67 y &#43;95 m&#44; respectivamente&#41;&#46; Todos los pacientes mejora-ron de clase funcional&#46; El seguimiento ecocardiogr&#225;fico no mostr&#243; diferencias estad&#237;sticamente significativas entre los valores basal y a los 6 y 12 meses de tratamiento de la pre-si&#243;n sist&#243;lica en la arteria pulmonar&#46; No observamos efectos adversos significativos&#44; aun cuando se retir&#243; el tratamiento con sildenafilo en un paciente por cefalea persistente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los hallazgos de este estudio confirman que el sildenafilo es un f&#225;rmaco eficaz para el manejo de la hipertensi&#243;n arterial pulmonar y la HP tromboemb&#243;lica cr&#243;nica y no quir&#250;rgica&#44; tanto a corto como a medio-largo plazo&#44; con buena tolerancia y escasos efectos secundarios&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:27 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Introduction&#46; Diagnosis and management of pulmonary arterial hypertension&#58; ACCP evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "LJ Rubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.126.1_suppl.7S"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "126"
                        "paginaInicial" => "7S"
                        "paginaFinal" => "10S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15249491"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical treatments&#47;interventions for pulmonary arterial hypertension&#46; ACCP evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "RL Doyle"
                            1 => "D McCrory"
                            2 => "RN Channick"
                            3 => "G Simmoneau"
                            4 => "J Conte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.126.1_suppl.63S"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "126"
                        "paginaInicial" => "63S"
                        "paginaFinal" => "71S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15249495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M Humbert"
                            1 => "O Sitbon"
                            2 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra040291"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "1425"
                        "paginaFinal" => "1436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15459304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disfunci&#243;n endotelial en la hipertensi&#243;n pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JC Caraballo Fonseca"
                            1 => "CD Mart&#237;nez Blanco"
                            2 => "R S&#225;nchez de Le&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "389"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16029733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T Higenbottam"
                            1 => "D Wheeldon"
                            2 => "F Wells"
                            3 => "J Wallwork"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1984"
                        "volumen" => "1"
                        "paginaInicial" => "1046"
                        "paginaFinal" => "1047"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2566001"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled iloprost for severe pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H Olschewski"
                            1 => "G Simonneau"
                            2 => "N Galie"
                            3 => "T Higenbottan"
                            4 => "R Naeije"
                            5 => "LJ Rubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa020204"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "347"
                        "paginaInicial" => "322"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12151469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous subcutaneous infusion of treprostinil&#44; a prostacyclin analogue&#44; in patients with pulmonary arterial hypertension&#58; a double-blind randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "for the Treprostinil study group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G Simonneau"
                            1 => "RJ Barst"
                            2 => "N Galie"
                            3 => "R Naeije"
                            4 => "R Rich"
                            5 => "RC Bourge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.165.6.2106079"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "165"
                        "paginaInicial" => "800"
                        "paginaFinal" => "804"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11897647"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bosentan therapy for pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "LJ Rubin"
                            1 => "DB Badesch"
                            2 => "RJ Barst"
                            3 => "N Galie"
                            4 => "CM Black"
                            5 => "A Keogh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa012212"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "346"
                        "paginaInicial" => "896"
                        "paginaFinal" => "903"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11907289"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sitaxsentan therapy for pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "STRIDE-1 study group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "RJ Barst"
                            1 => "D Langleben"
                            2 => "A Frost"
                            3 => "EM Horn"
                            4 => "R Oudiz"
                            5 => "S Shapiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200307-957OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2004"
                        "volumen" => "169"
                        "paginaInicial" => "441"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14630619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T Reffelman"
                            1 => "RA Kloner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "volumen" => "239"
                        "paginaInicial" => "239"
                        "paginaFinal" => "244"
                        "itemHostRev" => array:3 [
                          "pii" => "S0210480611000684"
                          "estado" => "S300"
                          "issn" => "02104806"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil versus endothelin receptor antagonist for pulmonary hypertension &#40;SERAPH&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MR Wilkins"
                            1 => "GA Paul"
                            2 => "JW Strange"
                            3 => "N Tunariu"
                            4 => "W Gin-Sing"
                            5 => "W Banya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200410-1411OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "1292"
                        "paginaFinal" => "1297"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15750042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil citrate therapy for pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "for the Sildenafil Use in Pulmonary Arterial Hypertension &#40;SUPER&#41; study group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Galie"
                            1 => "HA Ghofrani"
                            2 => "A Torbicki"
                            3 => "RJ Barst"
                            4 => "LJ Rubin"
                            5 => "D Badesch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa050010"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2005"
                        "volumen" => "353"
                        "paginaInicial" => "2148"
                        "paginaFinal" => "2157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16291984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmaceutical industry sponsorship and research outcome and quality&#58; systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Lexchin"
                            1 => "LA Bero"
                            2 => "B Djulbegovic"
                            3 => "O Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2003"
                        "volumen" => "326"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12705247"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESC guidelines&#46; Guidelines on diagnosis and treatment of pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Galie"
                            1 => "A Torbicki"
                            2 => "R Barst"
                            3 => "P Dartevelle"
                            4 => "S Haworth"
                            5 => "T Higenbottam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ehj.2004.09.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "2243"
                        "paginaFinal" => "2278"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15589643"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Medical therapy for pulmonary arterial hypertension&#46; ACCP evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D Badesch"
                            1 => "SH Abman"
                            2 => "GS Ahearn"
                            3 => "RJ Barst"
                            4 => "DC McCrory"
                            5 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "126"
                        "paginaInicial" => "S35"
                        "paginaFinal" => "S62"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension&#58; comparison with inhaled nitric oxide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E Michelackis"
                            1 => "W Tymchak"
                            2 => "D Lien"
                            3 => "L Webster"
                            4 => "K Hashimoto"
                            5 => "S Archer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "2398"
                        "paginaFinal" => "2403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12021227"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil in primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S Prasad"
                            1 => "J Wilkinson"
                            2 => "MA Gatzoulis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200011023431814"
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "volumen" => "343"
                        "paginaInicial" => "1342"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11183578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension&#46; Comparison with inhaled nitric oxide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E Michelakis"
                            1 => "W Tymchak"
                            2 => "D Lien"
                            3 => "L Webster"
                            4 => "K Hashimoto"
                            5 => "S Archer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "2398"
                        "paginaFinal" => "2403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12021227"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and haemodynamic effects of sildenafil in pulmonary hypertension&#58; acute and mid-term effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "GW Mikhail"
                            1 => "SK Prasad"
                            2 => "W Li"
                            3 => "P Rogers"
                            4 => "AH Chester"
                            5 => "S Bayne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ehj.2004.01.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "431"
                        "paginaFinal" => "436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15033256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension&#46; Twelve-month clinical trial of a single-drug&#44; open label&#44; pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T Humpl"
                            1 => "T Reyes"
                            2 => "HH Holtby"
                            3 => "D Sthephens"
                            4 => "I Adatia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.104.473371"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2005"
                        "volumen" => "111"
                        "paginaInicial" => "3274"
                        "paginaFinal" => "3280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15956137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical efficacy of sildenafil in primary pulmonary hypertension&#46; A randomized&#44; placebo-controlled&#44; double blind&#44; crossover study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "BKS Sastry"
                            1 => "C Narasimhan"
                            2 => "NK Reddy"
                            3 => "BS Raju"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2003.10.056"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "1149"
                        "paginaFinal" => "1153"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15063421"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prostacyclin therapy before pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Nagaya"
                            1 => "N Sasaki"
                            2 => "M Ando"
                            3 => "H Ogino"
                            4 => "F Sakamaki"
                            5 => "S Kyotani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "338"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12576349"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "HA Ghofrani"
                            1 => "RT Schermuly"
                            2 => "F Rose"
                            3 => "R Wiedermann"
                            4 => "MG Kohstall"
                            5 => "A Kreckel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200210-1157BC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2003"
                        "volumen" => "167"
                        "paginaInicial" => "1139"
                        "paginaFinal" => "1141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12684251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MM Hoeper"
                            1 => "T Kramm"
                            2 => "H Wilkens"
                            3 => "C Schulze"
                            4 => "HJ Sch&#228;fers"
                            5 => "T Welte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2363"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2363"
                        "paginaFinal" => "2367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236895"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Gali&#232;"
                            1 => "L Alan"
                            2 => "AL Hinderliter"
                            3 => "A Torbicki"
                            4 => "T Fourme"
                            5 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "1380"
                        "paginaFinal" => "1386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14563578"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1474442210701939"
                          "estado" => "S300"
                          "issn" => "14744422"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension&#46; Comparison with cardiopulmonary exercise testing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S Miyamoto"
                            1 => "N Nagaya"
                            2 => "T Satoh"
                            3 => "S Kyotani"
                            4 => "F Sakamaki"
                            5 => "M Fujita"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.161.2.9906015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "161"
                        "paginaInicial" => "487"
                        "paginaFinal" => "492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10673190"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of brain natriuretic peptide in long term follow up of primary pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "HH Leuchte"
                            1 => "M Holzapfel"
                            2 => "RA Baumgartner"
                            3 => "C Neurohr"
                            4 => "M Vogeser"
                            5 => "J Behr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2368"
                        "paginaFinal" => "2374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600664/v1_201305150317/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004300000005/v1_201305150317/S1579212907600664/v1_201305150317/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600664?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original Articles
Clinical Efficacy of Sildenafil in Patients With Pulmonary Hypertension in Functional Class II or III
Isabel Otero González
Corresponding author
iotero@canalejo.org

Correspondence: Dra. I. Otero González. Servicio de Neumología. Complexo Hospitalario Universitario Juan Canalejo. Xubias de Arriba, 84. 15006 A Coruña. España
, Marina Blanco Aparicio, Ana Souto Alonso, Inés Raposo Sonnenfeld, Héctor Verea Hernando
Servicio de Neumología, Complexo Hospitalario Universitario Juan Canalejo, A Coruña, Spain
Read
5305
Times
was read the article
1621
Total PDF
3684
Total HTML
Share statistics
 array:23 [
  "pii" => "S1579212907600664"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60066-4"
  "estado" => "S300"
  "fechaPublicacion" => "2007-01-01"
  "aid" => "60066"
  "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
  "copyrightAnyo" => "2007"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2007;43:272-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3291
    "formatos" => array:3 [
      "EPUB" => 78
      "HTML" => 2689
      "PDF" => 524
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907600676"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60067-6"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60067"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:277-82"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2766
      "formatos" => array:3 [
        "EPUB" => 82
        "HTML" => 2071
        "PDF" => 613
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Influence of Thoracentesis and Pleural Biopsy on Biochemical Parameters and Cytology of Pleural Fluid"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "277"
          "paginaFinal" => "282"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Haro-Estarriol Manuel, Alberto &#193;lvarez-Castillo Luis, Bald&#243;-Padr&#243; Xavier, Manuel Ram&#237;rez-Malag&#243;n Jos&#233;, Rubio-Goday Manuel, Sendra-Salillas Salvi"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Haro-Estarriol"
              "apellidos" => "Manuel"
            ]
            1 => array:2 [
              "nombre" => "Alberto &#193;lvarez-Castillo"
              "apellidos" => "Luis"
            ]
            2 => array:2 [
              "nombre" => "Bald&#243;-Padr&#243;"
              "apellidos" => "Xavier"
            ]
            3 => array:2 [
              "nombre" => "Manuel Ram&#237;rez-Malag&#243;n"
              "apellidos" => "Jos&#233;"
            ]
            4 => array:2 [
              "nombre" => "Rubio-Goday"
              "apellidos" => "Manuel"
            ]
            5 => array:2 [
              "nombre" => "Sendra-Salillas"
              "apellidos" => "Salvi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600676?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600676/v1_201305150317/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212907600652"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60065-2"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60065"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:267-71"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2132
      "formatos" => array:3 [
        "EPUB" => 92
        "HTML" => 1457
        "PDF" => 583
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Noninvasive&#44; Indirect Measurement of Pulmonary Artery Pressure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "267"
          "paginaFinal" => "271"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Isabel Blanco Vich, Jos&#233; Belda Ram&#237;rez, Pere Casan Clar&#224;"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Isabel Blanco"
              "apellidos" => "Vich"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Belda"
              "apellidos" => "Ram&#237;rez"
            ]
            2 => array:2 [
              "nombre" => "Pere Casan"
              "apellidos" => "Clar&#224;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600652?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600652/v1_201305150317/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Clinical Efficacy of Sildenafil in Patients With Pulmonary Hypertension in Functional Class II or III"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "272"
        "paginaFinal" => "276"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Isabel Otero Gonz&#225;lez, Marina Blanco Aparicio, Ana Souto Alonso, In&#233;s Raposo Sonnenfeld, H&#233;ctor Verea Hernando"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Isabel Otero"
            "apellidos" => "Gonz&#225;lez"
            "email" => array:1 [
              0 => "iotero&#64;canalejo&#46;org"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Marina Blanco"
            "apellidos" => "Aparicio"
          ]
          2 => array:2 [
            "nombre" => "Ana Souto"
            "apellidos" => "Alonso"
          ]
          3 => array:2 [
            "nombre" => "In&#233;s Raposo"
            "apellidos" => "Sonnenfeld"
          ]
          4 => array:2 [
            "nombre" => "H&#233;ctor Verea"
            "apellidos" => "Hernando"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Complexo Hospitalario Universitario Juan Canalejo&#44; A Coru&#241;a&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dra&#46; I&#46; Otero Gonz&#225;lez&#46; Servicio de Neumolog&#237;a&#46; Complexo Hospitalario Universitario Juan Canalejo&#46; Xubias de Arriba&#44; 84&#46; 15006 A Coru&#241;a&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-02-06"
    "fechaAceptado" => "2006-11-07"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154869"
          "palabras" => array:4 [
            0 => "Pulmonary hypertension"
            1 => "Inoperable chronic thromboembolic pulmonary hypertension"
            2 => "Sildenafil"
            3 => "Clinical efficacy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec154868"
          "palabras" => array:4 [
            0 => "Hipertensi&#243;n pulmonar"
            1 => "Hipertensi&#243;n pulmonar tromboemb&#243;lica cr&#243;nica y no quir&#250;rgica"
            2 => "Sildenafilo"
            3 => "Eficacia"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To assess the efficacy of treatment with sildenafil monotherapy in patients with pulmonary hypertension&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">An observational study was undertaken in 11 patients with pulmonary hypertension in functional class II or III who received treatment with sildenafil &#40;150 mg&#47;day&#41;&#46; Seven of the patients had inoperable chronic thromboembolic pulmonary hypertension and 4 had pulmonary arterial hypertension&#46; To assess treatment response&#44; the following parameters were assessed during follow-up at 3&#44; 6&#44; and 12 months&#58; exercise tolerance in the 6-minute walk test&#44; change in functional class&#44; and systolic pulmonary arterial pressure measured by echocardiography&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We observed a significant improvement in exercise tolerance&#44; as shown by increased 6-minute walk distance after 3&#44; 6&#44; and 12 months of treatment &#40;increases of 20&#44; 67&#44; and 95 m&#44; respectively&#41;&#46; All patients showed an improvement in functional class&#46; The results of echocardiography did not reveal statistically significant differences in systolic pulmonary arterial pressure between baseline and 6 or 12 months of treatment&#46; No significant adverse effects were observed&#44; although sildenafil treatment was suspended in 1 patient due to persistent headache&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of this study confirm that sildenafil is an effective drug for the management of pulmonary arterial hypertension and inoperable chronic thromboembolic pulmonary hypertension both in the short term and medium to long term&#44; and that the drug is well tolerated and shows few side effects&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Valorar la eficacia del tratamiento con sildena-filo en monoterapia en pacientes con hipertensi&#243;n pulmonar &#40;HP&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio obser-vacional de 11 pacientes con HP en clases funcionales II y III&#44; a quienes se administr&#243; tratamiento con sildenafilo &#40;150 mg&#47;d&#237;a&#41;&#46; Siete presentaban HP tromboemb&#243;lica cr&#243;nica y no quir&#250;rgica y 4&#44; hipertensi&#243;n arterial pulmonar&#46; Para valo-rar la respuesta analizamos a los 3&#44; 6 y 12 meses los siguien-tes par&#225;metros&#58; tolerancia al esfuerzo mediante el test de la marcha de 6 min&#44; cambio de clase funcional y ecocardiogra-ma para valorar la presi&#243;n sist&#243;lica en la arteria pulmonar&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Encontramos una mejor&#237;a significativa de la tolerancia al esfuerzo&#44; con un incremento de la distancia ca-minada en 6 min&#44; a los 3&#44; 6 y 12 meses de tratamiento &#40;&#43;20&#44; &#43;67 y &#43;95 m&#44; respectivamente&#41;&#46; Todos los pacientes mejora-ron de clase funcional&#46; El seguimiento ecocardiogr&#225;fico no mostr&#243; diferencias estad&#237;sticamente significativas entre los valores basal y a los 6 y 12 meses de tratamiento de la pre-si&#243;n sist&#243;lica en la arteria pulmonar&#46; No observamos efectos adversos significativos&#44; aun cuando se retir&#243; el tratamiento con sildenafilo en un paciente por cefalea persistente&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los hallazgos de este estudio confirman que el sildenafilo es un f&#225;rmaco eficaz para el manejo de la hipertensi&#243;n arterial pulmonar y la HP tromboemb&#243;lica cr&#243;nica y no quir&#250;rgica&#44; tanto a corto como a medio-largo plazo&#44; con buena tolerancia y escasos efectos secundarios&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:27 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Introduction&#46; Diagnosis and management of pulmonary arterial hypertension&#58; ACCP evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "LJ Rubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.126.1_suppl.7S"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "126"
                        "paginaInicial" => "7S"
                        "paginaFinal" => "10S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15249491"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical treatments&#47;interventions for pulmonary arterial hypertension&#46; ACCP evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "RL Doyle"
                            1 => "D McCrory"
                            2 => "RN Channick"
                            3 => "G Simmoneau"
                            4 => "J Conte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.126.1_suppl.63S"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "126"
                        "paginaInicial" => "63S"
                        "paginaFinal" => "71S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15249495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M Humbert"
                            1 => "O Sitbon"
                            2 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra040291"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "1425"
                        "paginaFinal" => "1436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15459304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disfunci&#243;n endotelial en la hipertensi&#243;n pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JC Caraballo Fonseca"
                            1 => "CD Mart&#237;nez Blanco"
                            2 => "R S&#225;nchez de Le&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "389"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16029733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T Higenbottam"
                            1 => "D Wheeldon"
                            2 => "F Wells"
                            3 => "J Wallwork"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1984"
                        "volumen" => "1"
                        "paginaInicial" => "1046"
                        "paginaFinal" => "1047"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2566001"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhaled iloprost for severe pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H Olschewski"
                            1 => "G Simonneau"
                            2 => "N Galie"
                            3 => "T Higenbottan"
                            4 => "R Naeije"
                            5 => "LJ Rubin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa020204"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "347"
                        "paginaInicial" => "322"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12151469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous subcutaneous infusion of treprostinil&#44; a prostacyclin analogue&#44; in patients with pulmonary arterial hypertension&#58; a double-blind randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "for the Treprostinil study group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G Simonneau"
                            1 => "RJ Barst"
                            2 => "N Galie"
                            3 => "R Naeije"
                            4 => "R Rich"
                            5 => "RC Bourge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.165.6.2106079"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "165"
                        "paginaInicial" => "800"
                        "paginaFinal" => "804"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11897647"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bosentan therapy for pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "LJ Rubin"
                            1 => "DB Badesch"
                            2 => "RJ Barst"
                            3 => "N Galie"
                            4 => "CM Black"
                            5 => "A Keogh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa012212"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "346"
                        "paginaInicial" => "896"
                        "paginaFinal" => "903"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11907289"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sitaxsentan therapy for pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "STRIDE-1 study group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "RJ Barst"
                            1 => "D Langleben"
                            2 => "A Frost"
                            3 => "EM Horn"
                            4 => "R Oudiz"
                            5 => "S Shapiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200307-957OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2004"
                        "volumen" => "169"
                        "paginaInicial" => "441"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14630619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T Reffelman"
                            1 => "RA Kloner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "volumen" => "239"
                        "paginaInicial" => "239"
                        "paginaFinal" => "244"
                        "itemHostRev" => array:3 [
                          "pii" => "S0210480611000684"
                          "estado" => "S300"
                          "issn" => "02104806"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil versus endothelin receptor antagonist for pulmonary hypertension &#40;SERAPH&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MR Wilkins"
                            1 => "GA Paul"
                            2 => "JW Strange"
                            3 => "N Tunariu"
                            4 => "W Gin-Sing"
                            5 => "W Banya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200410-1411OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "1292"
                        "paginaFinal" => "1297"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15750042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil citrate therapy for pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "for the Sildenafil Use in Pulmonary Arterial Hypertension &#40;SUPER&#41; study group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Galie"
                            1 => "HA Ghofrani"
                            2 => "A Torbicki"
                            3 => "RJ Barst"
                            4 => "LJ Rubin"
                            5 => "D Badesch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa050010"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2005"
                        "volumen" => "353"
                        "paginaInicial" => "2148"
                        "paginaFinal" => "2157"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16291984"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmaceutical industry sponsorship and research outcome and quality&#58; systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Lexchin"
                            1 => "LA Bero"
                            2 => "B Djulbegovic"
                            3 => "O Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2003"
                        "volumen" => "326"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12705247"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESC guidelines&#46; Guidelines on diagnosis and treatment of pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Galie"
                            1 => "A Torbicki"
                            2 => "R Barst"
                            3 => "P Dartevelle"
                            4 => "S Haworth"
                            5 => "T Higenbottam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ehj.2004.09.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "2243"
                        "paginaFinal" => "2278"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15589643"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Medical therapy for pulmonary arterial hypertension&#46; ACCP evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D Badesch"
                            1 => "SH Abman"
                            2 => "GS Ahearn"
                            3 => "RJ Barst"
                            4 => "DC McCrory"
                            5 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "126"
                        "paginaInicial" => "S35"
                        "paginaFinal" => "S62"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension&#58; comparison with inhaled nitric oxide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E Michelackis"
                            1 => "W Tymchak"
                            2 => "D Lien"
                            3 => "L Webster"
                            4 => "K Hashimoto"
                            5 => "S Archer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "2398"
                        "paginaFinal" => "2403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12021227"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil in primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S Prasad"
                            1 => "J Wilkinson"
                            2 => "MA Gatzoulis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200011023431814"
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "volumen" => "343"
                        "paginaInicial" => "1342"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11183578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension&#46; Comparison with inhaled nitric oxide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E Michelakis"
                            1 => "W Tymchak"
                            2 => "D Lien"
                            3 => "L Webster"
                            4 => "K Hashimoto"
                            5 => "S Archer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "2398"
                        "paginaFinal" => "2403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12021227"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and haemodynamic effects of sildenafil in pulmonary hypertension&#58; acute and mid-term effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "GW Mikhail"
                            1 => "SK Prasad"
                            2 => "W Li"
                            3 => "P Rogers"
                            4 => "AH Chester"
                            5 => "S Bayne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ehj.2004.01.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "431"
                        "paginaFinal" => "436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15033256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension&#46; Twelve-month clinical trial of a single-drug&#44; open label&#44; pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T Humpl"
                            1 => "T Reyes"
                            2 => "HH Holtby"
                            3 => "D Sthephens"
                            4 => "I Adatia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.104.473371"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2005"
                        "volumen" => "111"
                        "paginaInicial" => "3274"
                        "paginaFinal" => "3280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15956137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical efficacy of sildenafil in primary pulmonary hypertension&#46; A randomized&#44; placebo-controlled&#44; double blind&#44; crossover study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "BKS Sastry"
                            1 => "C Narasimhan"
                            2 => "NK Reddy"
                            3 => "BS Raju"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2003.10.056"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "1149"
                        "paginaFinal" => "1153"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15063421"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prostacyclin therapy before pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Nagaya"
                            1 => "N Sasaki"
                            2 => "M Ando"
                            3 => "H Ogino"
                            4 => "F Sakamaki"
                            5 => "S Kyotani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "338"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12576349"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "HA Ghofrani"
                            1 => "RT Schermuly"
                            2 => "F Rose"
                            3 => "R Wiedermann"
                            4 => "MG Kohstall"
                            5 => "A Kreckel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200210-1157BC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2003"
                        "volumen" => "167"
                        "paginaInicial" => "1139"
                        "paginaFinal" => "1141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12684251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MM Hoeper"
                            1 => "T Kramm"
                            2 => "H Wilkens"
                            3 => "C Schulze"
                            4 => "HJ Sch&#228;fers"
                            5 => "T Welte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2363"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2363"
                        "paginaFinal" => "2367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236895"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Gali&#232;"
                            1 => "L Alan"
                            2 => "AL Hinderliter"
                            3 => "A Torbicki"
                            4 => "T Fourme"
                            5 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "1380"
                        "paginaFinal" => "1386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14563578"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1474442210701939"
                          "estado" => "S300"
                          "issn" => "14744422"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension&#46; Comparison with cardiopulmonary exercise testing"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S Miyamoto"
                            1 => "N Nagaya"
                            2 => "T Satoh"
                            3 => "S Kyotani"
                            4 => "F Sakamaki"
                            5 => "M Fujita"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.161.2.9906015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "161"
                        "paginaInicial" => "487"
                        "paginaFinal" => "492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10673190"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of brain natriuretic peptide in long term follow up of primary pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "HH Leuchte"
                            1 => "M Holzapfel"
                            2 => "RA Baumgartner"
                            3 => "C Neurohr"
                            4 => "M Vogeser"
                            5 => "J Behr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2368"
                        "paginaFinal" => "2374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004300000005/v1_201305150317/S1579212907600664/v1_201305150317/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004300000005/v1_201305150317/S1579212907600664/v1_201305150317/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600664?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 5 3 8
2024 October 49 16 65
2024 September 34 17 51
2024 August 59 38 97
2024 July 33 17 50
2024 June 46 24 70
2024 May 42 25 67
2024 April 25 24 49
2024 March 26 20 46
2024 February 24 24 48
2023 March 4 3 7
2023 February 17 20 37
2023 January 18 27 45
2022 December 19 22 41
2022 November 23 22 45
2022 October 29 29 58
2022 September 55 33 88
2022 August 31 33 64
2022 July 24 41 65
2022 June 13 27 40
2022 May 20 23 43
2022 April 19 27 46
2022 March 18 36 54
2022 February 21 35 56
2022 January 22 32 54
2021 December 14 44 58
2021 November 15 58 73
2021 October 11 36 47
2021 September 22 65 87
2021 August 19 37 56
2021 July 17 17 34
2021 June 18 34 52
2021 May 16 28 44
2021 April 43 41 84
2021 March 14 15 29
2021 February 7 20 27
2021 January 11 9 20
2020 December 8 11 19
2020 November 7 5 12
2020 October 10 5 15
2020 September 4 2 6
2020 August 18 7 25
2020 July 9 13 22
2020 June 13 5 18
2020 May 15 6 21
2020 April 10 11 21
2020 March 16 8 24
2020 February 11 11 22
2020 January 11 12 23
2019 December 16 9 25
2019 November 5 7 12
2019 October 9 7 16
2019 September 5 13 18
2019 August 11 7 18
2019 July 9 14 23
2019 June 4 4 8
2019 May 10 9 19
2019 April 23 14 37
2019 March 7 9 16
2019 February 12 10 22
2019 January 11 4 15
2018 December 15 12 27
2018 November 13 5 18
2018 October 39 12 51
2018 September 8 9 17
2018 May 9 0 9
2018 April 13 5 18
2018 March 4 5 9
2018 February 4 5 9
2018 January 3 6 9
2017 December 3 5 8
2017 November 3 5 8
2017 October 6 11 17
2017 September 5 10 15
2017 August 9 8 17
2017 July 4 8 12
2017 June 6 13 19
2017 May 4 5 9
2017 April 3 6 9
2017 March 2 2 4
2017 February 1 1 2
2017 January 1 4 5
2016 December 8 6 14
2016 November 11 6 17
2016 October 22 8 30
2016 September 6 11 17
2016 August 13 5 18
2016 July 8 4 12
2016 March 1 0 1
2016 February 1 0 1
2016 January 1 0 1
2015 December 2 0 2
2015 October 56 6 62
2015 September 69 10 79
2015 August 28 7 35
2015 July 43 5 48
2015 June 40 3 43
2015 May 53 13 66
2015 April 62 7 69
2015 March 68 7 75
2015 February 48 7 55
2015 January 71 7 78
2014 December 70 4 74
2014 November 48 6 54
2014 October 57 9 66
2014 September 54 4 58
2014 August 42 7 49
2014 July 63 8 71
2014 June 49 8 57
2014 May 37 11 48
2014 April 71 6 77
2014 March 76 3 79
2014 February 292 11 303
2014 January 265 5 270
2013 December 165 8 173
2013 November 186 4 190
2013 October 48 12 60
2013 September 41 4 45
2013 August 35 5 40
2013 July 68 12 80
2013 June 38 7 45
2013 May 44 5 49
2013 April 25 7 32
2013 March 7 1 8
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?