array:23 [
  "pii" => "S1579212907600391"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60039-1"
  "estado" => "S300"
  "fechaPublicacion" => "2007-01-01"
  "aid" => "60039"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2007"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2007;43:150-5"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2552
    "formatos" => array:3 [
      "EPUB" => 89
      "HTML" => 1704
      "PDF" => 759
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907600408"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60040-8"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60040"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:156-60"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2577
      "formatos" => array:3 [
        "EPUB" => 84
        "HTML" => 1916
        "PDF" => 577
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Bronchial Hyperresponsiveness to Methacholine Assessed by Means of Tracheal Auscultation of Healthy Children Aged Under 4 Years"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "156"
          "paginaFinal" => "160"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "In&#233;s de Mir Messa, Antonio Moreno Gald&#243;, Nicol&#225;s Cobos Barroso, Santos Li&#241;&#225;n Cort&#233;s, Silvia Gartner, Gerardo Vizmanos Lamotte"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "In&#233;s"
              "apellidos" => "de Mir Messa"
            ]
            1 => array:2 [
              "nombre" => "Antonio Moreno"
              "apellidos" => "Gald&#243;"
            ]
            2 => array:2 [
              "nombre" => "Nicol&#225;s Cobos"
              "apellidos" => "Barroso"
            ]
            3 => array:2 [
              "nombre" => "Santos Li&#241;&#225;n"
              "apellidos" => "Cort&#233;s"
            ]
            4 => array:2 [
              "nombre" => "Silvia"
              "apellidos" => "Gartner"
            ]
            5 => array:2 [
              "nombre" => "Gerardo Vizmanos"
              "apellidos" => "Lamotte"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600408?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000003/v1_201305150311/S1579212907600408/v1_201305150311/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S157921290760038X"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60038-X"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60038"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:143-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2477
      "formatos" => array:3 [
        "EPUB" => 75
        "HTML" => 1868
        "PDF" => 534
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Risk Factors in Bronchogenic Carcinoma Surger"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "143"
          "paginaFinal" => "149"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jos&#233; Luis Duque, Ramon Rami-Porta, Ana Almaraz, Manuel Castanedo, Jorge Freixinet, Antonio Fern&#225;ndez de Rota"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Jos&#233; Luis"
              "apellidos" => "Duque"
            ]
            1 => array:2 [
              "nombre" => "Ramon"
              "apellidos" => "Rami-Porta"
            ]
            2 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Almaraz"
            ]
            3 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Castanedo"
            ]
            4 => array:2 [
              "nombre" => "Jorge"
              "apellidos" => "Freixinet"
            ]
            5 => array:2 [
              "nombre" => "Antonio Fern&#225;ndez"
              "apellidos" => "de Rota"
            ]
            6 => array:1 [
              "colaborador" => "the Bronchogenic Carcinoma Cooperative Group &#40;GCCB-S&#41; of the Spanish Society of Pulmonology and Thoracic Surgery &#40;SEPAR&#41;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290760038X?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000003/v1_201305150311/S157921290760038X/v1_201305150311/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Physiologic Effects of Noninvasive Ventilation in Patients With Chronic Obstructive Pulmonary Diseas"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "150"
        "paginaFinal" => "155"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jorge Y&#46; Neme, Amalia M&#46; Guti&#233;rrez, M&#46; Cristina Santos, Marta Ber&#243;n, Cristina Ekroth, Jos&#233; P&#46; Arcos, H&#233;ctor P&#237;riz, F Javier Hurtado"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Jorge Y&#46;"
            "apellidos" => "Neme"
            "email" => array:1 [
              0 => "jneme&#64;montevideo&#46;com&#46;uy"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Amalia M&#46;"
            "apellidos" => "Guti&#233;rrez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46; Cristina"
            "apellidos" => "Santos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Marta"
            "apellidos" => "Ber&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Cristina"
            "apellidos" => "Ekroth"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Jos&#233; P&#46;"
            "apellidos" => "Arcos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "H&#233;ctor"
            "apellidos" => "P&#237;riz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "F Javier"
            "apellidos" => "Hurtado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Fisiopatolog&#237;a&#44; Hospital de Cl&#237;nicas&#44; Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Laboratorio de Exploraci&#243;n Funcional Respiratoria&#44; Hospital de Cl&#237;nicas&#44; Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Centro de Tratamiento Intensivo&#44; Hospital de Cl&#237;nicas&#44; Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; J&#46;Y&#46; Neme&#46; Departamento de Fisiopatolog&#237;a&#46; Hospital de Cl&#237;nicas&#46; Avda&#46; Italia&#44; s&#47;n&#44; 15&#46;&#186; piso&#46; Montevideo&#46; Uruguay"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-06-10"
    "fechaAceptado" => "2006-09-12"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154796"
          "palabras" => array:7 [
            0 => "Noninvasive ventilation"
            1 => "Pressure support ventilation"
            2 => "Chronic respiratory failure"
            3 => "Work of breathing"
            4 => "Pulmonary disease&#44; chronic obstructive"
            5 => "COPD"
            6 => "Continuous positive airway pressure"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec154795"
          "palabras" => array:6 [
            0 => "Ventilaci&#243;n no invasiva"
            1 => "Presi&#243;n de soporte"
            2 => "Insuficiencia respiratoria cr&#243;nica"
            3 => "Trabajo respiratorio"
            4 => "EPOC"
            5 => "Presi&#243;n positiva continua de la v&#237;a a&#233;rea"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Noninvasive mechanical ventilation has been of use in the treatment of some forms of chronic and acute respiratory failure&#46; However&#44; the benefits of its use in patients in the stable phase of severe chronic obstructive pulmonary disease &#40;COPD&#41; remain unclear&#46; A combination of continuous positive airway pressure &#40;CPAP&#41; and pressure support ventilation &#40;PSV&#41; may improve respiratory mechanics and alveolar ventilation&#44; and reduce inspiratory muscle effort&#46; In this study&#44; we analyzed the physiologic effects of differing levels of CPAP and CPAP plus PSV in patients with stable severe COPD&#46;</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">Work of breathing&#44; breathing pattern&#44; oxygen saturation measured by pulse oximetry&#44; PaO<span class="elsevierStyleInf">2</span>&#44; and PaCO<span class="elsevierStyleInf">2</span> were analyzed in a group of 18 patients under the following conditions&#58; a&#41; baseline&#59; b&#41; CPAP&#44; 3 cm H<span class="elsevierStyleInf">2</span>0&#59; c&#41; CPAP&#44; 6 cm H<span class="elsevierStyleInf">2</span>0&#59; d&#41; CPAP 3 cm H<span class="elsevierStyleInf">2</span>0 plus PSV 8 cm H<span class="elsevierStyleInf">2</span>0&#59; and e&#41; CPAP 3 cm H<span class="elsevierStyleInf">2</span>0 plus PSV 12 cm H<span class="elsevierStyleInf">2</span>0&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">CPAP at pressures of 3 and 6 cm H<span class="elsevierStyleInf">2</span>0 was associated with an increase in tidal volume &#40;V<span class="elsevierStyleInf">T</span>&#41; from a mean &#40;SD&#41; baseline value of 0&#46;52 &#40;0&#46;04&#41; L to 0&#46;62 &#40;0&#46;04&#41; and 0&#46;61 &#40;0&#46;03&#41; L&#44; respectively&#46; Minute ventilation increased from 8&#46;6 &#40;0&#46;5&#41; L&#47;min to 10&#46;8 &#40;0&#46;6&#41; and 10&#46;9 &#40;0&#46;5&#41; L&#47;min&#44; respectively&#46; Mean inspiratory flow &#40;V<span class="elsevierStyleInf">T</span>&#47;Ti&#41; increased from 0&#46;35 &#40;0&#46;02&#41; L&#47;s to 0&#46;44 &#40;0&#46;02&#41; and 0&#46;41 &#40;0&#46;02&#41; L&#47;s&#44; respectively&#44; and dynamic intrinsic positive end-expiratory pressure &#40;PEEPi&#44;dyn&#41; was reduced from 1&#46;63 &#40;0&#46;7&#41; cm H<span class="elsevierStyleInf">2</span>0 to 1&#46;1 &#40;0&#46;06&#41; and 0&#46;37 &#40;0&#46;4&#41; cm H<span class="elsevierStyleInf">2</span>0&#44; respectively&#46; CPAP did not reduce the work of breathing&#46; Association of CPAP at 3 cm H<span class="elsevierStyleInf">2</span>0 with PSV of 8 or 12 cm H<span class="elsevierStyleInf">2</span>0 increased V<span class="elsevierStyleInf">T</span> to 0&#46;72 &#40;0&#46;07&#41; and 0&#46;87 &#40;0&#46;08&#41; L&#44; respectively&#44; while minute ventilation increased to 12&#46;9 &#40;0&#46;8&#41; and 14&#46;9 &#40;1&#46;1&#41; L&#47;s&#44; respectively&#46; Mean inspiratory flow also increased to 0&#46;50 &#40;0&#46;03&#41; and 0&#46;57 &#40;0&#46;03&#41; L&#47;s&#44; respectively&#46; Work of breathing was reduced from 0&#46;90 &#40;0&#46;01&#41; J&#47;L to 0&#46;48 &#40;0&#46;06&#41; and 0&#46;30 &#40;0&#46;06&#41; J&#47;L&#44; respectively&#44; while PEEPi&#44;dyn increased to 1&#46;30 &#40;0&#46;02&#41; and 2&#46;42 &#40;0&#46;08&#41; cm H<span class="elsevierStyleInf">2</span>0&#44; respectively&#46; With combined CPAP of 3 cm H<span class="elsevierStyleInf">2</span>0 and PSV of 12 cm H<span class="elsevierStyleInf">2</span>0&#44; PaCO<span class="elsevierStyleInf">2</span> was reduced from a baseline value of 41&#46;2 &#40;1&#46;5&#41; mm Hg to 38&#46;7 &#40;1&#46;9&#41; mm Hg&#46; All of the changes were statistically significant &#40;P&#60;&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">CPAP of 3 cm H<span class="elsevierStyleInf">2</span>0 in combination with PSV improved breathing pattern&#44; increased alveolar ventilation&#44; and reduced work of breathing&#46; These results offer a rational basis for the use of noninvasive mechanical ventilation in the treatment of patients with stable severe COPD&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La ventilaci&#243;n mec&#225;nica no invasiva ha sido &#250;til en el tratamiento de algunas formas de insuficiencia respiratoria aguda y cr&#243;nica&#46; Sin embargo&#44; sus posibles beneficios para pacientes con enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; grave en fase estable contin&#250;an siendo objeto de controversia&#46; La combinaci&#243;n de presi&#243;n positiva continua de la v&#237;a a&#233;rea &#40;CPAP&#41; y presi&#243;n de soporte &#40;PS&#41; puede mejorar la mec&#225;nica respiratoria&#44; el trabajo muscular y la ventilaci&#243;n alveolar&#46; Estudiamos los efectos fisiol&#243;gicos de diferentes cifras de CPAP y CPAP &#43; PS en pacientes con EPOC grave en fase estable&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">En 18 pacientes se determinaron el trabajo respiratorio&#44; el patr&#243;n respiratorio&#44; la oximetr&#237;a de pulso y los gases sangu&#237;neos en las siguientes condiciones&#58; a&#41; basal&#59; b&#41; CPAP&#58; 3 cmH<span class="elsevierStyleInf">2</span>O&#59; c&#41; CPAP&#58; 6 cmH<span class="elsevierStyleInf">2</span>O&#59; d&#41; CPAP &#43; PS&#58; 3 y 8 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#44; y e&#41; CPAP &#43; PS&#58; 3 y 12 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La CPAP de 3 y 6 cmH<span class="elsevierStyleInf">2</span>O se asoci&#243; con aumento del volumen corriente &#40;Vc&#41;&#44; que de un valor basal medio &#40;&#177; desviaci&#243;n est&#225;ndar&#41; de 0&#44;52 &#177; 0&#44;04 pas&#243; a 0&#44;62 &#177; 0&#44;04 y 0&#44;61 &#177; 0&#44;03 l&#44; respectivamente&#46; La ventilaci&#243;n minuto aument&#243; de 8&#44;6 &#177; 0&#44;5 a 10&#44;8 &#177; 0&#44;6 y 10&#44;9 &#177; 0&#44;5 l&#47;min&#44; respectivamente&#46; El flujo medio inspiratorio &#40;Vc&#47;Ti&#41; pas&#243; de 0&#44;35 &#177; 0&#44;02 a 0&#44;44 &#177; 0&#44;02 y 0&#44;41 &#177; 0&#44;02 ml&#47;min&#44; y la presi&#243;n positiva al final de la inspiraci&#243;n intr&#237;nseca &#40;PEEPi din&#225;mica&#41; disminuy&#243; de 1&#44;63 &#177; 0&#44;7 a 1&#44;1 &#177; 0&#44;06 y 0&#44;37 &#177; 0&#44;4 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#46; La CPAP no disminuy&#243; el trabajo respiratorio&#46; La asociaci&#243;n de CPAP de 3 cmH<span class="elsevierStyleInf">2</span>O con PS de 8 y 12 cmH<span class="elsevierStyleInf">2</span>O aument&#243; el Vc a 0&#44;72 &#177; 0&#44;07 y 0&#44;87 &#177; 0&#44;08 l&#44; mientras la ventilaci&#243;n minuto aument&#243; a 12&#44;9 &#177; 0&#44;8 y 14&#44;9 &#177; 1&#44;1 l&#47;min&#44; respectivamente&#46; El Vc&#47;Ti tambi&#233;n aument&#243; a 0&#44;50 &#177; 0&#44;03 y 0&#44;57 &#177; 0&#44;03 l&#47;s&#44; respectivamente&#46; El trabajo respiratorio disminuy&#243; desde 0&#44;90 &#177; 0&#44;01 a 0&#44;48 &#177; 0&#44;06 y 0&#44;30 &#177; 0&#44;06 J&#47;l&#44; mientras que la PEEPi din&#225;mica aument&#243; a 1&#44;30 &#177; 0&#44;02 y 2&#44;42 &#177; 0&#44;08 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#46; Con CPAP de 3 cmH<span class="elsevierStyleInf">2</span>O y PS de 12 cmH<span class="elsevierStyleInf">2</span>O la presi&#243;n arterial de anh&#237;drido carb&#243;nico disminuy&#243; de un valor basal de 41&#44;2 &#177; 1&#44;5 a 38&#44;7 &#177; 1&#44;9 Torr&#46; Todos estos cambios fueron estad&#237;sticamente significativos &#40;p &#60; 0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El uso de CPAP de 3 cmH<span class="elsevierStyleInf">2</span>O con PS mejor&#243; el patr&#243;n ventilatorio&#44; aument&#243; la ventilaci&#243;n alveolar y disminuy&#243; el trabajo respiratorio&#46; Estos resultados ofrecen fundamentos para un uso racional de la ventilaci&#243;n mec&#225;nica no invasiva para el tratamiento de los pacientes con EPOC grave en fase estable&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:32 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L Brochard"
                            1 => "J Mancebo"
                            2 => "M Wysocki"
                            3 => "F Lofaso"
                            4 => "G Conti"
                            5 => "A Rauss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199509283331301"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1995"
                        "volumen" => "333"
                        "paginaInicial" => "817"
                        "paginaFinal" => "822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7651472"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive face mask ventilation in patients with acute respiratory failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "GU Meduri"
                            1 => "CC Conoscenti"
                            2 => "P Menashe"
                            3 => "S Nair"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1989"
                        "volumen" => "95"
                        "paginaInicial" => "865"
                        "paginaFinal" => "870"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2924616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Italian multicenter study on noninvasive ventilation in chronic obstructive pulmonary disease patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E Clini"
                            1 => "C Sturani"
                            2 => "A Rossi"
                            3 => "S Viaggi"
                            4 => "A Corrado"
                            5 => "C Donner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "529"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12358325"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S Mehta"
                            1 => "NS Hill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.2.9906116"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "540"
                        "paginaFinal" => "577"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11179136"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of noninvasive ventilation on lung hyperinflation in stable hypercapnic COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O D&#237;az"
                            1 => "P B&#233;gin"
                            2 => "B Torrealba"
                            3 => "E Jover"
                            4 => "C Lisboa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "1490"
                        "paginaFinal" => "1498"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12503709"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical indications for non-invasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease&#44; COPD&#44; and nocturnal hypoventilation&#46; A consensus conference report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Consensus Conference"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "521"
                        "paginaFinal" => "534"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10453883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Domiciliary nocturnal nasal positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease&#58; effects on sleep and life quality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "MW Elliot"
                            1 => "AK Simond"
                            2 => "MP Carroll"
                            3 => "JA Wedzicha"
                            4 => "MA Branthwaite"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1992"
                        "volumen" => "47"
                        "paginaInicial" => "342"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1609376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory muscle rest using nasal BiPAP ventilation in patients with stable COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JP Renston"
                            1 => "AF DiMarco"
                            2 => "GS Supinski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1994"
                        "volumen" => "105"
                        "paginaInicial" => "1053"
                        "paginaFinal" => "1060"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8162724"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "13140216"
                          "estado" => "S300"
                          "issn" => "03008932"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nasal pressure support ventilation plus oxygen compared with oxygen therapy in hypercapnic COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DJ Meecham Jones"
                            1 => "EA Paul"
                            2 => "PW Jones"
                            3 => "JA Wedzicha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.2.7633704"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "538"
                        "paginaFinal" => "544"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7633704"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reflexiones para la organizaci&#243;n y desarrollo de una unidad de ventilaci&#243;n mec&#225;nica no invasiva y domiciliaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S D&#237;az-Lobato"
                            1 => "S Mayorales-Alises"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "579"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16266672"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Domiciliary noninvasive ventilatory support"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S Nava"
                            1 => "P Navalesi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Lung biology in health and disease&#46; Clinical management of chronic obstructive pulmonary disease"
                        "paginaInicial" => "813"
                        "paginaFinal" => "848"
                        "serieFecha" => "2002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of positive vs&#46; negative pressure ventilation in unloading the respiratory muscles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "MS Belman"
                            1 => "GWS Hoo"
                            2 => "SH Kuei"
                            3 => "R Shadmehr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1990"
                        "volumen" => "98"
                        "paginaInicial" => "850"
                        "paginaFinal" => "856"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2119950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventilatory muscle support in respiratory failure with positive pressure ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Z Carrey"
                            1 => "SB Gottfried"
                            2 => "RD Levy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1990"
                        "volumen" => "97"
                        "paginaInicial" => "150"
                        "paginaFinal" => "158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2403893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nasal continuous positive airway pressure in patients with COPD in acute respiratory failure&#46; A study of the immediate effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P de Lucas"
                            1 => "C Taranc&#243;n"
                            2 => "L Puente"
                            3 => "C Rodr&#237;guez"
                            4 => "E Tatey"
                            5 => "J Monturiol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1993"
                        "volumen" => "104"
                        "paginaInicial" => "1694"
                        "paginaFinal" => "1697"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8252944"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physiologic effects of positive end-expiratory pressure and mask pressure support during exacerbations of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:5 [
                            0 => "L Apendini"
                            1 => "A Patessio"
                            2 => "S Zanaboni"
                            3 => "M Carone"
                            4 => "B Gukov"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.149.5.8173743"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1994"
                        "volumen" => "149"
                        "paginaInicial" => "1069"
                        "paginaFinal" => "1076"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8173743"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "1152"
                        "paginaInicial" => "S77"
                        "paginaFinal" => "S121"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global strategy for the diagnosis&#44; management and prevention of chronic obstructive lung disease&#58; NHLBI&#47;WHO Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41; workshop summary"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "RA Pauwels"
                            1 => "AS Buist"
                            2 => "PMA Calverley"
                            3 => "CR Jenkins"
                            4 => "SS Hurd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.5.2101039"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "1256"
                        "paginaFinal" => "1276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11316667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A simple method for assessing the validity of the esophageal balloon technique"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Baydur"
                            1 => "P Behrakis"
                            2 => "W Zin"
                            3 => "M Jaeger"
                            4 => "J Milic-Emili"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1982.126.5.788"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1982"
                        "volumen" => "126"
                        "paginaInicial" => "788"
                        "paginaFinal" => "791"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7149443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous positive airway pressure reduces work of breathing and dyspnea during weaning from mechanical ventilation in severe chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "BJ Petrof"
                            1 => "M Legar&#233;"
                            2 => "P Goldberg"
                            3 => "J Milic-Emili"
                            4 => "S Gottfried"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/141.2.281"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1990"
                        "volumen" => "141"
                        "paginaInicial" => "281"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2405757"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inspiratory pressure support prevents diaphragmatic fatigue during weaning from mechanical ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L Brochard"
                            1 => "A Harf"
                            2 => "H Lorino"
                            3 => "F Lemaire"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/139.2.513"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "139"
                        "paginaInicial" => "513"
                        "paginaFinal" => "521"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2643905"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S014067360960372X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monitorizaci&#243;n de las fugas en ventilaci&#243;n no invasiva"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "CA Rabec"
                            1 => "O Reybet-Deget"
                            2 => "P Bonniaud"
                            3 => "A Fanton"
                            4 => "P Camus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "508"
                        "paginaFinal" => "517"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15530343"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous positive airway pressure in patients with COPD in acute hypercapnic respiratory failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "AM Miro"
                            1 => "U Shivaram"
                            2 => "I Hertig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1993"
                        "volumen" => "103"
                        "paginaInicial" => "266"
                        "paginaFinal" => "268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8417894"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of PEEP on lung mechanics and work of breathing in severe airflow obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "TC Smith"
                            1 => "JJ Marini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1988"
                        "volumen" => "65"
                        "paginaInicial" => "1488"
                        "paginaFinal" => "1499"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3053583"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of CPAP on intrinsic PEEP&#44; inspiratory effort&#44; and lung volume in severe stable COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "FJ O&#39;Donoghue"
                            1 => "PG Catcheside"
                            2 => "AS Jordan"
                            3 => "AD Bersten"
                            4 => "RD McEvoy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2002"
                        "volumen" => "57"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12037230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Work of breathing during mechanical ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "CSH Sassoon"
                            1 => "CK Mahutte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Lung biology in health and disease&#46; Physiological basis of ventilatory support"
                        "paginaInicial" => "261"
                        "paginaFinal" => "310"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intrinsic PEEP and arterial PaCO<span class="elsevierStyleInf">2</span> in stable patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Haluzka"
                            1 => "DA Chartrand"
                            2 => "A Grassino"
                            3 => "J Milic-Emili"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/141.5_Pt_1.1194"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1990"
                        "volumen" => "141"
                        "paginaInicial" => "1194"
                        "paginaFinal" => "1197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2111105"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of carbon dioxide rebreathing during pressure support ventilation with airway management system &#40;BiPAP&#41; devices"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F Lofaso"
                            1 => "L Brochard"
                            2 => "D Touchard"
                            3 => "T Hang"
                            4 => "A Harf"
                            5 => "D Isabey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1995"
                        "volumen" => "108"
                        "paginaInicial" => "772"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7656632"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CO<span class="elsevierStyleInf">2</span> rebreathing during BiPAP ventilatory assistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "GT Ferguson"
                            1 => "M Gilmartin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.151.4.7697242"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "151"
                        "paginaInicial" => "1126"
                        "paginaFinal" => "1135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7697242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "International Consensus Conference in Intensive Care Medicine&#58; non-invasive positive pressure ventilation in acute respiratory failure"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.1.ats1000"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "283"
                        "paginaFinal" => "291"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11208659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards&#58; a multicenter randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "PK Plant"
                            1 => "JL Owen"
                            2 => "MW Elliott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2000"
                        "volumen" => "355"
                        "paginaInicial" => "1931"
                        "paginaFinal" => "1935"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10859037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pro-con debate&#58; noninvasive ventilation has been shown to be effective&#47;ineffective in stable COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Rossi"
                            1 => "NS Hill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.161.3.16135a"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "161"
                        "paginaInicial" => "688"
                        "paginaFinal" => "691"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10712304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of noninvasive ventilation on pulmonary gas exchange and hemodynamics during acute hypercapnic exacerbations of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O D&#237;az"
                            1 => "R Iglesia"
                            2 => "M Ferrer"
                            3 => "E Zavala"
                            4 => "C Santos"
                            5 => "P Wagner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.156.6.9701027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1997"
                        "volumen" => "156"
                        "paginaInicial" => "1840"
                        "paginaFinal" => "1845"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9412564"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004300000003/v1_201305150311/S1579212907600391/v1_201305150311/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004300000003/v1_201305150311/S1579212907600391/v1_201305150311/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600391?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original Articles
Physiologic Effects of Noninvasive Ventilation in Patients With Chronic Obstructive Pulmonary Diseas
Jorge Y. Nemea,
Corresponding author
jneme@montevideo.com.uy

Correspondence: Dr. J.Y. Neme. Departamento de Fisiopatología. Hospital de Clínicas. Avda. Italia, s/n, 15.º piso. Montevideo. Uruguay
, Amalia M. Gutiérrezb, M. Cristina Santosb, Marta Berónc, Cristina Ekrothb, José P. Arcosb, Héctor Píriza, F Javier Hurtadoa
a Departamento de Fisiopatología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
b Laboratorio de Exploración Funcional Respiratoria, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
c Centro de Tratamiento Intensivo, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
Read
4600
Times
was read the article
1894
Total PDF
2706
Total HTML
Share statistics
 array:23 [
  "pii" => "S1579212907600391"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60039-1"
  "estado" => "S300"
  "fechaPublicacion" => "2007-01-01"
  "aid" => "60039"
  "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
  "copyrightAnyo" => "2007"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2007;43:150-5"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2552
    "formatos" => array:3 [
      "EPUB" => 89
      "HTML" => 1704
      "PDF" => 759
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907600408"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60040-8"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60040"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:156-60"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2577
      "formatos" => array:3 [
        "EPUB" => 84
        "HTML" => 1916
        "PDF" => 577
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Bronchial Hyperresponsiveness to Methacholine Assessed by Means of Tracheal Auscultation of Healthy Children Aged Under 4 Years"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "156"
          "paginaFinal" => "160"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "In&#233;s de Mir Messa, Antonio Moreno Gald&#243;, Nicol&#225;s Cobos Barroso, Santos Li&#241;&#225;n Cort&#233;s, Silvia Gartner, Gerardo Vizmanos Lamotte"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "In&#233;s"
              "apellidos" => "de Mir Messa"
            ]
            1 => array:2 [
              "nombre" => "Antonio Moreno"
              "apellidos" => "Gald&#243;"
            ]
            2 => array:2 [
              "nombre" => "Nicol&#225;s Cobos"
              "apellidos" => "Barroso"
            ]
            3 => array:2 [
              "nombre" => "Santos Li&#241;&#225;n"
              "apellidos" => "Cort&#233;s"
            ]
            4 => array:2 [
              "nombre" => "Silvia"
              "apellidos" => "Gartner"
            ]
            5 => array:2 [
              "nombre" => "Gerardo Vizmanos"
              "apellidos" => "Lamotte"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600408?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000003/v1_201305150311/S1579212907600408/v1_201305150311/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S157921290760038X"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60038-X"
    "estado" => "S300"
    "fechaPublicacion" => "2007-01-01"
    "aid" => "60038"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2007;43:143-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2477
      "formatos" => array:3 [
        "EPUB" => 75
        "HTML" => 1868
        "PDF" => 534
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Risk Factors in Bronchogenic Carcinoma Surger"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "143"
          "paginaFinal" => "149"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jos&#233; Luis Duque, Ramon Rami-Porta, Ana Almaraz, Manuel Castanedo, Jorge Freixinet, Antonio Fern&#225;ndez de Rota"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Jos&#233; Luis"
              "apellidos" => "Duque"
            ]
            1 => array:2 [
              "nombre" => "Ramon"
              "apellidos" => "Rami-Porta"
            ]
            2 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Almaraz"
            ]
            3 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Castanedo"
            ]
            4 => array:2 [
              "nombre" => "Jorge"
              "apellidos" => "Freixinet"
            ]
            5 => array:2 [
              "nombre" => "Antonio Fern&#225;ndez"
              "apellidos" => "de Rota"
            ]
            6 => array:1 [
              "colaborador" => "the Bronchogenic Carcinoma Cooperative Group &#40;GCCB-S&#41; of the Spanish Society of Pulmonology and Thoracic Surgery &#40;SEPAR&#41;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290760038X?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004300000003/v1_201305150311/S157921290760038X/v1_201305150311/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Physiologic Effects of Noninvasive Ventilation in Patients With Chronic Obstructive Pulmonary Diseas"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "150"
        "paginaFinal" => "155"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jorge Y&#46; Neme, Amalia M&#46; Guti&#233;rrez, M&#46; Cristina Santos, Marta Ber&#243;n, Cristina Ekroth, Jos&#233; P&#46; Arcos, H&#233;ctor P&#237;riz, F Javier Hurtado"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Jorge Y&#46;"
            "apellidos" => "Neme"
            "email" => array:1 [
              0 => "jneme&#64;montevideo&#46;com&#46;uy"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Amalia M&#46;"
            "apellidos" => "Guti&#233;rrez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46; Cristina"
            "apellidos" => "Santos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Marta"
            "apellidos" => "Ber&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Cristina"
            "apellidos" => "Ekroth"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Jos&#233; P&#46;"
            "apellidos" => "Arcos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "H&#233;ctor"
            "apellidos" => "P&#237;riz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "F Javier"
            "apellidos" => "Hurtado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Fisiopatolog&#237;a&#44; Hospital de Cl&#237;nicas&#44; Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Laboratorio de Exploraci&#243;n Funcional Respiratoria&#44; Hospital de Cl&#237;nicas&#44; Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Centro de Tratamiento Intensivo&#44; Hospital de Cl&#237;nicas&#44; Facultad de Medicina&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; J&#46;Y&#46; Neme&#46; Departamento de Fisiopatolog&#237;a&#46; Hospital de Cl&#237;nicas&#46; Avda&#46; Italia&#44; s&#47;n&#44; 15&#46;&#186; piso&#46; Montevideo&#46; Uruguay"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-06-10"
    "fechaAceptado" => "2006-09-12"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154796"
          "palabras" => array:7 [
            0 => "Noninvasive ventilation"
            1 => "Pressure support ventilation"
            2 => "Chronic respiratory failure"
            3 => "Work of breathing"
            4 => "Pulmonary disease&#44; chronic obstructive"
            5 => "COPD"
            6 => "Continuous positive airway pressure"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec154795"
          "palabras" => array:6 [
            0 => "Ventilaci&#243;n no invasiva"
            1 => "Presi&#243;n de soporte"
            2 => "Insuficiencia respiratoria cr&#243;nica"
            3 => "Trabajo respiratorio"
            4 => "EPOC"
            5 => "Presi&#243;n positiva continua de la v&#237;a a&#233;rea"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Noninvasive mechanical ventilation has been of use in the treatment of some forms of chronic and acute respiratory failure&#46; However&#44; the benefits of its use in patients in the stable phase of severe chronic obstructive pulmonary disease &#40;COPD&#41; remain unclear&#46; A combination of continuous positive airway pressure &#40;CPAP&#41; and pressure support ventilation &#40;PSV&#41; may improve respiratory mechanics and alveolar ventilation&#44; and reduce inspiratory muscle effort&#46; In this study&#44; we analyzed the physiologic effects of differing levels of CPAP and CPAP plus PSV in patients with stable severe COPD&#46;</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">Work of breathing&#44; breathing pattern&#44; oxygen saturation measured by pulse oximetry&#44; PaO<span class="elsevierStyleInf">2</span>&#44; and PaCO<span class="elsevierStyleInf">2</span> were analyzed in a group of 18 patients under the following conditions&#58; a&#41; baseline&#59; b&#41; CPAP&#44; 3 cm H<span class="elsevierStyleInf">2</span>0&#59; c&#41; CPAP&#44; 6 cm H<span class="elsevierStyleInf">2</span>0&#59; d&#41; CPAP 3 cm H<span class="elsevierStyleInf">2</span>0 plus PSV 8 cm H<span class="elsevierStyleInf">2</span>0&#59; and e&#41; CPAP 3 cm H<span class="elsevierStyleInf">2</span>0 plus PSV 12 cm H<span class="elsevierStyleInf">2</span>0&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">CPAP at pressures of 3 and 6 cm H<span class="elsevierStyleInf">2</span>0 was associated with an increase in tidal volume &#40;V<span class="elsevierStyleInf">T</span>&#41; from a mean &#40;SD&#41; baseline value of 0&#46;52 &#40;0&#46;04&#41; L to 0&#46;62 &#40;0&#46;04&#41; and 0&#46;61 &#40;0&#46;03&#41; L&#44; respectively&#46; Minute ventilation increased from 8&#46;6 &#40;0&#46;5&#41; L&#47;min to 10&#46;8 &#40;0&#46;6&#41; and 10&#46;9 &#40;0&#46;5&#41; L&#47;min&#44; respectively&#46; Mean inspiratory flow &#40;V<span class="elsevierStyleInf">T</span>&#47;Ti&#41; increased from 0&#46;35 &#40;0&#46;02&#41; L&#47;s to 0&#46;44 &#40;0&#46;02&#41; and 0&#46;41 &#40;0&#46;02&#41; L&#47;s&#44; respectively&#44; and dynamic intrinsic positive end-expiratory pressure &#40;PEEPi&#44;dyn&#41; was reduced from 1&#46;63 &#40;0&#46;7&#41; cm H<span class="elsevierStyleInf">2</span>0 to 1&#46;1 &#40;0&#46;06&#41; and 0&#46;37 &#40;0&#46;4&#41; cm H<span class="elsevierStyleInf">2</span>0&#44; respectively&#46; CPAP did not reduce the work of breathing&#46; Association of CPAP at 3 cm H<span class="elsevierStyleInf">2</span>0 with PSV of 8 or 12 cm H<span class="elsevierStyleInf">2</span>0 increased V<span class="elsevierStyleInf">T</span> to 0&#46;72 &#40;0&#46;07&#41; and 0&#46;87 &#40;0&#46;08&#41; L&#44; respectively&#44; while minute ventilation increased to 12&#46;9 &#40;0&#46;8&#41; and 14&#46;9 &#40;1&#46;1&#41; L&#47;s&#44; respectively&#46; Mean inspiratory flow also increased to 0&#46;50 &#40;0&#46;03&#41; and 0&#46;57 &#40;0&#46;03&#41; L&#47;s&#44; respectively&#46; Work of breathing was reduced from 0&#46;90 &#40;0&#46;01&#41; J&#47;L to 0&#46;48 &#40;0&#46;06&#41; and 0&#46;30 &#40;0&#46;06&#41; J&#47;L&#44; respectively&#44; while PEEPi&#44;dyn increased to 1&#46;30 &#40;0&#46;02&#41; and 2&#46;42 &#40;0&#46;08&#41; cm H<span class="elsevierStyleInf">2</span>0&#44; respectively&#46; With combined CPAP of 3 cm H<span class="elsevierStyleInf">2</span>0 and PSV of 12 cm H<span class="elsevierStyleInf">2</span>0&#44; PaCO<span class="elsevierStyleInf">2</span> was reduced from a baseline value of 41&#46;2 &#40;1&#46;5&#41; mm Hg to 38&#46;7 &#40;1&#46;9&#41; mm Hg&#46; All of the changes were statistically significant &#40;P&#60;&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">CPAP of 3 cm H<span class="elsevierStyleInf">2</span>0 in combination with PSV improved breathing pattern&#44; increased alveolar ventilation&#44; and reduced work of breathing&#46; These results offer a rational basis for the use of noninvasive mechanical ventilation in the treatment of patients with stable severe COPD&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La ventilaci&#243;n mec&#225;nica no invasiva ha sido &#250;til en el tratamiento de algunas formas de insuficiencia respiratoria aguda y cr&#243;nica&#46; Sin embargo&#44; sus posibles beneficios para pacientes con enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; grave en fase estable contin&#250;an siendo objeto de controversia&#46; La combinaci&#243;n de presi&#243;n positiva continua de la v&#237;a a&#233;rea &#40;CPAP&#41; y presi&#243;n de soporte &#40;PS&#41; puede mejorar la mec&#225;nica respiratoria&#44; el trabajo muscular y la ventilaci&#243;n alveolar&#46; Estudiamos los efectos fisiol&#243;gicos de diferentes cifras de CPAP y CPAP &#43; PS en pacientes con EPOC grave en fase estable&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">En 18 pacientes se determinaron el trabajo respiratorio&#44; el patr&#243;n respiratorio&#44; la oximetr&#237;a de pulso y los gases sangu&#237;neos en las siguientes condiciones&#58; a&#41; basal&#59; b&#41; CPAP&#58; 3 cmH<span class="elsevierStyleInf">2</span>O&#59; c&#41; CPAP&#58; 6 cmH<span class="elsevierStyleInf">2</span>O&#59; d&#41; CPAP &#43; PS&#58; 3 y 8 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#44; y e&#41; CPAP &#43; PS&#58; 3 y 12 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La CPAP de 3 y 6 cmH<span class="elsevierStyleInf">2</span>O se asoci&#243; con aumento del volumen corriente &#40;Vc&#41;&#44; que de un valor basal medio &#40;&#177; desviaci&#243;n est&#225;ndar&#41; de 0&#44;52 &#177; 0&#44;04 pas&#243; a 0&#44;62 &#177; 0&#44;04 y 0&#44;61 &#177; 0&#44;03 l&#44; respectivamente&#46; La ventilaci&#243;n minuto aument&#243; de 8&#44;6 &#177; 0&#44;5 a 10&#44;8 &#177; 0&#44;6 y 10&#44;9 &#177; 0&#44;5 l&#47;min&#44; respectivamente&#46; El flujo medio inspiratorio &#40;Vc&#47;Ti&#41; pas&#243; de 0&#44;35 &#177; 0&#44;02 a 0&#44;44 &#177; 0&#44;02 y 0&#44;41 &#177; 0&#44;02 ml&#47;min&#44; y la presi&#243;n positiva al final de la inspiraci&#243;n intr&#237;nseca &#40;PEEPi din&#225;mica&#41; disminuy&#243; de 1&#44;63 &#177; 0&#44;7 a 1&#44;1 &#177; 0&#44;06 y 0&#44;37 &#177; 0&#44;4 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#46; La CPAP no disminuy&#243; el trabajo respiratorio&#46; La asociaci&#243;n de CPAP de 3 cmH<span class="elsevierStyleInf">2</span>O con PS de 8 y 12 cmH<span class="elsevierStyleInf">2</span>O aument&#243; el Vc a 0&#44;72 &#177; 0&#44;07 y 0&#44;87 &#177; 0&#44;08 l&#44; mientras la ventilaci&#243;n minuto aument&#243; a 12&#44;9 &#177; 0&#44;8 y 14&#44;9 &#177; 1&#44;1 l&#47;min&#44; respectivamente&#46; El Vc&#47;Ti tambi&#233;n aument&#243; a 0&#44;50 &#177; 0&#44;03 y 0&#44;57 &#177; 0&#44;03 l&#47;s&#44; respectivamente&#46; El trabajo respiratorio disminuy&#243; desde 0&#44;90 &#177; 0&#44;01 a 0&#44;48 &#177; 0&#44;06 y 0&#44;30 &#177; 0&#44;06 J&#47;l&#44; mientras que la PEEPi din&#225;mica aument&#243; a 1&#44;30 &#177; 0&#44;02 y 2&#44;42 &#177; 0&#44;08 cmH<span class="elsevierStyleInf">2</span>O&#44; respectivamente&#46; Con CPAP de 3 cmH<span class="elsevierStyleInf">2</span>O y PS de 12 cmH<span class="elsevierStyleInf">2</span>O la presi&#243;n arterial de anh&#237;drido carb&#243;nico disminuy&#243; de un valor basal de 41&#44;2 &#177; 1&#44;5 a 38&#44;7 &#177; 1&#44;9 Torr&#46; Todos estos cambios fueron estad&#237;sticamente significativos &#40;p &#60; 0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El uso de CPAP de 3 cmH<span class="elsevierStyleInf">2</span>O con PS mejor&#243; el patr&#243;n ventilatorio&#44; aument&#243; la ventilaci&#243;n alveolar y disminuy&#243; el trabajo respiratorio&#46; Estos resultados ofrecen fundamentos para un uso racional de la ventilaci&#243;n mec&#225;nica no invasiva para el tratamiento de los pacientes con EPOC grave en fase estable&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:32 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L Brochard"
                            1 => "J Mancebo"
                            2 => "M Wysocki"
                            3 => "F Lofaso"
                            4 => "G Conti"
                            5 => "A Rauss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199509283331301"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1995"
                        "volumen" => "333"
                        "paginaInicial" => "817"
                        "paginaFinal" => "822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7651472"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive face mask ventilation in patients with acute respiratory failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "GU Meduri"
                            1 => "CC Conoscenti"
                            2 => "P Menashe"
                            3 => "S Nair"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1989"
                        "volumen" => "95"
                        "paginaInicial" => "865"
                        "paginaFinal" => "870"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2924616"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Italian multicenter study on noninvasive ventilation in chronic obstructive pulmonary disease patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E Clini"
                            1 => "C Sturani"
                            2 => "A Rossi"
                            3 => "S Viaggi"
                            4 => "A Corrado"
                            5 => "C Donner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "529"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12358325"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S Mehta"
                            1 => "NS Hill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.2.9906116"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "540"
                        "paginaFinal" => "577"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11179136"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of noninvasive ventilation on lung hyperinflation in stable hypercapnic COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O D&#237;az"
                            1 => "P B&#233;gin"
                            2 => "B Torrealba"
                            3 => "E Jover"
                            4 => "C Lisboa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "1490"
                        "paginaFinal" => "1498"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12503709"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical indications for non-invasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease&#44; COPD&#44; and nocturnal hypoventilation&#46; A consensus conference report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Consensus Conference"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "521"
                        "paginaFinal" => "534"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10453883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Domiciliary nocturnal nasal positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease&#58; effects on sleep and life quality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "MW Elliot"
                            1 => "AK Simond"
                            2 => "MP Carroll"
                            3 => "JA Wedzicha"
                            4 => "MA Branthwaite"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1992"
                        "volumen" => "47"
                        "paginaInicial" => "342"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1609376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory muscle rest using nasal BiPAP ventilation in patients with stable COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "JP Renston"
                            1 => "AF DiMarco"
                            2 => "GS Supinski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1994"
                        "volumen" => "105"
                        "paginaInicial" => "1053"
                        "paginaFinal" => "1060"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8162724"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "13140216"
                          "estado" => "S300"
                          "issn" => "03008932"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nasal pressure support ventilation plus oxygen compared with oxygen therapy in hypercapnic COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "DJ Meecham Jones"
                            1 => "EA Paul"
                            2 => "PW Jones"
                            3 => "JA Wedzicha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.2.7633704"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "538"
                        "paginaFinal" => "544"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7633704"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reflexiones para la organizaci&#243;n y desarrollo de una unidad de ventilaci&#243;n mec&#225;nica no invasiva y domiciliaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S D&#237;az-Lobato"
                            1 => "S Mayorales-Alises"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "579"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16266672"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Domiciliary noninvasive ventilatory support"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S Nava"
                            1 => "P Navalesi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Lung biology in health and disease&#46; Clinical management of chronic obstructive pulmonary disease"
                        "paginaInicial" => "813"
                        "paginaFinal" => "848"
                        "serieFecha" => "2002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of positive vs&#46; negative pressure ventilation in unloading the respiratory muscles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "MS Belman"
                            1 => "GWS Hoo"
                            2 => "SH Kuei"
                            3 => "R Shadmehr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1990"
                        "volumen" => "98"
                        "paginaInicial" => "850"
                        "paginaFinal" => "856"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2119950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventilatory muscle support in respiratory failure with positive pressure ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Z Carrey"
                            1 => "SB Gottfried"
                            2 => "RD Levy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1990"
                        "volumen" => "97"
                        "paginaInicial" => "150"
                        "paginaFinal" => "158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2403893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nasal continuous positive airway pressure in patients with COPD in acute respiratory failure&#46; A study of the immediate effects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P de Lucas"
                            1 => "C Taranc&#243;n"
                            2 => "L Puente"
                            3 => "C Rodr&#237;guez"
                            4 => "E Tatey"
                            5 => "J Monturiol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1993"
                        "volumen" => "104"
                        "paginaInicial" => "1694"
                        "paginaFinal" => "1697"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8252944"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physiologic effects of positive end-expiratory pressure and mask pressure support during exacerbations of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:5 [
                            0 => "L Apendini"
                            1 => "A Patessio"
                            2 => "S Zanaboni"
                            3 => "M Carone"
                            4 => "B Gukov"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.149.5.8173743"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1994"
                        "volumen" => "149"
                        "paginaInicial" => "1069"
                        "paginaFinal" => "1076"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8173743"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "1152"
                        "paginaInicial" => "S77"
                        "paginaFinal" => "S121"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global strategy for the diagnosis&#44; management and prevention of chronic obstructive lung disease&#58; NHLBI&#47;WHO Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41; workshop summary"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "RA Pauwels"
                            1 => "AS Buist"
                            2 => "PMA Calverley"
                            3 => "CR Jenkins"
                            4 => "SS Hurd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.5.2101039"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "1256"
                        "paginaFinal" => "1276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11316667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A simple method for assessing the validity of the esophageal balloon technique"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A Baydur"
                            1 => "P Behrakis"
                            2 => "W Zin"
                            3 => "M Jaeger"
                            4 => "J Milic-Emili"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1982.126.5.788"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1982"
                        "volumen" => "126"
                        "paginaInicial" => "788"
                        "paginaFinal" => "791"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7149443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous positive airway pressure reduces work of breathing and dyspnea during weaning from mechanical ventilation in severe chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "BJ Petrof"
                            1 => "M Legar&#233;"
                            2 => "P Goldberg"
                            3 => "J Milic-Emili"
                            4 => "S Gottfried"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/141.2.281"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1990"
                        "volumen" => "141"
                        "paginaInicial" => "281"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2405757"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inspiratory pressure support prevents diaphragmatic fatigue during weaning from mechanical ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L Brochard"
                            1 => "A Harf"
                            2 => "H Lorino"
                            3 => "F Lemaire"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/139.2.513"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "139"
                        "paginaInicial" => "513"
                        "paginaFinal" => "521"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2643905"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S014067360960372X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monitorizaci&#243;n de las fugas en ventilaci&#243;n no invasiva"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "CA Rabec"
                            1 => "O Reybet-Deget"
                            2 => "P Bonniaud"
                            3 => "A Fanton"
                            4 => "P Camus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "508"
                        "paginaFinal" => "517"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15530343"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous positive airway pressure in patients with COPD in acute hypercapnic respiratory failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "AM Miro"
                            1 => "U Shivaram"
                            2 => "I Hertig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1993"
                        "volumen" => "103"
                        "paginaInicial" => "266"
                        "paginaFinal" => "268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8417894"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of PEEP on lung mechanics and work of breathing in severe airflow obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "TC Smith"
                            1 => "JJ Marini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1988"
                        "volumen" => "65"
                        "paginaInicial" => "1488"
                        "paginaFinal" => "1499"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3053583"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of CPAP on intrinsic PEEP&#44; inspiratory effort&#44; and lung volume in severe stable COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "FJ O&#39;Donoghue"
                            1 => "PG Catcheside"
                            2 => "AS Jordan"
                            3 => "AD Bersten"
                            4 => "RD McEvoy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2002"
                        "volumen" => "57"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12037230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Work of breathing during mechanical ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "CSH Sassoon"
                            1 => "CK Mahutte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Lung biology in health and disease&#46; Physiological basis of ventilatory support"
                        "paginaInicial" => "261"
                        "paginaFinal" => "310"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intrinsic PEEP and arterial PaCO<span class="elsevierStyleInf">2</span> in stable patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Haluzka"
                            1 => "DA Chartrand"
                            2 => "A Grassino"
                            3 => "J Milic-Emili"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/141.5_Pt_1.1194"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1990"
                        "volumen" => "141"
                        "paginaInicial" => "1194"
                        "paginaFinal" => "1197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2111105"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of carbon dioxide rebreathing during pressure support ventilation with airway management system &#40;BiPAP&#41; devices"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F Lofaso"
                            1 => "L Brochard"
                            2 => "D Touchard"
                            3 => "T Hang"
                            4 => "A Harf"
                            5 => "D Isabey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1995"
                        "volumen" => "108"
                        "paginaInicial" => "772"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7656632"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CO<span class="elsevierStyleInf">2</span> rebreathing during BiPAP ventilatory assistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "GT Ferguson"
                            1 => "M Gilmartin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.151.4.7697242"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "151"
                        "paginaInicial" => "1126"
                        "paginaFinal" => "1135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7697242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "International Consensus Conference in Intensive Care Medicine&#58; non-invasive positive pressure ventilation in acute respiratory failure"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.1.ats1000"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "283"
                        "paginaFinal" => "291"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11208659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards&#58; a multicenter randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "PK Plant"
                            1 => "JL Owen"
                            2 => "MW Elliott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2000"
                        "volumen" => "355"
                        "paginaInicial" => "1931"
                        "paginaFinal" => "1935"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10859037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pro-con debate&#58; noninvasive ventilation has been shown to be effective&#47;ineffective in stable COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Rossi"
                            1 => "NS Hill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.161.3.16135a"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "161"
                        "paginaInicial" => "688"
                        "paginaFinal" => "691"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10712304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of noninvasive ventilation on pulmonary gas exchange and hemodynamics during acute hypercapnic exacerbations of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O D&#237;az"
                            1 => "R Iglesia"
                            2 => "M Ferrer"
                            3 => "E Zavala"
                            4 => "C Santos"
                            5 => "P Wagner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.156.6.9701027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1997"
                        "volumen" => "156"
                        "paginaInicial" => "1840"
                        "paginaFinal" => "1845"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9412564"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004300000003/v1_201305150311/S1579212907600391/v1_201305150311/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004300000003/v1_201305150311/S1579212907600391/v1_201305150311/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600391?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 5 6 11
2024 October 56 17 73
2024 September 38 14 52
2024 August 56 39 95
2024 July 36 19 55
2024 June 61 22 83
2024 May 28 24 52
2024 April 18 28 46
2024 March 24 16 40
2024 February 16 17 33
2023 March 5 2 7
2023 February 16 23 39
2023 January 14 26 40
2022 December 26 23 49
2022 November 28 25 53
2022 October 26 45 71
2022 September 28 18 46
2022 August 26 39 65
2022 July 23 43 66
2022 June 16 30 46
2022 May 21 34 55
2022 April 16 23 39
2022 March 18 41 59
2022 February 16 26 42
2022 January 15 27 42
2021 December 14 32 46
2021 November 14 40 54
2021 October 19 50 69
2021 September 20 64 84
2021 August 10 28 38
2021 July 13 22 35
2021 June 26 39 65
2021 May 24 31 55
2021 April 25 44 69
2021 March 13 16 29
2021 February 12 12 24
2021 January 16 16 32
2020 December 7 15 22
2020 November 8 11 19
2020 October 12 2 14
2020 September 10 5 15
2020 August 21 15 36
2020 July 15 10 25
2020 June 21 6 27
2020 May 27 16 43
2020 April 19 15 34
2020 March 10 13 23
2020 February 29 19 48
2020 January 23 19 42
2019 December 16 15 31
2019 November 12 15 27
2019 October 8 10 18
2019 September 14 22 36
2019 August 14 13 27
2019 July 8 20 28
2019 June 5 9 14
2019 May 9 23 32
2019 April 17 29 46
2019 March 6 22 28
2019 February 7 10 17
2019 January 1 9 10
2018 December 3 12 15
2018 November 34 14 48
2018 October 18 9 27
2018 September 13 12 25
2018 May 7 0 7
2018 April 3 9 12
2018 March 4 3 7
2018 February 5 4 9
2018 January 5 9 14
2017 December 3 5 8
2017 November 2 14 16
2017 October 4 6 10
2017 September 3 7 10
2017 August 4 13 17
2017 July 1 7 8
2017 June 9 13 22
2017 May 5 16 21
2017 April 1 7 8
2017 March 4 16 20
2017 February 1 8 9
2017 January 1 2 3
2016 December 7 7 14
2016 November 14 8 22
2016 October 14 11 25
2016 September 12 8 20
2016 August 15 6 21
2016 July 6 0 6
2016 March 2 0 2
2016 January 1 0 1
2015 December 2 0 2
2015 October 52 13 65
2015 September 38 12 50
2015 August 35 7 42
2015 July 38 9 47
2015 June 40 10 50
2015 May 47 13 60
2015 April 36 12 48
2015 March 44 10 54
2015 February 34 5 39
2015 January 29 5 34
2014 December 28 5 33
2014 November 32 4 36
2014 October 52 10 62
2014 September 48 6 54
2014 August 62 11 73
2014 July 50 9 59
2014 June 49 8 57
2014 May 64 18 82
2014 April 51 9 60
2014 March 62 13 75
2014 February 43 12 55
2014 January 38 13 51
2013 December 47 13 60
2013 November 35 3 38
2013 October 56 15 71
2013 September 44 10 54
2013 August 45 10 55
2013 July 57 17 74
2013 June 37 8 45
2013 May 33 8 41
2013 April 14 3 17
2013 March 6 3 9
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?