array:23 [
  "pii" => "S1579212907600032"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60003-2"
  "estado" => "S300"
  "fechaPublicacion" => "2006-12-01"
  "aid" => "60003"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2006"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2006;42:621-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2570
    "formatos" => array:3 [
      "EPUB" => 79
      "HTML" => 1788
      "PDF" => 703
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907600044"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60004-4"
    "estado" => "S300"
    "fechaPublicacion" => "2006-12-01"
    "aid" => "60004"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2006;42:627-32"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2999
      "formatos" => array:3 [
        "EPUB" => 90
        "HTML" => 2126
        "PDF" => 783
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Recording the Daily Physical Activity of COPD Patients With an Accelerometer&#58; An Analysis of Agreement and Repeatability"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "627"
          "paginaFinal" => "632"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Vanesa Lores, Francisco Garc&#237;a-R&#237;o, Blas Rojo, Sergio Alcolea, Olga Mediano"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Vanesa"
              "apellidos" => "Lores"
            ]
            1 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Garc&#237;a-R&#237;o"
            ]
            2 => array:2 [
              "nombre" => "Blas"
              "apellidos" => "Rojo"
            ]
            3 => array:2 [
              "nombre" => "Sergio"
              "apellidos" => "Alcolea"
            ]
            4 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Mediano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600044?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600044/v1_201305150234/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212907600020"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60002-0"
    "estado" => "S300"
    "fechaPublicacion" => "2006-12-01"
    "aid" => "60002"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2006;42:616-20"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2028
      "formatos" => array:3 [
        "EPUB" => 75
        "HTML" => 1376
        "PDF" => 577
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Long-term Outcomes of Treatment With Bosentan in Pulmonary Hypertension"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "616"
          "paginaFinal" => "620"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Antonio Rom&#225;n, Pilar Gispert, V&#237;ctor Monforte, Carlos Bravo, Enric Domingo, Ferran Morell"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Rom&#225;n"
            ]
            1 => array:2 [
              "nombre" => "Pilar"
              "apellidos" => "Gispert"
            ]
            2 => array:2 [
              "nombre" => "V&#237;ctor"
              "apellidos" => "Monforte"
            ]
            3 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Bravo"
            ]
            4 => array:2 [
              "nombre" => "Enric"
              "apellidos" => "Domingo"
            ]
            5 => array:2 [
              "nombre" => "Ferran"
              "apellidos" => "Morell"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600020?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600020/v1_201305150234/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Associations Between Family History of Allergy&#44; Exposure to Tobacco Smoke&#44; Active Smoking&#44; Obesity&#44; and Asthma in Adolescents"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "621"
        "paginaFinal" => "626"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Francisco V&#225;zquez Nava, Aten&#243;genes H&#46; Sald&#237;var Gonz&#225;lez, Gerardo Mart&#237;nez Perales, Dolores Lin Ochoa, Mar&#237;a del Carmen Barrientos G&#243;mez, Eliza Mireya V&#225;zquez Rodr&#237;guez, Carlos Francisco V&#225;zquez Rodr&#237;guez, Francisco Javier Beltr&#225;n Guzm&#225;n"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Francisco"
            "apellidos" => "V&#225;zquez Nava"
            "email" => array:1 [
              0 => "fvazqueznava&#64;yahoo&#46;com&#46;mx"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Aten&#243;genes H&#46;"
            "apellidos" => "Sald&#237;var Gonz&#225;lez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Gerardo Mart&#237;nez"
            "apellidos" => "Perales"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Dolores Lin"
            "apellidos" => "Ochoa"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;a"
            "apellidos" => "del Carmen Barrientos G&#243;mez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Eliza Mireya V&#225;zquez"
            "apellidos" => "Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Carlos Francisco V&#225;zquez"
            "apellidos" => "Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Francisco Javier Beltr&#225;n"
            "apellidos" => "Guzm&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Alergolog&#237;a e Inmunolog&#237;a&#44; Universidad Aut&#243;noma de Tamaulipas&#44; Tampico&#44; Tamaulipas&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n en Epidemiolog&#237;a Cl&#237;nica&#44; Hospital General N&#250;mero 6&#44; Instituto Mexicano del Seguro Social&#44; Ciudad Madero&#44; Tamaulipas&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Investigaci&#243;n&#44; Facultad de Medicina de Tampico&#44; Universidad Aut&#243;noma de Tamaulipas&#44; Tampico&#44; Tamaulipas&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; F&#46; V&#225;zquez Nava&#46; Matamoros&#44; 102&#46; Col&#46; Hip&#243;dromo&#46; 89560 Ciudad Madero&#46; Tamaulipas&#46; M&#233;xico"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-01-08"
    "fechaAceptado" => "2006-05-23"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154225"
          "palabras" => array:6 [
            0 => "Atopic hypersensitivity"
            1 => "familial"
            2 => "Tobacco use disorder"
            3 => "Obesity"
            4 => "Asthma"
            5 => "Adolescents"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras claves"
          "identificador" => "xpalclavsec154224"
          "palabras" => array:5 [
            0 => "Atopia familiar"
            1 => "Tabaquismo"
            2 => "Obesidad"
            3 => "Asma"
            4 => "Adolescentes"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The relationships between asthma in adolescents and various environmental and social exposures needs to be clarified&#46; The aim of this study was to determine the association between family history of allergy&#44; passive or active tobacco smoking&#44; obesity&#44; and asthma in adolescents&#46;</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A population-based case-control study was carried out&#46; A random sample of 4003 students aged 13 to 18 years old was selected from secondary and preparatory schools in an urban area in northeastern Mexico&#46; Data was gathered in physical examinations and with a questionnaire administered by trained staff&#46; Two study groups were formed&#58; a group of 253 adolescents with asthma and a control group of students without asthma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Variables associated with asthma were history of allergy &#40;odds ratio &#91;OR&#93;&#44; 1&#46;62&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;28-2&#46;06&#41;&#44; passive smoking &#40;OR&#44; 1&#46;53&#59; 95&#37; CI&#44; 1&#46;18-1&#46;99&#41;&#44; and obesity &#40;OR&#44; 1&#46;96&#59; 95&#37; CI&#44; 145-2&#46;65&#41;&#46; Female gender and active smoking were unrelated to asthma&#46; The percentage of obese adolescents was higher in the group of asthmatics &#40;18&#46;2&#37;&#41; than in the control group &#40;12&#46;8&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Family history of allergy&#44; passive tobacco smoking&#44; and obesity seem to be the main risk factors for the development of asthma in adolescents&#46; The relationship of active smoking and asthma requires further study&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Es necesario aclarar la relaci&#243;n entre varias exposiciones ambientales y sociales y el asma en la poblaci&#243;n adolescente&#46; El objetivo de este estudio ha sido determinar la asociaci&#243;n entre la atopia familiar&#44; la inhalaci&#243;n pasiva o acti-va de humo de tabaco&#44; la obesidad y el asma en adolescentes&#46;</p> <span class="elsevierStyleSectionTitle">Sujetos y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio de casos y controles basado en un estudio de poblaci&#243;n&#46; Se encuest&#243; a 4&#46;003 estudiantes de 13 a 18 a&#241;os de edad&#44; seleccionados ale-atoriamente&#44; que acud&#237;an a escuelas de secundaria y prepa-ratoria de un &#225;rea urbana del nordeste de M&#233;xico&#46; La informaci&#243;n sobre las variables estudiadas se recab&#243; a trav&#233;s de la exploraci&#243;n f&#237;sica y de la aplicaci&#243;n de un cuestionario por parte de personal capacitado&#46; Se formaron 2 grupos de estudio&#58; uno compuesto por 253 adolescentes con asma&#44; y un grupo control formado por estudiantes sin asma&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">De los resultados se desprende que la atopia familiar &#40;odds ratio &#91;OR&#93; &#61; 1&#44;62&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 1&#44;28-2&#44;06&#41;&#44; la exposici&#243;n involuntaria al humo de tabaco &#40;OR &#61; 1&#44;53&#59; IC del 95&#37;&#44; 1&#44;18-1&#44;99&#41; y la obesidad &#40;OR &#61; 1&#44;96&#59; IC del 95&#37;&#44; 1&#44;45-2&#44;65&#41; se encuentran asociadas con el asma en adolescentes&#46; El sexo femenino y el tabaquismo activo no se relacionan con dicha enfermedad&#46; El porcentaje de obesos fue mayor en el grupo de adolescentes con asma &#40;18&#44;2&#37;&#41; que en el grupo control &#40;12&#44;8&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La atopia familiar&#44; la inhalaci&#243;n involuntaria de humo de tabaco y la obesidad parecen ser los facto-res de riesgo m&#225;s importantes para el desarrollo de asma en adolescentes&#46; La relaci&#243;n entre tabaquismo activo y asma requiere una mejor evaluaci&#243;n&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of asthma and other allergic diseases in an adolescent population&#58; association with gender and race"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "JK Fagan"
                            1 => "PA Scheff"
                            2 => "D Hryhorezuk"
                            3 => "V Ramakrishnan"
                            4 => "M Ross"
                            5 => "V Persky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1081-1206(10)62688-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Allergy Asthma Immunol"
                        "fecha" => "2001"
                        "volumen" => "86"
                        "paginaInicial" => "177"
                        "paginaFinal" => "184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11258687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variaciones geogr&#225;ficas en la prevalencia de s&#237;ntomas de asma en los ni&#241;os y adolescentes espa&#241;oles&#46; International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41; fase III Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I Carvajal-Ure&#241;a"
                            1 => "L Garc&#237;a-Marcos"
                            2 => "R Busquets-Monge"
                            3 => "MM Su&#225;rez-Varela"
                            4 => "NA de Garc&#237;a"
                            5 => "J Batll&#233;s-Garrido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "659"
                        "paginaFinal" => "666"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16373042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early life risk factors for adult asthma&#58; a birth cohort study of subjects at risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "HL Rhodes"
                            1 => "R Sporik"
                            2 => "P Thomas"
                            3 => "ST Holgate"
                            4 => "JJ Cogswell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mai.2001.119151"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2001"
                        "volumen" => "108"
                        "paginaInicial" => "720"
                        "paginaFinal" => "725"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11692095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased prevalence of asthma and allied diseases among active adolescent tobacco smokers after controlling for passive smoking exposure&#46; A cause for concern&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I Annesi-Maesano"
                            1 => "MP Oryszczyn"
                            2 => "C Raherison"
                            3 => "C Kopferschmitt"
                            4 => "G Pauli"
                            5 => "A Taytard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2222.2004.02002.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Allergy"
                        "fecha" => "2004"
                        "volumen" => "34"
                        "paginaInicial" => "1017"
                        "paginaFinal" => "1023"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15248844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The incidence of asthma in young adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SF Thomsen"
                            1 => "CS Ulrik"
                            2 => "KO Kyvik"
                            3 => "K Larsen"
                            4 => "LR Skadhauge"
                            5 => "I Steffensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.127.6.1928"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "127"
                        "paginaInicial" => "1928"
                        "paginaFinal" => "1934"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development and prevention of allergic disease in childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "BB Bj&#246;rkst&#233;n"
                            1 => "N-IM Kjellman"
                            2 => "RS Zeiger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Middleton&#39;s allergy principles and practice"
                        "paginaInicial" => "816"
                        "paginaFinal" => "837"
                        "edicion" => "5th ed&#46;"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A longitudinal&#44; population-based&#44; cohort study of childhood asthma followed to adulthood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "MR Sears"
                            1 => "JM Greene"
                            2 => "AR Willan"
                            3 => "EM Wiecek"
                            4 => "DR Taylor"
                            5 => "EM Flannery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa022363"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "349"
                        "paginaInicial" => "1414"
                        "paginaFinal" => "1422"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14534334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are asthma and allergies in children and adolescents increasing&#63; Results from ISAAC phase 111 surveys in M&#252;nster&#44; Germany"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "W Maziak"
                            1 => "T Behrens"
                            2 => "TM Brasky"
                            3 => "H Duhme"
                            4 => "P Rzehak"
                            5 => "SK Weiland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2003"
                        "volumen" => "58"
                        "paginaInicial" => "572"
                        "paginaFinal" => "579"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12823113"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are environmental controls effective for house-dust-mite allergies&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Valero"
                            1 => "C Serrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "389"
                        "paginaFinal" => "391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15458613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary effects of smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "DR Patel"
                            1 => "DN Homnick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adolesc Med"
                        "fecha" => "2000"
                        "volumen" => "11"
                        "paginaInicial" => "567"
                        "paginaFinal" => "576"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11060554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The environmental predictors of allergic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E von Mutius"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2000"
                        "volumen" => "105"
                        "paginaInicial" => "9"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10629447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asma y humo de tabaco"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "PJ Romero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "414"
                        "paginaFinal" => "418"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15458618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for smoking among adolescents with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "SM Zbikowski"
                            1 => "RC Klesges"
                            2 => "LA Robinson"
                            3 => "CM Alfano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Adolesc Health"
                        "fecha" => "2002"
                        "volumen" => "30"
                        "paginaInicial" => "279"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11927240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking habits in adolescents with mild to moderate asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E Zimlichman"
                            1 => "D Mandel"
                            2 => "FB Mimouni"
                            3 => "T Shochat"
                            4 => "I Grotto"
                            5 => "Y Kreiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ppul.20080"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "2004"
                        "volumen" => "38"
                        "paginaInicial" => "193"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15274096"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking patterns among adolescents with asthma attending upper secondary schools&#58; a community-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "PD Hansen"
                            1 => "L Keiding"
                            2 => "M Madsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2003"
                        "volumen" => "111"
                        "paginaInicial" => "562"
                        "paginaFinal" => "568"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased effects of smoking and obesity on asthma among female Canadians&#58; the National Population Health Survey&#44; 1994-1995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y Chen"
                            1 => "R Dales"
                            2 => "D Krewski"
                            3 => "K Breithaupt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "150"
                        "paginaInicial" => "255"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10430229"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of asthma in Swedish teenagers&#58; relation to sex and smoking habits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L Larsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1995"
                        "volumen" => "50"
                        "paginaInicial" => "260"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7660339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemic of obesity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C Stein"
                            1 => "GA Colditz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2004-0288"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2004"
                        "volumen" => "89"
                        "paginaInicial" => "2522"
                        "paginaFinal" => "2525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15181019"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and trends in overweight among US children and adolescents&#44; 1999-2000"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "CL Ogden"
                            1 => "KM Flegal"
                            2 => "MD Carroll"
                            3 => "CL Johnson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2002"
                        "volumen" => "288"
                        "paginaInicial" => "1728"
                        "paginaFinal" => "1732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12365956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overweight in children and adolescents&#46; Pathophysiology&#44; consequences&#44; prevention&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SR Daniels"
                            1 => "DK Arnett"
                            2 => "RH Eckel"
                            3 => "SS Gidding"
                            4 => "LL Hayman"
                            5 => "S Kumanyika"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000161369.71722.10"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2005"
                        "volumen" => "111"
                        "paginaInicial" => "1999"
                        "paginaFinal" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15837955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there a causal relation between obesity and asthma&#63; Evidence from Chile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P Bustos"
                            1 => "H Amigo"
                            2 => "M Oyarz&#250;n"
                            3 => "RJ Rona"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes"
                        "fecha" => "2005"
                        "volumen" => "29"
                        "paginaInicial" => "804"
                        "paginaFinal" => "809"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weight history from birth through childhood and youth in relation to adult lung function&#44; in Danish juvenile obese and non-obese men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Bua"
                            1 => "E Prescott"
                            2 => "L Schack-Nielsen"
                            3 => "L Petersen"
                            4 => "NS Godtfredsen"
                            5 => "TIA Sorensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes"
                        "fecha" => "2005"
                        "volumen" => "29"
                        "paginaInicial" => "1055"
                        "paginaFinal" => "1062"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complex interactions in complex traits&#58; obesity and asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "KG Tantisira"
                            1 => "ST Weiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2001"
                        "volumen" => "56"
                        "numero" => "Suppl 11"
                        "paginaInicial" => "62"
                        "paginaFinal" => "74"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11120907"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity and the risk of newly diagnosed asthma in school-age children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "FD Gilliland"
                            1 => "K Berhane"
                            2 => "T Islam"
                            3 => "R McConnell"
                            4 => "WJ Gauderman"
                            5 => "S Gilliland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2003"
                        "volumen" => "158"
                        "paginaInicial" => "406"
                        "paginaFinal" => "415"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12936895"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of bronchial responsiveness to body mass in the ECRHS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S Chinn"
                            1 => "D Jarvis"
                            2 => "P Burney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2002"
                        "volumen" => "57"
                        "paginaInicial" => "1028"
                        "paginaFinal" => "1033"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12454296"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "LM Schachter"
                            1 => "CM Salome"
                            2 => "JK Peat"
                            3 => "AJ Woolcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2001"
                        "volumen" => "56"
                        "paginaInicial" => "4"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11120896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity is a risk factor for dyspnea but not for airflow obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "DD Sin"
                            1 => "RL Jones"
                            2 => "P Man"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2002"
                        "volumen" => "162"
                        "paginaInicial" => "1477"
                        "paginaFinal" => "1481"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12090884"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of obesity on asthma among adult Indian women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V Mishra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes"
                        "fecha" => "2004"
                        "volumen" => "28"
                        "paginaInicial" => "1048"
                        "paginaFinal" => "1058"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of body mass with pulmonary function in the childhood asthma management program"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "KG Tantisira"
                            1 => "AA Litonjua"
                            2 => "ST Weiss"
                            3 => "AL Fuhlbrigge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2003"
                        "volumen" => "58"
                        "paginaInicial" => "1036"
                        "paginaFinal" => "1041"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14645968"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between asthma and obesity in urban minority children and adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Gennuso"
                            1 => "L Epstein"
                            2 => "RA Paluch"
                            3 => "F Cerny"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Pediatr Adolesc Med"
                        "fecha" => "1998"
                        "volumen" => "152"
                        "paginaInicial" => "1197"
                        "paginaFinal" => "1200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9856429"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600032/v1_201305150234/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000012/v1_201305150234/S1579212907600032/v1_201305150234/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600032?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original Articles
Associations Between Family History of Allergy, Exposure to Tobacco Smoke, Active Smoking, Obesity, and Asthma in Adolescents
Francisco Vázquez Navaa,b,
Corresponding author
fvazqueznava@yahoo.com.mx

Correspondence: Dr. F. Vázquez Nava. Matamoros, 102. Col. Hipódromo. 89560 Ciudad Madero. Tamaulipas. México
, Atenógenes H. Saldívar Gonzálezb,c, Gerardo Martínez Peralesb,c, Dolores Lin Ochoab,c, María del Carmen Barrientos Gómezb,c, Eliza Mireya Vázquez Rodríguezc, Carlos Francisco Vázquez Rodríguezc, Francisco Javier Beltrán Guzmánc
a Departamento de Alergología e Inmunología, Universidad Autónoma de Tamaulipas, Tampico, Tamaulipas, Mexico
b Unidad de Investigación en Epidemiología Clínica, Hospital General Número 6, Instituto Mexicano del Seguro Social, Ciudad Madero, Tamaulipas, Mexico
c Departamento de Investigación, Facultad de Medicina de Tampico, Universidad Autónoma de Tamaulipas, Tampico, Tamaulipas, Mexico
Read
4667
Times
was read the article
1913
Total PDF
2754
Total HTML
Share statistics
 array:23 [
  "pii" => "S1579212907600032"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(07)60003-2"
  "estado" => "S300"
  "fechaPublicacion" => "2006-12-01"
  "aid" => "60003"
  "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
  "copyrightAnyo" => "2006"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2006;42:621-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2570
    "formatos" => array:3 [
      "EPUB" => 79
      "HTML" => 1788
      "PDF" => 703
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212907600044"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60004-4"
    "estado" => "S300"
    "fechaPublicacion" => "2006-12-01"
    "aid" => "60004"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2006;42:627-32"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2999
      "formatos" => array:3 [
        "EPUB" => 90
        "HTML" => 2126
        "PDF" => 783
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Recording the Daily Physical Activity of COPD Patients With an Accelerometer&#58; An Analysis of Agreement and Repeatability"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "627"
          "paginaFinal" => "632"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Vanesa Lores, Francisco Garc&#237;a-R&#237;o, Blas Rojo, Sergio Alcolea, Olga Mediano"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Vanesa"
              "apellidos" => "Lores"
            ]
            1 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Garc&#237;a-R&#237;o"
            ]
            2 => array:2 [
              "nombre" => "Blas"
              "apellidos" => "Rojo"
            ]
            3 => array:2 [
              "nombre" => "Sergio"
              "apellidos" => "Alcolea"
            ]
            4 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Mediano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600044?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600044/v1_201305150234/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212907600020"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(07)60002-0"
    "estado" => "S300"
    "fechaPublicacion" => "2006-12-01"
    "aid" => "60002"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2006;42:616-20"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2028
      "formatos" => array:3 [
        "EPUB" => 75
        "HTML" => 1376
        "PDF" => 577
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Long-term Outcomes of Treatment With Bosentan in Pulmonary Hypertension"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "616"
          "paginaFinal" => "620"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Antonio Rom&#225;n, Pilar Gispert, V&#237;ctor Monforte, Carlos Bravo, Enric Domingo, Ferran Morell"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Rom&#225;n"
            ]
            1 => array:2 [
              "nombre" => "Pilar"
              "apellidos" => "Gispert"
            ]
            2 => array:2 [
              "nombre" => "V&#237;ctor"
              "apellidos" => "Monforte"
            ]
            3 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Bravo"
            ]
            4 => array:2 [
              "nombre" => "Enric"
              "apellidos" => "Domingo"
            ]
            5 => array:2 [
              "nombre" => "Ferran"
              "apellidos" => "Morell"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600020?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600020/v1_201305150234/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Associations Between Family History of Allergy&#44; Exposure to Tobacco Smoke&#44; Active Smoking&#44; Obesity&#44; and Asthma in Adolescents"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "621"
        "paginaFinal" => "626"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Francisco V&#225;zquez Nava, Aten&#243;genes H&#46; Sald&#237;var Gonz&#225;lez, Gerardo Mart&#237;nez Perales, Dolores Lin Ochoa, Mar&#237;a del Carmen Barrientos G&#243;mez, Eliza Mireya V&#225;zquez Rodr&#237;guez, Carlos Francisco V&#225;zquez Rodr&#237;guez, Francisco Javier Beltr&#225;n Guzm&#225;n"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Francisco"
            "apellidos" => "V&#225;zquez Nava"
            "email" => array:1 [
              0 => "fvazqueznava&#64;yahoo&#46;com&#46;mx"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Aten&#243;genes H&#46;"
            "apellidos" => "Sald&#237;var Gonz&#225;lez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Gerardo Mart&#237;nez"
            "apellidos" => "Perales"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Dolores Lin"
            "apellidos" => "Ochoa"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;a"
            "apellidos" => "del Carmen Barrientos G&#243;mez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Eliza Mireya V&#225;zquez"
            "apellidos" => "Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Carlos Francisco V&#225;zquez"
            "apellidos" => "Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Francisco Javier Beltr&#225;n"
            "apellidos" => "Guzm&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Departamento de Alergolog&#237;a e Inmunolog&#237;a&#44; Universidad Aut&#243;noma de Tamaulipas&#44; Tampico&#44; Tamaulipas&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n en Epidemiolog&#237;a Cl&#237;nica&#44; Hospital General N&#250;mero 6&#44; Instituto Mexicano del Seguro Social&#44; Ciudad Madero&#44; Tamaulipas&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Investigaci&#243;n&#44; Facultad de Medicina de Tampico&#44; Universidad Aut&#243;noma de Tamaulipas&#44; Tampico&#44; Tamaulipas&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; F&#46; V&#225;zquez Nava&#46; Matamoros&#44; 102&#46; Col&#46; Hip&#243;dromo&#46; 89560 Ciudad Madero&#46; Tamaulipas&#46; M&#233;xico"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-01-08"
    "fechaAceptado" => "2006-05-23"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec154225"
          "palabras" => array:6 [
            0 => "Atopic hypersensitivity"
            1 => "familial"
            2 => "Tobacco use disorder"
            3 => "Obesity"
            4 => "Asthma"
            5 => "Adolescents"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras claves"
          "identificador" => "xpalclavsec154224"
          "palabras" => array:5 [
            0 => "Atopia familiar"
            1 => "Tabaquismo"
            2 => "Obesidad"
            3 => "Asma"
            4 => "Adolescentes"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The relationships between asthma in adolescents and various environmental and social exposures needs to be clarified&#46; The aim of this study was to determine the association between family history of allergy&#44; passive or active tobacco smoking&#44; obesity&#44; and asthma in adolescents&#46;</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A population-based case-control study was carried out&#46; A random sample of 4003 students aged 13 to 18 years old was selected from secondary and preparatory schools in an urban area in northeastern Mexico&#46; Data was gathered in physical examinations and with a questionnaire administered by trained staff&#46; Two study groups were formed&#58; a group of 253 adolescents with asthma and a control group of students without asthma&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Variables associated with asthma were history of allergy &#40;odds ratio &#91;OR&#93;&#44; 1&#46;62&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;28-2&#46;06&#41;&#44; passive smoking &#40;OR&#44; 1&#46;53&#59; 95&#37; CI&#44; 1&#46;18-1&#46;99&#41;&#44; and obesity &#40;OR&#44; 1&#46;96&#59; 95&#37; CI&#44; 145-2&#46;65&#41;&#46; Female gender and active smoking were unrelated to asthma&#46; The percentage of obese adolescents was higher in the group of asthmatics &#40;18&#46;2&#37;&#41; than in the control group &#40;12&#46;8&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Family history of allergy&#44; passive tobacco smoking&#44; and obesity seem to be the main risk factors for the development of asthma in adolescents&#46; The relationship of active smoking and asthma requires further study&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Es necesario aclarar la relaci&#243;n entre varias exposiciones ambientales y sociales y el asma en la poblaci&#243;n adolescente&#46; El objetivo de este estudio ha sido determinar la asociaci&#243;n entre la atopia familiar&#44; la inhalaci&#243;n pasiva o acti-va de humo de tabaco&#44; la obesidad y el asma en adolescentes&#46;</p> <span class="elsevierStyleSectionTitle">Sujetos y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio de casos y controles basado en un estudio de poblaci&#243;n&#46; Se encuest&#243; a 4&#46;003 estudiantes de 13 a 18 a&#241;os de edad&#44; seleccionados ale-atoriamente&#44; que acud&#237;an a escuelas de secundaria y prepa-ratoria de un &#225;rea urbana del nordeste de M&#233;xico&#46; La informaci&#243;n sobre las variables estudiadas se recab&#243; a trav&#233;s de la exploraci&#243;n f&#237;sica y de la aplicaci&#243;n de un cuestionario por parte de personal capacitado&#46; Se formaron 2 grupos de estudio&#58; uno compuesto por 253 adolescentes con asma&#44; y un grupo control formado por estudiantes sin asma&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">De los resultados se desprende que la atopia familiar &#40;odds ratio &#91;OR&#93; &#61; 1&#44;62&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 1&#44;28-2&#44;06&#41;&#44; la exposici&#243;n involuntaria al humo de tabaco &#40;OR &#61; 1&#44;53&#59; IC del 95&#37;&#44; 1&#44;18-1&#44;99&#41; y la obesidad &#40;OR &#61; 1&#44;96&#59; IC del 95&#37;&#44; 1&#44;45-2&#44;65&#41; se encuentran asociadas con el asma en adolescentes&#46; El sexo femenino y el tabaquismo activo no se relacionan con dicha enfermedad&#46; El porcentaje de obesos fue mayor en el grupo de adolescentes con asma &#40;18&#44;2&#37;&#41; que en el grupo control &#40;12&#44;8&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La atopia familiar&#44; la inhalaci&#243;n involuntaria de humo de tabaco y la obesidad parecen ser los facto-res de riesgo m&#225;s importantes para el desarrollo de asma en adolescentes&#46; La relaci&#243;n entre tabaquismo activo y asma requiere una mejor evaluaci&#243;n&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of asthma and other allergic diseases in an adolescent population&#58; association with gender and race"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "JK Fagan"
                            1 => "PA Scheff"
                            2 => "D Hryhorezuk"
                            3 => "V Ramakrishnan"
                            4 => "M Ross"
                            5 => "V Persky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1081-1206(10)62688-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Allergy Asthma Immunol"
                        "fecha" => "2001"
                        "volumen" => "86"
                        "paginaInicial" => "177"
                        "paginaFinal" => "184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11258687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variaciones geogr&#225;ficas en la prevalencia de s&#237;ntomas de asma en los ni&#241;os y adolescentes espa&#241;oles&#46; International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41; fase III Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I Carvajal-Ure&#241;a"
                            1 => "L Garc&#237;a-Marcos"
                            2 => "R Busquets-Monge"
                            3 => "MM Su&#225;rez-Varela"
                            4 => "NA de Garc&#237;a"
                            5 => "J Batll&#233;s-Garrido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "659"
                        "paginaFinal" => "666"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16373042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early life risk factors for adult asthma&#58; a birth cohort study of subjects at risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "HL Rhodes"
                            1 => "R Sporik"
                            2 => "P Thomas"
                            3 => "ST Holgate"
                            4 => "JJ Cogswell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mai.2001.119151"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2001"
                        "volumen" => "108"
                        "paginaInicial" => "720"
                        "paginaFinal" => "725"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11692095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased prevalence of asthma and allied diseases among active adolescent tobacco smokers after controlling for passive smoking exposure&#46; A cause for concern&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I Annesi-Maesano"
                            1 => "MP Oryszczyn"
                            2 => "C Raherison"
                            3 => "C Kopferschmitt"
                            4 => "G Pauli"
                            5 => "A Taytard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2222.2004.02002.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Allergy"
                        "fecha" => "2004"
                        "volumen" => "34"
                        "paginaInicial" => "1017"
                        "paginaFinal" => "1023"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15248844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The incidence of asthma in young adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SF Thomsen"
                            1 => "CS Ulrik"
                            2 => "KO Kyvik"
                            3 => "K Larsen"
                            4 => "LR Skadhauge"
                            5 => "I Steffensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.127.6.1928"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "127"
                        "paginaInicial" => "1928"
                        "paginaFinal" => "1934"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development and prevention of allergic disease in childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "BB Bj&#246;rkst&#233;n"
                            1 => "N-IM Kjellman"
                            2 => "RS Zeiger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Middleton&#39;s allergy principles and practice"
                        "paginaInicial" => "816"
                        "paginaFinal" => "837"
                        "edicion" => "5th ed&#46;"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A longitudinal&#44; population-based&#44; cohort study of childhood asthma followed to adulthood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "MR Sears"
                            1 => "JM Greene"
                            2 => "AR Willan"
                            3 => "EM Wiecek"
                            4 => "DR Taylor"
                            5 => "EM Flannery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa022363"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "349"
                        "paginaInicial" => "1414"
                        "paginaFinal" => "1422"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14534334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are asthma and allergies in children and adolescents increasing&#63; Results from ISAAC phase 111 surveys in M&#252;nster&#44; Germany"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "W Maziak"
                            1 => "T Behrens"
                            2 => "TM Brasky"
                            3 => "H Duhme"
                            4 => "P Rzehak"
                            5 => "SK Weiland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2003"
                        "volumen" => "58"
                        "paginaInicial" => "572"
                        "paginaFinal" => "579"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12823113"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are environmental controls effective for house-dust-mite allergies&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Valero"
                            1 => "C Serrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "389"
                        "paginaFinal" => "391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15458613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary effects of smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "DR Patel"
                            1 => "DN Homnick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adolesc Med"
                        "fecha" => "2000"
                        "volumen" => "11"
                        "paginaInicial" => "567"
                        "paginaFinal" => "576"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11060554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The environmental predictors of allergic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E von Mutius"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2000"
                        "volumen" => "105"
                        "paginaInicial" => "9"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10629447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asma y humo de tabaco"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "PJ Romero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "414"
                        "paginaFinal" => "418"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15458618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for smoking among adolescents with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "SM Zbikowski"
                            1 => "RC Klesges"
                            2 => "LA Robinson"
                            3 => "CM Alfano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Adolesc Health"
                        "fecha" => "2002"
                        "volumen" => "30"
                        "paginaInicial" => "279"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11927240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking habits in adolescents with mild to moderate asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E Zimlichman"
                            1 => "D Mandel"
                            2 => "FB Mimouni"
                            3 => "T Shochat"
                            4 => "I Grotto"
                            5 => "Y Kreiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ppul.20080"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "2004"
                        "volumen" => "38"
                        "paginaInicial" => "193"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15274096"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking patterns among adolescents with asthma attending upper secondary schools&#58; a community-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "PD Hansen"
                            1 => "L Keiding"
                            2 => "M Madsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2003"
                        "volumen" => "111"
                        "paginaInicial" => "562"
                        "paginaFinal" => "568"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased effects of smoking and obesity on asthma among female Canadians&#58; the National Population Health Survey&#44; 1994-1995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y Chen"
                            1 => "R Dales"
                            2 => "D Krewski"
                            3 => "K Breithaupt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "1999"
                        "volumen" => "150"
                        "paginaInicial" => "255"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10430229"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of asthma in Swedish teenagers&#58; relation to sex and smoking habits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L Larsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1995"
                        "volumen" => "50"
                        "paginaInicial" => "260"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7660339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemic of obesity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C Stein"
                            1 => "GA Colditz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2004-0288"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2004"
                        "volumen" => "89"
                        "paginaInicial" => "2522"
                        "paginaFinal" => "2525"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15181019"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and trends in overweight among US children and adolescents&#44; 1999-2000"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "CL Ogden"
                            1 => "KM Flegal"
                            2 => "MD Carroll"
                            3 => "CL Johnson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2002"
                        "volumen" => "288"
                        "paginaInicial" => "1728"
                        "paginaFinal" => "1732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12365956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overweight in children and adolescents&#46; Pathophysiology&#44; consequences&#44; prevention&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "SR Daniels"
                            1 => "DK Arnett"
                            2 => "RH Eckel"
                            3 => "SS Gidding"
                            4 => "LL Hayman"
                            5 => "S Kumanyika"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000161369.71722.10"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2005"
                        "volumen" => "111"
                        "paginaInicial" => "1999"
                        "paginaFinal" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15837955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there a causal relation between obesity and asthma&#63; Evidence from Chile"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P Bustos"
                            1 => "H Amigo"
                            2 => "M Oyarz&#250;n"
                            3 => "RJ Rona"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes"
                        "fecha" => "2005"
                        "volumen" => "29"
                        "paginaInicial" => "804"
                        "paginaFinal" => "809"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weight history from birth through childhood and youth in relation to adult lung function&#44; in Danish juvenile obese and non-obese men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Bua"
                            1 => "E Prescott"
                            2 => "L Schack-Nielsen"
                            3 => "L Petersen"
                            4 => "NS Godtfredsen"
                            5 => "TIA Sorensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes"
                        "fecha" => "2005"
                        "volumen" => "29"
                        "paginaInicial" => "1055"
                        "paginaFinal" => "1062"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complex interactions in complex traits&#58; obesity and asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "KG Tantisira"
                            1 => "ST Weiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2001"
                        "volumen" => "56"
                        "numero" => "Suppl 11"
                        "paginaInicial" => "62"
                        "paginaFinal" => "74"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11120907"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity and the risk of newly diagnosed asthma in school-age children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "FD Gilliland"
                            1 => "K Berhane"
                            2 => "T Islam"
                            3 => "R McConnell"
                            4 => "WJ Gauderman"
                            5 => "S Gilliland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2003"
                        "volumen" => "158"
                        "paginaInicial" => "406"
                        "paginaFinal" => "415"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12936895"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of bronchial responsiveness to body mass in the ECRHS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S Chinn"
                            1 => "D Jarvis"
                            2 => "P Burney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2002"
                        "volumen" => "57"
                        "paginaInicial" => "1028"
                        "paginaFinal" => "1033"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12454296"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "LM Schachter"
                            1 => "CM Salome"
                            2 => "JK Peat"
                            3 => "AJ Woolcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2001"
                        "volumen" => "56"
                        "paginaInicial" => "4"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11120896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity is a risk factor for dyspnea but not for airflow obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "DD Sin"
                            1 => "RL Jones"
                            2 => "P Man"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2002"
                        "volumen" => "162"
                        "paginaInicial" => "1477"
                        "paginaFinal" => "1481"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12090884"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of obesity on asthma among adult Indian women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V Mishra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes"
                        "fecha" => "2004"
                        "volumen" => "28"
                        "paginaInicial" => "1048"
                        "paginaFinal" => "1058"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of body mass with pulmonary function in the childhood asthma management program"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "KG Tantisira"
                            1 => "AA Litonjua"
                            2 => "ST Weiss"
                            3 => "AL Fuhlbrigge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2003"
                        "volumen" => "58"
                        "paginaInicial" => "1036"
                        "paginaFinal" => "1041"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14645968"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between asthma and obesity in urban minority children and adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J Gennuso"
                            1 => "L Epstein"
                            2 => "RA Paluch"
                            3 => "F Cerny"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Pediatr Adolesc Med"
                        "fecha" => "1998"
                        "volumen" => "152"
                        "paginaInicial" => "1197"
                        "paginaFinal" => "1200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9856429"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600032/v1_201305150234/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000012/v1_201305150234/S1579212907600032/v1_201305150234/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600032?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 3 4 7
2024 October 25 23 48
2024 September 29 20 49
2024 August 50 40 90
2024 July 25 20 45
2024 June 38 19 57
2024 May 38 28 66
2024 April 18 25 43
2024 March 23 16 39
2024 February 22 19 41
2023 March 2 5 7
2023 February 13 23 36
2023 January 15 21 36
2022 December 18 26 44
2022 November 21 27 48
2022 October 17 27 44
2022 September 21 28 49
2022 August 21 35 56
2022 July 22 42 64
2022 June 15 33 48
2022 May 14 28 42
2022 April 17 33 50
2022 March 24 40 64
2022 February 22 31 53
2022 January 12 36 48
2021 December 15 52 67
2021 November 16 49 65
2021 October 25 55 80
2021 September 18 62 80
2021 August 9 35 44
2021 July 14 28 42
2021 June 21 37 58
2021 May 27 28 55
2021 April 49 47 96
2021 March 27 25 52
2021 February 13 15 28
2021 January 15 15 30
2020 December 6 9 15
2020 November 6 13 19
2020 October 14 9 23
2020 September 5 5 10
2020 August 4 8 12
2020 July 15 16 31
2020 June 16 2 18
2020 May 29 13 42
2020 April 42 21 63
2020 March 31 11 42
2020 February 70 14 84
2020 January 77 17 94
2019 December 10 19 29
2019 November 25 14 39
2019 October 17 4 21
2019 September 12 21 33
2019 August 12 8 20
2019 July 12 11 23
2019 June 11 11 22
2019 May 14 16 30
2019 April 11 19 30
2019 March 11 17 28
2019 February 10 10 20
2019 January 6 11 17
2018 December 9 12 21
2018 November 13 5 18
2018 October 28 15 43
2018 September 7 9 16
2018 May 5 0 5
2018 April 4 7 11
2018 March 5 1 6
2018 February 7 10 17
2018 January 1 2 3
2017 December 5 7 12
2017 November 2 7 9
2017 October 7 3 10
2017 September 5 21 26
2017 August 4 10 14
2017 July 2 8 10
2017 June 6 9 15
2017 May 5 16 21
2017 April 2 5 7
2017 March 2 4 6
2017 February 0 3 3
2017 January 2 2 4
2016 December 9 6 15
2016 November 7 8 15
2016 October 17 6 23
2016 September 5 9 14
2016 August 8 5 13
2016 March 1 0 1
2016 February 2 0 2
2015 December 2 0 2
2015 October 45 16 61
2015 September 33 20 53
2015 August 41 17 58
2015 July 39 8 47
2015 June 35 6 41
2015 May 54 20 74
2015 April 41 11 52
2015 March 36 5 41
2015 February 41 2 43
2015 January 32 9 41
2014 December 39 7 46
2014 November 50 7 57
2014 October 39 10 49
2014 September 39 10 49
2014 August 41 14 55
2014 July 33 13 46
2014 June 57 12 69
2014 May 55 13 68
2014 April 69 12 81
2014 March 69 12 81
2014 February 45 7 52
2014 January 36 8 44
2013 December 46 7 53
2013 November 34 11 45
2013 October 39 9 48
2013 September 42 8 50
2013 August 53 12 65
2013 July 44 14 58
2013 June 38 6 44
2013 May 45 10 55
2013 April 23 8 31
2013 March 8 3 11
2013 February 1 0 1
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?