Original Articles
Long-term Outcomes of Treatment With Bosentan in Pulmonary Hypertension
Read
3946
Timeswas read the article
1670
Total PDF
2276
Total HTML
Share statistics
array:24 [ "pii" => "S1579212907600020" "issn" => "15792129" "doi" => "10.1016/S1579-2129(07)60002-0" "estado" => "S300" "fechaPublicacion" => "2006-12-01" "aid" => "60002" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:616-20" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2028 "formatos" => array:3 [ "EPUB" => 75 "HTML" => 1376 "PDF" => 577 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212907600032" "issn" => "15792129" "doi" => "10.1016/S1579-2129(07)60003-2" "estado" => "S300" "fechaPublicacion" => "2006-12-01" "aid" => "60003" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:621-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2570 "formatos" => array:3 [ "EPUB" => 79 "HTML" => 1788 "PDF" => 703 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Associations Between Family History of Allergy, Exposure to Tobacco Smoke, Active Smoking, Obesity, and Asthma in Adolescents" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "621" "paginaFinal" => "626" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Vázquez Nava, Atenógenes H. Saldívar González, Gerardo Martínez Perales, Dolores Lin Ochoa, María del Carmen Barrientos Gómez, Eliza Mireya Vázquez Rodríguez, Carlos Francisco Vázquez Rodríguez, Francisco Javier Beltrán Guzmán" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Vázquez Nava" ] 1 => array:2 [ "nombre" => "Atenógenes H." "apellidos" => "Saldívar González" ] 2 => array:2 [ "nombre" => "Gerardo Martínez" "apellidos" => "Perales" ] 3 => array:2 [ "nombre" => "Dolores Lin" "apellidos" => "Ochoa" ] 4 => array:2 [ "nombre" => "María" "apellidos" => "del Carmen Barrientos Gómez" ] 5 => array:2 [ "nombre" => "Eliza Mireya Vázquez" "apellidos" => "Rodríguez" ] 6 => array:2 [ "nombre" => "Carlos Francisco Vázquez" "apellidos" => "Rodríguez" ] 7 => array:2 [ "nombre" => "Francisco Javier Beltrán" "apellidos" => "Guzmán" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600032?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600032/v1_201305150234/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212907600019" "issn" => "15792129" "doi" => "10.1016/S1579-2129(07)60001-9" "estado" => "S300" "fechaPublicacion" => "2006-12-01" "aid" => "60001" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Arch Bronconeumol. 2006;42:613-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1668 "formatos" => array:3 [ "EPUB" => 83 "HTML" => 1081 "PDF" => 504 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Basic Research Into Asthma: Where Are We Heading?" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "613" "paginaFinal" => "615" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "David Ramos-Barbón" "autores" => array:1 [ 0 => array:2 [ "nombre" => "David" "apellidos" => "Ramos-Barbón" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600019?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600019/v1_201305150234/en/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S1579212907600603" "issn" => "15792129" "doi" => "10.1016/S1579-2129(07)60060-3" "estado" => "S300" "fechaPublicacion" => "2007-04-01" "aid" => "60060" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "err" "cita" => "Arch Bronconeumol. 2007;43:243" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2901 "formatos" => array:3 [ "EPUB" => 90 "HTML" => 1921 "PDF" => 890 ] ] "en" => array:7 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Erratum</span>" "titulo" => "Erratum" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "243" ] ] "contienePdf" => array:1 [ "en" => true ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600603?idApp=UINPBA00003Z" "url" => "/15792129/0000004300000004/v1_201305150314/S1579212907600603/v1_201305150314/en/main.assets" ] ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Long-term Outcomes of Treatment With Bosentan in Pulmonary Hypertension" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "616" "paginaFinal" => "620" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Antonio Román, Pilar Gispert, Víctor Monforte, Carlos Bravo, Enric Domingo, Ferran Morell" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Antonio" "apellidos" => "Román" "email" => array:1 [ 0 => "aroman@vhebron.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Pilar" "apellidos" => "Gispert" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Víctor" "apellidos" => "Monforte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Carlos" "apellidos" => "Bravo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Enric" "apellidos" => "Domingo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "Ferran" "apellidos" => "Morell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servei de Pneumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servei de Cardiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. A. Román. Servei de Pneumologia. Hospital Universitari Vall d'Hebron. Pg. Vall d'Hebron, 119-129. 08035 Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-12-20" "fechaAceptado" => "2006-05-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154223" "palabras" => array:3 [ 0 => "Bosentan" 1 => "Endothelin receptors" 2 => "Pulmonary hypertension" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154222" "palabras" => array:4 [ 0 => "Bosentán" 1 => "Receptores de la endotelina" 2 => "Endotelina" 3 => "Hipertensión arterial pulmonar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Treatment with bosentan improves exercise capacity in patients with pulmonary hypertension. Few studies have assessed treatment with this drug over long periods. The aim was therefore to assess long-term treatment with bosentan.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A group of 22 functional class III patients—18 women and 4 men, mean age, 45.5 years (range, 19-77 years)—with pulmonary hypertension were treated with bosentan between April 2002 and June 2005. Pulmonary hypertension was idiopathic in 10 patients. In the remaining patients, etiologies were associated with compensated heart failure (n=4), scleroderma (n=4), peripheral embolism (n=3), and portal hypertension (n=1). Clinical and hemodynamic variables and their changes between baseline and the end of study were analyzed.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The mean duration of follow-up of the patients was 15.7 months (range, 12.6-31.8 months). Functional class improved or stabilized after 3 months of treatment in 21 (95%) and after 1 year in 14 (64%). At 3 months, the distance covered in the 6-minute walk test increased by a mean of 64.5 m, an improvement that was maintained at 6, 12, and 18 months. Treatment was interrupted in 4 patients (18%). Reasons for discontinuation were death in 2 patients, deterioration in 1 patient, and intolerance of the medication in 1 patient. Treatment was ineffective for 4 patients (18%). No patient experienced notable liver toxicity.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of this study suggest that treatment with bosentan is associated with long-term improvement in clinical variables and exercise capacity in approximately two thirds of the patients with pulmonary hypertension.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El tratamiento con bosentán mejora la capacidad de ejercicio de los pacientes con hipertensión pulmonar. Son muy escasos los estudios que evalúan este tratamiento a largo plazo, que es el objetivo propuesto en el presente trabajo.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Un grupo de 22 pacientes −18 mu-jeres y 4 varones, con una edad media de 45,5 años (rango: 19-77 años)- con hipertensión pulmonar en clase funcional III recibieron tratamiento con bosentán entre abril de 2002 y junio de 2005. La hipertensión pulmonar era idiopática en 10 casos y estaba asociada a cardiopatía corregida (n = 4), escle-rodermia (n = 4), embolia periférica (n = 3) e hipertensión portal (n = 1) en los restantes. Se estudiaron los datos clínicos y hemodinámicos y los cambios que habían experimentado desde el inicio del tratamiento hasta el fin del estudio.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El seguimiento medio de los pacientes fue de 15,7 meses (rango: 12,6-31,8). La clase funcional mejoró o se estabilizó a los 3 meses de tratamiento en 21 (95%) y al año en 14 (64%). La distancia recorrida en la prueba de la mar-cha de 6 min se incrementó a los 3 meses de tratamiento una media de 64,5 m, mejoría que se mantuvo a los 6, 12 y 18 meses. El tratamiento se interrumpió en 4 pacientes (18%): por muerte en 2 casos, por empeoramiento en uno y por in-tolerancia a la medicación en otro. En otros 4 pacientes (18%) se objetivó falta de eficacia. Ningún paciente presentó hepatotoxicidad remarcable.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los resultados del presente estudio apo-yan la idea de que el tratamiento con bosentán se asocia a una mejoría clínica y de la capacidad de ejercicio a largo plazo en aproximadamente dos terceras partes de los pacientes con hipertensión pulmonar.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival in patients with primary pulmonary hypertension. Results from a national prospective registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "GE D'Alonzo" 1 => "RJ Barst" 2 => "SM Ayres" 3 => "EH Bergofsky" 4 => "BH Brundage" 5 => "KM Detre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1991" "volumen" => "115" "paginaInicial" => "343" "paginaFinal" => "349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1863023" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C Rubens" 1 => "R Ewert" 2 => "M Halank" 3 => "R Wensel" 4 => "HD Orzechowski" 5 => "HP Schultheiss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2001" "volumen" => "120" "paginaInicial" => "1562" "paginaFinal" => "1569" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11713135" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M Bauer" 1 => "HC Wilkens" 2 => "F Langer" 3 => "SO Schneider" 4 => "H Lausberg" 5 => "HJ Schafers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2002" "volumen" => "105" "paginaInicial" => "1034" "paginaFinal" => "1036" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11877350" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N Galie" 1 => "AL Hinderliter" 2 => "A Torbicki" 3 => "T Fourme" 4 => "G Simonneau" 5 => "T Pulido" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2003" "volumen" => "41" "paginaInicial" => "1380" "paginaFinal" => "1386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12706935" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "RN Channick" 1 => "G Simonneau" 2 => "O Sitbon" 3 => "IM Robbins" 4 => "A Frost" 5 => "VF Tapson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(01)06250-X" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2001" "volumen" => "358" "paginaInicial" => "1119" "paginaFinal" => "1123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11597664" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bosentan therapy for pulmonary arterial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "LJ Rubin" 1 => "DB Badesch" 2 => "RJ Barst" 3 => "N Galie" 4 => "CM Black" 5 => "A Keogh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa012212" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2002" "volumen" => "346" "paginaInicial" => "896" "paginaFinal" => "903" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11907289" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival in patients with class III idiopathic pulmonary arterial hypertension treated with first line oral bosentan compared with an historical cohort of patients started on intravenous epoprostenol" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O Sitbon" 1 => "VV McLaughlin" 2 => "DB Badesch" 3 => "RJ Barst" 4 => "C Black" 5 => "N Galie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2005.040618" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "1025" "paginaFinal" => "1030" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055621" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multivariable assessment of the 6-min walking test in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "HF van Stel" 1 => "JM Bogaard" 2 => "LHM Rijssenbeek-Nouwens" 3 => "VT Colland" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.7.2001071" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "163" "paginaInicial" => "1567" "paginaFinal" => "1571" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11401875" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term outcome with first-line bosentan therapy in idiopathic pulmonary arterial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S Provencher" 1 => "O Sitbon" 2 => "M Humbert" 3 => "S Cabrol" 4 => "X Jais" 5 => "G Simonneau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehi728" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2006" "volumen" => "27" "paginaInicial" => "589" "paginaFinal" => "595" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16431875" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival with first-line bosentan in patients with primary pulmonary hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "VV McLaughlin" 1 => "O Sitbon" 2 => "DB Badesch" 3 => "RJ Barst" 4 => "C Black" 5 => "N Galie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "25" "paginaInicial" => "942" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension–a 1-year follow-up study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O Sitbon" 1 => "DB Basesch" 2 => "RN Channick" 3 => "A Frost" 4 => "IM Robbins" 5 => "G Simonneau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "247" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12853530" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004200000012/v1_201305150234/S1579212907600020/v1_201305150234/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000012/v1_201305150234/S1579212907600020/v1_201305150234/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212907600020?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 1 | 9 |
| 2024 October | 30 | 13 | 43 |
| 2024 September | 31 | 17 | 48 |
| 2024 August | 49 | 33 | 82 |
| 2024 July | 24 | 21 | 45 |
| 2024 June | 31 | 20 | 51 |
| 2024 May | 35 | 32 | 67 |
| 2024 April | 17 | 20 | 37 |
| 2024 March | 21 | 18 | 39 |
| 2024 February | 20 | 17 | 37 |
| 2023 March | 2 | 0 | 2 |
| 2023 February | 14 | 14 | 28 |
| 2023 January | 19 | 22 | 41 |
| 2022 December | 22 | 28 | 50 |
| 2022 November | 18 | 22 | 40 |
| 2022 October | 18 | 36 | 54 |
| 2022 September | 21 | 26 | 47 |
| 2022 August | 17 | 41 | 58 |
| 2022 July | 19 | 42 | 61 |
| 2022 June | 15 | 27 | 42 |
| 2022 May | 26 | 34 | 60 |
| 2022 April | 20 | 22 | 42 |
| 2022 March | 27 | 38 | 65 |
| 2022 February | 19 | 29 | 48 |
| 2022 January | 17 | 32 | 49 |
| 2021 December | 18 | 49 | 67 |
| 2021 November | 18 | 49 | 67 |
| 2021 October | 28 | 55 | 83 |
| 2021 September | 17 | 55 | 72 |
| 2021 August | 25 | 29 | 54 |
| 2021 July | 13 | 23 | 36 |
| 2021 June | 13 | 22 | 35 |
| 2021 May | 15 | 27 | 42 |
| 2021 April | 41 | 44 | 85 |
| 2021 March | 19 | 12 | 31 |
| 2021 February | 12 | 12 | 24 |
| 2021 January | 13 | 14 | 27 |
| 2020 December | 9 | 16 | 25 |
| 2020 November | 10 | 9 | 19 |
| 2020 October | 6 | 8 | 14 |
| 2020 September | 9 | 4 | 13 |
| 2020 August | 8 | 5 | 13 |
| 2020 July | 7 | 15 | 22 |
| 2020 June | 13 | 6 | 19 |
| 2020 May | 14 | 8 | 22 |
| 2020 April | 23 | 14 | 37 |
| 2020 March | 23 | 11 | 34 |
| 2020 February | 15 | 7 | 22 |
| 2020 January | 15 | 16 | 31 |
| 2019 December | 18 | 5 | 23 |
| 2019 November | 6 | 5 | 11 |
| 2019 October | 5 | 2 | 7 |
| 2019 September | 14 | 12 | 26 |
| 2019 August | 8 | 6 | 14 |
| 2019 July | 9 | 13 | 22 |
| 2019 June | 10 | 9 | 19 |
| 2019 May | 19 | 6 | 25 |
| 2019 April | 12 | 13 | 25 |
| 2019 March | 9 | 18 | 27 |
| 2019 February | 6 | 9 | 15 |
| 2019 January | 3 | 9 | 12 |
| 2018 December | 5 | 14 | 19 |
| 2018 November | 25 | 6 | 31 |
| 2018 October | 21 | 13 | 34 |
| 2018 September | 10 | 8 | 18 |
| 2018 May | 13 | 1 | 14 |
| 2018 April | 7 | 5 | 12 |
| 2018 March | 6 | 4 | 10 |
| 2018 February | 7 | 7 | 14 |
| 2018 January | 2 | 4 | 6 |
| 2017 December | 3 | 5 | 8 |
| 2017 November | 3 | 3 | 6 |
| 2017 October | 5 | 5 | 10 |
| 2017 September | 5 | 9 | 14 |
| 2017 August | 5 | 17 | 22 |
| 2017 July | 5 | 3 | 8 |
| 2017 June | 7 | 10 | 17 |
| 2017 May | 6 | 4 | 10 |
| 2017 April | 2 | 3 | 5 |
| 2017 March | 1 | 10 | 11 |
| 2017 February | 1 | 2 | 3 |
| 2017 January | 2 | 1 | 3 |
| 2016 December | 6 | 4 | 10 |
| 2016 November | 11 | 7 | 18 |
| 2016 October | 12 | 5 | 17 |
| 2016 September | 11 | 3 | 14 |
| 2016 August | 10 | 2 | 12 |
| 2016 July | 6 | 2 | 8 |
| 2016 March | 3 | 0 | 3 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 23 | 7 | 30 |
| 2015 September | 30 | 15 | 45 |
| 2015 August | 31 | 17 | 48 |
| 2015 July | 21 | 7 | 28 |
| 2015 June | 30 | 3 | 33 |
| 2015 May | 38 | 7 | 45 |
| 2015 April | 25 | 10 | 35 |
| 2015 March | 28 | 8 | 36 |
| 2015 February | 17 | 5 | 22 |
| 2015 January | 25 | 6 | 31 |
| 2014 December | 25 | 5 | 30 |
| 2014 November | 27 | 5 | 32 |
| 2014 October | 49 | 11 | 60 |
| 2014 September | 27 | 8 | 35 |
| 2014 August | 32 | 13 | 45 |
| 2014 July | 32 | 13 | 45 |
| 2014 June | 37 | 13 | 50 |
| 2014 May | 41 | 15 | 56 |
| 2014 April | 37 | 9 | 46 |
| 2014 March | 45 | 11 | 56 |
| 2014 February | 46 | 11 | 57 |
| 2014 January | 35 | 6 | 41 |
| 2013 December | 38 | 11 | 49 |
| 2013 November | 35 | 9 | 44 |
| 2013 October | 37 | 12 | 49 |
| 2013 September | 42 | 7 | 49 |
| 2013 August | 37 | 12 | 49 |
| 2013 July | 43 | 10 | 53 |
| 2013 June | 32 | 8 | 40 |
| 2013 May | 34 | 9 | 43 |
| 2013 April | 18 | 5 | 23 |
| 2013 March | 13 | 3 | 16 |
Show all
