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Pleural Mesothelioma: Experience With 62 Cases in 9 Years
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"apellidos" => "Villena Garrido" "email" => array:1 [ 0 => "mvg01m@saludlia.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "López Encuentra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Echave-Sustaeta" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Álvarez Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "L." "apellidos" => "Rey Terrón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "M.T." "apellidos" => "Sotelo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 6 => array:3 [ "nombre" => "C." "apellidos" => "Ballestín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra. V. Villena. Servicio de Neumología. Hospital 12 de Octubre. Avda. de Córdoba, s/n. 28041 Madrid. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-07-09" "fechaAceptado" => "2003-11-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec153405" "palabras" => array:4 [ 0 => "Mesothelioma" 1 => "Malignant pleural effusion" 2 => "Pleural biopsy" 3 => "Survival" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153404" "palabras" => array:4 [ 0 => "Mesotelioma" 1 => "Derrame pleural maligno" 2 => "Biopsia pleural" 3 => "Supervivencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">TO describe the diagnostic approach, clinical and radiological characteristics, and survival of patients with pleural mesothelioma treated in our hospital over a 9-year period.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p class="elsevierStyleSimplePara elsevierViewall">All patients with a diagnosis of pleural mesothelioma diagnosed in our hospital from January 1992 through December 2000 were studied.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Sixty-two patients (49 men) with a mean age of 65 years (range, 45–85) were diagnosed. Probable or known contact with asbestos was established for 41 patients (66%). Ninety-four percent of the patients had chest pain or dyspnea at the onset of clinical assessment. The tumor was situated in the right hemithorax in 33 patients; 59 patients had pleural effusion, and 3 only had pleural thickening. The pleural fluid was bloody in 19% of patients, glucose levels were less than 60 mg/dL in 44%, and the pH of pleural fluid was less than 7.20 in 19%. The diagnosis was established by pleural biopsy for 52%, and by thoracoscopy or thoracotomy for 44%. The median survival was 11 months (95% confidence interval, 8–15); the probability of survival was 0.22 after 2 years, and 0.09 after 5. For the subgroup of patients with epithelial tumors the probability of survival was 0.31 after 2 years and 0.16 after 5 years. In the univariate analysis the predictors of survival were general clinical status (Karnofsky scale), platelet count, serum albumin level, pleural pH, glucose and lactate dehydrogenase levels, and histological type.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The clinical, radiological, and biochemical characteristics of the pleural fluid from patients with pleural mesothelioma and their survival rate were described.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir las características clínicas, radiológicas, el método diagnóstico y la evolución de los pacientes con mesotelioma pleural estudiados en nuestro hospital durante 9 años.</p> <span class="elsevierStyleSectionTitle">Pacientes y Método</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha incluido a todos los pacientes diagnosticados de mesotelioma pleural en nuestro hospital entre enero de 1992 y diciembre de 2000.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha incluido a 62 pacientes (49 varones), con una edad media de 65 años (rango: 45–85). De ellos, 41 (66%) tenían antecedentes de contacto con asbesto seguro o probable. El 94% presentaba dolor torácico o disnea al comenzar el estudio; el tumor era derecho en 33 pacientes, en 59 había derrame pleural y en 3 sólo engrosamiento pleural. El líquido pleural era hemático en el 19% de los pacientes. El 44% tenía concentraciones de glucosa inferiores a 60 mg/dl, y en el 19% el pH pleural era inferior a 7,20. El diagnóstico se realizó en el 52% de los pacientes mediante biop-sia pleural, y en el 44% mediante toracoscopia o toracotomía. La mediana de supervivencia fue de 11 meses (intervalo de confianza del 95%, 8–15); la probabilidad de supervivencia fue de 0,22 a los 2 años, y del 0,09 a los 5 años. Para los tumores epiteliales la probabilidad de supervivencia era de 0,31 a los 2 años y de 0,16 a los 5 años. En el análisis univariante se asociaron al pronóstico de supervivencia el estado clínico general (escala de Karnofsky), el número de plaquetas, la albúmina sérica, así como el pH, la glucosa y la lactatodeshidrogenasa pleurales y el tipo histológico.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Se describen las características clínicas, radiológicas, del líquido pleural y la supervivencia de los pacientes con mesotelioma pleural.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuing increase in mesothelioma mortality in Britain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J Peto" 1 => "JT Hodgson" 2 => "FE Mathews" 3 => "JR Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "345" "paginaInicial" => "535" "paginaFinal" => "539" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7776771" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The European mesothelioma epidemic" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J Peto" 1 => "A Decarli" 2 => "C la Vecchia" 3 => "F Levi" 4 => "E Negri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6690105" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1999" "volumen" => "79" "paginaInicial" => "666" "paginaFinal" => "672" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10027347" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of current trends in United States mesothelioma incidence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B Price" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 5 | 10 |
| 2024 October | 28 | 17 | 45 |
| 2024 September | 28 | 14 | 42 |
| 2024 August | 38 | 30 | 68 |
| 2024 July | 27 | 23 | 50 |
| 2024 June | 23 | 17 | 40 |
| 2024 May | 32 | 26 | 58 |
| 2024 April | 15 | 19 | 34 |
| 2024 March | 11 | 15 | 26 |
| 2024 February | 12 | 16 | 28 |
| 2023 March | 4 | 3 | 7 |
| 2023 February | 11 | 18 | 29 |
| 2023 January | 15 | 30 | 45 |
| 2022 December | 18 | 16 | 34 |
| 2022 November | 17 | 20 | 37 |
| 2022 October | 16 | 29 | 45 |
| 2022 September | 15 | 14 | 29 |
| 2022 August | 17 | 45 | 62 |
| 2022 July | 15 | 28 | 43 |
| 2022 June | 14 | 25 | 39 |
| 2022 May | 14 | 33 | 47 |
| 2022 April | 13 | 28 | 41 |
| 2022 March | 20 | 26 | 46 |
| 2022 February | 18 | 24 | 42 |
| 2022 January | 13 | 31 | 44 |
| 2021 December | 14 | 37 | 51 |
| 2021 November | 12 | 29 | 41 |
| 2021 October | 13 | 39 | 52 |
| 2021 September | 17 | 41 | 58 |
| 2021 August | 8 | 30 | 38 |
| 2021 July | 10 | 20 | 30 |
| 2021 June | 10 | 33 | 43 |
| 2021 May | 10 | 30 | 40 |
| 2021 April | 20 | 43 | 63 |
| 2021 March | 22 | 17 | 39 |
| 2021 February | 10 | 11 | 21 |
| 2021 January | 6 | 10 | 16 |
| 2020 December | 10 | 18 | 28 |
| 2020 November | 8 | 10 | 18 |
| 2020 October | 12 | 3 | 15 |
| 2020 September | 2 | 2 | 4 |
| 2020 August | 6 | 13 | 19 |
| 2020 July | 11 | 15 | 26 |
| 2020 June | 9 | 10 | 19 |
| 2020 May | 31 | 23 | 54 |
| 2020 April | 25 | 14 | 39 |
| 2020 March | 39 | 10 | 49 |
| 2020 February | 66 | 17 | 83 |
| 2020 January | 54 | 16 | 70 |
| 2019 December | 15 | 27 | 42 |
| 2019 November | 10 | 21 | 31 |
| 2019 October | 3 | 19 | 22 |
| 2019 September | 8 | 20 | 28 |
| 2019 August | 11 | 9 | 20 |
| 2019 July | 12 | 18 | 30 |
| 2019 June | 4 | 18 | 22 |
| 2019 May | 13 | 11 | 24 |
| 2019 April | 30 | 26 | 56 |
| 2019 March | 12 | 29 | 41 |
| 2019 February | 5 | 24 | 29 |
| 2019 January | 6 | 18 | 24 |
| 2018 December | 5 | 21 | 26 |
| 2018 November | 12 | 13 | 25 |
| 2018 October | 16 | 16 | 32 |
| 2018 September | 12 | 8 | 20 |
| 2018 May | 11 | 0 | 11 |
| 2018 April | 7 | 7 | 14 |
| 2018 March | 3 | 1 | 4 |
| 2018 February | 5 | 9 | 14 |
| 2018 January | 4 | 7 | 11 |
| 2017 December | 5 | 7 | 12 |
| 2017 November | 7 | 5 | 12 |
| 2017 October | 5 | 6 | 11 |
| 2017 September | 9 | 18 | 27 |
| 2017 August | 11 | 15 | 26 |
| 2017 July | 5 | 7 | 12 |
| 2017 June | 8 | 8 | 16 |
| 2017 May | 7 | 13 | 20 |
| 2017 April | 7 | 13 | 20 |
| 2017 March | 6 | 1 | 7 |
| 2017 February | 2 | 3 | 5 |
| 2017 January | 2 | 3 | 5 |
| 2016 December | 8 | 4 | 12 |
| 2016 November | 21 | 9 | 30 |
| 2016 October | 15 | 19 | 34 |
| 2016 September | 7 | 5 | 12 |
| 2016 August | 6 | 4 | 10 |
| 2016 July | 4 | 4 | 8 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 46 | 1 | 47 |
| 2015 September | 43 | 6 | 49 |
| 2015 August | 35 | 7 | 42 |
| 2015 July | 41 | 6 | 47 |
| 2015 June | 29 | 4 | 33 |
| 2015 May | 43 | 7 | 50 |
| 2015 April | 30 | 6 | 36 |
| 2015 March | 42 | 8 | 50 |
| 2015 February | 28 | 3 | 31 |
| 2015 January | 30 | 6 | 36 |
| 2014 December | 26 | 2 | 28 |
| 2014 November | 37 | 6 | 43 |
| 2014 October | 51 | 8 | 59 |
| 2014 September | 50 | 4 | 54 |
| 2014 August | 34 | 11 | 45 |
| 2014 July | 55 | 6 | 61 |
| 2014 June | 48 | 8 | 56 |
| 2014 May | 62 | 8 | 70 |
| 2014 April | 70 | 3 | 73 |
| 2014 March | 59 | 6 | 65 |
| 2014 February | 45 | 8 | 53 |
| 2014 January | 42 | 6 | 48 |
| 2013 December | 40 | 9 | 49 |
| 2013 November | 33 | 7 | 40 |
| 2013 October | 38 | 7 | 45 |
| 2013 September | 38 | 13 | 51 |
| 2013 August | 29 | 13 | 42 |
| 2013 July | 53 | 16 | 69 |
| 2013 June | 36 | 8 | 44 |
| 2013 May | 39 | 7 | 46 |
| 2013 April | 8 | 5 | 13 |
| 2013 March | 8 | 1 | 9 |
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