Correspondence: Dr. G.J. Rodrigo. Clínica Respirar. Obligado, 1180/203. Montevideo 11300. Uruguay
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"nombre" => "Olga Rajas" "apellidos" => "Naranjo" ] 1 => array:2 [ "nombre" => "Javier Aspa" "apellidos" => "Marco" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290660582X?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000010/v1_201305150229/S157921290660582X/v1_201305150229/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212906605806" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60580-6" "estado" => "S300" "fechaPublicacion" => "2006-10-01" "aid" => "60580" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:526-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2858 "formatos" => array:3 [ "EPUB" => 92 "HTML" => 2147 "PDF" => 619 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Use of Gene Therapy in a Subcutaneous Murine Model of Lung Cancer" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "526" "paginaFinal" => "532" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Manuel Rodrigo Garzón, Íñigo Tirapu Fernández de la Cuesta, Ainhoa Arina Iraeta, Miguel Noel Centelles Llorente, Javier Zulueta Francés" "autores" => array:5 [ 0 => array:3 [ "preGrado" => "Dr." "nombre" => "Manuel Rodrigo" "apellidos" => "Garzón" ] 1 => array:2 [ "nombre" => "Íñigo Tirapu" "apellidos" => "Fernández de la Cuesta" ] 2 => array:2 [ "nombre" => "Ainhoa Arina" "apellidos" => "Iraeta" ] 3 => array:2 [ "nombre" => "Miguel Noel" "apellidos" => "Centelles Llorente" ] 4 => array:2 [ "nombre" => "Javier Zulueta" "apellidos" => "Francés" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906605806?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000010/v1_201305150229/S1579212906605806/v1_201305150229/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>" "titulo" => "Inhaled Corticosteroids in the Treatment of Asthma Exacerbations: Essential Concepts" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "533" "paginaFinal" => "540" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gustavo Javier Rodrigo" "autores" => array:1 [ 0 => array:5 [ "preGrado" => "Dr." "nombre" => "Gustavo Javier" "apellidos" => "Rodrigo" "email" => array:1 [ 0 => "gurodrig@adinet.com.uy" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Clínica Respirar, Montevideo, Uruguay" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. G.J. Rodrigo. Clínica Respirar. Obligado, 1180/203. Montevideo 11300. Uruguay" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-01-02" "fechaAceptado" => "2006-05-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154198" "palabras" => array:5 [ 0 => "Corticosteroids" 1 => "Fluticasone" 2 => "Budesonide" 3 => "Beclomethasone" 4 => "Acute asthma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154197" "palabras" => array:5 [ 0 => "Corticoides" 1 => "Fluticasona" 2 => "Budesonida" 3 => "Beclometasona" 4 => "Asma aguda" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The use of systemic corticosteroids reduces hospitalizations in patients suffering an asthma attack and improves lung function within 6 to 12 hours of administration. However, despite the considerable body of positive evidence published in the last decade, doubts remain in regard to the effectiveness of inhaled corticosteroids. Analysis of this evidence has been cursory; crucial data on the mechanism of action of corticosteroids have been overlooked and there has been a failure to distinguish between antiinflammatory effects and so-called nongenomic effects. This review considers the biological basis for the effects of inhaled corticosteroids and analyzes the best data available on the use and therapeutic implications of inhaled corticosteroids for the treatment of asthma exacerbations.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El uso de corticoides sistémicos reduce las hospitalizaciones y mejora la función pulmonar al cabo de 6 a 12 h desde su administración en pacientes con crisis asmáticas. Sin embargo, a pesar de la considerable evidencia surgida de publicaciones durante la última década, los corticoides inhalados no se han considerado efectivos. El análisis de esta evidencia ha sido superficial, ya que se han obviado aspectos fundamentales relacionados con los mecanismos de acción y no se han distinguido los efectos antiinflamatorios de los denominados efectos no genómicos. Así pues, el objetivo de esta revision es aclarar las bases biológicas de los efectos de los corticoides inhalados, analizar la mejor evidencia disponible con respecto a su uso en el tratamiento de las exacerbaciones asmáticas y las repercusiones terapéuticas que surgen de ella.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Global Strategy for Asthma Management and Prevention. NIH Publication 02-3659, 2005" ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "Available from: www.ginasthma.com" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asma fatal o casi fatal: ¿entidad clínica o manejo inadecuado?" 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Year/Month | Html | Total | |
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2024 November | 10 | 4 | 14 |
2024 October | 65 | 31 | 96 |
2024 September | 54 | 26 | 80 |
2024 August | 75 | 40 | 115 |
2024 July | 34 | 28 | 62 |
2024 June | 50 | 37 | 87 |
2024 May | 70 | 28 | 98 |
2024 April | 25 | 26 | 51 |
2024 March | 17 | 25 | 42 |
2024 February | 26 | 22 | 48 |
2023 April | 0 | 1 | 1 |
2023 March | 8 | 4 | 12 |
2023 February | 45 | 35 | 80 |
2023 January | 35 | 57 | 92 |
2022 December | 33 | 34 | 67 |
2022 November | 43 | 33 | 76 |
2022 October | 47 | 36 | 83 |
2022 September | 32 | 25 | 57 |
2022 August | 49 | 35 | 84 |
2022 July | 50 | 49 | 99 |
2022 June | 32 | 45 | 77 |
2022 May | 30 | 35 | 65 |
2022 April | 35 | 28 | 63 |
2022 March | 48 | 37 | 85 |
2022 February | 46 | 37 | 83 |
2022 January | 37 | 40 | 77 |
2021 December | 43 | 48 | 91 |
2021 November | 37 | 56 | 93 |
2021 October | 37 | 64 | 101 |
2021 September | 32 | 66 | 98 |
2021 August | 14 | 31 | 45 |
2021 July | 22 | 39 | 61 |
2021 June | 25 | 48 | 73 |
2021 May | 17 | 31 | 48 |
2021 April | 45 | 49 | 94 |
2021 March | 22 | 23 | 45 |
2021 February | 10 | 20 | 30 |
2021 January | 11 | 16 | 27 |
2020 December | 11 | 47 | 58 |
2020 November | 13 | 24 | 37 |
2020 October | 5 | 13 | 18 |
2020 September | 7 | 12 | 19 |
2020 August | 11 | 10 | 21 |
2020 July | 16 | 24 | 40 |
2020 June | 12 | 11 | 23 |
2020 May | 19 | 19 | 38 |
2020 April | 23 | 18 | 41 |
2020 March | 20 | 13 | 33 |
2020 February | 14 | 19 | 33 |
2020 January | 20 | 13 | 33 |
2019 December | 15 | 17 | 32 |
2019 November | 11 | 15 | 26 |
2019 October | 8 | 19 | 27 |
2019 September | 6 | 21 | 27 |
2019 August | 14 | 14 | 28 |
2019 July | 15 | 32 | 47 |
2019 June | 7 | 13 | 20 |
2019 May | 6 | 9 | 15 |
2019 April | 12 | 29 | 41 |
2019 March | 7 | 24 | 31 |
2019 February | 7 | 10 | 17 |
2019 January | 6 | 9 | 15 |
2018 December | 11 | 20 | 31 |
2018 November | 13 | 7 | 20 |
2018 October | 23 | 13 | 36 |
2018 September | 10 | 5 | 15 |
2018 May | 7 | 0 | 7 |
2018 April | 5 | 7 | 12 |
2018 March | 6 | 5 | 11 |
2018 February | 6 | 9 | 15 |
2018 January | 3 | 5 | 8 |
2017 December | 4 | 12 | 16 |
2017 November | 3 | 8 | 11 |
2017 October | 1 | 5 | 6 |
2017 September | 4 | 6 | 10 |
2017 August | 7 | 12 | 19 |
2017 July | 4 | 5 | 9 |
2017 June | 14 | 15 | 29 |
2017 May | 13 | 6 | 19 |
2017 April | 7 | 3 | 10 |
2017 March | 8 | 7 | 15 |
2017 February | 2 | 2 | 4 |
2017 January | 2 | 3 | 5 |
2016 December | 8 | 10 | 18 |
2016 November | 21 | 7 | 28 |
2016 October | 17 | 9 | 26 |
2016 September | 20 | 10 | 30 |
2016 August | 15 | 2 | 17 |
2016 July | 8 | 3 | 11 |
2016 May | 1 | 0 | 1 |
2016 April | 1 | 0 | 1 |
2016 March | 2 | 0 | 2 |
2016 February | 1 | 0 | 1 |
2015 December | 3 | 0 | 3 |
2015 November | 1 | 0 | 1 |
2015 October | 361 | 24 | 385 |
2015 September | 302 | 17 | 319 |
2015 August | 220 | 13 | 233 |
2015 July | 237 | 13 | 250 |
2015 June | 188 | 2 | 190 |
2015 May | 246 | 13 | 259 |
2015 April | 250 | 11 | 261 |
2015 March | 283 | 7 | 290 |
2015 February | 228 | 4 | 232 |
2015 January | 187 | 9 | 196 |
2014 December | 228 | 7 | 235 |
2014 November | 322 | 15 | 337 |
2014 October | 347 | 10 | 357 |
2014 September | 231 | 10 | 241 |
2014 August | 242 | 8 | 250 |
2014 July | 178 | 8 | 186 |
2014 June | 203 | 10 | 213 |
2014 May | 192 | 8 | 200 |
2014 April | 204 | 12 | 216 |
2014 March | 230 | 5 | 235 |
2014 February | 155 | 15 | 170 |
2014 January | 114 | 12 | 126 |
2013 December | 97 | 12 | 109 |
2013 November | 77 | 11 | 88 |
2013 October | 80 | 7 | 87 |
2013 September | 65 | 13 | 78 |
2013 August | 63 | 12 | 75 |
2013 July | 64 | 15 | 79 |
2013 June | 58 | 11 | 69 |
2013 May | 58 | 4 | 62 |
2013 April | 29 | 7 | 36 |
2013 March | 6 | 2 | 8 |