Is the Incidence of Near-Fatal Asthma Decreasing in Spain?

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"tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "522" "paginaFinal" => "525" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jesús Bellido Casado, Vicente Plaza, Santiago Bardagí, Javier Cosano, Antolín Ló;pez Viña, Eva Martínez Moragón, Gema Rodríguez-Trigo, César Picado, Joaquim Sanchis" "autores" => array:9 [ 0 => array:3 [ "nombre" => "Jesús Bellido" "apellidos" => "Casado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 1 => array:5 [ "preGrado" => "Dr." "nombre" => "Vicente" "apellidos" => "Plaza" "email" => array:1 [ 0 => "vplaza@santpau.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "Santiago" "apellidos" => "Bardagí" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Javier" "apellidos" => "Cosano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Antolín Ló;pez" "apellidos" => "Viña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff4" ] ] ] 5 => array:3 [ "nombre" => "Eva Martínez" "apellidos" => "Moragón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff5" ] ] ] 6 => array:3 [ "nombre" => "Gema" "apellidos" => "Rodríguez-Trigo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "f" "identificador" => "aff6" ] ] ] 7 => array:3 [ "nombre" => "César" "apellidos" => "Picado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "g" "identificador" => "aff7" ] ] ] 8 => array:3 [ "nombre" => "Joaquim" "apellidos" => "Sanchis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Departament de Pneumologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Secció de Pneumologia, Hospital de Mataró, Mataró, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Reina Sofía, Córdoba, Spain" "etiqueta" => "c" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Hospital Puerta de Hierro, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Sección de Neumología, Hospital de Sagunto, Sagunto, Valencia, Spain" "etiqueta" => "e" "identificador" => "aff5" ] 5 => array:3 [ "entidad" => "Servicio de Neumología, Complejo Hospitalario Universitario Juan Canalejo, La Coruña, Spain" "etiqueta" => "f" "identificador" => "aff6" ] 6 => array:3 [ "entidad" => "Servei de Pneumologia i Al.lèrgia Respiratòria, Hospital Clínic, Barcelona, Spain" "etiqueta" => "g" "identificador" => "aff7" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. V. Plaza. Departament de Pneumologia. Hospital de la Santa Creu i Sant Pau. Sam Antoni M. Claret. 167.08025 Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-09-06" "fechaAceptado" => "2006-02-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154193" "palabras" => array:5 [ 0 => "Asthma" 1 => "Near-fatal asthma" 2 => "Orotracheal intubation" 3 => "Mechanical ventilation" 4 => "Asthma epidemiology" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154194" "palabras" => array:5 [ 0 => "Asma" 1 => "Asma de riesgo vital" 2 => "Intubación orotraqueal" 3 => "Ventilación mecánica" 4 => "Epidemiología del asma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "ObjectiveA number of studies have shown that both mortality and hospital admissions due to severe asthma have decreased in recent years in many parts of the world. However, the situation is Spain has not yet been analyzed. The aim of this study was to determine the incidence of very severe, near-fatal asthma in recent years in various Spanish hospitals. Patients and methodsA retrospective review of hospital records from 6 hospitals in 5 Spanish autonomous communities was conducted for the period 1997 to 2004 to determine the annual number of patients who required orotracheal intubation and mechanical ventilation due to an asthma attack. ResultsOf the 130 patients included in the study, 81 (62%) were women and 61 (47%) were aged between 51 and 75 years. The number of cases observed for the periods 2001–2002 and 2003–2004 (32 and 18, respectively) was significantly lower than that observed for the 1997–1998 and 1999–2000 periods (40 in both cases; P=.019). A significant increase in the incidence was observed in autumn and winter (n=81 [62%]; P=.018). Seventeen patients (13%) died and 8 (6%) developed serious sequelae. ConclusionsAlthough our sample of 6 hospitals is not widely representative of the entire population of hospitals in Spain, our findings strongly suggest a decrease in the incidence of near-fatal asthma in Spain in recent years" ] "es" => array:1 [ "resumen" => "ObjetivoEstudios recientes muestran un descenso de la mortalidad y del número de los ingresos hospitalarios por asma grave en los últimos años en diferentes lugares del mundo. Se desconoce la situación en nuestro país. El objetivo del presente estudio ha sido determinar la frecuencia anual de las crisis de asma de riesgo vital muy grave en los últimos años en diversos centros hospitalarios españoles. Pacientes y métodosSe revisaron retrospectivamente los registros hospitalarios de los pacientes que precisaron intubación orotraqueal y ventilación mecánica por una crisis de asma en 6 hospitales pertenecientes a 5 comunidades autónomas. El estudio recogió el número anual de casos observado durante el período comprendido entre 1997 y 2004. ResultadosDe los 130 pacientes incluidos, 81 (62%) eran mujeres y 61 (47%) tenían entre 51 y 75 años de edad. En los 2 últimos bienios (2001–2002 y 2003–2004) el número de pacientes recogidos (32 y 18, respectivamente) fue significativamente inferior al observado en los 2 primeros (1997–1998 y 1999–2000, con 40 cada bienio; p = 0,019). Se constató una incidencia significativamente mayor de casos (n = 81; 62%) durante las estaciones de otoño e invierno (p = 0,018). Fallecieron 17 pacientes (13%) y 8 (6%) presentaron secuelas graves. ConclusionesSi bien 6 centros hospitalarios no son lo bastante representativos de la totalidad de los centros españoles, los resultados del presente estudio podrían orientar hacia un muy probable descenso en nuestro país de los casos de asma de riesgo vital en los últimos años." ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "Study partially funded by grants from SEPAR (2004). La Marató de TV3 (2004), and Red Respira (RTIC-Instituto de Salud Carlos III and SEPAR)." ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surveillance for asthma-United States, 1980–1999" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "DM Mannino" 1 => "DM Homa" 2 => "LJ Akinbami" 3 => "JE Moorman" 4 => "C Gwynn" 5 => "SC Redd" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "MMWR Morb Mortal Wkly Rep" "fecha" => "2002" "volumen" => "51" "numero" => "Suppl 1" "paginaInicial" => "1" "paginaFinal" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15123988" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma epidemiology: has the crisis passed?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "JA Lawson" 1 => "A Senthilselvan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2005" "volumen" => "11" "paginaInicial" => "79" "paginaFinal" => "84" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15591893" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreases in asthma mortality in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "RM Sly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1081-1206(10)62451-9" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2000" "volumen" => "85" "paginaInicial" => "121" "paginaFinal" => "127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10982219" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolving differences in the presentation of severe asthma requiring intensive care unit admission" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P Han" 1 => "RP Cole" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000080629" "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "2004" "volumen" => "71" "paginaInicial" => "458" "paginaFinal" => "462" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15467322" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma mortality in Latin America" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H Neffen" 1 => "C Baena-Cagnani" 2 => "S Malka" 3 => "D Sole" 4 => "R Sepúlveda" 5 => "L Caraballo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "1997" "volumen" => "7" "paginaInicial" => "249" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9330190" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends in asthma mortality in Taiwan, 1981–2000" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "LC Kuo" 1 => "WY Shau" 2 => "PC Yang" 3 => "SH Kuo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Formos Med Assoc" "fecha" => "2003" "volumen" => "102" "paginaInicial" => "534" "paginaFinal" => "538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14569317" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma mortality in Uruguay, 19841998" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "JC Baluga" 1 => "A Sueta" 2 => "M Ceni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1081-1206(10)62200-4" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2001" "volumen" => "87" "paginaInicial" => "91" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11527254" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in fatal and near-fatal asthma in an urban area of South Africa from 1980–1997" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "HJ Zar" 1 => "D Stickells" 2 => "A Toerien" 3 => "D Wilson" 4 => "M Klein" 5 => "ED Bateman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2001" "volumen" => "18" "paginaInicial" => "33" "paginaFinal" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11510802" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma programme in Finland: a community problem needs community solutions" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "on the behalf of the Working Group of the Asthma Programme in Finland 1994–2004" "etal" => false "autores" => array:5 [ 0 => "T Haahtela" 1 => "T Klaukka" 2 => "K Koskela" 3 => "M Erhola" 4 => "LA Laitinen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "806" "paginaFinal" => "814" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11562522" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "en calidad de Comité Ejecutivo de la GEMA y en representación del grupo de redactores. Guía Española para el Manejo del Asma (GEMA)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V Plaza" 1 => "FJ Alvarez" 2 => "P Casan" 3 => "N Cobos" 4 => "A López Viña" 5 => "MA Llauger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2003" "volumen" => "39" "numero" => "Supl 5" "paginaInicial" => "1" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14587516" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global Strategy for Asthma Management and Prevention NHLBI/WHO Workshop Report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Global Initiative for Asthma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "Available from: http://www.ginasthma.com" "fecha" => "2002" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhaled corticosteroids: impact on asthma morbidity and mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S Suissa" 1 => "P Ernst" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mai.2001.115653" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2001" "volumen" => "107" "paginaInicial" => "937" "paginaFinal" => "944" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11398069" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio Europeo del Asma. Prevalencia de hiperreactividad bronquial y asma en adultos jóvenes de cinco áreas españolas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Grupo Español del Estudio Europeo del Asma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1996" "volumen" => "106" "paginaInicial" => "761" "paginaFinal" => "767" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Worldwide variations in the prevalence of asthma symptoms: the international study of asthma and allergies in childhood (ISAAC)" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1998" "volumen" => "12" "paginaInicial" => "315" "paginaFinal" => "335" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9727780" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of asthma symptoms in the Canary Islands: climatic influence?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G Julià Serdà" 1 => "P Cabrera Navarro" 2 => "O Acosta Fernández" 3 => "P Martín Pérez" 4 => "J Batista Martín" 5 => "F Alamo Santana" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1081/JAS-67621" "Revista" => array:6 [ "tituloSerie" => "J Asthma" "fecha" => "2005" "volumen" => "42" "paginaInicial" => "507" "paginaFinal" => "511" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16293547" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends in asthma mortality in Italy and Spain. 1980–1996" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M Soler" 1 => "L Chatenaud" 2 => "E Nefri" 3 => "C la Vecchia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Epidemiol" "fecha" => "2001" "volumen" => "17" "paginaInicial" => "545" "paginaFinal" => "549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11949727" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency and clinical characteristics of rapid-onset fatal and near-fatal asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V Plaza" 1 => "J Serrano" 2 => "C Picado" 3 => "J Sanchis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "19" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11843306" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "GA Viegi" 1 => "I Annesi" 2 => "G Matteelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir Mon" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "1" "paginaFinal" => "25" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Health Study (ECRHS)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "European Community Respiratory Health Survey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Resp J" "fecha" => "1996" "volumen" => "9" "paginaInicial" => "687" "paginaFinal" => "695" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuing decline in acute asthma episodes in the community" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "RS Sunderland" 1 => "DM Fleming" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Dis Chile" "fecha" => "2004" "volumen" => "89" "paginaInicial" => "282" "paginaFinal" => "285" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Signs of reversing trends in prevalence of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L von Hertzen" 1 => "T Haahtela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Allergy" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "183" "paginaFinal" => "292" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends in prevalence of asthma and allergy in Finnish young men: nationwide study. 1966–2003" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J Latvala" 1 => "L von Hertzen" 2 => "H Lindholm" 3 => "T Haahtela" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.38448.603924.AE" "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "2005" "volumen" => "330" "paginaInicial" => "1186" "paginaFinal" => "1187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15849204" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "KF Rabe" 1 => "PA Vermeire" 2 => "JB Soriano" 3 => "WC Maier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "802" "paginaFinal" => "807" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11153575" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute asthma in adults. A review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "GJ Rodrigo" 1 => "C Rodrigo" 2 => "JB Hall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "125" "paginaInicial" => "1081" "paginaFinal" => "1102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15006973" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asma fatal o casi fatal: ¿entidad clínica o manejo inadecuado?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "GJ Rodrigo" 1 => "C Rodrigo" 2 => "LJ Nannini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2004" "volumen" => "40" "paginaInicial" => "24" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14718118" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sex difference in hospitalization due to asthma in relation to age" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y Chen" 1 => "P Stewart" 2 => "H Johansen" 3 => "L McRae" 4 => "G Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Epidemiol" "fecha" => "2003" "volumen" => "56" "paginaInicial" => "180" "paginaFinal" => "187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12654413" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A population based time series analysis of asthma hospitalisations in Ontario, Canada: 1988 to 2000" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "EJ Crighton" 1 => "MM Mamdani" 2 => "REG Upshur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "Available from: http://www.biomedcentral.com/1472-6963/1/7" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of the seasonal patterns of asthma identified in general practitioner episodes, hospital admissions, and deaths" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "DM Fleming" 1 => "KW Cross" 2 => "R Sunderland" 3 => "AM Ross" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2000" "volumen" => "55" "paginaInicial" => "662" "paginaFinal" => "665" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10899242" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age-related seasonal patterns of emergency department visits for acute asthma in an urban environment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "RA Silverman" 1 => "L Stevenson" 2 => "HM Hastings" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/S0196064403004104" "Revista" => array:6 [ "tituloSerie" => "Ann Emerg Med" "fecha" => "2003" "volumen" => "42" "paginaInicial" => "577" "paginaFinal" => "586" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14520329" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardised mortality rates in females and males with COPD and asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T Ringbaek" 1 => "N Seersholm" 2 => "K Viskum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.05.00099204" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "25" "paginaInicial" => "891" "paginaFinal" => "895" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15863648" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004200000010/v1_201305150229/S157921290660579X/v1_201305150229/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000010/v1_201305150229/S157921290660579X/v1_201305150229/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290660579X?idApp=UINPBA00003Z"]