Original Articles
Effectiveness of a Specific Program for Patients With Chronic Obstructive Pulmonary Disease and Frequent Exacerbations
Juan José Solera,
, Miguel Ángel Martínez-Garcíaa, Pilar Románb, Rosa Orerob, Susana Terrazasb, Amparo Martínez-Pechuánb
Corresponding author
jjsoler@telefonica.net
Correspondence: Dr. J.J. Soler. Unidad de Neumología. Servicio de Medicina Intema. Hospital General de Requena. Paraje Casablanca, s/n. 46430 Requena. Valencia. España
Correspondence: Dr. J.J. Soler. Unidad de Neumología. Servicio de Medicina Intema. Hospital General de Requena. Paraje Casablanca, s/n. 46430 Requena. Valencia. España
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Soler. Unidad de Neumología. Servicio de Medicina Intema. Hospital General de Requena. Paraje Casablanca, s/n. 46430 Requena. Valencia. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-08-28" "fechaAceptado" => "2006-02-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154187" "palabras" => array:4 [ 0 => "Chronic obstructive pulmonary disease" 1 => "Exacerbations" 2 => "Hospitalization" 3 => "Education" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154188" "palabras" => array:4 [ 0 => "Enfermedad pulmonar obstructive crónica" 1 => "Exacerbaciones" 2 => "Hospitalización" 3 => "Educación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Patients with chronic obstructive pulmonary disease (CQPD) and a history of frequent exacerbations are a target population of particular interest from both a clinical and an economic standpoint. The objective of this study was to evaluate the effectiveness of a program designed specifically to manage patients in this subgroup.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">This was a 1-year randomized controlled trial designed to compare the effectiveness of a specific program (SP) with that of conventional management (CM) in a group of patients with a high frequency of exacerbations (3 or more per year). Within-group and between-group comparisons were carried out for a number of variables related to the patients' medical care, dyspnea, health-related quality of life (HRQL), inhaler technique, and pulmonary function.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A total of 26 patients were enrolled in the study (all men). The mean (SD) age was 73 (8) years, and mean forced expiratory volume in 1 second (FEV<span class="elsevierStyleInf">1</span>) expressed as a percentage of the reference value was 43% (15%). Exacerbations requiring hospital care (emergency department visits and/or admission) decreased in both groups: by 24.4% (<span class="elsevierStyleItalic">P</span> not significant) in the CM group and 44.1% (<span class="elsevierStyleItalic">P</span>=.061) in the SP group. Hospital admissions decreased 73.3% in the SP group and increased 22% in the CM group (<span class="elsevierStyleItalic">P</span><.001). While length of hospital stay decreased 773% in the SP group, this figure almost doubled in the CM group (<span class="elsevierStyleItalic">P</span>=.014). Dyspnea, HRQL, and inhaler technique improved in both groups. FEV<span class="elsevierStyleInf">1</span> fell by 46 mL/year in the CM group and increased 10 mL/year in the SP group (<span class="elsevierStyleItalic">P</span> not significant).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The use of a simple program to manage selected patients with a history of frequent exacerbations produces a significant reduction in the number of hospital admissions, an improvement in HRQL, and may improve prognosis.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes con enfermedad pulmonar obstructiva crónica que presentan frecuentes agudizaciones (AEPOC) constituyen una población diana de especial interés, tanto desde el pnnto de vista clínico como económico. El objetivo del estudio es evaluar la eficacia de un programa específico (PE) dirigido a este subgrupo de enfermos.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospectivo, aleatorizado y controlado de un año de duratión, en el que se ha comparado la eficacia del PE frente al tratamiento conventional (TC) en un grupo de pacientes con exacerbaciones frecuentes (3 o más AEPOC al año). Se efectuaron comparaciones intragrupo e intergrupo en diversos parámetros asistenciales, disnea, calidad de vida relacionada con la salud (CVRS), técnica inhalatoria y función pulmonar.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó en el estudio a 26 pacientes (todos varones), con una edad media (± desviación estándar) de 73 ± 8 años y volumen espiratorio forzado en el primer segundo, en porcentaje del valor de referencia, del 43 ± 15%. Las exacerbaciones que precisaron atención hospitalaria (visitas a urgencias y/u hospitalizaciones) disminuyeron en ambos grupos: un 24,4% (p = no significativo) en el grupo TC y un 44,1% (p = 0,061) en el grupo PE. Las hospitalizaciones se redujeron un 73,3% en el grupo de interventión, mientras que se incrementaron un 22% en el TC (p < 0,001). Los días de hospitalización disminuyeron un 77,3% en el PE, mientras que aumentaron casi el doble para el TC (p = 0,014). La disnea, la CVRS y la técnica inhalatoria mejoraron en ambos grupos. El volumen espiratorio forzado en el primer segundo presentó un descenso de 46 ml/año en grupo TC, mientras que se incrementó 10 ml/año para el grupo PE (p = no significative).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El empleo de un programa sencillo, dirigido a pacientes seleccionados con exacerbaciones frecuentes, comporta una reducción significativa del número de las hospitalizaciones, mayor CVRS y quizá mejor pronóstko.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "TAR Seemungal" 1 => "GC Donaldson" 2 => "EA Paul" 3 => "JC Bestall" 4 => "DJ Jeffries" 5 => "JA Wedzicha" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.157.5.9709032" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1998" "volumen" => "157" "paginaInicial" => "1418" "paginaFinal" => "1422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9603117" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impacto asistencial hospitalario de la EPOC. Peso específico del paciente con EPOC de alto consumo sanitario" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "JJ Soler" 1 => "L Sánchez" 2 => "M Latorre" 3 => "J Alamar" 4 => "P Román" 5 => "M Perpiñá" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2001" "volumen" => "37" "paginaInicial" => "375" "paginaFinal" => "381" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11674937" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Costes de la EPOC en España. Estimación a partir de un estudio epidemiológico poblacional" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JF Masa" 1 => "V Sobradillo" 2 => "C Villasante" 3 => "CA Jiménez-Ruiz" 4 => "L Femández-Fau" 5 => "JL Viejo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2004" "volumen" => "40" "paginaInicial" => "72" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14746730" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "JJ Soler-Cataluña" 1 => "MA Martínez-García" 2 => "P Román" 3 => "E Salcedo" 4 => "M Navarro" 5 => "R Ochando" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2005.040527" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "925" "paginaFinal" => "931" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055622" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of chronic obstructive pulmonary disease and its exacerbations in general practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M Miravitlles" 1 => "C Mayordomo" 2 => "M Artés" 3 => "L Sánchez-Agudo" 4 => "F Nicolau" 5 => "JL Segú" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Respir Med" "fecha" => "1999" "volumen" => "93" "paginaInicial" => "173" "paginaFinal" => "179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10464874" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1130634308759464" "estado" => "S300" "issn" => "11306343" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease; the ISOLDE trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "PS Burge" 1 => "PMA Calverley" 2 => "PW Jones" 3 => "S Spencer" 4 => "JA Anderson" 5 => "TK Maslen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "2000" "volumen" => "320" "paginaInicial" => "1297" "paginaFinal" => "1303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10807619" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors of emergency care and admissions in COPD patients with high consumption of health resources" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "JJ Soler" 1 => "L Sánchez" 2 => "P Román" 3 => "MA Martínez" 4 => "M Perpiña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Resp Med" "fecha" => "2004" "volumen" => "98" "paginaInicial" => "318" "paginaFinal" => "329" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "GC Donaldson" 1 => "TAR Seemungal" 2 => "A Bhowmik" 3 => "JA Wedzicha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2002" "volumen" => "57" "paginaInicial" => "847" "paginaFinal" => "852" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12324669" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of salmeterol xinafoate in the treatment of COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "DA Mahler" 1 => "JF Donohue" 2 => "RA Barbee" 3 => "MD Goldman" 4 => "NJ Gross" 5 => "ME Wisniewski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "115" "paginaInicial" => "957" "paginaFinal" => "965" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10208192" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V Brusasco" 1 => "R Hodder" 2 => "M Miravitlles" 3 => "L Korducki" 4 => "L Towse" 5 => "S Kesten" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "399" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12728159" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P Calverley" 1 => "R Pauwels" 2 => "J Vestbo" 3 => "P Jones" 4 => "N Pride" 5 => "A Gulsivik" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(03)12459-2" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2003" "volumen" => "361" "paginaInicial" => "449" "paginaFinal" => "456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12583942" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of oral long-term N-acetylcysteine in chronic broncopulmonary disease: a meta-analysis of published double-blind, placebo-controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "EM Grandjean" 1 => "P Berthet" 2 => "R Ruffmann" 3 => "P Leuenberger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0149-2918(00)88479-9" "Revista" => array:7 [ "tituloSerie" => "Clin Ther" "fecha" => "2000" "volumen" => "22" "paginaInicial" => "209" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10743980" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1130634308728083" "estado" => "S300" "issn" => "11306343" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results at 1 year of outpatient multidisciplinary rehabilitation: a randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "TL Griffiths" 1 => "ML Burr" 2 => "IA Campbell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2000" "volumen" => "355" "paginaInicial" => "362" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10665556" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation between influenza vaccination and outpatient visits, hospitalization and mortality in elderly persons with chronic lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "KL Nichol" 1 => "L Baken" 2 => "A Nelson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1999" "volumen" => "130" "paginaInicial" => "397" "paginaFinal" => "403" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10068413" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction of hospital utilization in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Bourbeau" 1 => "M Julien" 2 => "F Maltais" 3 => "M Rouleau" 4 => "A Beaupré" 5 => "R Begin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "2003" "volumen" => "163" "paginaInicial" => "585" "paginaFinal" => "591" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12622605" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Self-management education for patients with chronic obstructive pulmonary disease: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E Monninkhof" 1 => "P van der Valk" 2 => "J van der Palen" 3 => "C van Herwaarden" 4 => "MR Partridge" 5 => "G Ziehlhuis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "394" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12728158" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toward a consensus definition for COPD exacerbation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R Rodríguez-Roisin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "117" "paginaInicial" => "398S" "paginaFinal" => "401S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10843984" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Controlando la EPOC" "serieFecha" => "2001" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of clinical dyspnea ratings and psychophysical measurements of respiratory sensation in obstructive airway disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "DA Mahler" 1 => "RA Rosiello" 2 => "A Harver" 3 => "T Lentine" 4 => "JF Govern" 5 => "JA Daubenspeck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1987" "volumen" => "165" "paginaInicial" => "1229" "paginaFinal" => "1233" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validity and reliability of the St. George's Respiratory Questionnaire after adaptation to a different language and culture: the Spanish example" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Ferrer" 1 => "J Alonso" 2 => "L Prieto" 3 => "V Plaza" 4 => "E Monsó" 5 => "R Marrades" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1996" "volumen" => "9" "paginaInicial" => "1160" "paginaFinal" => "1166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8804932" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new method of classifying prognostic comorbidity in longitudinal studies: development and validation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "ME Charlson" 1 => "P Pompei" 2 => "KL Ales" 3 => "CRI MacKenzie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Chronic Dis" "fecha" => "1987" "volumen" => "40" "paginaInicial" => "373" "paginaFinal" => "383" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3558716" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normativa para la práclica de la espirometría forzada" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J Sanchis" 1 => "P Casan" 2 => "J Castillo" 3 => "N González" 4 => "L Palenciano" 5 => "J Roca" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1989" "volumen" => "25" "paginaInicial" => "132" "paginaFinal" => "142" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spirometric reference values for a Mediterranean population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Roca" 1 => "J Sanchis" 2 => "A Agustí-Vidal" 3 => "F Segarra" 4 => "D Nuvajas" 5 => "R Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bull Eur Physiopathol Respir" "fecha" => "1986" "volumen" => "22" "paginaInicial" => "217" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3730638" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normativa sobre la gasometría arterial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Grupo de Trabajo de la SEPAR para la práctica de la gasometría arterial" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1998" "volumen" => "34" "paginaInicial" => "142" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9611639" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1130634309724651" "estado" => "S300" "issn" => "11306343" ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The cost and efficacy of home care for patients with chronic lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M Bergner" 1 => "LD Hudson" 2 => "DA Conrad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Care" "fecha" => "1988" "volumen" => "26" "paginaInicial" => "566" "paginaFinal" => "579" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3379988" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomised controlled trial of the effectiveness of a respiratory health worker in reducing impairment, disability and handicap due to chronic airflow limitation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P Littlejohns" 1 => "CM Baveystock" 2 => "H Parnell" 3 => "PW Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1991" "volumen" => "46" "paginaInicial" => "559" "paginaFinal" => "564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1926024" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respi-care: an innovative home care program for the patient with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "MC Haggerty" 1 => "R Stockdale-Woolley" 2 => "S Nair" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1991" "volumen" => "100" "paginaInicial" => "607" "paginaFinal" => "612" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1889241" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case management may reduce length of hospital stay in patients with recurrent admissions for chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "PJ Poole" 1 => "B Chase" 2 => "A Frankel" 3 => "P Black" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respirology" "fecha" => "2001" "volumen" => "6" "paginaInicial" => "37" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11264761" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluación de un programa de hospitalización domiciliaria en pacientes con EPOC agudizada" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S Díaz" 1 => "F González" 2 => "MA Gómez" 3 => "S Mayoralas" 4 => "I Martín" 5 => "C Villasante" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "5" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15676129" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The St. George's Respiratory Questionnaire" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "PW Jones" 1 => "FH Quirk" 2 => "CM Baveystock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "1991" "volumen" => "85" "paginaInicial" => "25" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1759018" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "TM Wilkinson" 1 => "GC Donaldson" 2 => "JR Hurst" 3 => "TA Seemungal" 4 => "JA Wedzicha" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200310-1443OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2004" "volumen" => "169" "paginaInicial" => "1298" "paginaFinal" => "1303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14990395" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients hospitalized for COPD have a high prevalence of modifiable risk factors for exacerbation (EFRAM study)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "J García-Aymerich" 1 => "E Barreiro" 2 => "E Farrero" 3 => "RM Marrades" 4 => "J Morera" 5 => "JM Antó" 6 => "the EFRAM investigators" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "1037" "paginaFinal" => "1042" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11292102" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004200000010/v1_201305150229/S1579212906605764/v1_201305150229/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000010/v1_201305150229/S1579212906605764/v1_201305150229/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906605764?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 6 | 13 |
| 2024 October | 35 | 19 | 54 |
| 2024 September | 36 | 16 | 52 |
| 2024 August | 53 | 42 | 95 |
| 2024 July | 25 | 20 | 45 |
| 2024 June | 29 | 22 | 51 |
| 2024 May | 38 | 28 | 66 |
| 2024 April | 19 | 21 | 40 |
| 2024 March | 18 | 15 | 33 |
| 2024 February | 23 | 20 | 43 |
| 2023 March | 1 | 2 | 3 |
| 2023 February | 14 | 21 | 35 |
| 2023 January | 20 | 24 | 44 |
| 2022 December | 20 | 24 | 44 |
| 2022 November | 14 | 16 | 30 |
| 2022 October | 31 | 37 | 68 |
| 2022 September | 18 | 23 | 41 |
| 2022 August | 60 | 30 | 90 |
| 2022 July | 49 | 35 | 84 |
| 2022 June | 58 | 31 | 89 |
| 2022 May | 30 | 28 | 58 |
| 2022 April | 38 | 26 | 64 |
| 2022 March | 26 | 34 | 60 |
| 2022 February | 16 | 19 | 35 |
| 2022 January | 16 | 40 | 56 |
| 2021 December | 16 | 42 | 58 |
| 2021 November | 16 | 47 | 63 |
| 2021 October | 21 | 44 | 65 |
| 2021 September | 17 | 55 | 72 |
| 2021 August | 12 | 28 | 40 |
| 2021 July | 12 | 21 | 33 |
| 2021 June | 13 | 35 | 48 |
| 2021 May | 14 | 28 | 42 |
| 2021 April | 23 | 58 | 81 |
| 2021 March | 20 | 24 | 44 |
| 2021 February | 10 | 19 | 29 |
| 2021 January | 8 | 16 | 24 |
| 2020 December | 8 | 11 | 19 |
| 2020 November | 10 | 17 | 27 |
| 2020 October | 9 | 14 | 23 |
| 2020 September | 8 | 7 | 15 |
| 2020 August | 12 | 20 | 32 |
| 2020 July | 13 | 16 | 29 |
| 2020 June | 7 | 8 | 15 |
| 2020 May | 21 | 16 | 37 |
| 2020 April | 18 | 20 | 38 |
| 2020 March | 15 | 12 | 27 |
| 2020 February | 16 | 13 | 29 |
| 2020 January | 24 | 22 | 46 |
| 2019 December | 14 | 18 | 32 |
| 2019 November | 12 | 17 | 29 |
| 2019 October | 8 | 8 | 16 |
| 2019 September | 10 | 11 | 21 |
| 2019 August | 19 | 13 | 32 |
| 2019 July | 19 | 18 | 37 |
| 2019 June | 7 | 5 | 12 |
| 2019 May | 15 | 8 | 23 |
| 2019 April | 27 | 36 | 63 |
| 2019 March | 10 | 16 | 26 |
| 2019 February | 7 | 8 | 15 |
| 2019 January | 5 | 11 | 16 |
| 2018 December | 11 | 16 | 27 |
| 2018 November | 15 | 8 | 23 |
| 2018 October | 25 | 14 | 39 |
| 2018 September | 15 | 10 | 25 |
| 2018 May | 7 | 0 | 7 |
| 2018 April | 5 | 5 | 10 |
| 2018 March | 3 | 3 | 6 |
| 2018 February | 8 | 8 | 16 |
| 2018 January | 6 | 4 | 10 |
| 2017 December | 4 | 7 | 11 |
| 2017 November | 3 | 5 | 8 |
| 2017 October | 3 | 4 | 7 |
| 2017 September | 3 | 6 | 9 |
| 2017 August | 5 | 6 | 11 |
| 2017 July | 7 | 5 | 12 |
| 2017 June | 15 | 14 | 29 |
| 2017 May | 7 | 5 | 12 |
| 2017 April | 16 | 2 | 18 |
| 2017 March | 3 | 5 | 8 |
| 2017 February | 1 | 5 | 6 |
| 2017 January | 1 | 2 | 3 |
| 2016 December | 11 | 4 | 15 |
| 2016 November | 21 | 8 | 29 |
| 2016 October | 15 | 12 | 27 |
| 2016 September | 7 | 8 | 15 |
| 2016 August | 7 | 3 | 10 |
| 2016 July | 10 | 2 | 12 |
| 2016 March | 2 | 0 | 2 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 25 | 15 | 40 |
| 2015 September | 29 | 10 | 39 |
| 2015 August | 19 | 8 | 27 |
| 2015 July | 36 | 6 | 42 |
| 2015 June | 21 | 6 | 27 |
| 2015 May | 35 | 7 | 42 |
| 2015 April | 21 | 4 | 25 |
| 2015 March | 21 | 4 | 25 |
| 2015 February | 19 | 4 | 23 |
| 2015 January | 15 | 5 | 20 |
| 2014 December | 21 | 5 | 26 |
| 2014 November | 13 | 5 | 18 |
| 2014 October | 23 | 9 | 32 |
| 2014 September | 29 | 10 | 39 |
| 2014 August | 19 | 10 | 29 |
| 2014 July | 17 | 6 | 23 |
| 2014 June | 33 | 10 | 43 |
| 2014 May | 30 | 9 | 39 |
| 2014 April | 39 | 6 | 45 |
| 2014 March | 38 | 8 | 46 |
| 2014 February | 41 | 12 | 53 |
| 2014 January | 26 | 5 | 31 |
| 2013 December | 35 | 8 | 43 |
| 2013 November | 28 | 8 | 36 |
| 2013 October | 33 | 5 | 38 |
| 2013 September | 31 | 9 | 40 |
| 2013 August | 36 | 11 | 47 |
| 2013 July | 39 | 10 | 49 |
| 2013 June | 29 | 7 | 36 |
| 2013 May | 29 | 4 | 33 |
| 2013 April | 19 | 5 | 24 |
| 2013 March | 6 | 2 | 8 |
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