Case Report
Hepatopulmonary Syndrome in a Patient With Adenocarcinoma of the Colon Metastatic to the Liver and No Apparent Chronic Liver Disease
Read
4325
Timeswas read the article
1724
Total PDF
2601
Total HTML
Share statistics
array:23 [ "pii" => "S1579212906605715" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60571-5" "estado" => "S300" "fechaPublicacion" => "2006-09-01" "aid" => "60571" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2006;42:484-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2489 "formatos" => array:3 [ "EPUB" => 100 "HTML" => 1858 "PDF" => 531 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212906605727" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60572-7" "estado" => "S300" "fechaPublicacion" => "2006-09-01" "aid" => "60572" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2006;42:487" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1680 "formatos" => array:3 [ "EPUB" => 87 "HTML" => 1062 "PDF" => 531 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the Editor</span>" "titulo" => "On Lithoptysis and the Limitations of Bibliographic Databases" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "487" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Héctor R. Verea Hernando, Carlos González Guitián, Carmen Montero Martínez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Héctor R." "apellidos" => "Verea Hernando" ] 1 => array:2 [ "nombre" => "Carlos González" "apellidos" => "Guitián" ] 2 => array:2 [ "nombre" => "Carmen Montero" "apellidos" => "Martínez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906605727?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000009/v1_201305150254/S1579212906605727/v1_201305150254/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212906605703" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60570-3" "estado" => "S300" "fechaPublicacion" => "2006-09-01" "aid" => "60570" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2006;42:475-83" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1808 "formatos" => array:3 [ "EPUB" => 85 "HTML" => 1199 "PDF" => 524 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special Article</span>" "titulo" => "The A<span class="elsevierStyleSmallCaps">rchivos</span> Archive, 2005: an Overview of Research Published in Archivos de B<span class="elsevierStyleSmallCaps">ronconeumología</span>" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "475" "paginaFinal" => "483" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Alonso, José M. Marín" "autores" => array:2 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Alonso" ] 1 => array:3 [ "preGrado" => "Dr." "nombre" => "José M." "apellidos" => "Marín" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906605703?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000009/v1_201305150254/S1579212906605703/v1_201305150254/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Hepatopulmonary Syndrome in a Patient With Adenocarcinoma of the Colon Metastatic to the Liver and No Apparent Chronic Liver Disease" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "484" "paginaFinal" => "486" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Brian Vila Auli, Diego Pérez García, Conrado Fernández Rodríguez, Pilar Bañuls Polo, Julio Marín Pardo" "autores" => array:5 [ 0 => array:5 [ "preGrado" => "Dr." "nombre" => "Brian Vila" "apellidos" => "Auli" "email" => array:1 [ 0 => "brianvila@mixmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Diego Pérez" "apellidos" => "García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Conrado Fernández" "apellidos" => "Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Pilar Bañuls" "apellidos" => "Polo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Julio Marín" "apellidos" => "Pardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Clínico Universitario de Valencia, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Clínico Universitario de Valencia, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. B. Vila. Hospital Clínico Universitario. Avda. Vicente Blasco Ibáñez, 17. 46010 Valencia. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-11-07" "fechaAceptado" => "2005-12-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154548" "palabras" => array:4 [ 0 => "Hepatopulmonary syndrome" 1 => "Pulmonary vasodilation" 2 => "Liver disease" 3 => "Adenocarcinoma of the colon" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154547" "palabras" => array:4 [ 0 => "Síndrome hepatopulmonar" 1 => "Vasodilatación pulmonar" 2 => "Hepatopatía" 3 => "Adenocarcinoma de colon" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Hepatopulmonary syndrome consists of a clinical triad: arterial blood deoxygenation, intrapulmonary vasodilation, and liver disease. Both acute and chronic cases of this syndrome have been reported, and the most common cause is cirrhosis. The principle disease mechanism is dilation of the pulmonary blood vessels causing alterations in gas exchange. Increased pulmonary production of nitric acid has been implicated as the primary pathogenic mechanism of vasodilation although it has also been associated with imbalance between vasodilators and vasoconstrictors. We describe the case of a patient with hepatopulmonary syndrome and adenocarcinoma of the colon with metastases to a previously healthy liver.</p>" ] "es" => array:1 [ "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El síndrome hepatopulmonar comprende una tríada clínica caracterizada por desoxigenación arterial, dilataciones vascu-lares intrapulmonares y hepatopatía. Se han descrito tanto ca-sos agudos como crónicos, y la causa más frecuente es la cirro-sis. El mecanismo fisiopatológico principal es la dilatación de los vasos pulmonares, que produce una alteración del inter-cambio gaseoso. Se ha implicado la mayor producción pulmo-nar de óxido nítrico como mecanismo patogénico principal de la vasodilatación, aunque también se ha relacionado el dese-quilibrio entre sustancias vasodilatadoras y vasoconstrictoras. Describimos un caso en el que se produjo un síndrome hepatopulmonar en un paciente afectado de un adenocarcinoma de colon con metástasis hepáticas en un hígado previamente sano.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary-hepatic vascular disorders (PHD)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Rodríguez-Roisin R" 1 => "Krowka MJ" 2 => "Hervé PH" 3 => "Fallon MB" 4 => "on behalf of the ERS Task Force Pulmonary-Hepatic Vascular Disorders (PHD) Scientific Committee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.04.00010904" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J." "fecha" => "2004" "volumen" => "24" "paginaInicial" => "861" "paginaFinal" => "880" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15516683" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of the hepatopulmonary syndrome in patients with cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Schenk P" 1 => "Schöniger-Hekele M" 2 => "Fuhrmann V" 3 => "Madl C" 4 => "Silberhumer G" 5 => "Müller C" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "2003" "volumen" => "125" "paginaInicial" => "1042" "paginaFinal" => "1052" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14517788" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency, clinical characteristics, and respiratory parameters of hepatopulmonary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Lima B" 1 => "França A" 2 => "Pazin-Filho A" 3 => "Araújo W" 4 => "Martínez JA" 5 => "Maciel B" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4065/79.1.42" "Revista" => array:7 [ "tituloSerie" => "Mayo Clin Proc." "fecha" => "2004" "volumen" => "79" "paginaInicial" => "42" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14708947" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0190962211010681" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatopulmonary syndrome: prevalence and predictive value of various cut offs for arterial oxygenation and their clinical consequences" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Schenk P" 1 => "Furhrmann V" 2 => "Madl C" 3 => "Funk G" 4 => "Lehr S" 5 => "Kandel O" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gut." "fecha" => "2002" "volumen" => "51" "paginaInicial" => "853" "paginaFinal" => "859" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12427789" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Gómez FP" 1 => "Mantínez-Pallí G" 2 => "Barberà JA" 3 => "Roca J" 4 => "Navasa M" 5 => "Rodríguez-Roisin R" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.20358" "Revista" => array:6 [ "tituloSerie" => "Hepatology." "fecha" => "2004" "volumen" => "40" "paginaInicial" => "660" "paginaFinal" => "666" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15349905" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The lung in patients with cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Agustí A" 1 => "Roca J" 2 => "Bosch J" 3 => "Rodríguez-Roisin R" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol." "fecha" => "1990" "volumen" => "10" "paginaInicial" => "251" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2185300" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Carter EP" 1 => "Hartsfield CL" 2 => "Miyazono M" 3 => "Jakkula M" 4 => "Morris KG" 5 => "McMurtry IF" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol." "fecha" => "2002" "volumen" => "283" "paginaInicial" => "346" "paginaFinal" => "353" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Síndrome hepatopulmonar: relación con el grado de disfunción hepática y el trastorno hemodinámico de la cirrosis hepática" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Alonso JL" 1 => "Zozaya JM" 2 => "García JL" 3 => "Olaz-Preciado F" 4 => "Estébanez Estébanez C" 5 => "Berjón-Reyero J" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2004" "volumen" => "123" "paginaInicial" => "721" "paginaFinal" => "725" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transient hepatopulmonary syndrome in a patient with acute hepatitis A" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Regev A" 1 => "Yeshurun M" 2 => "Rodríguez M" 3 => "Sagie A" 4 => "Neff GW" 5 => "Molina EG" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Viral Hepat." "fecha" => "2001" "volumen" => "8" "paginaInicial" => "83" "paginaFinal" => "86" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11155156" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary gas exchange abnormalities in liver transplant candidates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Mohamed R" 1 => "Freeman JW" 2 => "Guest PJ" 3 => "Davies MK" 4 => "Neuberger JM" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jlts.2002.33746" "Revista" => array:6 [ "tituloSerie" => "Liver Transpl." "fecha" => "2002" "volumen" => "8" "paginaInicial" => "802" "paginaFinal" => "808" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12200782" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Abrams GA" 1 => "Jaffe CC" 2 => "Hoffer PB" 3 => "Binder HJ" 4 => "Fallon MB" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "1995" "volumen" => "109" "paginaInicial" => "1283" "paginaFinal" => "1288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7557096" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatopulmonary syndrome. Current concepts in diagnostic and therapeutic considerations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Krowka MJ" 1 => "Cortese DA" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1994" "volumen" => "105" "paginaInicial" => "1528" "paginaFinal" => "1537" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8181347" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Cheng TO" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cathet Cardiovasc Interv." "fecha" => "1999" "volumen" => "47" "paginaInicial" => "64" "paginaFinal" => "66" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrapulmonary vascular dilatations (IPVD) in liver transplant candidates: screening by two-dimensional contrast-enhanced echocardiography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Krowka MJ" 1 => "Tajik AJ" 2 => "Dickson ER" 3 => "Wiesner RH" 4 => "Cortese DA" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1990" "volumen" => "97" "paginaInicial" => "1165" "paginaFinal" => "1170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2331913" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esophageal varices and hepato-pulmonary syndrome in liver cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Caruso G" 1 => "Catalano D" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol." "fecha" => "1991" "volumen" => "12" "paginaInicial" => "262" "paginaFinal" => "263" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2051007" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe hypoxemia and liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Edel ES" 1 => "Cortese DA" 2 => "Krowka MJ" 3 => "Rehder K" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/140.6.1631" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis." "fecha" => "1989" "volumen" => "140" "paginaInicial" => "1631" "paginaFinal" => "1635" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2513764" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe intrapulmonary shunting associated with metastatic carcinoid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Lee DF" 1 => "Lepler LS" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "115" "paginaInicial" => "1203" "paginaFinal" => "1207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10208233" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoid-related intrapulmonary shunting may be associated with increased production of nitric oxide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Terramoto S" 1 => "Matsuse T" 2 => "Ouchi Y" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "116" "paginaInicial" => "1838" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10593824" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004200000009/v1_201305150254/S1579212906605715/v1_201305150254/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000009/v1_201305150254/S1579212906605715/v1_201305150254/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906605715?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 2 | 6 |
| 2024 October | 33 | 13 | 46 |
| 2024 September | 31 | 10 | 41 |
| 2024 August | 50 | 29 | 79 |
| 2024 July | 21 | 21 | 42 |
| 2024 June | 35 | 29 | 64 |
| 2024 May | 34 | 33 | 67 |
| 2024 April | 13 | 19 | 32 |
| 2024 March | 18 | 20 | 38 |
| 2024 February | 14 | 13 | 27 |
| 2023 March | 2 | 3 | 5 |
| 2023 February | 13 | 16 | 29 |
| 2023 January | 21 | 35 | 56 |
| 2022 December | 14 | 35 | 49 |
| 2022 November | 17 | 22 | 39 |
| 2022 October | 23 | 22 | 45 |
| 2022 September | 12 | 23 | 35 |
| 2022 August | 21 | 32 | 53 |
| 2022 July | 21 | 44 | 65 |
| 2022 June | 14 | 29 | 43 |
| 2022 May | 15 | 18 | 33 |
| 2022 April | 16 | 29 | 45 |
| 2022 March | 16 | 36 | 52 |
| 2022 February | 14 | 34 | 48 |
| 2022 January | 15 | 27 | 42 |
| 2021 December | 16 | 41 | 57 |
| 2021 November | 15 | 51 | 66 |
| 2021 October | 16 | 51 | 67 |
| 2021 September | 15 | 56 | 71 |
| 2021 August | 12 | 34 | 46 |
| 2021 July | 10 | 26 | 36 |
| 2021 June | 16 | 33 | 49 |
| 2021 May | 10 | 31 | 41 |
| 2021 April | 26 | 75 | 101 |
| 2021 March | 18 | 21 | 39 |
| 2021 February | 8 | 17 | 25 |
| 2021 January | 7 | 9 | 16 |
| 2020 December | 13 | 14 | 27 |
| 2020 November | 6 | 19 | 25 |
| 2020 October | 10 | 12 | 22 |
| 2020 September | 12 | 18 | 30 |
| 2020 August | 6 | 14 | 20 |
| 2020 July | 8 | 16 | 24 |
| 2020 June | 1 | 7 | 8 |
| 2020 May | 8 | 13 | 21 |
| 2020 April | 12 | 21 | 33 |
| 2020 March | 8 | 12 | 20 |
| 2020 February | 8 | 17 | 25 |
| 2020 January | 16 | 13 | 29 |
| 2019 December | 20 | 12 | 32 |
| 2019 November | 12 | 10 | 22 |
| 2019 October | 13 | 6 | 19 |
| 2019 September | 5 | 8 | 13 |
| 2019 August | 7 | 8 | 15 |
| 2019 July | 6 | 18 | 24 |
| 2019 June | 8 | 13 | 21 |
| 2019 May | 11 | 14 | 25 |
| 2019 April | 20 | 15 | 35 |
| 2019 March | 12 | 19 | 31 |
| 2019 February | 3 | 10 | 13 |
| 2019 January | 4 | 10 | 14 |
| 2018 December | 3 | 13 | 16 |
| 2018 November | 14 | 9 | 23 |
| 2018 October | 11 | 8 | 19 |
| 2018 September | 7 | 9 | 16 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 2 | 3 | 5 |
| 2018 March | 1 | 2 | 3 |
| 2018 February | 3 | 5 | 8 |
| 2018 January | 3 | 7 | 10 |
| 2017 December | 3 | 4 | 7 |
| 2017 November | 2 | 5 | 7 |
| 2017 October | 4 | 9 | 13 |
| 2017 September | 3 | 8 | 11 |
| 2017 August | 6 | 7 | 13 |
| 2017 July | 2 | 2 | 4 |
| 2017 June | 8 | 8 | 16 |
| 2017 May | 4 | 8 | 12 |
| 2017 April | 2 | 2 | 4 |
| 2017 March | 1 | 2 | 3 |
| 2017 February | 0 | 3 | 3 |
| 2017 January | 1 | 1 | 2 |
| 2016 December | 9 | 7 | 16 |
| 2016 November | 13 | 12 | 25 |
| 2016 October | 23 | 14 | 37 |
| 2016 September | 9 | 7 | 16 |
| 2016 August | 8 | 4 | 12 |
| 2016 July | 5 | 0 | 5 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 50 | 9 | 59 |
| 2015 September | 43 | 8 | 51 |
| 2015 August | 37 | 4 | 41 |
| 2015 July | 55 | 6 | 61 |
| 2015 June | 37 | 2 | 39 |
| 2015 May | 62 | 10 | 72 |
| 2015 April | 35 | 11 | 46 |
| 2015 March | 46 | 5 | 51 |
| 2015 February | 76 | 7 | 83 |
| 2015 January | 63 | 5 | 68 |
| 2014 December | 81 | 7 | 88 |
| 2014 November | 82 | 3 | 85 |
| 2014 October | 87 | 12 | 99 |
| 2014 September | 39 | 5 | 44 |
| 2014 August | 36 | 9 | 45 |
| 2014 July | 24 | 7 | 31 |
| 2014 June | 42 | 6 | 48 |
| 2014 May | 53 | 7 | 60 |
| 2014 April | 52 | 4 | 56 |
| 2014 March | 56 | 3 | 59 |
| 2014 February | 60 | 9 | 69 |
| 2014 January | 69 | 8 | 77 |
| 2013 December | 42 | 3 | 45 |
| 2013 November | 39 | 14 | 53 |
| 2013 October | 59 | 8 | 67 |
| 2013 September | 39 | 7 | 46 |
| 2013 August | 44 | 6 | 50 |
| 2013 July | 44 | 8 | 52 |
| 2013 June | 40 | 5 | 45 |
| 2013 May | 36 | 2 | 38 |
| 2013 April | 27 | 6 | 33 |
| 2013 March | 5 | 1 | 6 |
Show all
