Original Articles
The EpicliCP-2003 Study: a Multicenter Epidemiological and Clinical Study of Lung Cancer in Spain
Julio Sánchez de Cos Escuín**,a,
, Luis Miravet Sorribesb,*, José Abal Arcac,*, Ana Núñez Aresd,*, Jesús Hernández Hernándeze,*, Ana M. Castañar Joverf,*, Francisco Javier Muñoz Gutiérrezg, Luis García Arangüenah, Miguel Ángel Alonsoi, M. del Carmen Montero Martínezj, Jesús Allende Gonzálezk, Ignacio Sánchez Hernándezl
a Sección de Neumología, Hospital San Pedro de Alcántara, Cáceres, Spain
b Sección de Neumología, Hospital de Vinaroz, Vinaroz, Castellón de la Plana, Spain
c Sección de Neumología, Hospital Cristal-Piñor, Orense, Spain
d Sección de Neumología, Complejo Hospitalario de Albacete, Albacete, Spain
e Sección de Neumología, Hospital Nuestra Señora de Sonsoles, Ávila, Spain
f Sección de Neumología, Hospital de Mérida, Mérida, Badajoz, Spain
g Sección de Neumología, Hospital Nuestra Señora de Valme, Sevilla, Spain
h Sección de Neumología, Hospital Sierrallana, Torrelavega, Cantabria, Spain
i Sección de Neumología, Hospital Central de Asturias, Oviedo, Asturias, Spain
j Sección de Neumología, Hospital Juan Canalejo, La Coruña, Spain
k Sección de Neumología, Complejo Hospitalario de León, León, Spain
l Sección de Neumología, Hospital General de Guadalajara, Guadalajara, Spain
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Castañar Jover, Francisco Javier Muñoz Gutiérrez, Luis García Arangüena, Miguel Ángel Alonso, M. del Carmen Montero Martínez, Jesús Allende González, Ignacio Sánchez Hernández" "autores" => array:12 [ 0 => array:5 [ "preGrado" => "Dr." "nombre" => "Julio Sánchez" "apellidos" => "de Cos Escuín" "email" => array:1 [ 0 => "jsd01cc@saludalia.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] 1 => array:3 [ "nombre" => "Luis Miravet" "apellidos" => "Sorribes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] 2 => array:3 [ "nombre" => "José Abal" "apellidos" => "Arca" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] 3 => array:3 [ "nombre" => "Ana Núñez" "apellidos" => "Ares" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] 4 => array:3 [ "nombre" => "Jesús Hernández" "apellidos" => "Hernández" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] 5 => array:3 [ "nombre" => "Ana M." 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Sánchez de Cos Escuín. Sección de Neumología. Hospital San Pedro de Alcántara. Avda. Millán Astray, s/n. 10003 Cáceres. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-07-05" "fechaAceptado" => "2006-01-31" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154542" "palabras" => array:4 [ 0 => "Lung cancer" 1 => "Stages" 2 => "Epidemiology" 3 => "Spain" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154541" "palabras" => array:4 [ 0 => "Cáncer de pulmón" 1 => "Estadios" 2 => "Epidemiología" 3 => "España" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Mortality due to lung cancer in Spain is increasing continuously. The aim of the present study was to collect information on the hospital incidence of lung cancer, as well as information on clinical management, in different regions of Spain.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective observational study of patients diagnosed with lung cancer in 2003 was carried out in 13 centers in 9 autonomous communities. Epidemiological, clinical, diagnostic, and therapeutic variables were assessed.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Of a total population of 2 726 601 inhabitants (1 346 483 men and 1 380 118 women), 1064 male and 125 female lung cancer patients were included. The incidence standardized to the world population varied between 42.4/100 000 and 61.8/100 000 in men and between 1.5/100 000 and 8.6/100 000 in women. Overall, 51% were aged over 70 years, and 97.5% of the men and 32% of the women were smokers or ex-smokers. Cytologic or histologic confirmation was obtained for 93.1% of the cases (20.8% of which were small cell lung cancers and 79.2% were non-small cell lung cancers). The main initial symptoms were cough, chest pain, and weight loss. In 13.7%, lung cancer was suspected because of abnormal chest x-ray. The percentage with clinical TNM stages I and II ranged from 6.3% to 26.9%. The most common stage was stage IV in all centers. The percentage of patients undergoing surgery ranged from 2.5% to 20.6%, with a mean of 14.8% (19.9% of whom were patients with non-small cell lung cancer); 27% received palliative treatment only.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The proportion of women suffering from lung cancer increased with respect to previous studies, with notable differences among regions. Despite diagnostic improvements, the percentage of patients undergoing surgery is low, though interregional variation is considerable.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La mortalidad por cáncer de pulmón en España aumenta ininterrumpidamente. El objetivo del presente estudio ha sido conocer su incidencia hospitalaria, así como otros datos de manejo clínico, en varias regiones españolas.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospectivo observacional de los pacientes diagnosticados de cáncer de pulmón en 2003 en 13 centros de 9 comunidades autónomas. Se evaluaron variables epidemiológicas, clínicas, diagnósticas y terapéuticas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se han registrado 1.064 varones y 125 mujeres correspondientes a una población total de 2.726.601 habitantes (1.346.483 varones y 1.380.118 mujeres). Las tasas estandarizadas según población mundial variaron entre 42,4 y 61,8/100.000 en varones y entre 1,5 y 8,6/100.000 en mujeres. El 51% tenía más de 70 años. El 97,5% de los varones y el 32% de las mujeres eran fumadores o ex fumadores. Se obtuvo confirmación citohistológica en el 93,1% de los casos (un 20,8% microcíticos y un 79,2% no microcíticos). Los síntomas iniciales predominantes fueron tos, dolor torácico y pérdida de peso. En el 13,7% el diagnóstico se sospechó sólo por anormalidad radiológica. La proporción de estadios TNM clínicos I y II varió entre el 6,3 y el 26,9%. El estadio IV fue el más común en todos los centros. La tasa de intervenciones varió entre el 2,5 y el 20,6%; el promedio fue del 14,8% (un 19,9% del total de no microcíticos). El 27,0% sólo recibió medidas paliativas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Entre los casos de cáncer de pulmón aumenta la proporción de mujeres con respecto a estudios previos, con notables diferencias interregionales. Pese a las mejoras diagnósticas, la tasa de intervenciones, muy variable entre diferentes centros, es muy baja.</p>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">EpicliCP-2003 Study Group.</p>" ] 1 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">The project was supported by a grant from the Assembly on Oncology of the Spanish Society for Pulmonology and Thoracic Surgery (SEPAR)</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Instituto Nacional de Estadística. Defunciones según la causa de muerte en España 2002. Madrid, Spain, 2005. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 5 | 8 |
| 2024 October | 45 | 15 | 60 |
| 2024 September | 33 | 16 | 49 |
| 2024 August | 42 | 28 | 70 |
| 2024 July | 23 | 23 | 46 |
| 2024 June | 35 | 27 | 62 |
| 2024 May | 38 | 31 | 69 |
| 2024 April | 19 | 29 | 48 |
| 2024 March | 18 | 17 | 35 |
| 2024 February | 17 | 19 | 36 |
| 2023 October | 1 | 2 | 3 |
| 2023 May | 0 | 2 | 2 |
| 2023 April | 0 | 3 | 3 |
| 2023 March | 3 | 4 | 7 |
| 2023 February | 12 | 17 | 29 |
| 2023 January | 15 | 21 | 36 |
| 2022 December | 22 | 22 | 44 |
| 2022 November | 20 | 24 | 44 |
| 2022 October | 19 | 28 | 47 |
| 2022 September | 18 | 22 | 40 |
| 2022 August | 13 | 31 | 44 |
| 2022 July | 16 | 38 | 54 |
| 2022 June | 18 | 40 | 58 |
| 2022 May | 13 | 26 | 39 |
| 2022 April | 18 | 26 | 44 |
| 2022 March | 18 | 29 | 47 |
| 2022 February | 16 | 32 | 48 |
| 2022 January | 11 | 36 | 47 |
| 2021 December | 19 | 44 | 63 |
| 2021 November | 19 | 52 | 71 |
| 2021 October | 22 | 50 | 72 |
| 2021 September | 21 | 64 | 85 |
| 2021 August | 18 | 30 | 48 |
| 2021 July | 12 | 23 | 35 |
| 2021 June | 10 | 29 | 39 |
| 2021 May | 16 | 28 | 44 |
| 2021 April | 20 | 64 | 84 |
| 2021 March | 14 | 29 | 43 |
| 2021 February | 9 | 19 | 28 |
| 2021 January | 12 | 6 | 18 |
| 2020 December | 9 | 16 | 25 |
| 2020 November | 9 | 22 | 31 |
| 2020 October | 15 | 11 | 26 |
| 2020 September | 5 | 5 | 10 |
| 2020 August | 7 | 13 | 20 |
| 2020 July | 10 | 15 | 25 |
| 2020 June | 5 | 6 | 11 |
| 2020 May | 10 | 21 | 31 |
| 2020 April | 14 | 14 | 28 |
| 2020 March | 12 | 9 | 21 |
| 2020 February | 12 | 14 | 26 |
| 2020 January | 13 | 12 | 25 |
| 2019 December | 21 | 13 | 34 |
| 2019 November | 10 | 11 | 21 |
| 2019 October | 7 | 6 | 13 |
| 2019 September | 3 | 6 | 9 |
| 2019 August | 11 | 8 | 19 |
| 2019 July | 7 | 10 | 17 |
| 2019 June | 7 | 3 | 10 |
| 2019 May | 5 | 11 | 16 |
| 2019 April | 9 | 17 | 26 |
| 2019 March | 7 | 19 | 26 |
| 2019 February | 3 | 7 | 10 |
| 2019 January | 6 | 8 | 14 |
| 2018 December | 7 | 8 | 15 |
| 2018 November | 8 | 11 | 19 |
| 2018 October | 35 | 12 | 47 |
| 2018 September | 13 | 9 | 22 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 6 | 6 | 12 |
| 2018 March | 6 | 3 | 9 |
| 2018 February | 5 | 5 | 10 |
| 2018 January | 4 | 8 | 12 |
| 2017 December | 4 | 1 | 5 |
| 2017 November | 2 | 3 | 5 |
| 2017 October | 6 | 6 | 12 |
| 2017 September | 4 | 8 | 12 |
| 2017 August | 6 | 8 | 14 |
| 2017 July | 1 | 2 | 3 |
| 2017 June | 8 | 7 | 15 |
| 2017 May | 7 | 5 | 12 |
| 2017 April | 3 | 3 | 6 |
| 2017 March | 1 | 15 | 16 |
| 2017 February | 0 | 2 | 2 |
| 2017 January | 1 | 1 | 2 |
| 2016 December | 4 | 7 | 11 |
| 2016 November | 16 | 14 | 30 |
| 2016 October | 13 | 14 | 27 |
| 2016 September | 8 | 2 | 10 |
| 2016 August | 6 | 3 | 9 |
| 2016 July | 7 | 0 | 7 |
| 2016 March | 2 | 0 | 2 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 20 | 11 | 31 |
| 2015 September | 40 | 1 | 41 |
| 2015 August | 26 | 8 | 34 |
| 2015 July | 27 | 2 | 29 |
| 2015 June | 26 | 4 | 30 |
| 2015 May | 32 | 5 | 37 |
| 2015 April | 16 | 4 | 20 |
| 2015 March | 16 | 6 | 22 |
| 2015 February | 31 | 1 | 32 |
| 2015 January | 30 | 3 | 33 |
| 2014 December | 24 | 5 | 29 |
| 2014 November | 25 | 9 | 34 |
| 2014 October | 28 | 10 | 38 |
| 2014 September | 20 | 6 | 26 |
| 2014 August | 22 | 8 | 30 |
| 2014 July | 16 | 10 | 26 |
| 2014 June | 38 | 3 | 41 |
| 2014 May | 33 | 9 | 42 |
| 2014 April | 33 | 2 | 35 |
| 2014 March | 35 | 7 | 42 |
| 2014 February | 29 | 9 | 38 |
| 2014 January | 22 | 6 | 28 |
| 2013 December | 32 | 6 | 38 |
| 2013 November | 19 | 4 | 23 |
| 2013 October | 21 | 7 | 28 |
| 2013 September | 26 | 7 | 33 |
| 2013 August | 34 | 6 | 40 |
| 2013 July | 38 | 9 | 47 |
| 2013 June | 26 | 5 | 31 |
| 2013 May | 18 | 4 | 22 |
| 2013 April | 14 | 4 | 18 |
| 2013 March | 5 | 1 | 6 |
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