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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To describe a series of cases of bronchioloalveolar carcinoma &#40;BAC&#41; treated surgically between 1993 and 1997 in the 19 hospitals that make up the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pulmonology and Thoracic Surgery &#40;GCCB-S&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">From a total of 2944 cases of nonsmall cell lung cancer &#40;NSCLC&#41;&#44; 82 &#40;3&#37;&#41; were BAC&#46; The clinical characteristics and prognosis of patients with BAC were compared with those of the remaining 2862 patients with NSCLC&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The percentage of men was lower for BAC than for other types of NSCLC &#40;64&#46;6&#37; compared with 93&#46;5&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and BAC was associated with less comorbidity &#40;50&#37; vs 62&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#44; particularly in terms of chronic obstructive pulmonary disease &#40;33&#37; vs 47&#46;2&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; Other characteristics showing significant differences were the higher frequency of BAC as a chance finding and the lower likelihood of weight loss or reduced performance status at the time of diagnosis&#46; Classification as stage cI was significantly more common in patients with BAC &#40;87&#37; vs 75&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; and this difference between groups was more pronounced for stage pI &#40;68&#46;5&#37; vs 47&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;01&#41;&#46; Only taking into account patients classified as stage pI with complete resection of NSCLC and following exclusion of operative mortality&#44; patients with BAC presented an overall 5-year survival of 65&#37; &#40;95&#37; confidence interval &#91;CI&#93;&#44; 51&#37;-79&#37;&#41;&#44; compared with a significantly lower survival of 53&#37; &#40;95&#37; CI&#44; 50&#37;-56&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41; in patients with other forms of NSCLC&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In Spain&#44; among cases of lung cancer treated by surgery&#44; BAC is very rare &#40;3&#37;&#41; and displays clinical characteristics that are different from other forms of NSCLC&#46; Controlling for the most basic prognostic factors &#40;stage pI and complete resection&#41;&#44; survival is significantly higher for BAC&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir una serie de casos de carcinoma bronquioloalveolar &#40;CBA&#41; tratados quir&#250;rgicamente por los 19 hospitales del Grupo Cooperativo de Carcinoma Broncog&#233;nico de la Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;GCCB-S&#41; entre 1993 y 1997&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Del total de 2&#46;944 casos de carcinoma broncog&#233;nico no microc&#237;tico &#40;CBNM&#41;&#44; 82 &#40;3&#37;&#41; eran CBA&#46; Se compararon las caracter&#237;sticas cl&#237;nicas y el pron&#243;stico de los CBA con los de los restantes 2&#46;862 CBNM&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los CBA ocurren menos frecuentemente en varones &#40;el 64&#44;6 frente al 93&#44;5&#37;&#59; p &#61; 0&#44;001&#41;&#44; tienen menos comorbilidad en general &#40;el 50 frente al 62&#37;&#59; p &#60; 0&#44;05&#41; y enfermedad pulmonar obstructiva cr&#243;nica en particular &#40;el 33 frente al 47&#44;2&#37;&#59; p &#60; 0&#44;05&#41;&#46; Otras caracter&#237;sticas con diferencias significativas son la mayor frecuencia de que el CBA sea un hallazgo casual y la menor probabilidad de que en el momento del diagn&#243;stico exista historia de p&#233;rdida de peso o peor estado cl&#237;nico&#46; Por estadios cl&#237;nicos&#44; la clasificaci&#243;n Ic es significativamente m&#225;s frecuente en los CBA &#40;el 87 frente al 75&#37;&#59; p &#61; 0&#44;001&#41;&#44; diferencia que se incrementa en la estadificaci&#243;n Ip &#40;el 68&#44;5 frente al 47&#37;&#59; p &#60; 0&#44;01&#41;&#46; Considerando la poblaci&#243;n de CBNM con resecci&#243;n completa en estadio Ip&#44; y una vez excluida la mortalidad operatoria&#44; los CBA presentan una supervivencia global a los 5 a&#241;os del 65&#37; &#40;intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 51-79&#37;&#41;&#44; significativamente superior al resto de CBNM no CBA&#44; en que es del 53&#37; &#40;IC del 95&#37;&#44; 50-56&#37;&#41; &#40;p &#60; 0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">En Espa&#241;a&#44; entre los casos de c&#225;ncer de pulm&#243;n operado&#44; el CBA es muy infrecuente &#40;3&#37;&#41; y presenta caracter&#237;sticas cl&#237;nicas diferentes del resto de los CBNM&#46; Controlando con los factores pron&#243;sticos m&#225;s b&#225;sicos &#40;estadio Ip y resecci&#243;n completa&#41;&#44; la supervivencia del CBA es significativamente superior&#46;</p>"
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Original Articles
Bronchioloalveolar Carcinoma in Spain: A Rare and Different Form of Lung Cancer
Ángel López Encuentraa,**
Corresponding author
lencuent@h12o.es

Correspondence: Dr. A. López Encuentra. Servicio de Neumología. Hospital Universitario 12 de Octubre. Avda. Córdoba, 5. 28041 Madrid. España
, Francisco Pozo Rodrígueza, José Luis Martín de Nicolásb, Victoria Villenaa, Javier Sayas Catalána, the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pulmonology and Thoracic Surgery (GCCB-S) *
a Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain
b Servicio de Cirugía Toráeica, Hospital Universitario 12 de Octubre, Madrid, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To describe a series of cases of bronchioloalveolar carcinoma &#40;BAC&#41; treated surgically between 1993 and 1997 in the 19 hospitals that make up the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pulmonology and Thoracic Surgery &#40;GCCB-S&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">From a total of 2944 cases of nonsmall cell lung cancer &#40;NSCLC&#41;&#44; 82 &#40;3&#37;&#41; were BAC&#46; The clinical characteristics and prognosis of patients with BAC were compared with those of the remaining 2862 patients with NSCLC&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The percentage of men was lower for BAC than for other types of NSCLC &#40;64&#46;6&#37; compared with 93&#46;5&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and BAC was associated with less comorbidity &#40;50&#37; vs 62&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#44; particularly in terms of chronic obstructive pulmonary disease &#40;33&#37; vs 47&#46;2&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; Other characteristics showing significant differences were the higher frequency of BAC as a chance finding and the lower likelihood of weight loss or reduced performance status at the time of diagnosis&#46; Classification as stage cI was significantly more common in patients with BAC &#40;87&#37; vs 75&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; and this difference between groups was more pronounced for stage pI &#40;68&#46;5&#37; vs 47&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;01&#41;&#46; Only taking into account patients classified as stage pI with complete resection of NSCLC and following exclusion of operative mortality&#44; patients with BAC presented an overall 5-year survival of 65&#37; &#40;95&#37; confidence interval &#91;CI&#93;&#44; 51&#37;-79&#37;&#41;&#44; compared with a significantly lower survival of 53&#37; &#40;95&#37; CI&#44; 50&#37;-56&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41; in patients with other forms of NSCLC&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In Spain&#44; among cases of lung cancer treated by surgery&#44; BAC is very rare &#40;3&#37;&#41; and displays clinical characteristics that are different from other forms of NSCLC&#46; Controlling for the most basic prognostic factors &#40;stage pI and complete resection&#41;&#44; survival is significantly higher for BAC&#46;</p>"
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ISSN: 15792129
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