Correspondence: Dr. A. López Encuentra. Servicio de Neumología. Hospital Universitario 12 de Octubre. Avda. Córdoba, 5. 28041 Madrid. España
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"apellidos" => "Ferreiro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906605533?idApp=UINPBA00003Z" "url" => "/15792129/0000004200000008/v1_201305150251/S1579212906605533/v1_201305150251/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Bronchioloalveolar Carcinoma in Spain: A Rare and Different Form of Lung Cancer" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "399" "paginaFinal" => "403" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ángel López Encuentra, Francisco Pozo Rodríguez, José Luis Martín de Nicolás, Victoria Villena, Javier Sayas Catalán" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Ángel López" "apellidos" => "Encuentra" "email" => array:1 [ 0 => "lencuent@h12o.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor2" ] ] ] 1 => array:3 [ "nombre" => "Francisco Pozo" "apellidos" => "Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "José Luis Martín" "apellidos" => "de Nicolás" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Victoria" "apellidos" => "Villena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Javier Sayas" "apellidos" => "Catalán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:2 [ "colaborador" => "the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pulmonology and Thoracic Surgery (GCCB-S)" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Toráeica, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor2" "etiqueta" => "**" "correspondencia" => "Correspondence: Dr. A. López Encuentra. Servicio de Neumología. Hospital Universitario 12 de Octubre. Avda. Córdoba, 5. 28041 Madrid. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-10-26" "fechaAceptado" => "2006-01-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154486" "palabras" => array:4 [ 0 => "Lung cancer" 1 => "Staging" 2 => "Surgery" 3 => "Bronchioloalveolar carcinoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154485" "palabras" => array:4 [ 0 => "Cáncer de pulmón" 1 => "Estadificación" 2 => "Cirugía" 3 => "Carcinoma bronquioloalveolar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To describe a series of cases of bronchioloalveolar carcinoma (BAC) treated surgically between 1993 and 1997 in the 19 hospitals that make up the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pulmonology and Thoracic Surgery (GCCB-S).</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">From a total of 2944 cases of nonsmall cell lung cancer (NSCLC), 82 (3%) were BAC. The clinical characteristics and prognosis of patients with BAC were compared with those of the remaining 2862 patients with NSCLC.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The percentage of men was lower for BAC than for other types of NSCLC (64.6% compared with 93.5%; <span class="elsevierStyleItalic">P</span><.001) and BAC was associated with less comorbidity (50% vs 62%; <span class="elsevierStyleItalic">P</span><.05), particularly in terms of chronic obstructive pulmonary disease (33% vs 47.2%; <span class="elsevierStyleItalic">P</span><.05). Other characteristics showing significant differences were the higher frequency of BAC as a chance finding and the lower likelihood of weight loss or reduced performance status at the time of diagnosis. Classification as stage cI was significantly more common in patients with BAC (87% vs 75%; <span class="elsevierStyleItalic">P</span><.001), and this difference between groups was more pronounced for stage pI (68.5% vs 47%; <span class="elsevierStyleItalic">P</span><.01). Only taking into account patients classified as stage pI with complete resection of NSCLC and following exclusion of operative mortality, patients with BAC presented an overall 5-year survival of 65% (95% confidence interval [CI], 51%-79%), compared with a significantly lower survival of 53% (95% CI, 50%-56%; <span class="elsevierStyleItalic">P</span><.05) in patients with other forms of NSCLC.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In Spain, among cases of lung cancer treated by surgery, BAC is very rare (3%) and displays clinical characteristics that are different from other forms of NSCLC. Controlling for the most basic prognostic factors (stage pI and complete resection), survival is significantly higher for BAC.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir una serie de casos de carcinoma bronquioloalveolar (CBA) tratados quirúrgicamente por los 19 hospitales del Grupo Cooperativo de Carcinoma Broncogénico de la Sociedad Española de Neumología y Cirugía Torácica (GCCB-S) entre 1993 y 1997.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Del total de 2.944 casos de carcinoma broncogénico no microcítico (CBNM), 82 (3%) eran CBA. Se compararon las características clínicas y el pronóstico de los CBA con los de los restantes 2.862 CBNM.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los CBA ocurren menos frecuentemente en varones (el 64,6 frente al 93,5%; p = 0,001), tienen menos comorbilidad en general (el 50 frente al 62%; p < 0,05) y enfermedad pulmonar obstructiva crónica en particular (el 33 frente al 47,2%; p < 0,05). Otras características con diferencias significativas son la mayor frecuencia de que el CBA sea un hallazgo casual y la menor probabilidad de que en el momento del diagnóstico exista historia de pérdida de peso o peor estado clínico. Por estadios clínicos, la clasificación Ic es significativamente más frecuente en los CBA (el 87 frente al 75%; p = 0,001), diferencia que se incrementa en la estadificación Ip (el 68,5 frente al 47%; p < 0,01). Considerando la población de CBNM con resección completa en estadio Ip, y una vez excluida la mortalidad operatoria, los CBA presentan una supervivencia global a los 5 años del 65% (intervalo de confianza [IC] del 95%, 51-79%), significativamente superior al resto de CBNM no CBA, en que es del 53% (IC del 95%, 50-56%) (p < 0,05).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">En España, entre los casos de cáncer de pulmón operado, el CBA es muy infrecuente (3%) y presenta características clínicas diferentes del resto de los CBNM. Controlando con los factores pronósticos más básicos (estadio Ip y resección completa), la supervivencia del CBA es significativamente superior.</p>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">A complete list of the members of GCCB-S is contained in the appendix.</p>" ] 1 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This study was partially funded by grants FIS 97/0011, FEPAR-2002, RTIC-03/11-ISCIII-Red-Respira, and FIS 03/46, and support from the Autonomous Community of Castile and Leon and Fundación Menarini.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenocarcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "TV Colby" 1 => "M Noguchi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Tumours of the lung, pleura, thymus and heart" "paginaInicial" => "35" "paginaFinal" => "44" "serieFecha" => "2004" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "WD Travis" 1 => "K Garg" 2 => "WA Franklin" 3 => "II Wistuba" 4 => "B Sabloff" 5 => "M Noguchi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.15.776" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "3279" "paginaFinal" => "3287" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15886315" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic therapy of advanced bronchioloalveolar cell carcinoma: challenges and opportunities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "VA Miller" 1 => "FR Hirsch" 2 => "DH Johnson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.19.240" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "3288" "paginaFinal" => "3293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15886316" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cirugía del carcinoma broncogénico en España. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 6 | 2 | 8 |
2024 October | 29 | 18 | 47 |
2024 September | 31 | 22 | 53 |
2024 August | 39 | 32 | 71 |
2024 July | 24 | 21 | 45 |
2024 June | 31 | 32 | 63 |
2024 May | 39 | 42 | 81 |
2024 April | 15 | 20 | 35 |
2024 March | 18 | 19 | 37 |
2024 February | 18 | 19 | 37 |
2023 March | 1 | 4 | 5 |
2023 February | 20 | 13 | 33 |
2023 January | 17 | 31 | 48 |
2022 December | 24 | 34 | 58 |
2022 November | 22 | 23 | 45 |
2022 October | 23 | 26 | 49 |
2022 September | 16 | 17 | 33 |
2022 August | 19 | 31 | 50 |
2022 July | 20 | 40 | 60 |
2022 June | 16 | 30 | 46 |
2022 May | 17 | 33 | 50 |
2022 April | 14 | 27 | 41 |
2022 March | 17 | 44 | 61 |
2022 February | 23 | 30 | 53 |
2022 January | 20 | 33 | 53 |
2021 December | 21 | 44 | 65 |
2021 November | 20 | 53 | 73 |
2021 October | 22 | 54 | 76 |
2021 September | 20 | 61 | 81 |
2021 August | 8 | 27 | 35 |
2021 July | 11 | 26 | 37 |
2021 June | 16 | 41 | 57 |
2021 May | 16 | 25 | 41 |
2021 April | 28 | 55 | 83 |
2021 March | 21 | 26 | 47 |
2021 February | 14 | 20 | 34 |
2021 January | 16 | 12 | 28 |
2020 December | 14 | 12 | 26 |
2020 November | 13 | 26 | 39 |
2020 October | 11 | 13 | 24 |
2020 September | 9 | 5 | 14 |
2020 August | 11 | 14 | 25 |
2020 July | 13 | 14 | 27 |
2020 June | 6 | 7 | 13 |
2020 May | 33 | 16 | 49 |
2020 April | 28 | 20 | 48 |
2020 March | 16 | 18 | 34 |
2020 February | 41 | 20 | 61 |
2020 January | 65 | 22 | 87 |
2019 December | 29 | 23 | 52 |
2019 November | 42 | 21 | 63 |
2019 October | 30 | 8 | 38 |
2019 September | 3 | 7 | 10 |
2019 August | 14 | 12 | 26 |
2019 July | 17 | 15 | 32 |
2019 June | 5 | 5 | 10 |
2019 May | 15 | 22 | 37 |
2019 April | 32 | 37 | 69 |
2019 March | 17 | 22 | 39 |
2019 February | 13 | 15 | 28 |
2019 January | 15 | 10 | 25 |
2018 December | 17 | 12 | 29 |
2018 November | 13 | 9 | 22 |
2018 October | 15 | 14 | 29 |
2018 September | 12 | 10 | 22 |
2018 May | 3 | 1 | 4 |
2018 April | 5 | 6 | 11 |
2018 March | 2 | 4 | 6 |
2018 February | 7 | 8 | 15 |
2018 January | 6 | 4 | 10 |
2017 December | 5 | 4 | 9 |
2017 November | 4 | 5 | 9 |
2017 October | 6 | 8 | 14 |
2017 September | 2 | 1 | 3 |
2017 August | 9 | 12 | 21 |
2017 July | 4 | 5 | 9 |
2017 June | 9 | 8 | 17 |
2017 May | 4 | 5 | 9 |
2017 April | 1 | 5 | 6 |
2017 March | 2 | 3 | 5 |
2017 February | 1 | 7 | 8 |
2017 January | 3 | 0 | 3 |
2016 December | 9 | 6 | 15 |
2016 November | 13 | 7 | 20 |
2016 October | 14 | 7 | 21 |
2016 September | 19 | 9 | 28 |
2016 August | 11 | 3 | 14 |
2016 July | 10 | 0 | 10 |
2016 March | 1 | 0 | 1 |
2016 February | 1 | 0 | 1 |
2015 December | 2 | 0 | 2 |
2015 October | 34 | 13 | 47 |
2015 September | 30 | 11 | 41 |
2015 August | 30 | 8 | 38 |
2015 July | 36 | 6 | 42 |
2015 June | 30 | 44 | 74 |
2015 May | 42 | 4 | 46 |
2015 April | 21 | 7 | 28 |
2015 March | 25 | 7 | 32 |
2015 February | 25 | 4 | 29 |
2015 January | 22 | 4 | 26 |
2014 December | 31 | 4 | 35 |
2014 November | 28 | 7 | 35 |
2014 October | 32 | 7 | 39 |
2014 September | 25 | 6 | 31 |
2014 August | 32 | 9 | 41 |
2014 July | 29 | 7 | 36 |
2014 June | 44 | 7 | 51 |
2014 May | 38 | 8 | 46 |
2014 April | 45 | 4 | 49 |
2014 March | 54 | 7 | 61 |
2014 February | 44 | 6 | 50 |
2014 January | 43 | 7 | 50 |
2013 December | 50 | 10 | 60 |
2013 November | 36 | 5 | 41 |
2013 October | 52 | 7 | 59 |
2013 September | 35 | 8 | 43 |
2013 August | 59 | 8 | 67 |
2013 July | 53 | 8 | 61 |
2013 June | 39 | 9 | 48 |
2013 May | 34 | 2 | 36 |
2013 April | 19 | 4 | 23 |
2013 March | 9 | 1 | 10 |