Original Articles
Quantifying Plasma Levels of Transforming Growth Factor β1 in Idiopathic Pulmonary Fibrosis
María Molina-Molinaa,
, Sergio Lariob, Patricio Luburichc, José Ramírezd, María Teresa Carrióna, Antoni Xaubeta
Corresponding author
mariamolinamolina@hotmail.com
Correspondence: Dra. M. Molina-Molina. Servicio de Neumología. Hospital Clínic. Villarroel, 170. 08036 Barcelona. España
Correspondence: Dra. M. Molina-Molina. Servicio de Neumología. Hospital Clínic. Villarroel, 170. 08036 Barcelona. España
a Sectión de Neumología, Hospital Clinic, IDIBAPS, Universidad de Barcelona, Barcelona, Spain
b Unidad de Trasplante Renal, Hospital Clinic, IDIBAPS, Universidad de Barcelona, Barcelona, Spain
c Servicio de Radiodiagnóstico, Hospital Clínic, IDIBAPS, Universidad de Barcelona, Barcelona, Spain
d Servicio de Anatomía Patológica, Hospital Clínic, IDIBAPS, Universidad de Barcelona, Barcelona, Spain
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M. Molina-Molina. Servicio de Neumología. Hospital Clínic. Villarroel, 170. 08036 Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-08-24" "fechaAceptado" => "2005-11-22" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154475" "palabras" => array:4 [ 0 => "Idiopathic pulmonary fibrosis" 1 => "Interstitial pulmonary diseases" 2 => "Transforming growth factor β<span class="elsevierStyleInf">1</span>" 3 => "Serum markers" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154474" "palabras" => array:4 [ 0 => "Fibrosis pulmonar idiopática" 1 => "Enfermedades pulmonares intersticiales" 2 => "Factor transformador del crecimiento β<span class="elsevierStyleInf">1</span>" 3 => "Marcadores séricos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Transforming growth factor β<span class="elsevierStyleInf">1</span> (TGF-β<span class="elsevierStyleInf">1</span>) is one of the key profibrotic mediators in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The purpose of this study was to investigate the prognostic value of quantifying TGF-β<span class="elsevierStyleInf">1</span> levels in patients with IPF.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We conducted a prospective study of 29 IPF patients and 27 healthy controls. Enzyme-linked immunosorbent assays were used to quantify TGF-β<span class="elsevierStyleInf">1</span> levels.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Mean (SD) TGF-β<span class="elsevierStyleInf">1</span> levels were significantly higher in the IPF patients than in the control subjects (11.1 [7.5] ng/mL vs 4 [2.4] ng/mL; <span class="elsevierStyleItalic">P</span><.01). Weak inverse correlations were observed between TGF-β<span class="elsevierStyleInf">1</span> levels and both forced vital capacity and total lung capacity. Thirteen IPF patients were evaluated at 8 (1.2) months (range, 5–9 months). The mean TGF-β<span class="elsevierStyleInf">1</span> level was 18.2 (15) ng/mL and there were no significant differences with respect to the initial measurement of 11.1 (7.5) ng/mL.</p><p class="elsevierStyleSimplePara elsevierViewall">No correlation was observed between changes in respiratory function and changes in TGF-β<span class="elsevierStyleInf">1</span> levels.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Although plasma levels of TGF-β<span class="elsevierStyleInf">1</span> were high in the patients with IPF, they do not appear to be a useful prognostic marker of disease activity or therapeutic response.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El factor transformador del crecimiento β<span class="elsevierStyleInf">1</span> (TGF-β<span class="elsevierStyleInf">1</span>) es uno de los mediadores fibrogénicos con más relevancia en la patogenia de la fibrosis pulmonar idiopática (FPI). El objetivo del estudio ha sido investigar el valor pronóstico de la determinación en plasma del TGF-β<span class="elsevierStyleInf">1</span> en la FPI.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospective en el que se incluyó a 29 pacientes con FPI y 27 controles sanos. La determinación del TGF-β<span class="elsevierStyleInf">1</span> se realizó mediante enzimoinmunoanálisis.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La concentración de TGF-β<span class="elsevierStyleInf">1</span> de significativamente mayor en los pacientes con FPI que en los controles (media ± desviación estándar: 11,1 ± 7,5 frente a 4 ± 2,4 ng/ml; p < 0,01). Se observó una débil relación inversa de la concentración del TGF-β<span class="elsevierStyleInf">1</span> con los valores de la capacidad vital forzada y de la capacidad pulmonar total. Se evaluó a 13 pacientes con FPI a los 8 ± 1,2 meses (rango: 5–9 meses). La concentración de TGF-β<span class="elsevierStyleInf">1</span> fue de 18,2 ± 15 ng/ml, sin diferencias significativas respecto a la primera determinación (11,1 ± 7,5 ng/ml). No se observó ninguna relación entre los cambios evolutivos en la exploración funcional respiratoria y los cambios en la concentración de TGF-β<span class="elsevierStyleInf">1</span>.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque la concentración plasmática de TGF-β<span class="elsevierStyleInf">1</span> está elevada en los pacientes con FPI, este parámetro no parece ser útil como marcador del pronóstico de la enfermedad ni de la respuesta terapéutica.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This study was funded by grants from SEPAR: Fundación Respira 2000, FIS 00/371, and Red Respira V-2003-REDC 11 D-O.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic pulmonary fibrosis. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 3 | 5 |
| 2024 October | 34 | 27 | 61 |
| 2024 September | 32 | 25 | 57 |
| 2024 August | 39 | 31 | 70 |
| 2024 July | 34 | 31 | 65 |
| 2024 June | 41 | 28 | 69 |
| 2024 May | 40 | 38 | 78 |
| 2024 April | 12 | 25 | 37 |
| 2024 March | 20 | 29 | 49 |
| 2024 February | 21 | 27 | 48 |
| 2023 March | 2 | 3 | 5 |
| 2023 February | 12 | 17 | 29 |
| 2023 January | 19 | 34 | 53 |
| 2022 December | 24 | 43 | 67 |
| 2022 November | 24 | 26 | 50 |
| 2022 October | 30 | 30 | 60 |
| 2022 September | 26 | 21 | 47 |
| 2022 August | 19 | 35 | 54 |
| 2022 July | 16 | 47 | 63 |
| 2022 June | 18 | 27 | 45 |
| 2022 May | 18 | 33 | 51 |
| 2022 April | 19 | 37 | 56 |
| 2022 March | 25 | 38 | 63 |
| 2022 February | 17 | 27 | 44 |
| 2022 January | 14 | 40 | 54 |
| 2021 December | 19 | 50 | 69 |
| 2021 November | 26 | 58 | 84 |
| 2021 October | 21 | 67 | 88 |
| 2021 September | 21 | 59 | 80 |
| 2021 August | 11 | 47 | 58 |
| 2021 July | 11 | 21 | 32 |
| 2021 June | 15 | 61 | 76 |
| 2021 May | 10 | 64 | 74 |
| 2021 April | 48 | 109 | 157 |
| 2021 March | 43 | 32 | 75 |
| 2021 February | 21 | 23 | 44 |
| 2021 January | 12 | 21 | 33 |
| 2020 December | 20 | 19 | 39 |
| 2020 November | 12 | 19 | 31 |
| 2020 October | 9 | 19 | 28 |
| 2020 September | 10 | 12 | 22 |
| 2020 August | 9 | 16 | 25 |
| 2020 July | 8 | 23 | 31 |
| 2020 June | 8 | 12 | 20 |
| 2020 May | 20 | 13 | 33 |
| 2020 April | 20 | 19 | 39 |
| 2020 March | 13 | 17 | 30 |
| 2020 February | 14 | 17 | 31 |
| 2020 January | 21 | 18 | 39 |
| 2019 December | 14 | 22 | 36 |
| 2019 November | 9 | 11 | 20 |
| 2019 October | 16 | 12 | 28 |
| 2019 September | 8 | 16 | 24 |
| 2019 August | 10 | 6 | 16 |
| 2019 July | 8 | 12 | 20 |
| 2019 June | 5 | 5 | 10 |
| 2019 May | 16 | 15 | 31 |
| 2019 April | 29 | 17 | 46 |
| 2019 March | 16 | 29 | 45 |
| 2019 February | 16 | 24 | 40 |
| 2019 January | 8 | 14 | 22 |
| 2018 December | 5 | 12 | 17 |
| 2018 November | 8 | 13 | 21 |
| 2018 October | 20 | 19 | 39 |
| 2018 September | 9 | 22 | 31 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 7 | 14 | 21 |
| 2018 March | 2 | 11 | 13 |
| 2018 February | 5 | 9 | 14 |
| 2018 January | 2 | 16 | 18 |
| 2017 December | 6 | 9 | 15 |
| 2017 November | 2 | 11 | 13 |
| 2017 October | 7 | 13 | 20 |
| 2017 September | 4 | 7 | 11 |
| 2017 August | 5 | 15 | 20 |
| 2017 July | 2 | 15 | 17 |
| 2017 June | 17 | 25 | 42 |
| 2017 May | 5 | 10 | 15 |
| 2017 April | 3 | 23 | 26 |
| 2017 March | 1 | 22 | 23 |
| 2017 February | 1 | 14 | 15 |
| 2017 January | 5 | 10 | 15 |
| 2016 December | 10 | 8 | 18 |
| 2016 November | 18 | 8 | 26 |
| 2016 October | 24 | 12 | 36 |
| 2016 September | 17 | 7 | 24 |
| 2016 August | 8 | 2 | 10 |
| 2016 July | 10 | 0 | 10 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 46 | 9 | 55 |
| 2015 September | 36 | 4 | 40 |
| 2015 August | 31 | 11 | 42 |
| 2015 July | 44 | 3 | 47 |
| 2015 June | 29 | 7 | 36 |
| 2015 May | 52 | 9 | 61 |
| 2015 April | 29 | 5 | 34 |
| 2015 March | 20 | 7 | 27 |
| 2015 February | 28 | 3 | 31 |
| 2015 January | 27 | 6 | 33 |
| 2014 December | 28 | 3 | 31 |
| 2014 November | 38 | 6 | 44 |
| 2014 October | 47 | 11 | 58 |
| 2014 September | 27 | 7 | 34 |
| 2014 August | 36 | 7 | 43 |
| 2014 July | 27 | 10 | 37 |
| 2014 June | 40 | 5 | 45 |
| 2014 May | 32 | 8 | 40 |
| 2014 April | 47 | 6 | 53 |
| 2014 March | 33 | 10 | 43 |
| 2014 February | 38 | 10 | 48 |
| 2014 January | 41 | 2 | 43 |
| 2013 December | 43 | 10 | 53 |
| 2013 November | 34 | 3 | 37 |
| 2013 October | 34 | 8 | 42 |
| 2013 September | 28 | 11 | 39 |
| 2013 August | 41 | 9 | 50 |
| 2013 July | 46 | 11 | 57 |
| 2013 June | 41 | 6 | 47 |
| 2013 May | 41 | 6 | 47 |
| 2013 April | 8 | 4 | 12 |
| 2013 March | 8 | 2 | 10 |
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