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Primary Prevention and Treatment of Latent Tuberculosis Infection With Isoniazid: Efficacy of a Control Program, 1997-2002
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"apellidos" => "Martínez Sanchís" "email" => array:1 [ 0 => "martinez_adesan@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J.L." "apellidos" => "Calpe Calpe" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "G." "apellidos" => "Llavador Ros" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Ena Muñoz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Calpe Armero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Sección de Neumología, Hospital Marina Baixa, Villajoyosa, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Marina Baixa, Villajoyosa, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Diplomado en Enfermería, Hospital Marina Baixa, Villajoyosa, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra. A. Martínez Sanchís. Brasil, 4, 3.° B. 03008 Alicante. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-02-02" "fechaAceptado" => "2004-04-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153661" "palabras" => array:4 [ 0 => "Contact study" 1 => "Chemoprophylaxis" 2 => "Latent tuberculosis infection" 3 => "Isoniazid" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153662" "palabras" => array:6 [ 0 => "Liver toxicity" 1 => "Estudio de contactos" 2 => "Quimioprofilaxis" 3 => "Infección tuberculosa latente" 4 => "Isoniacida" 5 => "Hepatotoxicidad" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze the efficacy of a specific program for the study and follow up of tuberculosis contacts. To study factors related to low adherence to treatment and to the development of liver toxicity caused by isoniazid.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Between December 1996 and December 2002, we found 458 contacts of 79 cases of pulmonary tuberculosis in patients uninfected by human immunodeficiency virus. The contacts were screened for tuberculosis infection and chemoprophylaxis was prescribed according to the recommendations of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR).</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We identified 3 cases of tuberculosis among the contacts (prevalence 0.8%). Chemoprophylaxis with isoniazid was prescribed for 215 contacts. One hundred sixty-nine (79%) completed the prophylaxis protocol. The rate of adherence to treatment was lower in immigrants than in nonimmigrants (odds ratio, 3.42; 95% confidence interval, 1.03-11.04; P=.02). Forty-three patients (22%) developed liver toxicity during treatment, which had to be suspended in 3 cases. Duration of chemoprophylaxis was the only independent variable associated with liver toxicity (odds ratio, 3.80; 95% confidence interval, 1.10-13.13; P=.03).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Our study demonstrates the effectiveness of a specific program of study and follow up of tuberculosis contacts. Immigrants require tailored strategies to improve their adherence to the program. The duration of chemoprophylaxis plays an important role in the development of liver toxicity.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Analizar la eficacia de un programa específico para el estudio y seguimiento de los contactos de los pacien-tes con tuberculosis. Evaluar los factores relacionados con una baja adherencia al tratamiento y con el desarrollo de to-xicidad hepática por isoniacida.</p> <span class="elsevierStyleSectionTitle">Pacientes Y Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Entre diciembre de 1996 y diciembre de 2002 se censaron 458 contactos de 79 casos de tuberculosis pulmonar en pacientes sin infección por el virus de la inmunodeficiencia humana. Se realizó cribado de infección tuberculosa y se indicó quimioprofilaxis según la normativa vigente de la Sociedad Española de Neumología y Cirugía Torácica.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Encontramos 3 casos de tuberculosis entre los contactos (prevalencia del 0,8%). Se indicó quimioprofilaxis con isoniacida en 215 casos. Un total de 169 (79%) completaron el protocolo de quimioprofilaxis. Los inmi-grantes mostraron baja adherencia al tratamiento frente a los que no lo eran (<span class="elsevierStyleItalic">odds ratio</span> = 3,42; intervalo de confianza del 95%, 1,03-11,04; p = 0,02). Cuarenta y tres (22%) pacientes presentaron toxicidad hepática durante el tratamiento y en 3 de los casos tuvo que suspenderse. Sólo la duración de la quimioprofilaxis se asoció de forma independiente con el desarrollo de hepatotoxicidad <span class="elsevierStyleItalic">(odds ratio =</span> 3,80; intervalo de confianza del 95%, 1,10-13,13; p = 0,03).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio demuestra la efectividad de un programa específico de estudio y seguimiento de los contactos de pacientes con tuberculosis. Los inmigrantes requieren estrategias individuales para mejorar su adherencia al programa. La duración de la quimioprofilaxis es un factor importante en el desarrollo de hepatotoxicidad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Documento de consenso sobre el estudio de los contactos en los pacientes tuberculosos" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Grupo de Estudio de Contactos de la Unidad de Investigación en Tuberculosis de Barcelona (UITB)" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1999" "volumen" => "112" "paginaInicial" => "151" "paginaFinal" => "156" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculin sensitivity and the BCG scar in tuberculosis contacts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H Jonson" 1 => "B Lee" 2 => "E Doherty" 3 => "E Kelley" 4 => "T McDonnell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Tuberc LungDis." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 3 | 9 |
| 2024 October | 28 | 17 | 45 |
| 2024 September | 32 | 16 | 48 |
| 2024 August | 55 | 41 | 96 |
| 2024 July | 23 | 28 | 51 |
| 2024 June | 34 | 30 | 64 |
| 2024 May | 30 | 27 | 57 |
| 2024 April | 22 | 22 | 44 |
| 2024 March | 22 | 12 | 34 |
| 2024 February | 15 | 19 | 34 |
| 2023 March | 0 | 1 | 1 |
| 2023 February | 19 | 22 | 41 |
| 2023 January | 15 | 24 | 39 |
| 2022 December | 17 | 25 | 42 |
| 2022 November | 17 | 26 | 43 |
| 2022 October | 13 | 24 | 37 |
| 2022 September | 15 | 30 | 45 |
| 2022 August | 17 | 36 | 53 |
| 2022 July | 17 | 44 | 61 |
| 2022 June | 13 | 29 | 42 |
| 2022 May | 16 | 30 | 46 |
| 2022 April | 18 | 27 | 45 |
| 2022 March | 18 | 32 | 50 |
| 2022 February | 17 | 26 | 43 |
| 2022 January | 11 | 30 | 41 |
| 2021 December | 12 | 34 | 46 |
| 2021 November | 13 | 28 | 41 |
| 2021 October | 13 | 43 | 56 |
| 2021 September | 11 | 36 | 47 |
| 2021 August | 10 | 26 | 36 |
| 2021 July | 11 | 32 | 43 |
| 2021 June | 14 | 22 | 36 |
| 2021 May | 21 | 24 | 45 |
| 2021 April | 16 | 47 | 63 |
| 2021 March | 26 | 18 | 44 |
| 2021 February | 8 | 23 | 31 |
| 2021 January | 8 | 13 | 21 |
| 2020 December | 8 | 19 | 27 |
| 2020 November | 9 | 11 | 20 |
| 2020 October | 9 | 7 | 16 |
| 2020 September | 2 | 5 | 7 |
| 2020 August | 8 | 11 | 19 |
| 2020 July | 9 | 12 | 21 |
| 2020 June | 0 | 8 | 8 |
| 2020 May | 10 | 15 | 25 |
| 2020 April | 12 | 11 | 23 |
| 2020 March | 7 | 14 | 21 |
| 2020 February | 10 | 17 | 27 |
| 2020 January | 16 | 13 | 29 |
| 2019 December | 10 | 12 | 22 |
| 2019 November | 18 | 15 | 33 |
| 2019 October | 9 | 8 | 17 |
| 2019 September | 7 | 14 | 21 |
| 2019 August | 16 | 9 | 25 |
| 2019 July | 8 | 14 | 22 |
| 2019 June | 8 | 23 | 31 |
| 2019 May | 11 | 22 | 33 |
| 2019 April | 10 | 46 | 56 |
| 2019 March | 13 | 20 | 33 |
| 2019 February | 5 | 15 | 20 |
| 2019 January | 10 | 10 | 20 |
| 2018 December | 9 | 20 | 29 |
| 2018 November | 34 | 10 | 44 |
| 2018 October | 41 | 14 | 55 |
| 2018 September | 8 | 9 | 17 |
| 2018 May | 9 | 1 | 10 |
| 2018 April | 3 | 4 | 7 |
| 2018 March | 5 | 2 | 7 |
| 2018 February | 6 | 7 | 13 |
| 2018 January | 1 | 3 | 4 |
| 2017 December | 5 | 4 | 9 |
| 2017 November | 3 | 4 | 7 |
| 2017 October | 5 | 5 | 10 |
| 2017 September | 10 | 11 | 21 |
| 2017 August | 9 | 8 | 17 |
| 2017 July | 8 | 7 | 15 |
| 2017 June | 10 | 27 | 37 |
| 2017 May | 7 | 5 | 12 |
| 2017 April | 9 | 10 | 19 |
| 2017 March | 7 | 23 | 30 |
| 2017 February | 3 | 1 | 4 |
| 2017 January | 2 | 4 | 6 |
| 2016 December | 9 | 6 | 15 |
| 2016 November | 9 | 5 | 14 |
| 2016 October | 13 | 9 | 22 |
| 2016 September | 17 | 6 | 23 |
| 2016 August | 20 | 5 | 25 |
| 2016 July | 7 | 5 | 12 |
| 2016 March | 5 | 0 | 5 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 53 | 1 | 54 |
| 2015 September | 64 | 8 | 72 |
| 2015 August | 48 | 5 | 53 |
| 2015 July | 88 | 6 | 94 |
| 2015 June | 29 | 6 | 35 |
| 2015 May | 57 | 7 | 64 |
| 2015 April | 23 | 5 | 28 |
| 2015 March | 28 | 6 | 34 |
| 2015 February | 34 | 1 | 35 |
| 2015 January | 28 | 4 | 32 |
| 2014 December | 22 | 3 | 25 |
| 2014 November | 25 | 5 | 30 |
| 2014 October | 55 | 7 | 62 |
| 2014 September | 28 | 5 | 33 |
| 2014 August | 31 | 8 | 39 |
| 2014 July | 29 | 6 | 35 |
| 2014 June | 37 | 9 | 46 |
| 2014 May | 35 | 4 | 39 |
| 2014 April | 43 | 4 | 47 |
| 2014 March | 39 | 12 | 51 |
| 2014 February | 40 | 5 | 45 |
| 2014 January | 33 | 8 | 41 |
| 2013 December | 30 | 9 | 39 |
| 2013 November | 22 | 5 | 27 |
| 2013 October | 34 | 5 | 39 |
| 2013 September | 31 | 11 | 42 |
| 2013 August | 28 | 7 | 35 |
| 2013 July | 49 | 8 | 57 |
| 2013 June | 27 | 6 | 33 |
| 2013 May | 30 | 3 | 33 |
| 2013 April | 17 | 6 | 23 |
| 2013 March | 5 | 2 | 7 |
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