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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Lung preservation quality is a crucial factor in the success of a lung transplant&#46; In October 2000 we stopped using Euro-Collins &#40;EC&#41; lung preservation solution and began using a low potassium dextran solution &#40;Perfadex &#91;PER&#93;&#41;&#46; The objective of the present study was to assess outcome with the 2 solutions&#46;</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed the results of 68 lung transplants in which PER was used and compared the results with those of a historical control group consisting of the same number of transplants in which EC was used&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There were no significant differences in the ages and diagnoses of the recipients in the 2 groups&#46; Waiting list time was longer in the PER group&#46; The most frequent cause of donor death in the EC group was craniocerebral trauma &#40;62&#37;&#41;&#44; whereas in the PER group it was cerebral hemorrhage &#40;54&#37;&#41;&#46; In the PER group more double lung transplants were performed than in the EC group &#40;78&#37; and 53&#37; respectively&#59; <span class="elsevierStyleItalic">P</span> &#61; &#46;002&#41;&#46; There were no differences in the use of extracorporal circulation or ischemia time between the 2 groups&#46; Early graft function&#44; based on the patient&#39;s oxygenation index &#40;ratio of PaO<span class="elsevierStyleInf">2</span> to inspired oxygen fraction &#91;FiO<span class="elsevierStyleInf">2</span>&#93;&#41; on arrival at the intensive care unit&#44; was similar in the 2 groups&#46; The incidence of severe graft failure &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#60;150 mm Hg&#41; was significantly lower in the PER group than in the EC group &#40;16&#37; and 37&#37; respectively&#59; <span class="elsevierStyleItalic">P</span> &#61; &#46;01&#41;&#46; No significant differences in hours of mechanical ventilation or postoperative mortality between the 2 patient series were found&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Use of the newer lung preservation solution &#8212;PER&#8212; led to a 50&#37; lower incidence of severe ischemia -reperfusion graft injury during the early recovery from lung transplantation&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Mejoras en la preservaci&#243;n pulmonar&#46; Tres a&#241;os de experiencia con una soluci&#243;n de dextrano bajo en potasio</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La calidad de la preservaci&#243;n pulmonar es uno de los aspectos m&#225;s determinantes en el &#233;xito del trasplante pulmonar&#46; En octubre del a&#241;o 2000 modificamos nuestra so-luci&#243;n de preservaci&#243;n pulmonar&#44; que hasta entonces era el Euro-Collins &#40;EC&#41;&#44; y comenzamos a utilizar una soluci&#243;n de dextrano bajo en potasio&#44; comercializada como Perfadex &#40;PER&#41;&#46; El objetivo de este estudio es analizar los resultados de ambos m&#233;todos&#46;</p> <span class="elsevierStyleSectionTitle">Material y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos analizado los resultados de 68 trasplantes pulmonares con PER y los hemos comparado con los de una serie retrospectiva del mismo n&#250;mero de trasplantes realizados con EC&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">NO existen diferencias significativas respecto a la edad o el diagn&#243;stico de los receptores entre ambos grupos&#46; El tiempo en lista de espera fue mayor en el grupo de PER&#46; La causa de muerte del donante m&#225;s frecuente del grupo EC fue el traumatismo craneoencef&#225;lico &#40;62&#37;&#41;&#44; mientras que en el grupo de PER fue la hemorragia cerebral &#40;54&#37;&#41;&#46; En el grupo de PER se realizaron m&#225;s trasplantes bi-pulmonares que en el de EC &#40;el 78 y el 53 &#37;&#44; respectivamente&#59; p &#61; 0&#44;002&#41;&#46; No hay diferencias en la indicaci&#243;n de circulaci&#243;n extracorp&#243;rea o tiempos de isquemia entre ambos grupos&#46; Se evalu&#243; la funci&#243;n pulmonar temprana a trav&#233;s del &#237;ndice de oxigenaci&#243;n &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41; a la llegada a la uni-dad de cuidados intensivos&#44; que fue comparable entre ambos grupos&#46; La incidencia de disfunci&#243;n grave del injerto &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> &#60; 150 mmHg&#41; fue significativamente inferior en el grupo de PER frente al de EC &#40;el 16 y el 37&#37;&#44; respectivamente&#59; p &#61; 0&#44;01&#41;&#46; No encontramos diferencias significativas respecto a las horas de ventilaci&#243;n mec&#225;nica ni en cuanto a la mortalidad postoperatoria entre las 2 series&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Con la aplicaci&#243;n cl&#237;nica de esta nueva soluci&#243;n de preservaci&#243;n pulmonar se obtiene una reducci&#243;n del 50&#37; en la incidencia de la lesi&#243;n de isquemia-reperfusi&#243;n grave del injerto en el postoperatorio inmediato del trasplante pulmonar&#46;</p>"
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Original Article
Improvements in Lung Preservation: 3 Years' Experience With a Low-Potassium Dextran Solution
P. Gámeza,
Corresponding author
pgamez.hpth@salud.madrid.org

Correspondence: Dr. P. Gámez García. Servicio de Cirugía Torácica y Cardiovascular. Hospital Universitario Puerta de Hierro. San Martín de Porres, 4. 28035 Madrid. España
, M. Córdobaa, I. Millánb, L. Madrigala, F. Alfagemea, R. Álvareza, I. Núñeza, A. Varelaa
a Servicio de Cirugía Torácica y Cardiovascular, Hospital Universitario Puerta de Hierro, Madrid, Spain
b Servicio de Estadística, Hospital Universitario Puerta de Hierro, Madrid, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La calidad de la preservaci&#243;n pulmonar es uno de los aspectos m&#225;s determinantes en el &#233;xito del trasplante pulmonar&#46; En octubre del a&#241;o 2000 modificamos nuestra so-luci&#243;n de preservaci&#243;n pulmonar&#44; que hasta entonces era el Euro-Collins &#40;EC&#41;&#44; y comenzamos a utilizar una soluci&#243;n de dextrano bajo en potasio&#44; comercializada como Perfadex &#40;PER&#41;&#46; El objetivo de este estudio es analizar los resultados de ambos m&#233;todos&#46;</p> <span class="elsevierStyleSectionTitle">Material y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos analizado los resultados de 68 trasplantes pulmonares con PER y los hemos comparado con los de una serie retrospectiva del mismo n&#250;mero de trasplantes realizados con EC&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">NO existen diferencias significativas respecto a la edad o el diagn&#243;stico de los receptores entre ambos grupos&#46; El tiempo en lista de espera fue mayor en el grupo de PER&#46; La causa de muerte del donante m&#225;s frecuente del grupo EC fue el traumatismo craneoencef&#225;lico &#40;62&#37;&#41;&#44; mientras que en el grupo de PER fue la hemorragia cerebral &#40;54&#37;&#41;&#46; En el grupo de PER se realizaron m&#225;s trasplantes bi-pulmonares que en el de EC &#40;el 78 y el 53 &#37;&#44; respectivamente&#59; p &#61; 0&#44;002&#41;&#46; No hay diferencias en la indicaci&#243;n de circulaci&#243;n extracorp&#243;rea o tiempos de isquemia entre ambos grupos&#46; Se evalu&#243; la funci&#243;n pulmonar temprana a trav&#233;s del &#237;ndice de oxigenaci&#243;n &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41; a la llegada a la uni-dad de cuidados intensivos&#44; que fue comparable entre ambos grupos&#46; La incidencia de disfunci&#243;n grave del injerto &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> &#60; 150 mmHg&#41; fue significativamente inferior en el grupo de PER frente al de EC &#40;el 16 y el 37&#37;&#44; respectivamente&#59; p &#61; 0&#44;01&#41;&#46; No encontramos diferencias significativas respecto a las horas de ventilaci&#243;n mec&#225;nica ni en cuanto a la mortalidad postoperatoria entre las 2 series&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Con la aplicaci&#243;n cl&#237;nica de esta nueva soluci&#243;n de preservaci&#243;n pulmonar se obtiene una reducci&#243;n del 50&#37; en la incidencia de la lesi&#243;n de isquemia-reperfusi&#243;n grave del injerto en el postoperatorio inmediato del trasplante pulmonar&#46;</p>"
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