Original Articles
Study of Mucociliary Transport and Nasal Ciliary Ultrastructure in Patients With Kartagener's Syndrome
M. Armengot Carcellera,
, C. Carda Batallab, A. Escribanoc, G.J. Samperd
Corresponding author
miar@eresmas.net
Correspondence: Dr. M. Armengot Carceller. Mediterrani, 33. 46134 Foios. Valencia. España
Correspondence: Dr. M. Armengot Carceller. Mediterrani, 33. 46134 Foios. Valencia. España
a Servicio de Otorrinolaringología, Hospital General Universitario, Facultad de Medicina, Valencia, Spain
b Departamento de Patología, Facultad de Medicina, Valencia, Spain
c Servicio de Pediatría, Hospital Clínico Universitario, Facultad de Medicina, Valencia, Spain
d Servicio de Neumología, Hospital General Universitario, Facultad de Medicina, Valencia, Spain
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"apellidos" => "Villasante Fernández-Montes" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290660387X?idApp=UINPBA00003Z" "url" => "/15792129/0000004100000001/v1_201305150128/S157921290660387X/v1_201305150128/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Study of Mucociliary Transport and Nasal Ciliary Ultrastructure in Patients With Kartagener's Syndrome" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "11" "paginaFinal" => "15" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Armengot Carceller, C. Carda Batalla, A. Escribano, G.J. Samper" "autores" => array:4 [ 0 => array:5 [ "preGrado" => "Dr." "nombre" => "M." "apellidos" => "Armengot Carceller" "email" => array:1 [ 0 => "miar@eresmas.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Carda Batalla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Escribano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "G.J." "apellidos" => "Samper" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Otorrinolaringología, Hospital General Universitario, Facultad de Medicina, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Patología, Facultad de Medicina, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Pediatría, Hospital Clínico Universitario, Facultad de Medicina, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Neumología, Hospital General Universitario, Facultad de Medicina, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. M. Armengot Carceller. Mediterrani, 33. 46134 Foios. Valencia. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-01-23" "fechaAceptado" => "2004-05-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153649" "palabras" => array:3 [ 0 => "Primary ciliary dyskinesia" 1 => "Situs inversus" 2 => "Mucociliary function" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153648" "palabras" => array:3 [ 0 => "Discinesia ciliar primaria" 1 => "Situs inversus" 2 => "Función mucociliar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Kartagener's syndrome (KS) is a clinical variant of primary ciliary dyskinesia involving situs inversus associated with chronic airway infections. The ciliary defect associated with this syndrome is the absence of dynein arms. The aim of this study was to evaluate mucociliary transport and ciliary ultrastructure in 14 patients with KS.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We studied nasal mucociliary transport using a radioisotopic technique and ciliary ultrastructure in 14 patients with KS.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Thirteen patients had mucociliary stasis and 1 had severely slowed transport (1.3 mm/min). Four patients (29%) had cilia with normal dynein arms, 2 patients (14%) had short inner dynein arms, and 8 patients (57.1%) had total absence of inner and outer dynein arms.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We conclude that the typical clinical presentation, together with altered mucociliary transport as identified by an isotopic technique, is diagnostic of KS, even when the ciliary ultrastructure is normal. KS is clinically homogenous and morphologically heterogenous.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El síndrome de Kartagener (SK) es una variante clínica de la discinesia ciliar primaria que asocia a las infecciones crónicas de las vías respiratorias un <span class="elsevierStyleItalic">situs inversus.</span> La ausencia de brazos de dineína ha sido el defecto ciliar asociado a este síndrome. El objeto de este trabajo es el estudio del transporte mucociliar y de la ultraestructura ciliar en 14 pacientes con SK.</p> <span class="elsevierStyleSectionTitle">Pacientes Y Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado el transporte mucociliar nasal, mediante una técnica radioisotópica, y la ultraestructura ciliar en 14 pacientes con SK.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En 13 pacientes había estasis mucociliar y en uno, un transporte muy enlentecido (1,3 mm/min). Mostraban cilios con brazos de dineína normales 4 pacientes (29%); brazos internos de dineína cortos, 2 pacientes (14%), y ausencia completa de brazos internos y externos de dineína, 8 casos (57,1 %).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Concluimos que la presentación clínica típica junto con un transporte mucociliar alterado, objetivado con una técnica isotópica, es diagnóstica del SK, aunque la ultraestructura ciliar sea normal. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 3 | 7 |
| 2024 October | 28 | 17 | 45 |
| 2024 September | 35 | 17 | 52 |
| 2024 August | 47 | 35 | 82 |
| 2024 July | 25 | 28 | 53 |
| 2024 June | 36 | 22 | 58 |
| 2024 May | 31 | 28 | 59 |
| 2024 April | 14 | 24 | 38 |
| 2024 March | 22 | 12 | 34 |
| 2024 February | 14 | 14 | 28 |
| 2023 March | 0 | 1 | 1 |
| 2023 February | 15 | 20 | 35 |
| 2023 January | 19 | 25 | 44 |
| 2022 December | 13 | 19 | 32 |
| 2022 November | 14 | 20 | 34 |
| 2022 October | 21 | 31 | 52 |
| 2022 September | 11 | 26 | 37 |
| 2022 August | 14 | 34 | 48 |
| 2022 July | 18 | 42 | 60 |
| 2022 June | 11 | 25 | 36 |
| 2022 May | 15 | 30 | 45 |
| 2022 April | 20 | 29 | 49 |
| 2022 March | 28 | 33 | 61 |
| 2022 February | 31 | 22 | 53 |
| 2022 January | 14 | 31 | 45 |
| 2021 December | 20 | 40 | 60 |
| 2021 November | 17 | 35 | 52 |
| 2021 October | 31 | 45 | 76 |
| 2021 September | 22 | 37 | 59 |
| 2021 August | 12 | 29 | 41 |
| 2021 July | 17 | 33 | 50 |
| 2021 June | 17 | 33 | 50 |
| 2021 May | 13 | 19 | 32 |
| 2021 April | 47 | 53 | 100 |
| 2021 March | 16 | 14 | 30 |
| 2021 February | 19 | 16 | 35 |
| 2021 January | 13 | 17 | 30 |
| 2020 December | 14 | 14 | 28 |
| 2020 November | 10 | 11 | 21 |
| 2020 October | 10 | 3 | 13 |
| 2020 September | 9 | 2 | 11 |
| 2020 August | 9 | 5 | 14 |
| 2020 July | 13 | 13 | 26 |
| 2020 June | 4 | 11 | 15 |
| 2020 May | 15 | 18 | 33 |
| 2020 April | 14 | 7 | 21 |
| 2020 March | 15 | 10 | 25 |
| 2020 February | 9 | 14 | 23 |
| 2020 January | 15 | 17 | 32 |
| 2019 December | 16 | 15 | 31 |
| 2019 November | 13 | 27 | 40 |
| 2019 October | 4 | 6 | 10 |
| 2019 September | 7 | 20 | 27 |
| 2019 August | 10 | 13 | 23 |
| 2019 July | 13 | 25 | 38 |
| 2019 June | 2 | 18 | 20 |
| 2019 May | 8 | 19 | 27 |
| 2019 April | 10 | 20 | 30 |
| 2019 March | 7 | 24 | 31 |
| 2019 February | 9 | 11 | 20 |
| 2019 January | 5 | 8 | 13 |
| 2018 December | 5 | 12 | 17 |
| 2018 November | 16 | 11 | 27 |
| 2018 October | 25 | 18 | 43 |
| 2018 September | 9 | 10 | 19 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 7 | 6 | 13 |
| 2018 March | 3 | 3 | 6 |
| 2018 February | 7 | 9 | 16 |
| 2018 January | 5 | 3 | 8 |
| 2017 December | 10 | 9 | 19 |
| 2017 November | 2 | 2 | 4 |
| 2017 October | 3 | 5 | 8 |
| 2017 September | 5 | 9 | 14 |
| 2017 August | 5 | 12 | 17 |
| 2017 July | 6 | 10 | 16 |
| 2017 June | 10 | 14 | 24 |
| 2017 May | 5 | 8 | 13 |
| 2017 April | 2 | 5 | 7 |
| 2017 March | 1 | 17 | 18 |
| 2017 February | 2 | 1 | 3 |
| 2017 January | 2 | 5 | 7 |
| 2016 December | 10 | 10 | 20 |
| 2016 November | 12 | 9 | 21 |
| 2016 October | 12 | 13 | 25 |
| 2016 September | 22 | 12 | 34 |
| 2016 August | 20 | 4 | 24 |
| 2016 July | 7 | 5 | 12 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2016 January | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 56 | 1 | 57 |
| 2015 September | 56 | 11 | 67 |
| 2015 August | 44 | 9 | 53 |
| 2015 July | 47 | 5 | 52 |
| 2015 June | 45 | 4 | 49 |
| 2015 May | 49 | 11 | 60 |
| 2015 April | 29 | 8 | 37 |
| 2015 March | 45 | 7 | 52 |
| 2015 February | 39 | 5 | 44 |
| 2015 January | 27 | 7 | 34 |
| 2014 December | 38 | 5 | 43 |
| 2014 November | 46 | 5 | 51 |
| 2014 October | 71 | 7 | 78 |
| 2014 September | 52 | 7 | 59 |
| 2014 August | 58 | 7 | 65 |
| 2014 July | 45 | 8 | 53 |
| 2014 June | 66 | 9 | 75 |
| 2014 May | 44 | 9 | 53 |
| 2014 April | 57 | 5 | 62 |
| 2014 March | 65 | 15 | 80 |
| 2014 February | 59 | 14 | 73 |
| 2014 January | 43 | 5 | 48 |
| 2013 December | 41 | 10 | 51 |
| 2013 November | 52 | 8 | 60 |
| 2013 October | 49 | 10 | 59 |
| 2013 September | 50 | 12 | 62 |
| 2013 August | 43 | 6 | 49 |
| 2013 July | 46 | 10 | 56 |
| 2013 June | 42 | 6 | 48 |
| 2013 May | 47 | 7 | 54 |
| 2013 April | 35 | 16 | 51 |
| 2013 March | 10 | 1 | 11 |
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