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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The ratio of PaO<span class="elsevierStyleInf">2</span> to the fraction of inspired oxygen &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span>&#41; is commonly used to determine the severity of acute lung injury and acute respiratory distress syndrome &#40;ARDS&#41;&#46; The research presented here used computational models of the lung to analyze the effect of altitude on the PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span> ratio and pulmonary shunt&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">At a given shunt&#44; the PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span> ratio is lower at higher altitudes&#46; Therefore&#44; when evaluating for ARDS based on a PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span> ratio of &#60;200 mm Hg&#44; patients residing at high altitudes will have less shunt and&#44; presumably&#44; less severe lung injury than patients at sea level&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">This should be taken into consideration when comparing patients from different altitudes&#46; Shunt should more often be measured directly or be estimated assuming a constant arteriovenous oxygen content difference&#46;</p>"
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Original Articles
Altitude, the Ratio of PaO2 to Fraction of Inspired Oxygen, and Shunt: Impact on the Assessment of Acute Lung Injury
J.R. Pérez-Padilla
Corresponding author
perezpad@servidor.unam.mx

Correspondence: Dr. J.R. Pérez-Padilla. Departamento de Fisiología Pulmonar y Clínica de Sueño. Instituto Nacional de Enfermedades Respiratorias. Tlalpan 4502. México DF. México
Departamento de Fisiología Pulmonar and Clínica de Sueño, Instituto Nacional de Enfermedades Respiratorias, México DF, Mexico
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            2 => "PaO2&#47;FiO<span class="elsevierStyleInf">2</span>"
            3 => "S&#237;ndrome de insuficiencia respiratoria progresiva del adulto &#40;SIR-PA&#41;"
            4 => "Altitud"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The ratio of PaO<span class="elsevierStyleInf">2</span> to the fraction of inspired oxygen &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span>&#41; is commonly used to determine the severity of acute lung injury and acute respiratory distress syndrome &#40;ARDS&#41;&#46; The research presented here used computational models of the lung to analyze the effect of altitude on the PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span> ratio and pulmonary shunt&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">At a given shunt&#44; the PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span> ratio is lower at higher altitudes&#46; Therefore&#44; when evaluating for ARDS based on a PaO<span class="elsevierStyleInf">2</span>&#47;FIO<span class="elsevierStyleInf">2</span> ratio of &#60;200 mm Hg&#44; patients residing at high altitudes will have less shunt and&#44; presumably&#44; less severe lung injury than patients at sea level&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">This should be taken into consideration when comparing patients from different altitudes&#46; Shunt should more often be measured directly or be estimated assuming a constant arteriovenous oxygen content difference&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El cociente presi&#243;n arterial de ox&#237;geno&#47;fracci&#243;n inspiratoria de ox&#237;geno &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41; se utiliza com&#250;nmente para definir el grado de lesi&#243;n pulmonar y el s&#237;ndrome de insuficiencia respiratoria progresiva del adulto&#46; En el presente trabajo se analizan las modificaciones que experimenta el &#237;ndice con la altura sobre el nivel del mar y con los cortocircuitos en modelos computacionales de pulm&#243;n&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">El cociente PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> disminuye con la altura sobre el nivel del mar al mismo cortocircuito&#46; Por lo tanto&#44; los pacientes que residen a alturas considerables sobre el nivel del mar tienen un cortocircuito menor y presumiblemente un grado de da&#241;o pulmonar menor que los residentes al nivel del mar en el momento de cumplir el criterio de s&#237;ndrome de insuficiencia respiratoria progresiva del adulto con un cociente PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> de 200 Torr&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Esta variaci&#243;n debe tomarse en cuenta para la comparaci&#243;n de pacientes cuando provienen de alturas diferentes e indica que se ha de utilizar m&#225;s frecuentemente la medici&#243;n directa del cortocircuito o bien el cortocircuito calculado&#44; asumiendo una diferencia arteriovenosa del contenido de ox&#237;geno constante&#46;</p>"
      ]
    ]
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Article information
ISSN: 15792129
Original language: English
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