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Human Leukocyte Antigens A and B in Turkish Patients With Sarcoidosis
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"apellidos" => "Solsona Peiró" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603558?idApp=UINPBA00003Z" "url" => "/15792129/0000004000000010/v1_201305141820/S1579212906603558/v1_201305141820/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212906603534" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60353-4" "estado" => "S300" "fechaPublicacion" => "2004-10-01" "aid" => "60353" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2004;40:443-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2316 "formatos" => array:3 [ "EPUB" => 96 "HTML" => 1566 "PDF" => 654 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Four-Year Results After Lung Volume Reduction Surgery for Emphysema" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "443" "paginaFinal" => "448" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "G. Juan Samper, M. Ramón Capilla, A. Cantó Armengol, M.L. Martínez Pérez, T. Lloret Pérez, E. Rubio Gomis, J. Marín Pardo" "autores" => array:7 [ 0 => array:3 [ "preGrado" => "Prof" "nombre" => "G." "apellidos" => "Juan Samper" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Ramón Capilla" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Cantó Armengol" ] 3 => array:2 [ "nombre" => "M.L." "apellidos" => "Martínez Pérez" ] 4 => array:2 [ "nombre" => "T." "apellidos" => "Lloret Pérez" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Rubio Gomis" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Marín Pardo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603534?idApp=UINPBA00003Z" "url" => "/15792129/0000004000000010/v1_201305141820/S1579212906603534/v1_201305141820/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Human Leukocyte Antigens A and B in Turkish Patients With Sarcoidosis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "449" "paginaFinal" => "452" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "G. Çelik, E. Şen, A.F. Ülger, Ö. Özdemir-Kumbasar, D. Alper, A.H. Elhan, H. Tutkak, A. Çetinyürek" "autores" => array:8 [ 0 => array:5 [ "preGrado" => "Prof" "nombre" => "G." "apellidos" => "Çelik" "email" => array:1 [ 0 => "celik@medicine.ankara.edu.tr" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "Şen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "A.F." "apellidos" => "Ülger" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Ö." "apellidos" => "Özdemir-Kumbasar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "D." "apellidos" => "Alper" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "A.H." "apellidos" => "Elhan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 6 => array:3 [ "nombre" => "H." "apellidos" => "Tutkak" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 7 => array:3 [ "nombre" => "A." "apellidos" => "Çetinyürek" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Pulmonary Disease and Tuberculosis, School of Medicine, Ankara University, Ankara, Turkey" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Department of Biostatistics, School of Medicine, Ankara University, Ankara, Turkey" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Department of Immunology, School of Medicine, Ankara University, Ankara, Turkey" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Assoc. Prof G. Çelik. Kazakistan cad. 102/14 Emek, 06510. Ankara. Turkey" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-11-11" "fechaAceptado" => "2004-04-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153130" "palabras" => array:3 [ 0 => "Human leukocyte antigens" 1 => "Sarcoidosis" 2 => "Turkish patients" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153131" "palabras" => array:3 [ 0 => "Antígenos HLA" 1 => "Sarcoidosis" 2 => "Pacientes turcos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Associations between human leukocyte antigens (HLA) and sarcoidosis have been reported in several studies. We aimed to investigate these associations in Turkish patients.</p> <span class="elsevierStyleSectionTitle">Patients and Method</span><p class="elsevierStyleSimplePara elsevierViewall">We performed HLA-A, HLA-B, HLA-C, and HLA-D typing in 83 patients with sarcoidosis and in 250 healthy controls using a microlymphocytotoxicity method to investigate genetic susceptibility to the disease.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Because of significant violation of Hardy-Weinberg equilibrium at HLA-C and HLA-DQB1 loci, only results obtained at other HLA loci were used. Although HLA-A9, HLA-B5, and HLA-B8 allele frequencies were significantly higher in the patient group compared to the controls (odds ratio [OR]= 21.8, <span class="elsevierStyleItalic">P</span> = .015; OR=9.34, <span class="elsevierStyleItalic">P</span> = .049; OR=2.26, <span class="elsevierStyleItalic">P</span> = .031, respectively), none of the differences remained significant after applying the Bonferroni correction. HLA-A24, HLA-A26, and HLA-B62 alleles were significantly less frequent in the patient group compared to the controls (OR=0.48, <span class="elsevierStyleItalic">P</span> = .018; OR=0.19, <span class="elsevierStyleItalic">P</span> = .003; OR= 0.11, <span class="elsevierStyleItalic">P</span> = .044, respectively). However, the differences also failed to remain significant after Bonferroni correction.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">These results suggest that both HLA may play significant roles (either increasing or reducing risk) in the pathogenesis of sarcoidosis and in its distinct clinical forms and laboratory findings.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">En varios estudios se ha demostrado la existen-cia de asociaciones entre los antígenos leucocitarios humanos (HLA) y la sarcoidosis. El objetivo de nuestro estudio ha sido la investigación de estas asociaciones en pacientes turcos.</p> <span class="elsevierStyleSectionTitle">Pacientes Y Método</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado la tipificación HLA-A, HLA-B, HLA-C y HLA-C en 83 pacientes con sarcoidosis y en 250 controles sanos mediante un método de microlinfo-citotoxicidad, con objeto de determinar la susceptibilidad frente a la enfermedad.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Debido a la importante violación del equili-brio de Hardy-Weinberg en los <span class="elsevierStyleItalic">loci</span> HLA-C y HLA-DQB1, sólo se utilizaron los resultados obtenidos en los demás <span class="elsevierStyleItalic">loci</span> HLA. Aunque las frecuencias de los alelos HLA-A9, HLA-B5 y HLA-B8 fueron significativamente mayores en el gru-po de pacientes que en el grupo control (cociente de posibili-dades [CP] = 21,8, p = 0,015; CP = 9,34, p = 0,049; CP = 2,26, p = 0,031, respectivamente), ninguna de estas diferen-cias mantuvo la significación estadística tras la aplicación de la corrección de Bonferroni. Los alelos HLA-A24, HLA-A26 y HLA-B62 fueron significativamente menos frecuentes en el grupo de pacientes que en el grupo de controles (CP = 0,48, p = 0,018; CP = 0,19, p = 0,003; CP = 0,11, p = 0,044, respectivamente). Sin embargo, las diferencias tampoco fueron estadísticamente significativas después de la corrección de Bonferroni.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Estos resultados indican que los HLA pueden desempeñar una función significativa (con aumento o reducción del riesgo) en la patogenia de la sarcoidosis, así como en sus diferentes formas clínicas y en sus alteraciones analíticas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLADRB1<span class="elsevierStyleSup">*</span>03, DRB1<span class="elsevierStyleSup">*</span>11 or DRB1<span class="elsevierStyleSup">*</span>12 and their respective DRB3 specificities in clinical variants of sarcoidosis" "autores" => array:1 [ 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 34 | 12 | 46 |
| 2024 September | 27 | 17 | 44 |
| 2024 August | 44 | 36 | 80 |
| 2024 July | 27 | 23 | 50 |
| 2024 June | 31 | 25 | 56 |
| 2024 May | 32 | 26 | 58 |
| 2024 April | 17 | 21 | 38 |
| 2024 March | 17 | 14 | 31 |
| 2024 February | 15 | 19 | 34 |
| 2023 March | 4 | 5 | 9 |
| 2023 February | 13 | 23 | 36 |
| 2023 January | 14 | 28 | 42 |
| 2022 December | 16 | 26 | 42 |
| 2022 November | 17 | 17 | 34 |
| 2022 October | 19 | 35 | 54 |
| 2022 September | 12 | 23 | 35 |
| 2022 August | 20 | 32 | 52 |
| 2022 July | 20 | 40 | 60 |
| 2022 June | 20 | 27 | 47 |
| 2022 May | 15 | 29 | 44 |
| 2022 April | 21 | 27 | 48 |
| 2022 March | 20 | 41 | 61 |
| 2022 February | 17 | 22 | 39 |
| 2022 January | 14 | 29 | 43 |
| 2021 December | 16 | 38 | 54 |
| 2021 November | 16 | 39 | 55 |
| 2021 October | 10 | 34 | 44 |
| 2021 September | 9 | 42 | 51 |
| 2021 August | 12 | 38 | 50 |
| 2021 July | 6 | 24 | 30 |
| 2021 June | 15 | 31 | 46 |
| 2021 May | 11 | 24 | 35 |
| 2021 April | 17 | 21 | 38 |
| 2021 March | 24 | 23 | 47 |
| 2021 February | 8 | 14 | 22 |
| 2021 January | 7 | 13 | 20 |
| 2020 December | 7 | 11 | 18 |
| 2020 November | 6 | 17 | 23 |
| 2020 October | 5 | 10 | 15 |
| 2020 September | 4 | 2 | 6 |
| 2020 August | 6 | 7 | 13 |
| 2020 July | 14 | 20 | 34 |
| 2020 June | 15 | 22 | 37 |
| 2020 May | 15 | 21 | 36 |
| 2020 April | 12 | 18 | 30 |
| 2020 March | 12 | 14 | 26 |
| 2020 February | 11 | 10 | 21 |
| 2020 January | 11 | 20 | 31 |
| 2019 December | 10 | 12 | 22 |
| 2019 November | 7 | 11 | 18 |
| 2019 October | 4 | 12 | 16 |
| 2019 September | 4 | 12 | 16 |
| 2019 August | 11 | 8 | 19 |
| 2019 July | 8 | 16 | 24 |
| 2019 June | 7 | 9 | 16 |
| 2019 May | 11 | 9 | 20 |
| 2019 April | 21 | 21 | 42 |
| 2019 March | 14 | 21 | 35 |
| 2019 February | 7 | 15 | 22 |
| 2019 January | 9 | 9 | 18 |
| 2018 December | 4 | 20 | 24 |
| 2018 November | 17 | 14 | 31 |
| 2018 October | 25 | 24 | 49 |
| 2018 September | 7 | 17 | 24 |
| 2018 May | 3 | 1 | 4 |
| 2018 April | 4 | 10 | 14 |
| 2018 March | 3 | 5 | 8 |
| 2018 February | 3 | 7 | 10 |
| 2018 January | 7 | 10 | 17 |
| 2017 December | 5 | 6 | 11 |
| 2017 November | 1 | 4 | 5 |
| 2017 October | 6 | 12 | 18 |
| 2017 September | 2 | 7 | 9 |
| 2017 August | 9 | 13 | 22 |
| 2017 July | 3 | 4 | 7 |
| 2017 June | 10 | 24 | 34 |
| 2017 May | 9 | 12 | 21 |
| 2017 April | 3 | 4 | 7 |
| 2017 March | 3 | 8 | 11 |
| 2017 February | 1 | 5 | 6 |
| 2017 January | 2 | 2 | 4 |
| 2016 December | 9 | 5 | 14 |
| 2016 November | 11 | 11 | 22 |
| 2016 October | 16 | 9 | 25 |
| 2016 September | 11 | 10 | 21 |
| 2016 August | 11 | 5 | 16 |
| 2016 July | 5 | 5 | 10 |
| 2016 March | 3 | 0 | 3 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 33 | 1 | 34 |
| 2015 September | 33 | 13 | 46 |
| 2015 August | 29 | 12 | 41 |
| 2015 July | 31 | 9 | 40 |
| 2015 June | 39 | 6 | 45 |
| 2015 May | 37 | 3 | 40 |
| 2015 April | 30 | 12 | 42 |
| 2015 March | 32 | 7 | 39 |
| 2015 February | 30 | 5 | 35 |
| 2015 January | 38 | 7 | 45 |
| 2014 December | 28 | 8 | 36 |
| 2014 November | 13 | 7 | 20 |
| 2014 October | 44 | 10 | 54 |
| 2014 September | 26 | 9 | 35 |
| 2014 August | 26 | 10 | 36 |
| 2014 July | 32 | 7 | 39 |
| 2014 June | 39 | 7 | 46 |
| 2014 May | 35 | 6 | 41 |
| 2014 April | 40 | 9 | 49 |
| 2014 March | 42 | 10 | 52 |
| 2014 February | 35 | 10 | 45 |
| 2014 January | 25 | 6 | 31 |
| 2013 December | 28 | 9 | 37 |
| 2013 November | 22 | 9 | 31 |
| 2013 October | 28 | 8 | 36 |
| 2013 September | 25 | 7 | 32 |
| 2013 August | 26 | 9 | 35 |
| 2013 July | 46 | 13 | 59 |
| 2013 June | 22 | 16 | 38 |
| 2013 May | 30 | 5 | 35 |
| 2013 April | 25 | 8 | 33 |
| 2013 March | 8 | 2 | 10 |
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