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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">While the short-term results of lung volume reduction surgery are known&#44; follow-up over several years has not often been described&#46; The purpose of the present study was to describe results in terms of functional improvement&#44; dyspnea&#44; quality of life&#44; and mortality over a 4-year period in patients with advanced emphysema&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Fourteen successive patients were enrolled between 1996 and 2000 and studied prospectively for 4 years&#46; All patients served as their own controls and initially received pulmonary rehabilitation and medication&#46; Preoperative data were used as baseline and were compared to postoperative data over 4 years&#46; The data analyzed were&#58; functional improvement &#40;forced expiratory volume in 1 second &#91;FEV<span class="elsevierStyleInf">1</span>&#93;&#41;&#44; quality of life&#44; dyspnea&#44; and patient loss due to death or referral to a lung transplantation program&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Patients with advanced emphysema &#40;mean FEV<span class="elsevierStyleInf">1</span> &#91;SD&#93;&#58; 22&#46;8&#37; &#91;11&#37;&#93; of predicted&#41; were studied&#46; Postoperative mortality was 14&#37;&#46; Overall mortality &#40;postoperative plus deaths due to respiratory insufficiency&#41; was 28&#37; at 1 year and 35&#37; at 4 years&#46; Two patients died of cancer and 5 were referred for transplantation&#46; At 3 months&#44; FEV<span class="elsevierStyleInf">1</span> had improved more than 15&#37; in 9 patients &#40;64&#37;&#41;&#59; the improvement was maintained in 43&#37; of patients at 1 year and 7&#37; at 4 years&#46; Improvement in dyspnea paralleled improvement in FEV<span class="elsevierStyleInf">1</span>&#46; Overall&#44; at 3 months mean FEV<span class="elsevierStyleInf">1</span> had improved 41&#46;9&#37; &#40;68&#37;&#41;&#44; transitional dyspnea index 2&#46;7 &#40;3&#41;&#44; and quality of life questionnaire score 1 &#40;0&#46;9&#41;&#46; Thus&#44; improvements were considerable&#44; but there was great variation&#46; Preoperative mean decrease in FEV<span class="elsevierStyleInf">1</span> was 50 &#40;32&#41; mL&#47;y&#44; and postoperative decrease 194 &#40;70&#41; mL&#47;y&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">With the inclusion criteria used&#44; there was considerable variation in the results&#46; Significant overall functional improvement was maintained in 50&#37; of the patients 1 year following surgery and in 7&#37; 4 years after surgery&#46; Given such results&#44; together with a surgical mortality rate of 14&#37; and overall mortality of 28&#37; in the first year&#44; we believe that the criteria for using lung reduction surgery should be revised&#46;</p>"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "348"
                        "paginaInicial" => "2059"
                        "paginaFinal" => "2073"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Emphysema Treatment Trial Research Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMsa030448"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "348"
                        "paginaInicial" => "2092"
                        "paginaFinal" => "2102"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12759480"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A prospective evaluation of lung volume reduction surgery in 200 consecutive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "RD Yusen"
                            1 => "SS Lefrak"
                            2 => "DS Gierada"
                            3 => "GE Davis"
                            4 => "BF Meyers"
                            5 => "GA Patterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "1026"
                        "paginaFinal" => "1037"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12684290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiology of pulmonary emphysema and lung reduction surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "RM Slone"
                            1 => "DS Gierada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Thorac Cardiovasc Surg"
                        "fecha" => "1996"
                        "volumen" => "8"
                        "paginaInicial" => "61"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8679752"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CT measurements of lung density in life can quantitate distal air space enlargement&#58; an essential defining feature of human emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "GA Gould"
                            1 => "W MacNee"
                            2 => "A McLean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/137.2.380"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1988"
                        "volumen" => "137"
                        "paginaInicial" => "380"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3341629"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung volume reduction surgery for severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J Cooper"
                            1 => "G Patterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Thorac Cardiovasc Surg"
                        "fecha" => "1996"
                        "volumen" => "8"
                        "paginaInicial" => "52"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8679751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardization of spirometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1979.119.5.831"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1979"
                        "volumen" => "119"
                        "paginaInicial" => "831"
                        "paginaFinal" => "838"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/453705"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The measurement of dyspnea&#58; contents&#44; interobserver agreement and physiologic correlates of two clinical indexes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "DA Mahler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "85"
                        "paginaInicial" => "751"
                        "paginaFinal" => "758"
                        "itemHostRev" => array:3 [
                          "pii" => "S0300893211002685"
                          "estado" => "S300"
                          "issn" => "03008932"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A measure of quality of life for clinical trials in chronic lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "GH Guyatt"
                            1 => "LB Berman"
                            2 => "M Townsend"
                            3 => "SO Pugsley"
                            4 => "LW Chambers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "773"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3321537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Traducci&#243;n espa&#241;ola y validaci&#243;n de un cuestionario de calidad de vida en pacientes con enfermedad pulmonar obstructiva cr&#243;nica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R G&#252;ell"
                            1 => "P Casan"
                            2 => "J Sangenis"
                            3 => "F Morante"
                            4 => "JM Borras"
                            5 => "G Guyatt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1995"
                        "volumen" => "31"
                        "paginaInicial" => "202"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7788081"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patients at high risk of death after lung-volume-reduction surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Emphysema Treatment Trial Research Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa11798"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2001"
                        "volumen" => "345"
                        "paginaInicial" => "1075"
                        "paginaFinal" => "1083"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11596586"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improvement in pulmonary function and elastic recoil after lung-reduction surgery for diffuse emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "FC Sciurba"
                            1 => "RM Rogers"
                            2 => "RJ Keenan"
                            3 => "WA Slivka"
                            4 => "J Gorcsan"
                            5 => "PF Ferson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1996"
                        "volumen" => "334"
                        "paginaInicial" => "1095"
                        "paginaFinal" => "1099"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The current status of lung volume reduction operations for emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K Naunheim"
                            1 => "MK Ferguson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1996"
                        "volumen" => "62"
                        "paginaInicial" => "601"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8694645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of bullectomy on diaphragm strength"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J Travaline"
                            1 => "P Addonizio"
                            2 => "GJ Giner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.5.7582315"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "1697"
                        "paginaFinal" => "1701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7582315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Int&#233;r&#234;t de l&#39;exploration h&#233;modynamique dans les indications chirurgicales des emphys&#232;mes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M Dahan"
                            1 => "F Salerin"
                            2 => "J Berjaud"
                            3 => "J Renella"
                            4 => "J Gaillart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Chir"
                        "fecha" => "1989"
                        "volumen" => "43"
                        "paginaInicial" => "669"
                        "paginaFinal" => "672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2589802"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short- and long-term functional results after lung volume reduction surgery for severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H Teschler"
                            1 => "AB Thompson"
                            2 => "G Stamatis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "13"
                        "paginaInicial" => "1170"
                        "paginaFinal" => "1176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10414422"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective randomized trial comparing bilateral lung volume reduction surgery to pulmonary rehabilitation in severe chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "GJ Criner"
                            1 => "FC Cordova"
                            2 => "S Furukawa"
                            3 => "AM Kuzma"
                            4 => "JM Travaline"
                            5 => "V Leyenson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.160.6.9902117"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "160"
                        "paginaInicial" => "2018"
                        "paginaFinal" => "2027"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10588623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of lung-volume-reduction surgery in patients with severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D Geddes"
                            1 => "M Davis"
                            2 => "H Koyoma"
                            3 => "D Hansell"
                            4 => "U Pastorino"
                            5 => "J Pepper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200007273430402"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "volumen" => "343"
                        "paginaInicial" => "239"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10911005"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cirug&#237;a combinada para c&#225;ncer de pulm&#243;n y reducci&#243;n de volumen en pacientes con enfisema avanzado"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G Juan"
                            1 => "M Ram&#243;n"
                            2 => "A Cant&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1999"
                        "volumen" => "35"
                        "paginaInicial" => "78"
                        "paginaFinal" => "79"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neumorreducci&#243;n en el tratamiento del enfisema pulmonar&#46; Resultados preliminares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G Juan"
                            1 => "C P&#233;rez"
                            2 => "M Ram&#243;n"
                            3 => "A Arnau"
                            4 => "A Cant&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1997"
                        "volumen" => "33"
                        "paginaInicial" => "418"
                        "paginaFinal" => "421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9376943"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health-care technology assessment of surgical procedures&#46; The case of reduction pneumoplasty for emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "GL Snider"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.153.4.8616543"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1996"
                        "volumen" => "153"
                        "paginaInicial" => "1208"
                        "paginaFinal" => "1213"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8616543"
                            "web" => "Medline"
                          ]
                        ]
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                      "titulo" => "Two-year results after lung volume reduction surgery in alfa-1-antitrypsin deficiency versus smoker&#39;s emphysema"
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                        "link" => array:1 [
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                      ]
                    ]
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                        "tituloSerie" => "Arch Bronconeumol"
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                  "referenciaCompleta" => "Juan G&#44; Ram&#243;n M&#44; Cant&#243; A&#44; Lloret T&#44; Rubio E&#44; Fontana I&#44; et al&#46; Masa corporal&#44; disnea y calidad de vida como predictores de &#233;xito en la cirug&#237;a de reducci&#243;n de volumen en el enfisema &#91;in press&#93;&#46; Rev Clin Esp&#46;"
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                          "etal" => false
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Original Articles
Four-Year Results After Lung Volume Reduction Surgery for Emphysema
G. Juan Sampera,
Corresponding author
gustavo.juan@uv.es

Correspondence: Prof. G. Juan Samper. Unidad de Neumología. Departamento de Medicina. Facultad de Medicina. Universidad de Valencia. Avda. Blasco Ibáñez, 15. 46010 Valencia. España
, M. Ramón Capillab, A. Cantó Armengolc, M.L. Martínez Pérezb, T. Lloret Pérezb, E. Rubio Gomisd, J. Marín Pardoa
a Unidad de Neumología, Departamento de Medicina, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
b Servicio de Neumología, Hospital General Universitario, Valencia, Spain
c Servicio de Cirugía de Tórax, Hospital General Universitario, Valencia, Spain
d Departamento de Farmacología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">While the short-term results of lung volume reduction surgery are known&#44; follow-up over several years has not often been described&#46; The purpose of the present study was to describe results in terms of functional improvement&#44; dyspnea&#44; quality of life&#44; and mortality over a 4-year period in patients with advanced emphysema&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Fourteen successive patients were enrolled between 1996 and 2000 and studied prospectively for 4 years&#46; All patients served as their own controls and initially received pulmonary rehabilitation and medication&#46; Preoperative data were used as baseline and were compared to postoperative data over 4 years&#46; The data analyzed were&#58; functional improvement &#40;forced expiratory volume in 1 second &#91;FEV<span class="elsevierStyleInf">1</span>&#93;&#41;&#44; quality of life&#44; dyspnea&#44; and patient loss due to death or referral to a lung transplantation program&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Patients with advanced emphysema &#40;mean FEV<span class="elsevierStyleInf">1</span> &#91;SD&#93;&#58; 22&#46;8&#37; &#91;11&#37;&#93; of predicted&#41; were studied&#46; Postoperative mortality was 14&#37;&#46; Overall mortality &#40;postoperative plus deaths due to respiratory insufficiency&#41; was 28&#37; at 1 year and 35&#37; at 4 years&#46; Two patients died of cancer and 5 were referred for transplantation&#46; At 3 months&#44; FEV<span class="elsevierStyleInf">1</span> had improved more than 15&#37; in 9 patients &#40;64&#37;&#41;&#59; the improvement was maintained in 43&#37; of patients at 1 year and 7&#37; at 4 years&#46; Improvement in dyspnea paralleled improvement in FEV<span class="elsevierStyleInf">1</span>&#46; Overall&#44; at 3 months mean FEV<span class="elsevierStyleInf">1</span> had improved 41&#46;9&#37; &#40;68&#37;&#41;&#44; transitional dyspnea index 2&#46;7 &#40;3&#41;&#44; and quality of life questionnaire score 1 &#40;0&#46;9&#41;&#46; Thus&#44; improvements were considerable&#44; but there was great variation&#46; Preoperative mean decrease in FEV<span class="elsevierStyleInf">1</span> was 50 &#40;32&#41; mL&#47;y&#44; and postoperative decrease 194 &#40;70&#41; mL&#47;y&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">With the inclusion criteria used&#44; there was considerable variation in the results&#46; Significant overall functional improvement was maintained in 50&#37; of the patients 1 year following surgery and in 7&#37; 4 years after surgery&#46; Given such results&#44; together with a surgical mortality rate of 14&#37; and overall mortality of 28&#37; in the first year&#44; we believe that the criteria for using lung reduction surgery should be revised&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque se conocen los resultados de la cirug&#237;a de reducci&#243;n de volumen a corto plazo&#44; son pocas las series que describen el seguimiento durante varios a&#241;os&#46; El prop&#243;sito de este estudio es describir los resultados&#44; en relaci&#243;n con la mejor&#237;a funcional&#44; disnea&#44; calidad de vida y mortalidad&#44; a lo largo de 4 a&#241;os en pacientes con enfisema avanzado&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes Y M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha estudiado de forma prospectiva a 14 pacientes incluidos sucesivamente entre los a&#241;os 1996 y 2000&#44; y seguidos a lo largo de 4 a&#241;os&#46; Cada paciente fue su propio control y recibi&#243; inicialmente tratamiento rehabilitador y farmacol&#243;gico&#46; Se utilizaron los datos preoperatorios como basales y se compararon con los postoperatorios a lo largo de 4 a&#241;os&#46; Los datos analizados fueron&#58; mejor&#237;a mec&#225;nica &#8212;volumen espiratorio forzado en el primer segundo &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#8212;&#44; calidad de vida&#44; disnea y p&#233;rdida del paciente&#44; tanto por fallecimiento como por remitirlo a un programa de trasplante pulmonar&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a pacientes con enfisema avanzado &#40;FEV<span class="elsevierStyleInf">1</span>&#58; 22&#44;8 &#177; 11&#37;&#41;&#46; La mortalidad postoperatoria fue del 14&#37; y&#44; unida a la originada por la insuficiencia respiratoria&#44; del 28 y el 35&#37; al a&#241;o y a los 4 a&#241;os&#44; respectivamente&#46; Dos pacientes murieron por c&#225;ncer y 5 se remitieron a trasplante&#46; A los 3 meses&#44; 9 pacientes &#40;64&#37;&#41; hab&#237;an mejorado m&#225;s del 15&#37; el FEV<span class="elsevierStyleInf">1</span> y esta mejor&#237;a se mantuvo en el 43&#37; al a&#241;o y en el 7&#37; a los 4 a&#241;os&#46; La mejor&#237;a de la disnea fue paralela a la mejor&#237;a del FEV<span class="elsevierStyleInf">1</span>&#46; Globalmente&#44; a los 3 meses el FEV<span class="elsevierStyleInf">1</span> hab&#237;a mejorado un 41&#44;9 &#177; 68&#37;&#44; el &#237;ndice transicional de disnea un 2&#44;7 &#177; 3 y la calidad de vida 1 &#177; 0&#44;9&#44; es decir&#44; mejor&#237;as importantes pero con mucha dispersi&#243;n&#46; La ca&#237;da del FEV<span class="elsevierStyleInf">1</span> prequir&#250;rgica fue de 50 &#177; 32 ml&#47;a&#241;o&#44; y la posquir&#250;rgica de 194 &#177; 70 ml&#47;a&#241;o&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Con los criterios de inclusi&#243;n seguidos&#44; hay una importante variabilidad en los resultados y&#44; globalmente&#44; se mantiene una mejor&#237;a funcional significativa en el 50&#37; de los pacientes al a&#241;o de la cirug&#237;a y del 7&#37; a los 4 a&#241;os&#46; Estos hechos&#44; unidos a una mortalidad operatoria del 14&#37; y global del 28&#37; en el primer a&#241;o&#44; hacen que se tengan que revisar los criterios de indicaci&#243;n de esta cirug&#237;a&#46;</p>"
      ]
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    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:31 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis in chronic obstructive pulmonary diseases&#58; results from multicenter trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "NF Anthonisen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "140"
                        "paginaInicial" => "595"
                        "paginaFinal" => "599"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Results of 150 consecutive bilateral lung volume reduction procedures in patients with severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "JD Cooper"
                            1 => "GA Patterson"
                            2 => "RS Sundaresan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0022-5223(96)70147-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "1996"
                        "volumen" => "112"
                        "paginaInicial" => "1319"
                        "paginaFinal" => "1330"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8911330"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0300893211002016"
                          "estado" => "S300"
                          "issn" => "03008932"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung function 5 yr after lung volume reduction surgery for emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "AF Gelb"
                            1 => "RJ McKenna"
                            2 => "M Brenner"
                            3 => "JD Epstein"
                            4 => "N Zamel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.7.2009048"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "1562"
                        "paginaFinal" => "1566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11401874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Emphysema Treatment Trial Research Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "348"
                        "paginaInicial" => "2059"
                        "paginaFinal" => "2073"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Emphysema Treatment Trial Research Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMsa030448"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "348"
                        "paginaInicial" => "2092"
                        "paginaFinal" => "2102"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12759480"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A prospective evaluation of lung volume reduction surgery in 200 consecutive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "RD Yusen"
                            1 => "SS Lefrak"
                            2 => "DS Gierada"
                            3 => "GE Davis"
                            4 => "BF Meyers"
                            5 => "GA Patterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "1026"
                        "paginaFinal" => "1037"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12684290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiology of pulmonary emphysema and lung reduction surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "RM Slone"
                            1 => "DS Gierada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Thorac Cardiovasc Surg"
                        "fecha" => "1996"
                        "volumen" => "8"
                        "paginaInicial" => "61"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8679752"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CT measurements of lung density in life can quantitate distal air space enlargement&#58; an essential defining feature of human emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "GA Gould"
                            1 => "W MacNee"
                            2 => "A McLean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/137.2.380"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1988"
                        "volumen" => "137"
                        "paginaInicial" => "380"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3341629"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung volume reduction surgery for severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J Cooper"
                            1 => "G Patterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Thorac Cardiovasc Surg"
                        "fecha" => "1996"
                        "volumen" => "8"
                        "paginaInicial" => "52"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8679751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardization of spirometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1979.119.5.831"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1979"
                        "volumen" => "119"
                        "paginaInicial" => "831"
                        "paginaFinal" => "838"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/453705"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The measurement of dyspnea&#58; contents&#44; interobserver agreement and physiologic correlates of two clinical indexes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "DA Mahler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "85"
                        "paginaInicial" => "751"
                        "paginaFinal" => "758"
                        "itemHostRev" => array:3 [
                          "pii" => "S0300893211002685"
                          "estado" => "S300"
                          "issn" => "03008932"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A measure of quality of life for clinical trials in chronic lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "GH Guyatt"
                            1 => "LB Berman"
                            2 => "M Townsend"
                            3 => "SO Pugsley"
                            4 => "LW Chambers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "773"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3321537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Traducci&#243;n espa&#241;ola y validaci&#243;n de un cuestionario de calidad de vida en pacientes con enfermedad pulmonar obstructiva cr&#243;nica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R G&#252;ell"
                            1 => "P Casan"
                            2 => "J Sangenis"
                            3 => "F Morante"
                            4 => "JM Borras"
                            5 => "G Guyatt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1995"
                        "volumen" => "31"
                        "paginaInicial" => "202"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7788081"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patients at high risk of death after lung-volume-reduction surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Emphysema Treatment Trial Research Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa11798"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2001"
                        "volumen" => "345"
                        "paginaInicial" => "1075"
                        "paginaFinal" => "1083"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11596586"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improvement in pulmonary function and elastic recoil after lung-reduction surgery for diffuse emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "FC Sciurba"
                            1 => "RM Rogers"
                            2 => "RJ Keenan"
                            3 => "WA Slivka"
                            4 => "J Gorcsan"
                            5 => "PF Ferson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1996"
                        "volumen" => "334"
                        "paginaInicial" => "1095"
                        "paginaFinal" => "1099"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The current status of lung volume reduction operations for emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K Naunheim"
                            1 => "MK Ferguson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1996"
                        "volumen" => "62"
                        "paginaInicial" => "601"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8694645"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of bullectomy on diaphragm strength"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J Travaline"
                            1 => "P Addonizio"
                            2 => "GJ Giner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.5.7582315"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "1697"
                        "paginaFinal" => "1701"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7582315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Int&#233;r&#234;t de l&#39;exploration h&#233;modynamique dans les indications chirurgicales des emphys&#232;mes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M Dahan"
                            1 => "F Salerin"
                            2 => "J Berjaud"
                            3 => "J Renella"
                            4 => "J Gaillart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Chir"
                        "fecha" => "1989"
                        "volumen" => "43"
                        "paginaInicial" => "669"
                        "paginaFinal" => "672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2589802"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short- and long-term functional results after lung volume reduction surgery for severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H Teschler"
                            1 => "AB Thompson"
                            2 => "G Stamatis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "13"
                        "paginaInicial" => "1170"
                        "paginaFinal" => "1176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10414422"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective randomized trial comparing bilateral lung volume reduction surgery to pulmonary rehabilitation in severe chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "GJ Criner"
                            1 => "FC Cordova"
                            2 => "S Furukawa"
                            3 => "AM Kuzma"
                            4 => "JM Travaline"
                            5 => "V Leyenson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.160.6.9902117"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "160"
                        "paginaInicial" => "2018"
                        "paginaFinal" => "2027"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10588623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of lung-volume-reduction surgery in patients with severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D Geddes"
                            1 => "M Davis"
                            2 => "H Koyoma"
                            3 => "D Hansell"
                            4 => "U Pastorino"
                            5 => "J Pepper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200007273430402"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "volumen" => "343"
                        "paginaInicial" => "239"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10911005"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cirug&#237;a combinada para c&#225;ncer de pulm&#243;n y reducci&#243;n de volumen en pacientes con enfisema avanzado"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G Juan"
                            1 => "M Ram&#243;n"
                            2 => "A Cant&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1999"
                        "volumen" => "35"
                        "paginaInicial" => "78"
                        "paginaFinal" => "79"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neumorreducci&#243;n en el tratamiento del enfisema pulmonar&#46; Resultados preliminares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G Juan"
                            1 => "C P&#233;rez"
                            2 => "M Ram&#243;n"
                            3 => "A Arnau"
                            4 => "A Cant&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1997"
                        "volumen" => "33"
                        "paginaInicial" => "418"
                        "paginaFinal" => "421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9376943"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health-care technology assessment of surgical procedures&#46; The case of reduction pneumoplasty for emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "GL Snider"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.153.4.8616543"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1996"
                        "volumen" => "153"
                        "paginaInicial" => "1208"
                        "paginaFinal" => "1213"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8616543"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two-year results after lung volume reduction surgery in alfa-1-antitrypsin deficiency versus smoker&#39;s emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "PC Cassina"
                            1 => "H Teschler"
                            2 => "N Konietzko"
                            3 => "D Theergarten"
                            4 => "G Stamatis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1998"
                        "volumen" => "12"
                        "paginaInicial" => "1028"
                        "paginaFinal" => "1032"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9863992"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung function after bilateral lower lobe lung reduction surgery for alfa1-antitrypsin emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "AF Gelb"
                            1 => "RJ McKenna"
                            2 => "M Brenner"
                            3 => "R Fischel"
                            4 => "N Zamel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "paginaInicial" => "928"
                        "paginaFinal" => "933"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10573244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung volume reduction surgery&#46; Is less really more&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "HE Fessler"
                            1 => "R Wise"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.159.4.9808060"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "1031"
                        "paginaFinal" => "1035"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10194142"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0140673610620375"
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                  ]
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              ]
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              "etiqueta" => "28"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Lung volume reduction surgery&#44; where are we now&#63;"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "BR Celli"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "ur Respir Rev"
                        "fecha" => "2000"
                        "volumen" => "10"
                        "paginaInicial" => "343"
                        "paginaFinal" => "348"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consecuencias fisiopatol&#243;gicas de la cirug&#237;a de la reducci&#243;n de volumen pulmonar en pacientes con enfisema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A de Pablo"
                            1 => "P Ussetti"
                            2 => "P G&#243;mez"
                            3 => "A Valera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "paginaInicial" => "464"
                        "paginaFinal" => "468"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14533996"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "30"
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                0 => array:1 [
                  "referenciaCompleta" => "Juan G&#44; Ram&#243;n M&#44; Cant&#243; A&#44; Lloret T&#44; Rubio E&#44; Fontana I&#44; et al&#46; Masa corporal&#44; disnea y calidad de vida como predictores de &#233;xito en la cirug&#237;a de reducci&#243;n de volumen en el enfisema &#91;in press&#93;&#46; Rev Clin Esp&#46;"
                ]
              ]
            ]
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              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rate of FEV<span class="elsevierStyleInf">1</span> change following lung volume reduction surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M Brenner"
                            1 => "RJ McKenna"
                            2 => "AF Gelb"
                            3 => "RJ Fischer"
                            4 => "AF Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
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                        "paginaInicial" => "652"
                        "paginaFinal" => "659"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9515838"
                            "web" => "Medline"
                          ]
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              ]
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