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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">TO incorporate a new fast&#44; safe&#44; and reversible anesthetic procedure into the experimental model of lung transplantation &#40;LT&#41; using a cuff technique originally described by Mizuta&#46;</p> <span class="elsevierStyleSectionTitle">Material and Method</span><p class="elsevierStyleSimplePara elsevierViewall">Eighty-eight Sprague-Dawley rats were used in the experimental model&#46; Thirty left LTs were performed&#44; using 60 rats&#46; The donor heart-lung block was excised by median sternotomy with dissection of the left lung and cuffs &#40;intravenous catheters cut into 3-mm sections&#41; were put in place&#46; The left lung was implanted in the recipient by lateral thoracotomy using the cuffs for anastomoses&#46; The duration of surgery and postoperative complications were recorded&#46; Also noted were signs of ischemia-reperfusion injury&#44; and acute rejection of the transplanted lung&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We discarded lungs excised from 8 animals when developing the experimental model&#46; Transplants could not be completed in 10 rats due to technical problems&#44; despite satisfactory excision&#46; Of the rats who received a transplant&#44; 4 died in the first 24 hours and 26 survived to 48 hours&#46; They were then killed and examined&#46; The state of the anastomoses was good and signs of ischemia-reperfusion injury&#44; as well as acute rejection were observed in the parenchyma of the transplanted lung&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">LT with cuffs in rats is a valid&#44; reliable&#44; reproducible&#44; and cheap model for studying ischemia-reperfusion injury and rejection in LT&#46; The surgical technique is complex&#44; requiring experienced surgeons and a long learning process&#46; Modification of the technique to more closely resemble the surgical procedure in humans is possible&#44; thus facilitating interpretation and allowing more reliable extrapolation to humans&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Desarrollar el modelo experimental de trasplante pulmonar &#40;TP&#41; con <span class="elsevierStyleItalic">cuffs</span> &#40;t&#233;cnica de manguito&#41;&#44; inicialmente descrito por Mizuta&#44; como medio de estudio del TP en nuestro medio incorporando un nuevo protocolo anest&#233;sico r&#225;pido&#44; seguro y reversible&#46;</p> <span class="elsevierStyleSectionTitle">Material Y M&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">Se han utilizado ratas Sprague-Dawley &#40;n &#61; 88&#41; para el desarrollo del modelo experimental y se han logrado realizar 30 TP izquierdos &#40;n &#61; 60&#41;&#46; En el animal donante se han efectuado una esternotom&#237;a media y extracci&#243;n del bloque cardiopulmonar con disecci&#243;n del pulm&#243;n izquierdo y colocaci&#243;n de los <span class="elsevierStyleItalic">cuffs</span> &#40;cat&#233;teres de venopunci&#243;n cortados en cilindros de 3 mm&#41;&#46; En el receptor&#44; a trav&#233;s de una toracotom&#237;a lateral&#44; se ha llevado a cabo el implante del pulm&#243;n izquierdo mediante las anastomosis con <span class="elsevierStyleItalic">cuffs&#46;</span> Se han valorado el tiempo quir&#250;rgico y las complicaciones postoperatorias&#44; as&#237; como la presencia de signos de lesi&#243;n de isquemia-reperfusi&#243;n y rechazo agudo en el pulm&#243;n trasplantado&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Durante el desarrollo del modelo experimental rechazamos a 8 animales en la extracci&#243;n&#46; Tras com-pletarla satisfactoriamente&#44; no se pudo realizar el implante en 10 ratas por problemas t&#233;cnicos&#46; De los animales trasplantados&#44; 4 fallecieron en las primeras 24 h y 26 ratas sobrevivieron hasta las 48 h&#44; momento en que fueron sacrificadas&#46; Hallamos un buen estado de las anastomosis y signos de lesi&#243;n de isquemia-reperfusi&#243;n y rechazo agudo en el par&#233;nquima pulmonar del pulm&#243;n trasplantado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El TP con <span class="elsevierStyleItalic">cuffs</span> en ratas es un modelo v&#225;lido&#44; fiable&#44; reproducible y econ&#243;mico para el estudio del TP y de los fen&#243;menos de isquemia-reperfusi&#243;n y rechazo&#46; La t&#233;cnica quir&#250;rgica es compleja&#44; tiene una larga curva de aprendizaje y requiere personal con experiencia quir&#250;rgica&#46; Adem&#225;s&#44; es subsidiaria de modificaciones que hagan que se asemeje m&#225;s a la t&#233;cnica quir&#250;rgica utilizada en cl&#237;nica humana para interpretar mejor y poder extrapolar los resultados al humano con m&#225;s fiabilidad&#46;</p>"
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Original Articles
Lung Transplantation in Rats: a Viable Experimental Model
N. Santana Rodrígueza,
Corresponding author
norbesr@terra.es

Correspondence: Dr. N. Santana Rodríguez. Unidad de Cirugía Torácica. Clínica San Roque. C/ Juan E. Doreste, 11. 35001 Las Palmas de Gran Canaria. España
, J.L. Martín Barrasab, A. López Garcíac, P. Rodríguez Suárezb, M. Ponce Gonzálezb, J. Freixinet Gilartb
a Unidad de Cirugía Torácica, Clínica San Roque, Las Palmas de Gran Canaria, Spain
b Unidad de Cirugía Torácica, Unidad de Investigación, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain
c Servicio de Anatomía Patológica, Hospital Universitario Puerta de Hierro, Madrid, Spain
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec153123"
          "palabras" => array:3 [
            0 => "Trasplante pulmonar"
            1 => "Cirug&#237;a experimental"
            2 => "Trasplante experimental"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">TO incorporate a new fast&#44; safe&#44; and reversible anesthetic procedure into the experimental model of lung transplantation &#40;LT&#41; using a cuff technique originally described by Mizuta&#46;</p> <span class="elsevierStyleSectionTitle">Material and Method</span><p class="elsevierStyleSimplePara elsevierViewall">Eighty-eight Sprague-Dawley rats were used in the experimental model&#46; Thirty left LTs were performed&#44; using 60 rats&#46; The donor heart-lung block was excised by median sternotomy with dissection of the left lung and cuffs &#40;intravenous catheters cut into 3-mm sections&#41; were put in place&#46; The left lung was implanted in the recipient by lateral thoracotomy using the cuffs for anastomoses&#46; The duration of surgery and postoperative complications were recorded&#46; Also noted were signs of ischemia-reperfusion injury&#44; and acute rejection of the transplanted lung&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We discarded lungs excised from 8 animals when developing the experimental model&#46; Transplants could not be completed in 10 rats due to technical problems&#44; despite satisfactory excision&#46; Of the rats who received a transplant&#44; 4 died in the first 24 hours and 26 survived to 48 hours&#46; They were then killed and examined&#46; The state of the anastomoses was good and signs of ischemia-reperfusion injury&#44; as well as acute rejection were observed in the parenchyma of the transplanted lung&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">LT with cuffs in rats is a valid&#44; reliable&#44; reproducible&#44; and cheap model for studying ischemia-reperfusion injury and rejection in LT&#46; The surgical technique is complex&#44; requiring experienced surgeons and a long learning process&#46; Modification of the technique to more closely resemble the surgical procedure in humans is possible&#44; thus facilitating interpretation and allowing more reliable extrapolation to humans&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Desarrollar el modelo experimental de trasplante pulmonar &#40;TP&#41; con <span class="elsevierStyleItalic">cuffs</span> &#40;t&#233;cnica de manguito&#41;&#44; inicialmente descrito por Mizuta&#44; como medio de estudio del TP en nuestro medio incorporando un nuevo protocolo anest&#233;sico r&#225;pido&#44; seguro y reversible&#46;</p> <span class="elsevierStyleSectionTitle">Material Y M&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">Se han utilizado ratas Sprague-Dawley &#40;n &#61; 88&#41; para el desarrollo del modelo experimental y se han logrado realizar 30 TP izquierdos &#40;n &#61; 60&#41;&#46; En el animal donante se han efectuado una esternotom&#237;a media y extracci&#243;n del bloque cardiopulmonar con disecci&#243;n del pulm&#243;n izquierdo y colocaci&#243;n de los <span class="elsevierStyleItalic">cuffs</span> &#40;cat&#233;teres de venopunci&#243;n cortados en cilindros de 3 mm&#41;&#46; En el receptor&#44; a trav&#233;s de una toracotom&#237;a lateral&#44; se ha llevado a cabo el implante del pulm&#243;n izquierdo mediante las anastomosis con <span class="elsevierStyleItalic">cuffs&#46;</span> Se han valorado el tiempo quir&#250;rgico y las complicaciones postoperatorias&#44; as&#237; como la presencia de signos de lesi&#243;n de isquemia-reperfusi&#243;n y rechazo agudo en el pulm&#243;n trasplantado&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Durante el desarrollo del modelo experimental rechazamos a 8 animales en la extracci&#243;n&#46; Tras com-pletarla satisfactoriamente&#44; no se pudo realizar el implante en 10 ratas por problemas t&#233;cnicos&#46; De los animales trasplantados&#44; 4 fallecieron en las primeras 24 h y 26 ratas sobrevivieron hasta las 48 h&#44; momento en que fueron sacrificadas&#46; Hallamos un buen estado de las anastomosis y signos de lesi&#243;n de isquemia-reperfusi&#243;n y rechazo agudo en el par&#233;nquima pulmonar del pulm&#243;n trasplantado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El TP con <span class="elsevierStyleItalic">cuffs</span> en ratas es un modelo v&#225;lido&#44; fiable&#44; reproducible y econ&#243;mico para el estudio del TP y de los fen&#243;menos de isquemia-reperfusi&#243;n y rechazo&#46; La t&#233;cnica quir&#250;rgica es compleja&#44; tiene una larga curva de aprendizaje y requiere personal con experiencia quir&#250;rgica&#46; Adem&#225;s&#44; es subsidiaria de modificaciones que hagan que se asemeje m&#225;s a la t&#233;cnica quir&#250;rgica utilizada en cl&#237;nica humana para interpretar mejor y poder extrapolar los resultados al humano con m&#225;s fiabilidad&#46;</p>"
      ]
    ]
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      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">This project was funded by the Health Research Fund &#40;FIS&#41;&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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2013 September 55 7 62
2013 August 39 14 53
2013 July 71 17 88
2013 June 65 8 73
2013 May 47 15 62
2013 April 20 7 27
2013 March 8 4 12
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Archivos de Bronconeumología

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