Original Articles
Association Between the Forced Midexpiratory Flow/Forced Vital Capacity Ratio and Bronchial Hyperresponsiveness
I. Urrutiaa,
, A. Capelasteguia, J.M. Quintanab, N. Muniozgurenc, F. Payod, J. Martínez Moratallae, J.A. Maldonadof, X. Basaganag, J.M. Antoh, J. Sunyerh, the Spanish Group of the European Community Respiratory Health Survey (ECRHS-I) *
Corresponding author
isabhelurrutia@airtel.net
Correspondence: Dra. I. Urrutia. Servicio de Neumología. Hospital de Galdakao. B.° Labeaga, s/n. 48960 Galdakao. Vizcaya. España
Correspondence: Dra. I. Urrutia. Servicio de Neumología. Hospital de Galdakao. B.° Labeaga, s/n. 48960 Galdakao. Vizcaya. España
a Servicio de Neumología, Hospital de Galdakao, Galdakao, Vizcaya, Spain
b Unidad de Epidemiología de Investigación Clínica, Hospital de Galdakao, Galdakao, Vizcaya, Spain
c Departamento de Sanidad del Gobierno Vasco, Bilbao, Spain
d Hospital de Asturias, Oviedo, Spain
e Complejo Universitario, Albacete, Spain
f Hospital Juan Ramón Jiménez, Huelva, Spain
g Unidad de Investigación Respiratoria y Ambiental, Instituto Municipal de Investigación MeAdica, Barcelona, Spain
h Unidad de Investigación Respiratoria y Ambiental, Instituto Municipal de Investigación Médica, Departamento de Ciencias Experimentales y de la Salud, Universidad Pompeu Fabra, Barcelona, Spain
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I. Urrutia. Servicio de Neumología. Hospital de Galdakao. B.° Labeaga, s/n. 48960 Galdakao. Vizcaya. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-10-02" "fechaAceptado" => "2004-01-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153607" "palabras" => array:3 [ 0 => "Bronchial hyperresponsiveness" 1 => "Lung size" 2 => "FEF<span class="elsevierStyleInf">25%-75%</span>/FVC." ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153608" "palabras" => array:3 [ 0 => "Hiperreactividad bronquial" 1 => "Talla pulmonar" 2 => "FEF<span class="elsevierStyleInf">25-75%</span>/FVC." ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">A long-standing hypothesis is that a low ratio of airway caliber to lung size is associated with bronchial hyperresponsiveness (BHR). The aim of our study was to measure the association between airway caliber relative to lung size (expressed as the ratio between forced expiratory flow, midexpiratory phase, divided by forced vital capacity [FEF<span class="elsevierStyleInf">25%-75%</span>/FVC]) and BHR measured by a methacholine challenge test, adjusting for age, height, sex, smoking history, geographic area, respiratory symptoms, and baseline forced expiratory volume in 1 second (FEV<span class="elsevierStyleInf">1</span>).</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We carried out a multicenter cross-sectional study of the general Spanish population in 2647 subjects from the European Community Respiratory Health Survey (ECRHS I). The ECRHS questionnaire was administered, total and specific immunoglobulin E were measured, and skin tests, spirometry, and a methacholine challenge test were performed.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We show the relationship of the various clinical and sociodemographic variables with the 2 parameters indicative of a positive methacholine test. The lower the FEF<span class="elsevierStyleInf">25%-75%</span>/FVC ratio was, the greater the risk of HRB, after adjustment for variables (odds ratio [OR]=0.09; 95% confidence interval [CI], 0.04-0.018 for the concentration provoking a 20% decrease in FEV<span class="elsevierStyleInf">1</span>, and OR=0.06; 95% CI, 0.03-0.12 for the dose provoking a 20% decrease in FEV<span class="elsevierStyleInf">1</span>).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">There is a significant association between the FEF<span class="elsevierStyleInf">25%-75%</span>/FVC ratio and BHR after adjustment for age, atopy, smoking, geographic area, respiratory symptoms, and initial FEV<span class="elsevierStyleInf">1</span>.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La desproporción entre el calibre de la vía aeArea y el pareAnquima pulmonar tiene una relación negativa con la presencia de hiperreactividad bronquial (HRB).</p><p class="elsevierStyleSimplePara elsevierViewall">El objetivo del presente estudio es medir la asociación entre el calibre de la vía aeArea relativa a la talla pulmonar, expresado por el cociente entre el flujo mesoespiratorio entre el 25 y el 75% de la capacidad vital forzada dividido por la capacidad vital forzada (FEF<span class="elsevierStyleInf">25-75%</span>/FVC), con la HRB medida por el test de metacolina, ajustando por edad, altura, sexo, consumo de tabaco, área geográfica, síntomas respiratorios y volumen espiratorio forzado en el primer segundo previo.</p> <span class="elsevierStyleSectionTitle">Material y Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio multiceAntrico transversal sobre población general española (2.647 sujetos) del Estudio de Salud Respiratoria de la Comunidad Europea (ECRHS-I). Se aplicó un cuestionario llamado ECRHS, se determinó la inmunoglobulina E total y específica, y se realizaron pruebas cutáneas, espirometría y test de metacolina.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se presenta la relación entre las diferentes variables sociodemográficas y clínicas con los 2 parámetros de positividad del test de metacolina. Hay aumento del ries-go de HRB a menor cociente FEF25 75%/FVC ajustado por diferentes variables (<span class="elsevierStyleItalic">odds ratio</span> = 0,09; intervalo de confianza del 95%, 0,04-0,18, para PC<span class="elsevierStyleInf">20</span>, y <span class="elsevierStyleItalic">odds ratio</span> = 0,06; intervalo de confianza del 95%, 0,03-0,12 para PD<span class="elsevierStyleInf">20</span>).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El cociente FEF<span class="elsevierStyleInf">25-75%</span>/FVC está asociado significativamente a la HRB, independientemente de la edad, la existencia de atopia, el consumo de tabaco, el área geográfica, los síntomas respiratorios y el volumen espiratorio forzado en el primer segundo.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">The ECRHS has received support from the European Economic Community and grants FIS 91/00160600E-OSE and 93/0393.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis and hyperreactivity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "PJ Barnes" 1 => "ST Holgate" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Respiratory medicine" "paginaInicial" => "558" "paginaFinal" => "603" "serieFecha" => "1990" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The host factor in bronchitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "NGM Orie" 1 => "HJ Switer" 2 => "K de Uries" 3 => "GJ Tammeling" 4 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 3 | 7 |
| 2024 October | 28 | 12 | 40 |
| 2024 September | 35 | 18 | 53 |
| 2024 August | 43 | 40 | 83 |
| 2024 July | 26 | 20 | 46 |
| 2024 June | 29 | 22 | 51 |
| 2024 May | 29 | 27 | 56 |
| 2024 April | 18 | 31 | 49 |
| 2024 March | 19 | 17 | 36 |
| 2024 February | 21 | 14 | 35 |
| 2023 March | 1 | 2 | 3 |
| 2023 February | 12 | 17 | 29 |
| 2023 January | 21 | 27 | 48 |
| 2022 December | 15 | 27 | 42 |
| 2022 November | 15 | 28 | 43 |
| 2022 October | 19 | 36 | 55 |
| 2022 September | 15 | 19 | 34 |
| 2022 August | 23 | 37 | 60 |
| 2022 July | 21 | 37 | 58 |
| 2022 June | 22 | 27 | 49 |
| 2022 May | 47 | 29 | 76 |
| 2022 April | 15 | 28 | 43 |
| 2022 March | 25 | 33 | 58 |
| 2022 February | 24 | 24 | 48 |
| 2022 January | 15 | 22 | 37 |
| 2021 December | 12 | 42 | 54 |
| 2021 November | 22 | 31 | 53 |
| 2021 October | 24 | 27 | 51 |
| 2021 September | 13 | 40 | 53 |
| 2021 August | 13 | 35 | 48 |
| 2021 July | 11 | 16 | 27 |
| 2021 June | 21 | 32 | 53 |
| 2021 May | 16 | 25 | 41 |
| 2021 April | 18 | 93 | 111 |
| 2021 March | 18 | 27 | 45 |
| 2021 February | 13 | 8 | 21 |
| 2021 January | 5 | 12 | 17 |
| 2020 December | 15 | 16 | 31 |
| 2020 November | 10 | 8 | 18 |
| 2020 October | 3 | 5 | 8 |
| 2020 September | 41 | 5 | 46 |
| 2020 August | 53 | 5 | 58 |
| 2020 July | 27 | 14 | 41 |
| 2020 June | 10 | 4 | 14 |
| 2020 May | 27 | 13 | 40 |
| 2020 April | 38 | 10 | 48 |
| 2020 March | 13 | 9 | 22 |
| 2020 February | 66 | 14 | 80 |
| 2020 January | 44 | 23 | 67 |
| 2019 December | 12 | 16 | 28 |
| 2019 November | 19 | 10 | 29 |
| 2019 October | 16 | 12 | 28 |
| 2019 September | 9 | 22 | 31 |
| 2019 August | 9 | 10 | 19 |
| 2019 July | 15 | 20 | 35 |
| 2019 June | 5 | 21 | 26 |
| 2019 May | 13 | 14 | 27 |
| 2019 April | 19 | 45 | 64 |
| 2019 March | 11 | 20 | 31 |
| 2019 February | 7 | 8 | 15 |
| 2019 January | 6 | 9 | 15 |
| 2018 December | 10 | 11 | 21 |
| 2018 November | 12 | 4 | 16 |
| 2018 October | 22 | 10 | 32 |
| 2018 September | 7 | 11 | 18 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 7 | 4 | 11 |
| 2018 March | 2 | 4 | 6 |
| 2018 February | 4 | 9 | 13 |
| 2018 January | 3 | 3 | 6 |
| 2017 December | 7 | 5 | 12 |
| 2017 November | 2 | 6 | 8 |
| 2017 October | 8 | 5 | 13 |
| 2017 September | 4 | 5 | 9 |
| 2017 August | 10 | 13 | 23 |
| 2017 July | 4 | 7 | 11 |
| 2017 June | 7 | 14 | 21 |
| 2017 May | 8 | 14 | 22 |
| 2017 April | 3 | 4 | 7 |
| 2017 March | 2 | 5 | 7 |
| 2017 February | 1 | 5 | 6 |
| 2017 January | 2 | 2 | 4 |
| 2016 December | 10 | 9 | 19 |
| 2016 November | 18 | 16 | 34 |
| 2016 October | 10 | 15 | 25 |
| 2016 September | 12 | 8 | 20 |
| 2016 August | 7 | 2 | 9 |
| 2016 July | 8 | 5 | 13 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 29 | 1 | 30 |
| 2015 September | 31 | 13 | 44 |
| 2015 August | 22 | 10 | 32 |
| 2015 July | 32 | 10 | 42 |
| 2015 June | 35 | 7 | 42 |
| 2015 May | 44 | 14 | 58 |
| 2015 April | 27 | 8 | 35 |
| 2015 March | 28 | 9 | 37 |
| 2015 February | 22 | 8 | 30 |
| 2015 January | 22 | 6 | 28 |
| 2014 December | 28 | 6 | 34 |
| 2014 November | 33 | 12 | 45 |
| 2014 October | 33 | 11 | 44 |
| 2014 September | 20 | 6 | 26 |
| 2014 August | 32 | 8 | 40 |
| 2014 July | 26 | 9 | 35 |
| 2014 June | 45 | 7 | 52 |
| 2014 May | 52 | 7 | 59 |
| 2014 April | 46 | 4 | 50 |
| 2014 March | 46 | 13 | 59 |
| 2014 February | 41 | 10 | 51 |
| 2014 January | 37 | 6 | 43 |
| 2013 December | 26 | 10 | 36 |
| 2013 November | 23 | 12 | 35 |
| 2013 October | 27 | 10 | 37 |
| 2013 September | 32 | 10 | 42 |
| 2013 August | 46 | 4 | 50 |
| 2013 July | 51 | 14 | 65 |
| 2013 June | 30 | 9 | 39 |
| 2013 May | 32 | 12 | 44 |
| 2013 April | 23 | 4 | 27 |
| 2013 March | 8 | 2 | 10 |
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