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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO investigate the prevalence of bacterial contamination of ventilators and colonization of patients&#44; the bacteria implicated&#44; and predisposing factors in noninvasive home ventilation&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Forty patients on a home noninvasive ventilation program &#40;mean &#91;SD&#93; age&#58; 63&#46;1 &#91;12&#93; years&#59; time on ventilation&#58; 30&#46;7 &#91;25&#93; months&#59; daily use&#58; 8&#46;1 &#91;2&#93; hours&#41; were enrolled in this descriptive cross-sectional study&#46; Microbiological samples for semiquantitative cultures were swabbed from the ventilator &#40;mask and tubing&#41; and the nostrils&#46; A questionnaire was completed on the underlying disease&#44; time on the ventilation program&#44; type of ventilator&#44; presence of a humidifier&#44; and attention to ventilator cleanliness and maintenance&#46; We defined &#8220;colonization&#8221; as the presence of microorganisms in the nostrils without evidence of a host immune response&#44; and &#8220;contamination&#8221; as the presence of surface microorganisms &#40;on tubing or the nasal mask&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Potentially pathogenic bacteria were isolated from 6 ventilators &#40;15&#37;&#41; and the nasal swabs of 10 patients &#40;25&#37;&#41;&#46; <span class="elsevierStyleItalic">Staphylococcus aureus</span> was the most frequently isolated one &#40;in 5 ventilators and 6 patients&#8212;contamination coinciding with colonization in 3 cases&#41;&#46; Other potentially pathogenic bacteria isolated were <span class="elsevierStyleItalic">Proteus</span> species &#40;from the nostrils of 2 patients&#41; and an unidentified gram-negative bacillus from the ventilator&#46; On analysis by underlying disease&#44; 60&#37; of the patients with obesity had been colonized&#46; No other findings of note were obtained for other diseases&#46; Contamination and colonization correlated with attention to cleanliness and maintenance of the ventilator but not with type of ventilator&#44; time on the ventilation program&#44; or use of a humidifier&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Home mechanical ventilators are a potential source of nasal colonization&#46; The most frequently encountered microorganism was <span class="elsevierStyleItalic">S&#46; aureus&#46;</span> The degree of ventilator cleaning and disinfection seems to affect contamination&#59; thus it is necessary to impress on patients the need for adequate maintenance of their ventilators&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer la prevalencia de contaminaci&#243;n bacteriana de los ventiladores utilizados en la ventilaci&#243;n mec&#225;nica no invasiva domiciliaria&#44; la colonizaci&#243;n en los pacientes&#44; los microorganismos implicados y los factores favorecedores&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio descriptivo transversal en 40 pacientes en programa de ventilaci&#243;n mec&#225;nica no invasiva domiciliaria &#40;edad media&#58; 63&#44;1 &#177; 12 a&#241;os&#59; tiempo en ventilaci&#243;n&#58; 30&#44;7 &#177; 25 meses&#59; utilizaci&#243;n diaria&#58; 8&#44;1 &#177; 2 h&#41;&#46; Se tomaron muestras microbiol&#243;gicas mediante escobi-llado del equipo de ventilaci&#243;n &#40;mascarilla y tubuladuras&#41; y de las fosas nasales para realizar cultivos semicuantitativos&#44; y se complet&#243; un cuestionario que inclu&#237;a enfermedad de base&#44; tiempo en programa de ventilaci&#243;n&#44; tipo de ventilador&#44; existen-cia de humidificador y h&#225;bitos y grado de limpieza&#46; Definimos como &#8220;colonizaci&#243;n&#8221; la presencia de microorganismos en las fosas nasales sin evidencia de respuesta org&#225;nica por parte del hu&#233;sped&#44; y &#8220;contaminaci&#243;n&#8221; como la presencia de microorganismos en una superficie &#40;tubuladura y mascarilla nasal&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se aislaron microorganismos potencialmen-te pat&#243;genos en las conexiones de 6 equipos &#40;15&#37;&#41; y en el frotis nasal de 10 pacientes &#40;25&#37;&#41;&#46; <span class="elsevierStyleItalic">Staphylococcus aureus</span> fue el aislado con mayor frecuencia &#40;5 equipos y 6 pacientes&#59; fue coincidente en 3 casos&#41;&#46; Otros g&#233;rmenes aislados fueron <span class="elsevierStyleItalic">Proteus</span> spp&#46; &#40;2 casos en fosas nasales&#41;&#44; <span class="elsevierStyleItalic">Streptococcus pneu-moniae</span> &#40;2 casos en fosas nasales&#41; y un bacilo gramnegativo no tipificable en las conexiones&#46; Por patolog&#237;as&#44; el &#250;nico dato destacable fue que en el 60&#37; de los pacientes con obesidad exist&#237;a colonizaci&#243;n&#44; sin que hubiera datos significativos en el resto de enfermedades&#46; Existe correlaci&#243;n positiva entre el grado de limpieza macrosc&#243;pico y los aislamientos&#44; pero no entre la contaminaci&#243;n&#44; la colonizaci&#243;n y factores como tipo de ventilador&#44; tiempo en ventilaci&#243;n o uso de humidificador&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los equipos de ventilaci&#243;n mec&#225;nica do-miciliario pueden representar una fuente potencial de colonizaci&#243;n nasal&#46; El microorganismo m&#225;s representativo en-contrado fue <span class="elsevierStyleItalic">S&#46; aureus&#46;</span> El grado de limpieza de los equipos parece influir en la contaminaci&#243;n&#44; por lo que es necesario insistir en el adecuado mantenimiento de estos equipos&#46;</p>"
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Original Articles
Bacterial Colonization and Home Mechanical Ventilation: Prevalence and Risk Factors
J.M. Rodríguez González-Moroa, G. Andrade Viverob, J. de Miguel Díeza, S. López Martína, C. Sánchezc, J.L. Izquierdo Alonsod, P. de Lucas Ramosa,
Corresponding author
pdr01m@saludalia.com

Correspondence: Dra. P. de Lucas Ramos. Servicio de Neumología. Hospital General Universitario Gregorio Marañón. C/ Dr. Esquerdo, 46. 28007 Madrid. España
a Sección de Soporte Ventilatorio y Trastornos del Sueño, Servicio de Neumología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Servicio de Cuidados Intensivos, Hospital General Universitario Gregorio Marañón, Madrid, Spain
c Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
d Sección de Neumología, Hospital Universitario de Guadalajara, Guadalajara, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO investigate the prevalence of bacterial contamination of ventilators and colonization of patients&#44; the bacteria implicated&#44; and predisposing factors in noninvasive home ventilation&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Forty patients on a home noninvasive ventilation program &#40;mean &#91;SD&#93; age&#58; 63&#46;1 &#91;12&#93; years&#59; time on ventilation&#58; 30&#46;7 &#91;25&#93; months&#59; daily use&#58; 8&#46;1 &#91;2&#93; hours&#41; were enrolled in this descriptive cross-sectional study&#46; Microbiological samples for semiquantitative cultures were swabbed from the ventilator &#40;mask and tubing&#41; and the nostrils&#46; A questionnaire was completed on the underlying disease&#44; time on the ventilation program&#44; type of ventilator&#44; presence of a humidifier&#44; and attention to ventilator cleanliness and maintenance&#46; We defined &#8220;colonization&#8221; as the presence of microorganisms in the nostrils without evidence of a host immune response&#44; and &#8220;contamination&#8221; as the presence of surface microorganisms &#40;on tubing or the nasal mask&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Potentially pathogenic bacteria were isolated from 6 ventilators &#40;15&#37;&#41; and the nasal swabs of 10 patients &#40;25&#37;&#41;&#46; <span class="elsevierStyleItalic">Staphylococcus aureus</span> was the most frequently isolated one &#40;in 5 ventilators and 6 patients&#8212;contamination coinciding with colonization in 3 cases&#41;&#46; Other potentially pathogenic bacteria isolated were <span class="elsevierStyleItalic">Proteus</span> species &#40;from the nostrils of 2 patients&#41; and an unidentified gram-negative bacillus from the ventilator&#46; On analysis by underlying disease&#44; 60&#37; of the patients with obesity had been colonized&#46; No other findings of note were obtained for other diseases&#46; Contamination and colonization correlated with attention to cleanliness and maintenance of the ventilator but not with type of ventilator&#44; time on the ventilation program&#44; or use of a humidifier&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Home mechanical ventilators are a potential source of nasal colonization&#46; The most frequently encountered microorganism was <span class="elsevierStyleItalic">S&#46; aureus&#46;</span> The degree of ventilator cleaning and disinfection seems to affect contamination&#59; thus it is necessary to impress on patients the need for adequate maintenance of their ventilators&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer la prevalencia de contaminaci&#243;n bacteriana de los ventiladores utilizados en la ventilaci&#243;n mec&#225;nica no invasiva domiciliaria&#44; la colonizaci&#243;n en los pacientes&#44; los microorganismos implicados y los factores favorecedores&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio descriptivo transversal en 40 pacientes en programa de ventilaci&#243;n mec&#225;nica no invasiva domiciliaria &#40;edad media&#58; 63&#44;1 &#177; 12 a&#241;os&#59; tiempo en ventilaci&#243;n&#58; 30&#44;7 &#177; 25 meses&#59; utilizaci&#243;n diaria&#58; 8&#44;1 &#177; 2 h&#41;&#46; Se tomaron muestras microbiol&#243;gicas mediante escobi-llado del equipo de ventilaci&#243;n &#40;mascarilla y tubuladuras&#41; y de las fosas nasales para realizar cultivos semicuantitativos&#44; y se complet&#243; un cuestionario que inclu&#237;a enfermedad de base&#44; tiempo en programa de ventilaci&#243;n&#44; tipo de ventilador&#44; existen-cia de humidificador y h&#225;bitos y grado de limpieza&#46; Definimos como &#8220;colonizaci&#243;n&#8221; la presencia de microorganismos en las fosas nasales sin evidencia de respuesta org&#225;nica por parte del hu&#233;sped&#44; y &#8220;contaminaci&#243;n&#8221; como la presencia de microorganismos en una superficie &#40;tubuladura y mascarilla nasal&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se aislaron microorganismos potencialmen-te pat&#243;genos en las conexiones de 6 equipos &#40;15&#37;&#41; y en el frotis nasal de 10 pacientes &#40;25&#37;&#41;&#46; <span class="elsevierStyleItalic">Staphylococcus aureus</span> fue el aislado con mayor frecuencia &#40;5 equipos y 6 pacientes&#59; fue coincidente en 3 casos&#41;&#46; Otros g&#233;rmenes aislados fueron <span class="elsevierStyleItalic">Proteus</span> spp&#46; &#40;2 casos en fosas nasales&#41;&#44; <span class="elsevierStyleItalic">Streptococcus pneu-moniae</span> &#40;2 casos en fosas nasales&#41; y un bacilo gramnegativo no tipificable en las conexiones&#46; Por patolog&#237;as&#44; el &#250;nico dato destacable fue que en el 60&#37; de los pacientes con obesidad exist&#237;a colonizaci&#243;n&#44; sin que hubiera datos significativos en el resto de enfermedades&#46; Existe correlaci&#243;n positiva entre el grado de limpieza macrosc&#243;pico y los aislamientos&#44; pero no entre la contaminaci&#243;n&#44; la colonizaci&#243;n y factores como tipo de ventilador&#44; tiempo en ventilaci&#243;n o uso de humidificador&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los equipos de ventilaci&#243;n mec&#225;nica do-miciliario pueden representar una fuente potencial de colonizaci&#243;n nasal&#46; El microorganismo m&#225;s representativo en-contrado fue <span class="elsevierStyleItalic">S&#46; aureus&#46;</span> El grado de limpieza de los equipos parece influir en la contaminaci&#243;n&#44; por lo que es necesario insistir en el adecuado mantenimiento de estos equipos&#46;</p>"
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ISSN: 15792129
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