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Nontuberculous Mycobacteria in Patients With Cystic Fibrosis
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"apellidos" => "Martínez-Puentes" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290660284X?idApp=UINPBA00003Z" "url" => "/15792129/0000004100000010/v1_201305150131/S157921290660284X/v1_201305150131/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212906602826" "issn" => "15792129" "doi" => "10.1016/S1579-2129(06)60282-6" "estado" => "S300" "fechaPublicacion" => "2005-10-01" "aid" => "60282" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2005;41:553-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2477 "formatos" => array:3 [ "EPUB" => 102 "HTML" => 1644 "PDF" => 731 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Cystic Fibrosis in Adults: Inter- and Intraobserver Agreement for the Brasfield and Chrispin-Norman Chest Radiography Scoring Systems and Correlation With Clinical Data and Spirometry" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "553" "paginaFinal" => "559" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Gutiérrez, M.J. Olivera, R.M. Girón, F. Rodríguez-Salvanés, P. Caballero" "autores" => array:5 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Gutiérrez" ] 1 => array:2 [ "nombre" => "M.J." "apellidos" => "Olivera" ] 2 => array:2 [ "nombre" => "R.M." "apellidos" => "Girón" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Rodríguez-Salvanés" ] 4 => array:3 [ "preGrado" => "Dra." "nombre" => "P." "apellidos" => "Caballero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906602826?idApp=UINPBA00003Z" "url" => "/15792129/0000004100000010/v1_201305150131/S1579212906602826/v1_201305150131/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Nontuberculous Mycobacteria in Patients With Cystic Fibrosis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "560" "paginaFinal" => "565" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R.M. Girón, D. Domingo, B. Buendía, E. Antón, L.M. Ruiz-Velasco, J. Ancochea" "autores" => array:6 [ 0 => array:5 [ "preGrado" => "Dra." "nombre" => "R.M." "apellidos" => "Girón" "email" => array:1 [ 0 => "med002861@nacom.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "D." "apellidos" => "Domingo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Buendía" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Antón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "L.M." "apellidos" => "Ruiz-Velasco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "Ancochea" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario de la Princesa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital Universitario de la Princesa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Área de Laboratorio, Clínica Moncloa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra. R.M. Girón. Servicio de Neumología. Hospital Universitario de la Princesa. Diego deLeón, 62. 28006 Madrid. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-08-24" "fechaAceptado" => "2005-05-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153714" "palabras" => array:4 [ 0 => "Cystic fibrosis" 1 => "Nontuberculous mycobacteria" 2 => "Mycobacterium avium complex" 3 => "Mycobacterium abscessus" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153713" "palabras" => array:4 [ 0 => "Fibrosis quística" 1 => "Micobacterias ambientales" 2 => "Mycobacterium avium" 3 => "Mycobacterium abscessus" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Patients with cystic fibrosis are at great risk of infection by nontuberculous mycobacteria from the environment because of certain predisposing factors such as bronchiectasis, malnutrition, and diabetes. The aim of this study was to analyze the mycobacterial content of sputum smears and cultures from adult patients with cystic fibrosis attended at a specialized unit for adults from March 1997 through December 2001.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Sputum samples were collected prospectively according to a protocol applied at each visit, and during most exacerbations staining and culture for mycobacteria were ordered in addition to the usual cultures for bacteria and fungi. A tuberculin test was performed at the end of the study.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Twenty-eight patients (16 men) with cystic fibrosis were enrolled. The mean (SD) age was 25.3 (6.7) years. A total of 251 samples were cultured (range in number of samples per patient, 1-31). The mean period of follow up was 40.3 (22.1) months. The sputum smear was positive in 29 cases (4 patients); the culture was positive in 7 patients. More than 3 samples were positive in only 4 patients. <span class="elsevierStyleItalic">Mycobacterium abscessus</span> was isolated in 3 cases, <span class="elsevierStyleItalic">Mycobacterium avium</span> complex in 2 and <span class="elsevierStyleItalic">Mycobacterium simiae</span> in 1 and other an unidentified rapid growth <span class="elsevierStyleItalic">Mycobacterium</span> species. The Mantoux test was positive in 5 patients. Two of the 4 patients in whose samples mycobacteria were isolated repeatedly required treatment.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The prevalence of nontuberculous mycobacterial infection is high in patients with cystic fibrosis. Staining and culture for mycobacteria should be carried out regularly and whenever exacerbation of pulmonary symptoms cannot be attributed to bacteria usually found in such patients. Patients with recurrent isolations of mycobacteria should be monitored closely.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">LOS pacientes con fibrosis quística (FQ) presentan un mayor riesgo de infección por micobacterias ambientales en relación con ciertos factores predisponentes como bronquiectasias, desnutrición y diabetes. El objetivo del presente estudio es analizar los resultados de las baciloscopias y cultivos de micobacterias de esputos de pacientes con FQ de una unidad de adultos, entre marzo de 1997 y diciembre de 2001.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Las muestras de esputo se recogieron de forma prospectiva y protocolizada en cada visita y en la mayoría de las exacerbaciones, en las que, además de los cultivos bacterianos habituales y de hongos, se solicitaron tinción y cultivo para micobacterias. Se realizó la prueba de la tuberculina al final del estudio.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó a 28 pacientes con FQ, 16 varones, con una edad media (± DE) de 25,3 ± 6,7 años. Se cultivaron un total de 251 muestras (rango por paciente de 1 a 31). El tiempo medio de seguimiento fue de 40,3 ± 22,1 meses. En 29 casos (4 pacientes) la baciloscopia fue positiva y se obtuvieron cultivos positivos en 7 pacientes, sólo en 4 en más de 3 muestras. Se aislaron: <span class="elsevierStyleItalic">Mycobacterium abscessus</span> en 3 casos, <span class="elsevierStyleItalic">M. avium complex</span> en 2 y <span class="elsevierStyleItalic">M. simiae</span> en uno y en otro una especie de crecimiento rápido no identificada. En 5 pacientes el Mantoux fue positivo. Dos de los 4 pacientes con aislamientos reiterados presentaron deterioro clínico y requirieron tratamiento.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Hay una alta prevalencia de micobacterias ambientales en pacientes con FQ. Habría que realizar tinción y cultivo para micobacterias de forma periódica y en caso de exacerbación pulmonar no atribuible a infección bacteriana habitual. Hay que vigilar estrechamente a los pacientes con aislamientos repetidos.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This study was financed by Red Respira (RTIC C03/011)-SEPAR (Spanish Society of Pulmonology and Thoracic Surgery).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Newborn screening for cystic fibrosis: the practical implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "KW Southern" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J R Soc Med" "fecha" => "2004" "volumen" => "97" "paginaInicial" => "57" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15239296" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology and management of pulmonary infection in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R Gibson" 1 => "J Burn" 2 => "B Ramsey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200304-505SO" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "168" "paginaInicial" => "918" "paginaFinal" => "951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14555458" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Cystic Fibrosis Foundation" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Patient Registry Annual Data Report 1999" "fecha" => "2000" "editorial" => "Cystic Fibrosis Foundation" "editorialLocalizacion" => "Bethesda" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patógenos multirresistentes en la fibrosis quística" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R Cantón" 1 => "RM Girón" 2 => "L Martínez-Martínez" 3 => "A Oliver" 4 => "A Solé" 5 => "S Valdezate" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2002" "volumen" => "38" "paginaInicial" => "376" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12199920" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontuberculous mycobacteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "SM Holland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med Sci" "fecha" => "2001" "volumen" => "321" "paginaInicial" => "49" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11202480" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of nontuberculous mycobacterial infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D Griffith" 1 => "R Wallace" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "UpToDate" "serieFecha" => "2004" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infecciones respiratorias por micobacterias ambientales" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J García" 1 => "J Palacios" 2 => "A Sánchez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "206" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15826531" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontuberculous mycobacteria. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 2 | 4 |
| 2024 October | 34 | 17 | 51 |
| 2024 September | 30 | 17 | 47 |
| 2024 August | 42 | 32 | 74 |
| 2024 July | 26 | 19 | 45 |
| 2024 June | 28 | 33 | 61 |
| 2024 May | 45 | 36 | 81 |
| 2024 April | 19 | 34 | 53 |
| 2024 March | 19 | 15 | 34 |
| 2024 February | 18 | 25 | 43 |
| 2023 March | 6 | 2 | 8 |
| 2023 February | 19 | 17 | 36 |
| 2023 January | 20 | 28 | 48 |
| 2022 December | 21 | 24 | 45 |
| 2022 November | 18 | 22 | 40 |
| 2022 October | 25 | 24 | 49 |
| 2022 September | 14 | 23 | 37 |
| 2022 August | 20 | 33 | 53 |
| 2022 July | 23 | 43 | 66 |
| 2022 June | 15 | 28 | 43 |
| 2022 May | 16 | 34 | 50 |
| 2022 April | 20 | 26 | 46 |
| 2022 March | 12 | 36 | 48 |
| 2022 February | 11 | 26 | 37 |
| 2022 January | 17 | 32 | 49 |
| 2021 December | 12 | 44 | 56 |
| 2021 November | 20 | 50 | 70 |
| 2021 October | 24 | 43 | 67 |
| 2021 September | 17 | 43 | 60 |
| 2021 August | 14 | 24 | 38 |
| 2021 July | 12 | 34 | 46 |
| 2021 June | 12 | 28 | 40 |
| 2021 May | 12 | 29 | 41 |
| 2021 April | 26 | 42 | 68 |
| 2021 March | 28 | 14 | 42 |
| 2021 February | 22 | 18 | 40 |
| 2021 January | 10 | 6 | 16 |
| 2020 December | 5 | 14 | 19 |
| 2020 November | 13 | 7 | 20 |
| 2020 October | 5 | 8 | 13 |
| 2020 September | 5 | 7 | 12 |
| 2020 August | 5 | 13 | 18 |
| 2020 July | 12 | 13 | 25 |
| 2020 June | 6 | 5 | 11 |
| 2020 May | 11 | 16 | 27 |
| 2020 April | 18 | 14 | 32 |
| 2020 March | 10 | 17 | 27 |
| 2020 February | 23 | 16 | 39 |
| 2020 January | 16 | 14 | 30 |
| 2019 December | 17 | 22 | 39 |
| 2019 November | 8 | 14 | 22 |
| 2019 October | 8 | 8 | 16 |
| 2019 September | 11 | 11 | 22 |
| 2019 August | 12 | 11 | 23 |
| 2019 July | 11 | 25 | 36 |
| 2019 June | 8 | 13 | 21 |
| 2019 May | 9 | 13 | 22 |
| 2019 April | 11 | 38 | 49 |
| 2019 March | 6 | 20 | 26 |
| 2019 February | 6 | 11 | 17 |
| 2019 January | 4 | 13 | 17 |
| 2018 December | 8 | 17 | 25 |
| 2018 November | 10 | 4 | 14 |
| 2018 October | 14 | 14 | 28 |
| 2018 September | 10 | 8 | 18 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 6 | 7 | 13 |
| 2018 March | 9 | 3 | 12 |
| 2018 February | 5 | 5 | 10 |
| 2018 January | 3 | 6 | 9 |
| 2017 December | 6 | 5 | 11 |
| 2017 November | 2 | 6 | 8 |
| 2017 October | 8 | 5 | 13 |
| 2017 September | 5 | 13 | 18 |
| 2017 August | 12 | 19 | 31 |
| 2017 July | 6 | 2 | 8 |
| 2017 June | 7 | 23 | 30 |
| 2017 May | 7 | 20 | 27 |
| 2017 April | 4 | 8 | 12 |
| 2017 March | 3 | 10 | 13 |
| 2017 February | 1 | 9 | 10 |
| 2017 January | 3 | 5 | 8 |
| 2016 December | 9 | 11 | 20 |
| 2016 November | 10 | 5 | 15 |
| 2016 October | 13 | 7 | 20 |
| 2016 September | 13 | 6 | 19 |
| 2016 August | 15 | 3 | 18 |
| 2016 July | 5 | 0 | 5 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 89 | 1 | 90 |
| 2015 September | 86 | 5 | 91 |
| 2015 August | 76 | 9 | 85 |
| 2015 July | 127 | 9 | 136 |
| 2015 June | 77 | 11 | 88 |
| 2015 May | 83 | 10 | 93 |
| 2015 April | 87 | 7 | 94 |
| 2015 March | 97 | 6 | 103 |
| 2015 February | 121 | 5 | 126 |
| 2015 January | 52 | 4 | 56 |
| 2014 December | 77 | 6 | 83 |
| 2014 November | 89 | 5 | 94 |
| 2014 October | 98 | 7 | 105 |
| 2014 September | 70 | 7 | 77 |
| 2014 August | 68 | 6 | 74 |
| 2014 July | 72 | 10 | 82 |
| 2014 June | 83 | 12 | 95 |
| 2014 May | 111 | 10 | 121 |
| 2014 April | 113 | 5 | 118 |
| 2014 March | 87 | 11 | 98 |
| 2014 February | 81 | 12 | 93 |
| 2014 January | 59 | 8 | 67 |
| 2013 December | 60 | 13 | 73 |
| 2013 November | 55 | 3 | 58 |
| 2013 October | 51 | 11 | 62 |
| 2013 September | 45 | 5 | 50 |
| 2013 August | 51 | 13 | 64 |
| 2013 July | 68 | 20 | 88 |
| 2013 June | 40 | 5 | 45 |
| 2013 May | 53 | 8 | 61 |
| 2013 April | 34 | 5 | 39 |
| 2013 March | 9 | 3 | 12 |
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