Original Articles
Use of Blood Products in Patients Treated Surgically for Stage I Non-Small Cell Lung Cancer
J.C. Peñalver
, J. Padilla, C. Jordá, J. Escrivá, J. Cerón, V. Calvo, A. García, J. Pastor, E. Blasco
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jpenalve@ono.com
Correspondence: Dr. J.C. Peñalver. Servicio de Cirugía Torácica. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
Correspondence: Dr. J.C. Peñalver. Servicio de Cirugía Torácica. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España
Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia, Spain
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García-Clemente, C. Escudero-Bueno" "autores" => array:4 [ 0 => array:3 [ "preGrado" => "Dr." "nombre" => "M.A." "apellidos" => "Alonso-Fernández" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "García-Clemente" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Escudero-Bueno" ] 3 => array:1 [ "colaborador" => "for the Asturian Society of Respiratory Disease (ASTURPAR) Lung Cancer Working Group (GACP)" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906602668?idApp=UINPBA00003Z" "url" => "/15792129/0000004100000009/v1_201305150225/S1579212906602668/v1_201305150225/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Use of Blood Products in Patients Treated Surgically for Stage I Non-Small Cell Lung Cancer" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "484" "paginaFinal" => "488" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.C. Peñalver, J. Padilla, C. Jordá, J. Escrivá, J. Cerón, V. Calvo, A. García, J. Pastor, E. Blasco" "autores" => array:9 [ 0 => array:5 [ "preGrado" => "Dr." "nombre" => "J.C." "apellidos" => "Peñalver" "email" => array:1 [ 0 => "jpenalve@ono.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Padilla" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Jordá" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Escrivá" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Cerón" ] 5 => array:2 [ "nombre" => "V." "apellidos" => "Calvo" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "García" ] 7 => array:2 [ "nombre" => "J." "apellidos" => "Pastor" ] 8 => array:2 [ "nombre" => "E." "apellidos" => "Blasco" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. J.C. Peñalver. Servicio de Cirugía Torácica. Hospital Universitario La Fe. Avda. de Campanar, 21. 46009 Valencia. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-09-30" "fechaAceptado" => "2005-01-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec154145" "palabras" => array:4 [ 0 => "Bronchogenic carcinoma" 1 => "Stage I" 2 => "Surgery" 3 => "Transfusion" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154146" "palabras" => array:4 [ 0 => "Carcinoma broncogénico" 1 => "Estadio I" 2 => "Cirugía" 3 => "Transfusión" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Retrospective study on the relation between the use of blood products and survival rates in patients treated surgically for stage I non-small cell lung cancer (NSCLC).</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 856 patients who underwent surgical resection from 1969 to 2000 for stage I NSCLC, classified histologically according to the current guidelines of the Spanish Society of Pulmonary and Thoracic Surgery (SEPAR). Patients who died in the postoperative period were excluded from the study. A series of clinicopathological variables were recorded, including the perioperative use or not of blood products. Descriptive, univariate, and multivariate statistical analyses were performed. Follow up concluded in December of 2003.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">One hundred twenty-five patients (14.6%) underwent a perioperative transfusion. A significant association was found between the use of blood products and tumor size (<span class="elsevierStyleItalic">P</span><.001), pneumectomy (<span class="elsevierStyleItalic">P</span><.001), and cell type (<span class="elsevierStyleItalic">P</span><.05). The respective 2, 5, and 10-year survival rates were 78%, 63%, and 54% for the nontransfusion group, and 73%, 59%, and 46% for the transfusion group. Both survival curves were compared and no significant differences were found (<span class="elsevierStyleItalic">P</span> = .23). Multivariate regression analysis included tumor size, patient age, and histologic cell type (squamous cell carcinoma or not); no relation between transfusion and survival was found.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In our series, we found no difference in survival rates for patients with stage I NSCLC after perioperative blood transfusion.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo sobre la influencia del uso de hemoderivados en la supervivencia del carcinoma broncopulmonar no anaplásico de células pequeñas (CB-NACP) en estadio I sometido a tratamiento quirúrgico.</p> <span class="elsevierStyleSectionTitle">Pacientesy métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó en el estudio a 856 pacientes (1969-2000) diagnosticados de CBNACP, que se resecaron y clasificaron como estadio I patológico según la actual normativa SEPAR, y se excluyó la mortalidad postoperatoria. Se recogieron una serie de variables clinicopatológicas, incluida la utilización o no de hemoderivados en el perioperatorio, y se aplicaron análisis estadísticos descriptivos, univariante y multivariante. El seguimiento finalizó en diciembre de 2003.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En el perioperatorio se transfundió a 125 pacientes (14,6%). La utilización de hemoderivados se relacionó significativamente con el tamaño tumoral (p < 0,001), la realización de una neumonectomía (p < 0,001) y el tipo histológico (p < 0,05). La supervivencia fue del 78, el 63 y el 54% a los 2, 5 y 10 años, respectivamente, para el grupo de pacientes no transfundidos, y del 73, el 59 y el 46% para el grupo de transfundidos. La comparación de ambas curvas de supervivencia no mostró diferencias significativas (p = 0,23). En el análisis multivariante entraron en regresión el tamaño tumoral, la edad y la variedad histológica epidermoide/no epidermoide. En este análisis no se demostró ninguna relación de la transfusión con la supervivencia.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">No se ha encontrado, en nuestra serie, ninguna variación en la supervivencia del CBNACP en estadio I tras el uso de hemoderivados en el perioperatorio inmediato.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of blood transfusion on T-suppressor cells in renal dialysis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "MD Smith" 1 => "JD Williams" 2 => "GA Coles" 3 => "JR Salaman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Transplant Proc" "fecha" 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 31 | 20 | 51 |
| 2024 September | 37 | 15 | 52 |
| 2024 August | 51 | 31 | 82 |
| 2024 July | 27 | 20 | 47 |
| 2024 June | 38 | 23 | 61 |
| 2024 May | 33 | 29 | 62 |
| 2024 April | 15 | 20 | 35 |
| 2024 March | 21 | 17 | 38 |
| 2024 February | 16 | 23 | 39 |
| 2023 March | 2 | 4 | 6 |
| 2023 February | 14 | 14 | 28 |
| 2023 January | 17 | 25 | 42 |
| 2022 December | 17 | 20 | 37 |
| 2022 November | 20 | 23 | 43 |
| 2022 October | 24 | 30 | 54 |
| 2022 September | 18 | 19 | 37 |
| 2022 August | 22 | 38 | 60 |
| 2022 July | 21 | 36 | 57 |
| 2022 June | 16 | 31 | 47 |
| 2022 May | 19 | 37 | 56 |
| 2022 April | 19 | 35 | 54 |
| 2022 March | 25 | 32 | 57 |
| 2022 February | 15 | 28 | 43 |
| 2022 January | 60 | 36 | 96 |
| 2021 December | 13 | 36 | 49 |
| 2021 November | 40 | 48 | 88 |
| 2021 October | 75 | 44 | 119 |
| 2021 September | 37 | 42 | 79 |
| 2021 August | 42 | 29 | 71 |
| 2021 July | 57 | 29 | 86 |
| 2021 June | 16 | 39 | 55 |
| 2021 May | 22 | 25 | 47 |
| 2021 April | 24 | 56 | 80 |
| 2021 March | 29 | 17 | 46 |
| 2021 February | 16 | 21 | 37 |
| 2021 January | 8 | 15 | 23 |
| 2020 December | 7 | 10 | 17 |
| 2020 November | 10 | 10 | 20 |
| 2020 October | 12 | 5 | 17 |
| 2020 September | 4 | 5 | 9 |
| 2020 August | 9 | 15 | 24 |
| 2020 July | 13 | 17 | 30 |
| 2020 June | 4 | 3 | 7 |
| 2020 May | 11 | 15 | 26 |
| 2020 April | 11 | 16 | 27 |
| 2020 March | 5 | 14 | 19 |
| 2020 February | 8 | 15 | 23 |
| 2020 January | 18 | 15 | 33 |
| 2019 December | 15 | 9 | 24 |
| 2019 November | 12 | 17 | 29 |
| 2019 October | 13 | 5 | 18 |
| 2019 September | 6 | 12 | 18 |
| 2019 August | 10 | 10 | 20 |
| 2019 July | 12 | 14 | 26 |
| 2019 June | 3 | 7 | 10 |
| 2019 May | 18 | 13 | 31 |
| 2019 April | 15 | 31 | 46 |
| 2019 March | 5 | 16 | 21 |
| 2019 February | 6 | 13 | 19 |
| 2019 January | 5 | 9 | 14 |
| 2018 December | 5 | 11 | 16 |
| 2018 November | 11 | 11 | 22 |
| 2018 October | 19 | 17 | 36 |
| 2018 September | 10 | 11 | 21 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 6 | 8 | 14 |
| 2018 March | 6 | 2 | 8 |
| 2018 February | 3 | 10 | 13 |
| 2018 January | 11 | 12 | 23 |
| 2017 December | 2 | 7 | 9 |
| 2017 November | 3 | 5 | 8 |
| 2017 October | 5 | 9 | 14 |
| 2017 September | 3 | 12 | 15 |
| 2017 August | 8 | 10 | 18 |
| 2017 July | 2 | 4 | 6 |
| 2017 June | 9 | 9 | 18 |
| 2017 May | 8 | 12 | 20 |
| 2017 April | 1 | 2 | 3 |
| 2017 March | 3 | 7 | 10 |
| 2017 February | 3 | 4 | 7 |
| 2017 January | 2 | 4 | 6 |
| 2016 December | 7 | 10 | 17 |
| 2016 November | 5 | 6 | 11 |
| 2016 October | 13 | 5 | 18 |
| 2016 September | 12 | 9 | 21 |
| 2016 August | 7 | 5 | 12 |
| 2016 July | 3 | 4 | 7 |
| 2016 March | 4 | 0 | 4 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 1 | 0 | 1 |
| 2015 October | 29 | 1 | 30 |
| 2015 September | 32 | 11 | 43 |
| 2015 August | 21 | 12 | 33 |
| 2015 July | 29 | 5 | 34 |
| 2015 June | 24 | 8 | 32 |
| 2015 May | 45 | 12 | 57 |
| 2015 April | 24 | 6 | 30 |
| 2015 March | 23 | 6 | 29 |
| 2015 February | 24 | 3 | 27 |
| 2015 January | 20 | 5 | 25 |
| 2014 December | 21 | 5 | 26 |
| 2014 November | 17 | 6 | 23 |
| 2014 October | 27 | 11 | 38 |
| 2014 September | 20 | 3 | 23 |
| 2014 August | 26 | 7 | 33 |
| 2014 July | 24 | 6 | 30 |
| 2014 June | 26 | 8 | 34 |
| 2014 May | 37 | 8 | 45 |
| 2014 April | 41 | 4 | 45 |
| 2014 March | 29 | 11 | 40 |
| 2014 February | 33 | 7 | 40 |
| 2014 January | 19 | 7 | 26 |
| 2013 December | 28 | 10 | 38 |
| 2013 November | 22 | 5 | 27 |
| 2013 October | 23 | 6 | 29 |
| 2013 September | 30 | 9 | 39 |
| 2013 August | 31 | 7 | 38 |
| 2013 July | 36 | 11 | 47 |
| 2013 June | 23 | 6 | 29 |
| 2013 May | 31 | 5 | 36 |
| 2013 April | 14 | 5 | 19 |
| 2013 March | 6 | 1 | 7 |
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