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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO gather information on the disease characteristics and survival rate of patients diagnosed with bronchogenic carcinoma in the respiratory medicine departments of hospitals in Asturias&#44; Spain&#46;</p> <span class="elsevierStyleSectionTitle">Patientsand methods</span><p class="elsevierStyleSimplePara elsevierViewall">This was a retrospective observational study carried out using a standardized data collection protocol&#46; All cases of lung cancer diagnosed during 2001 were included provided there was cytologic or histologic confirmation or they fulfilled a series of clinical&#44; radiological&#44; and&#47;or endoscopic criteria consistent with such a diagnosis&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Standard incidence rates adjusted to the world population were 22&#46;4&#44; 42&#46;6&#44; and 4&#46;6 per 100&#8200;000 population for the whole population&#44; men&#44; and women respectively&#46; The mean &#40;SD&#41; age was 67 &#40;10&#46;9&#41; years&#44; and 92&#37; of the patients were men&#46; Overall&#44; 98&#37; of the men and 44&#37; of the women were smokers&#46; Diagnosis was confirmed by cytologic or histologic findings in 92&#37; of patients&#44; and the majority were non-small cell tumors &#40;81&#46;4&#37;&#41;&#46; At the time of diagnosis&#44; 65&#37; of the patients had advanced disease&#44; with distant metastasis in 26&#46;6&#37; of the non-small cell cancers and 52&#46;8&#37; of the small cell cancers&#46; Patients received surgical treatment in 21&#46;3&#37; of cases&#44; chemotherapy alone or combined with radiation therapy in 43&#46;1&#37;&#44; and radiation therapy alone in 9&#46;3&#37;&#46; In 26&#46;2&#37; of patients only palliative care was given&#46; Overall&#44; median survival in weeks was 36&#46;4 &#40;95&#37; confidence interval &#91;CI&#93;&#44; 29&#46;4-43&#46;4&#41;&#46; Median survival by treatment type was as follows&#58; 69&#46;3 &#40;95&#37; CI&#44; 49-9&#46;5&#41; for surgery&#59; 39&#46;6 &#40;95&#37; CI&#44; 31&#46;2-48&#41; for chemotherapy alone or with radiation therapy&#59; 30 &#40;95&#37; CI&#44; 15&#46;4-44&#46;6&#41; for radiation therapy alone&#59; and 13&#46;3 &#40;95&#37; CI&#44; 5&#46;9-20&#46;6&#41; for patients who received palliative care alone &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The findings with respect to age&#44; sex&#44; incidence&#44; histology&#44; extent of tumor&#44; and smoking status of patients with bronchogenic carcinoma in our region do not differ significantly from those reported for other areas of Spain&#46; Current smoking is the primary cause of the high prevalence of this disease&#46; Twenty-six percent of patients received only palliative care&#46; The percentage of patients treated with surgery was low&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer las caracter&#237;sticas y supervivencia del carcinoma broncog&#233;nico &#40;CB&#41; diagnosticado en las unidades de neumolog&#237;a del Principado de Asturias&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional retrospectivo en el que se ha empleado un protocolo com&#250;n de recogida de datos&#46; Se incluyeron los CB diagnosticados en el a&#241;o 2001 con confirmaci&#243;n citohistol&#243;gica o por concordancia basada en datos cl&#237;nicos&#44; radiol&#243;gicos y&#47;o endosc&#243;picos&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Las tasas de incidencia est&#225;ndar para toda la poblaci&#243;n&#44; varones y mujeres&#44; ajustadas a la poblaci&#243;n mundial fueron de 22&#44;4&#44; 42&#44;6 y 4&#44;6&#47;100&#46;000 habitantes&#44; respectivamente&#46; El 92&#37; era var&#243;n&#59; la edad media &#40;&#177; desviaci&#243;n est&#225;ndar&#41; fue de 67 &#177; 10&#44;9 a&#241;os&#46; Ten&#237;a h&#225;bito tab&#225;quico el 98&#37; de los varones y el 44&#37; de las mujeres&#46; Se alcanz&#243; confirmaci&#243;n citohistol&#243;gica en el 92&#37; y la mayor&#237;a era CB no microc&#237;ticos &#40;81&#44;4&#37;&#41;&#46; En el momento del diagn&#243;stico el 65&#37; de los pacientes ten&#237;a enfermedad avanzada&#44; con met&#225;stasis a distancia en el 26&#44;6&#37; de los CB no microc&#237;ticos y en el 52&#44;8&#37; de los de c&#233;lulas peque&#241;as&#46; Se trat&#243; con cirug&#237;a el 21&#44;3&#37; de los casos&#44; con quimioterapia sola o asociada a radioterapia el 43&#44;1&#37;&#44; con radioterapia exclusivamente el 9&#44;3&#37; y recibi&#243; tratamiento paliativo el 26&#44;2&#37;&#46; La mediana de supervivencia global&#44; en semanas&#44; fue de 36&#44;4 &#40;intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 29&#44;4-43&#44;4&#41; y para los distintos tratamientos fue la siguiente&#58; para la cirug&#237;a&#44; 69&#44;3 &#40;IC del 95&#37;&#44; 49-9&#44;5&#41;&#59; para la quimioterapia sola o asociada a radioterapia&#44; 39&#44;6 &#40;IC del 95&#37;&#44; 31&#44;2-48&#41;&#59; para la radioterapia sola&#44; 30 &#40;IC del 95&#37;&#44; 15&#44;4-44&#44;6&#41;&#44; y para el paliativo&#44; 13&#44;3 &#40;IC del 95&#37;&#44; 5&#44;9-20&#44;6&#41; &#40;p &#60; 0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">En nuestra regi&#243;n&#44; las caracter&#237;sticas del CB en cuanto a edad&#44; sexo&#44; incidencia&#44; histolog&#237;a&#44; extensi&#243;n tumoral y tabaquismo no difieren significativamente de las halladas en otras &#225;reas del &#225;mbito nacional&#46; El tabaquismo activo es la causa fundamental de su alta prevalencia&#46; Se ofreci&#243; solamente tratamiento de soporte al 26&#37;&#46; El porcentaje de pacientes quir&#250;rgicos es bajo&#46;</p>"
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Original Articles
Characteristics of Lung Cancer in a Region in Northern Spain
M.A. Alonso-Fernández
Corresponding author
migu67@separ.es

Correspondence: Dr. M.A. Alonso-Fernández. Servicio de Neumología I. Hospital Universitario Central de Asturias. Dr. Bellmunt, s/n. 33006 Oviedo. Asturias. España
, M. García-Clemente, C. Escudero-Bueno, for the Asturian Society of Respiratory Disease (ASTURPAR) Lung Cancer Working Group (GACP)
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO gather information on the disease characteristics and survival rate of patients diagnosed with bronchogenic carcinoma in the respiratory medicine departments of hospitals in Asturias&#44; Spain&#46;</p> <span class="elsevierStyleSectionTitle">Patientsand methods</span><p class="elsevierStyleSimplePara elsevierViewall">This was a retrospective observational study carried out using a standardized data collection protocol&#46; All cases of lung cancer diagnosed during 2001 were included provided there was cytologic or histologic confirmation or they fulfilled a series of clinical&#44; radiological&#44; and&#47;or endoscopic criteria consistent with such a diagnosis&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Standard incidence rates adjusted to the world population were 22&#46;4&#44; 42&#46;6&#44; and 4&#46;6 per 100&#8200;000 population for the whole population&#44; men&#44; and women respectively&#46; The mean &#40;SD&#41; age was 67 &#40;10&#46;9&#41; years&#44; and 92&#37; of the patients were men&#46; Overall&#44; 98&#37; of the men and 44&#37; of the women were smokers&#46; Diagnosis was confirmed by cytologic or histologic findings in 92&#37; of patients&#44; and the majority were non-small cell tumors &#40;81&#46;4&#37;&#41;&#46; At the time of diagnosis&#44; 65&#37; of the patients had advanced disease&#44; with distant metastasis in 26&#46;6&#37; of the non-small cell cancers and 52&#46;8&#37; of the small cell cancers&#46; Patients received surgical treatment in 21&#46;3&#37; of cases&#44; chemotherapy alone or combined with radiation therapy in 43&#46;1&#37;&#44; and radiation therapy alone in 9&#46;3&#37;&#46; In 26&#46;2&#37; of patients only palliative care was given&#46; Overall&#44; median survival in weeks was 36&#46;4 &#40;95&#37; confidence interval &#91;CI&#93;&#44; 29&#46;4-43&#46;4&#41;&#46; Median survival by treatment type was as follows&#58; 69&#46;3 &#40;95&#37; CI&#44; 49-9&#46;5&#41; for surgery&#59; 39&#46;6 &#40;95&#37; CI&#44; 31&#46;2-48&#41; for chemotherapy alone or with radiation therapy&#59; 30 &#40;95&#37; CI&#44; 15&#46;4-44&#46;6&#41; for radiation therapy alone&#59; and 13&#46;3 &#40;95&#37; CI&#44; 5&#46;9-20&#46;6&#41; for patients who received palliative care alone &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The findings with respect to age&#44; sex&#44; incidence&#44; histology&#44; extent of tumor&#44; and smoking status of patients with bronchogenic carcinoma in our region do not differ significantly from those reported for other areas of Spain&#46; Current smoking is the primary cause of the high prevalence of this disease&#46; Twenty-six percent of patients received only palliative care&#46; The percentage of patients treated with surgery was low&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer las caracter&#237;sticas y supervivencia del carcinoma broncog&#233;nico &#40;CB&#41; diagnosticado en las unidades de neumolog&#237;a del Principado de Asturias&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio observacional retrospectivo en el que se ha empleado un protocolo com&#250;n de recogida de datos&#46; Se incluyeron los CB diagnosticados en el a&#241;o 2001 con confirmaci&#243;n citohistol&#243;gica o por concordancia basada en datos cl&#237;nicos&#44; radiol&#243;gicos y&#47;o endosc&#243;picos&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Las tasas de incidencia est&#225;ndar para toda la poblaci&#243;n&#44; varones y mujeres&#44; ajustadas a la poblaci&#243;n mundial fueron de 22&#44;4&#44; 42&#44;6 y 4&#44;6&#47;100&#46;000 habitantes&#44; respectivamente&#46; El 92&#37; era var&#243;n&#59; la edad media &#40;&#177; desviaci&#243;n est&#225;ndar&#41; fue de 67 &#177; 10&#44;9 a&#241;os&#46; Ten&#237;a h&#225;bito tab&#225;quico el 98&#37; de los varones y el 44&#37; de las mujeres&#46; Se alcanz&#243; confirmaci&#243;n citohistol&#243;gica en el 92&#37; y la mayor&#237;a era CB no microc&#237;ticos &#40;81&#44;4&#37;&#41;&#46; En el momento del diagn&#243;stico el 65&#37; de los pacientes ten&#237;a enfermedad avanzada&#44; con met&#225;stasis a distancia en el 26&#44;6&#37; de los CB no microc&#237;ticos y en el 52&#44;8&#37; de los de c&#233;lulas peque&#241;as&#46; Se trat&#243; con cirug&#237;a el 21&#44;3&#37; de los casos&#44; con quimioterapia sola o asociada a radioterapia el 43&#44;1&#37;&#44; con radioterapia exclusivamente el 9&#44;3&#37; y recibi&#243; tratamiento paliativo el 26&#44;2&#37;&#46; La mediana de supervivencia global&#44; en semanas&#44; fue de 36&#44;4 &#40;intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 29&#44;4-43&#44;4&#41; y para los distintos tratamientos fue la siguiente&#58; para la cirug&#237;a&#44; 69&#44;3 &#40;IC del 95&#37;&#44; 49-9&#44;5&#41;&#59; para la quimioterapia sola o asociada a radioterapia&#44; 39&#44;6 &#40;IC del 95&#37;&#44; 31&#44;2-48&#41;&#59; para la radioterapia sola&#44; 30 &#40;IC del 95&#37;&#44; 15&#44;4-44&#44;6&#41;&#44; y para el paliativo&#44; 13&#44;3 &#40;IC del 95&#37;&#44; 5&#44;9-20&#44;6&#41; &#40;p &#60; 0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">En nuestra regi&#243;n&#44; las caracter&#237;sticas del CB en cuanto a edad&#44; sexo&#44; incidencia&#44; histolog&#237;a&#44; extensi&#243;n tumoral y tabaquismo no difieren significativamente de las halladas en otras &#225;reas del &#225;mbito nacional&#46; El tabaquismo activo es la causa fundamental de su alta prevalencia&#46; Se ofreci&#243; solamente tratamiento de soporte al 26&#37;&#46; El porcentaje de pacientes quir&#250;rgicos es bajo&#46;</p>"
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