Original Articles
Changes in Exercise Tolerance, Health Related Quality of Life, and Peripheral Muscle Characteristics of Chronic Obstructive Pulmonary Disease Patients After 6 Weeks' Training
M. Montes de Ocaa,
, S.H. Torresb, Y. Gonzáleza, E. Romeroc, N. Hernándezb, C. Tálamoa
Corresponding author
mmdeoca@cantv.net
Correspondence: Dra M. Montes de Oca. CCS 5150, PO Box 025323, Miami, FL 33102-5323, USA
Correspondence: Dra M. Montes de Oca. CCS 5150, PO Box 025323, Miami, FL 33102-5323, USA
a Servicio de Neumonología, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela
b Sección de Adaptación Muscular, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
c Instituto Nacional de Enfermedades Respiratorias, Universidad Nacional Autónoma de México, México DF, Mexico
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González, E. Romero, N. Hernández, C. Tálamo" "autores" => array:6 [ 0 => array:5 [ "preGrado" => "Dra." "nombre" => "M." "apellidos" => "Montes de Oca" "email" => array:1 [ 0 => "mmdeoca@cantv.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "S.H." "apellidos" => "Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Y." "apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "N." "apellidos" => "Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "C." "apellidos" => "Tálamo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neumonología, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Sección de Adaptación Muscular, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Instituto Nacional de Enfermedades Respiratorias, Universidad Nacional Autónoma de México, México DF, Mexico" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dra M. Montes de Oca. CCS 5150, PO Box 025323, Miami, FL 33102-5323, USA" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-07-30" "fechaAceptado" => "2004-11-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec154123" "palabras" => array:3 [ 0 => "Chronic obstructive pulmonary disease (COPD)" 1 => "Respiratory rehabilitation" 2 => "Skeletal muscles" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154124" "palabras" => array:3 [ 0 => "Enfermedad pulmonar obstructiva crónica (EPOC)" 1 => "Rehabilitación respiratoria" 2 => "Músculos esqueléticos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">This study was designed to assess changes in skeletal muscle characteristics after 6 weeks' high-intensity physical training of patients with moderate to severe chronic obstructive pulmonary disease (COPD) and to determine how the changes were related to improvements in exercise tolerance and health related quality of life (HRQL).</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Ten patients with a mean (SD) age of 60 (10) years and a forced expiratory volume in 1 second of 32% (9%) were enrolled. The effect of training on the 6-minute walk test, HRQL questionnaires, and skeletal muscles was examined for the 8 patients who completed the program. The structural and chemical characteristics of skeletal muscles before and after training were studied in vastus lateralis muscle biopsies.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Training significantly modified the 6-minute walk test (<span class="elsevierStyleItalic">P</span> <.01), HRQL (<span class="elsevierStyleItalic">P</span> <.05), and citrate synthetase activity (<span class="elsevierStyleItalic">P</span> <.05). Changes in distances walked during the 6-minute walk test were significantly related to changes in the mean area of fibers (r=0.81).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of this study indicate that 6 weeks of high-intensity physical training of COPD patients produces moderate changes in skeletal muscles which could partly explain improvements observed in exercise tolerance after respiratory rehabilitation.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Este estudio se diseñó para evaluar los cambios en las características de los músculos esqueléticos después de 6 semanas de entrenamiento físico de alta intensidad, en pacientes con enfermedad pulmonar obstructiva crónica (EPOC) moderada-grave, y para determinar cómo se relacionan con la mejoría de la tolerancia al esfuerzo y la calidad de vida relacionada con la salud (CVRS).</p> <span class="elsevierStyleSectionTitle">Pacientes t métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudió a 10 pacientes (edad media ± desviación estándar: 60 ± 10 años) con un volumen espiratorio forzado en el primer segundo del 32 ± 9%. Se analizaron el efecto del entrenamiento sobre la marcha de 6 min (M6M), cuestionarios de CVRS y músculos esqueléticos en los 8 pacientes que completaron el programa. Se estudia-ron las características histoquímicas y morfológicas de los músculos esqueléticos antes y después del entrenamiento en biopsias del <span class="elsevierStyleItalic">vastus lateralis.</span></p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La intervención de estos pacientes modificó significativamente la M6M (p < 0,01), la CVRS (p < 0,05) y la actividad de la citrato sintetasa (p < 0,05). El cambio en la distancia recorrida durante la M6M se relacionó significativamente con el cambio en el área promedio de las fibras (r = 0,81).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los resultados de este trabajo indican que la intervención con 6 semanas de entrenamiento físico de alta intensidad en pacientes con EPOC induce cambios mo-destos en los músculos esqueléticos, que podrían explicar en parte los beneficios observados en la tolerancia al esfuerzo tras la rehabilitación respiratoria.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation" "autores" => 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 1 | 4 |
| 2024 October | 29 | 26 | 55 |
| 2024 September | 24 | 18 | 42 |
| 2024 August | 43 | 37 | 80 |
| 2024 July | 25 | 14 | 39 |
| 2024 June | 25 | 19 | 44 |
| 2024 May | 42 | 30 | 72 |
| 2024 April | 15 | 28 | 43 |
| 2024 March | 20 | 18 | 38 |
| 2024 February | 17 | 21 | 38 |
| 2023 March | 3 | 4 | 7 |
| 2023 February | 19 | 19 | 38 |
| 2023 January | 15 | 29 | 44 |
| 2022 December | 18 | 27 | 45 |
| 2022 November | 27 | 31 | 58 |
| 2022 October | 27 | 38 | 65 |
| 2022 September | 17 | 27 | 44 |
| 2022 August | 26 | 35 | 61 |
| 2022 July | 26 | 47 | 73 |
| 2022 June | 23 | 34 | 57 |
| 2022 May | 24 | 36 | 60 |
| 2022 April | 24 | 45 | 69 |
| 2022 March | 24 | 39 | 63 |
| 2022 February | 21 | 49 | 70 |
| 2022 January | 13 | 33 | 46 |
| 2021 December | 23 | 38 | 61 |
| 2021 November | 18 | 48 | 66 |
| 2021 October | 24 | 66 | 90 |
| 2021 September | 19 | 48 | 67 |
| 2021 August | 7 | 34 | 41 |
| 2021 July | 10 | 27 | 37 |
| 2021 June | 17 | 51 | 68 |
| 2021 May | 14 | 28 | 42 |
| 2021 April | 25 | 37 | 62 |
| 2021 March | 15 | 12 | 27 |
| 2021 February | 12 | 19 | 31 |
| 2021 January | 18 | 11 | 29 |
| 2020 December | 9 | 12 | 21 |
| 2020 November | 4 | 17 | 21 |
| 2020 October | 8 | 7 | 15 |
| 2020 September | 38 | 6 | 44 |
| 2020 August | 71 | 13 | 84 |
| 2020 July | 33 | 21 | 54 |
| 2020 June | 5 | 6 | 11 |
| 2020 May | 29 | 14 | 43 |
| 2020 April | 37 | 22 | 59 |
| 2020 March | 29 | 12 | 41 |
| 2020 February | 72 | 17 | 89 |
| 2020 January | 57 | 18 | 75 |
| 2019 December | 21 | 14 | 35 |
| 2019 November | 18 | 18 | 36 |
| 2019 October | 13 | 7 | 20 |
| 2019 September | 9 | 2 | 11 |
| 2019 August | 17 | 14 | 31 |
| 2019 July | 10 | 14 | 24 |
| 2019 June | 10 | 6 | 16 |
| 2019 May | 15 | 8 | 23 |
| 2019 April | 34 | 21 | 55 |
| 2019 March | 16 | 12 | 28 |
| 2019 February | 15 | 13 | 28 |
| 2019 January | 7 | 9 | 16 |
| 2018 December | 11 | 28 | 39 |
| 2018 November | 22 | 9 | 31 |
| 2018 October | 17 | 10 | 27 |
| 2018 September | 10 | 12 | 22 |
| 2018 May | 8 | 0 | 8 |
| 2018 April | 4 | 7 | 11 |
| 2018 March | 6 | 4 | 10 |
| 2018 February | 4 | 8 | 12 |
| 2018 January | 8 | 7 | 15 |
| 2017 December | 6 | 8 | 14 |
| 2017 November | 3 | 4 | 7 |
| 2017 October | 6 | 13 | 19 |
| 2017 September | 3 | 8 | 11 |
| 2017 August | 4 | 15 | 19 |
| 2017 July | 1 | 8 | 9 |
| 2017 June | 5 | 17 | 22 |
| 2017 May | 6 | 9 | 15 |
| 2017 April | 0 | 1 | 1 |
| 2017 March | 3 | 9 | 12 |
| 2017 February | 7 | 10 | 17 |
| 2017 January | 2 | 2 | 4 |
| 2016 December | 7 | 6 | 13 |
| 2016 November | 10 | 7 | 17 |
| 2016 October | 6 | 5 | 11 |
| 2016 September | 5 | 2 | 7 |
| 2016 August | 5 | 2 | 7 |
| 2016 July | 1 | 3 | 4 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 40 | 10 | 50 |
| 2015 September | 39 | 7 | 46 |
| 2015 August | 20 | 14 | 34 |
| 2015 July | 32 | 9 | 41 |
| 2015 June | 32 | 3 | 35 |
| 2015 May | 51 | 2 | 53 |
| 2015 April | 39 | 15 | 54 |
| 2015 March | 47 | 7 | 54 |
| 2015 February | 56 | 4 | 60 |
| 2015 January | 75 | 7 | 82 |
| 2014 December | 43 | 9 | 52 |
| 2014 November | 68 | 18 | 86 |
| 2014 October | 102 | 25 | 127 |
| 2014 September | 84 | 15 | 99 |
| 2014 August | 40 | 10 | 50 |
| 2014 July | 70 | 10 | 80 |
| 2014 June | 56 | 4 | 60 |
| 2014 May | 44 | 8 | 52 |
| 2014 April | 54 | 7 | 61 |
| 2014 March | 57 | 12 | 69 |
| 2014 February | 42 | 7 | 49 |
| 2014 January | 31 | 6 | 37 |
| 2013 December | 34 | 8 | 42 |
| 2013 November | 32 | 8 | 40 |
| 2013 October | 38 | 6 | 44 |
| 2013 September | 31 | 12 | 43 |
| 2013 August | 29 | 6 | 35 |
| 2013 July | 44 | 15 | 59 |
| 2013 June | 31 | 5 | 36 |
| 2013 May | 32 | 3 | 35 |
| 2013 April | 18 | 7 | 25 |
| 2013 March | 7 | 2 | 9 |
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