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                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Primary pulmonary hypertension&#46; Executive summary from the World Symposium on Primary Pulmonary Hypertension"
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                      ]
                    ]
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              ]
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                          "etal" => true
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                            2 => "H Ahn"
                            3 => "J Strother"
                            4 => "T Morris"
                            5 => "E Masliah"
                          ]
                        ]
                      ]
                    ]
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                          "autores" => array:6 [
                            0 => "S Lee"
                            1 => "K Shroyer"
                            2 => "N Markham"
                            3 => "C Cool"
                            4 => "N Voelkel"
                            5 => "R Tuder"
                          ]
                        ]
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                    ]
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                        "paginaInicial" => "927"
                        "paginaFinal" => "934"
                        "link" => array:1 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J Lloyd"
                            1 => "M Butler"
                            2 => "T Foroud"
                            3 => "P Conneally"
                            4 => "J Phillips"
                            5 => "J Newman"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "93"
                        "paginaFinal" => "97"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7599869"
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                    0 => array:2 [
                      "titulo" => "Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "D Koller"
                            2 => "B Slovis"
                            3 => "T Foroud"
                            4 => "V Terry"
                            5 => "N Arnold"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "paginaFinal" => "280"
                        "link" => array:1 [
                          0 => array:2 [
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                          "etal" => false
                          "autores" => array:6 [
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                            1 => "A Jones"
                            2 => "R Barst"
                            3 => "S Hodge"
                            4 => "K Wilhelmsen"
                            5 => "T Nygaard"
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                        ]
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                    ]
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                        "link" => array:1 [
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "L Wheeler"
                            2 => "K Lane"
                            3 => "E Loyd"
                            4 => "R Gaddipati"
                            5 => "J Phillips"
                          ]
                        ]
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                          "etal" => true
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                            2 => "M Pauciulo"
                            3 => "N Morgan"
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                            5 => "G Elliott"
                          ]
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "P Upton"
                            3 => "K Jourdan"
                            4 => "N Morgan"
                            5 => "K Sheares"
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                          "autores" => array:6 [
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                            2 => "S Kimura"
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                      "Revista" => array:5 [
                        "tituloSerie" => "J Hypertens Suppl"
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                      "titulo" => "Expression of endothelin-1 in the lungs of patients with pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A Giaid"
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                            2 => "D Langleben"
                            3 => "R Michel"
                            4 => "R Levy"
                            5 => "H Shennib"
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                        "paginaFinal" => "1739"
                        "link" => array:1 [
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                0 => array:2 [
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                      "titulo" => "Expression of the serotonin 1b receptor in experimental pulmonary hypertension"
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                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "B Rondelet"
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                            2 => "F Kerbaul"
                            3 => "S Motte"
                            4 => "P Fesler"
                            5 => "K McEntee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
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                        "paginaInicial" => "408"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
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                ]
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                      "titulo" => "Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension&#58; a randomised placebo-controlled study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "O Sitbon"
                            3 => "I Robbins"
                            4 => "A Frost"
                            5 => "V Tapson"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
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                        "paginaFinal" => "1123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11597664"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
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              "etiqueta" => "16"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension&#58; a 1-year follow-up study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "D Badesch"
                            2 => "R Channick"
                            3 => "A Frost"
                            4 => "I Robbins"
                            5 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "247"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12853530"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Galie"
                            1 => "A Hinderliter"
                            2 => "A Torbicki"
                            3 => "T Fourme"
                            4 => "G Simonneau"
                            5 => "T Pulido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "1380"
                        "paginaFinal" => "1386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12706935"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Signaling molecules in nonfamilial pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L Du"
                            1 => "C Sullivan"
                            2 => "D Chu"
                            3 => "A Cho"
                            4 => "M Kido"
                            5 => "P Wolf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa021650"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "348"
                        "paginaInicial" => "500"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12571257"
                            "web" => "Medline"
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                ]
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                    0 => array:2 [
                      "titulo" => "Induction of pulmonary hypertension by an angiopoietin 1&#47;TIE2&#47;serotonin pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            1 => "L Du"
                            2 => "D Chu"
                            3 => "A Cho"
                            4 => "M Kido"
                            5 => "P Wolf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.1933740100"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "2003"
                        "volumen" => "100"
                        "paginaInicial" => "12331"
                        "paginaFinal" => "12336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14512515"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A Dinh-Xuan"
                            1 => "T Higenbottam"
                            2 => "C Clelland"
                            3 => "J Pepke-Zaba"
                            4 => "G Cremona"
                            5 => "A Butt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199105303242203"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1991"
                        "volumen" => "324"
                        "paginaInicial" => "1539"
                        "paginaFinal" => "1547"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2027358"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafilo como sustituto de la prostaciclina subcut&#225;nea en la hipertensi&#243;n pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "L Cea-Calvo"
                            1 => "P Escribano"
                            2 => "R Tello"
                            3 => "M G&#243;mez"
                            4 => "J Delgado"
                            5 => "C S&#225;enz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "paginaInicial" => "476"
                        "paginaFinal" => "477"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14533998"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Giaid"
                            1 => "D Saleh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199507273330403"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1995"
                        "volumen" => "333"
                        "paginaInicial" => "214"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7540722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered arterial expression patterns of inducible and endothelial nitric oxide synthase in pulmonary plexogenic arteriopathy caused by congenital heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R Berger"
                            1 => "R Geiger"
                            2 => "J Hess"
                            3 => "A Bogers"
                            4 => "W Mooi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.6.9908137"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "1493"
                        "paginaFinal" => "1499"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11371423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R Tuder"
                            1 => "C Cool"
                            2 => "M Geraci"
                            3 => "J Wang"
                            4 => "S Abman"
                            5 => "L Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.159.6.9804054"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "1925"
                        "paginaFinal" => "1932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10351941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iloprost en la hipertensi&#243;n pulmonar tromboemb&#243;lica cr&#243;nica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V Roig"
                            1 => "A Herrero"
                            2 => "N de la Torre"
                            3 => "E Hern&#225;ndez"
                            4 => "J Aller"
                            5 => "J Cabello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "326"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15225519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysfunctional voltage-gated K<span class="elsevierStyleSup">&#43;</span> channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Yuan"
                            1 => "A Aldinger"
                            2 => "M Juhaszova"
                            3 => "J Wang"
                            4 => "J Conte"
                            5 => "S Gaine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "1400"
                        "paginaFinal" => "1406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9760294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of human herpesvirus 8 in primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C Cool"
                            1 => "P Rai"
                            2 => "M Yeager"
                            3 => "D Hern&#225;ndez-Saavedra"
                            4 => "A Serls"
                            5 => "T Bull"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa035115"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "349"
                        "paginaInicial" => "1113"
                        "paginaFinal" => "1122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13679525"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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Review Article
Endothelial Dysfunction in Pulmonary Hypertension
J.C. Caraballo Fonseca, C.D. Martínez Balzano, R. Sánchez de León
Corresponding author
rsdl@telcel.net.ve

Correspondence: Dr. R. Sánchez de León. POBA international #1-20312, Miami, Florida 33102-5255, USA
Sección de Fisiología Respiratoria, Facultad de Medicina, Escuela de Medicina Luis Razetti, Universidad Central de Venezuela, Caracas, Venezuela
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                          "etal" => false
                          "autores" => array:1 [
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                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Primary pulmonary hypertension&#46; Executive summary from the World Symposium on Primary Pulmonary Hypertension"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
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              ]
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              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension&#46; A morphometric and immunohistochemical study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E Yi"
                            1 => "H Kim"
                            2 => "H Ahn"
                            3 => "J Strother"
                            4 => "T Morris"
                            5 => "E Masliah"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.162.4.9912131"
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                        "tituloSerie" => "Am J Respir Crit Care Med"
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                        "paginaFinal" => "1586"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11029379"
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              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S Lee"
                            1 => "K Shroyer"
                            2 => "N Markham"
                            3 => "C Cool"
                            4 => "N Voelkel"
                            5 => "R Tuder"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1172/JCI1910"
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                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1998"
                        "volumen" => "101"
                        "paginaInicial" => "927"
                        "paginaFinal" => "934"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9486960"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J Lloyd"
                            1 => "M Butler"
                            2 => "T Foroud"
                            3 => "P Conneally"
                            4 => "J Phillips"
                            5 => "J Newman"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.152.1.7599869"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1995"
                        "volumen" => "152"
                        "paginaInicial" => "93"
                        "paginaFinal" => "97"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7599869"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W Nichols"
                            1 => "D Koller"
                            2 => "B Slovis"
                            3 => "T Foroud"
                            4 => "V Terry"
                            5 => "N Arnold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0397-277"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1997"
                        "volumen" => "15"
                        "paginaInicial" => "277"
                        "paginaFinal" => "280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9054941"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Mapping of familial primary pulmonary hypertension locus &#40;PPH1&#41; to chromosome 2q31-q32"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J Morse"
                            1 => "A Jones"
                            2 => "R Barst"
                            3 => "S Hodge"
                            4 => "K Wilhelmsen"
                            5 => "T Nygaard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1997"
                        "volumen" => "95"
                        "paginaInicial" => "2603"
                        "paginaFinal" => "2606"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9193425"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Newman"
                            1 => "L Wheeler"
                            2 => "K Lane"
                            3 => "E Loyd"
                            4 => "R Gaddipati"
                            5 => "J Phillips"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200108023450502"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2001"
                        "volumen" => "345"
                        "paginaInicial" => "319"
                        "paginaFinal" => "324"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
                          ]
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              "identificador" => "bib9"
              "etiqueta" => "9"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II&#44; a receptor member of the TGF-beta family"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Thomson"
                            1 => "R Machado"
                            2 => "M Pauciulo"
                            3 => "N Morgan"
                            4 => "M Humbert"
                            5 => "G Elliott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
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                        "volumen" => "37"
                        "paginaInicial" => "741"
                        "paginaFinal" => "745"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11015450"
                            "web" => "Medline"
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              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta and bone morphogenetic proteins"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Morrell"
                            1 => "X Yang"
                            2 => "P Upton"
                            3 => "K Jourdan"
                            4 => "N Morgan"
                            5 => "K Sheares"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
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                        "volumen" => "104"
                        "paginaInicial" => "790"
                        "paginaFinal" => "795"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11502704"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R Trembath"
                            1 => "J Thomson"
                            2 => "R Machado"
                            3 => "N Morgan"
                            4 => "C Atkinson"
                            5 => "I Winship"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200108023450503"
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                        "fecha" => "2001"
                        "volumen" => "345"
                        "paginaInicial" => "325"
                        "paginaFinal" => "334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11484689"
                            "web" => "Medline"
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              "etiqueta" => "12"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A novel peptide vasoconstrictor&#44; endothelin&#44; is produced by vascular endothelium and modulates smooth muscle Ca<span class="elsevierStyleSup">2&#43;</span> channels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M Yanagisawa"
                            1 => "H Kurihara"
                            2 => "S Kimura"
                            3 => "K Goto"
                            4 => "T Masaki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Hypertens Suppl"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "88"
                        "paginaFinal" => "91"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of endothelin-1 in the lungs of patients with pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A Giaid"
                            1 => "M Yanagisawa"
                            2 => "D Langleben"
                            3 => "R Michel"
                            4 => "R Levy"
                            5 => "H Shennib"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199306173282402"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "328"
                        "paginaInicial" => "1732"
                        "paginaFinal" => "1739"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8497283"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of the serotonin 1b receptor in experimental pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B Rondelet"
                            1 => "R van Beneden"
                            2 => "F Kerbaul"
                            3 => "S Motte"
                            4 => "P Fesler"
                            5 => "K McEntee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
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                        "volumen" => "22"
                        "paginaInicial" => "408"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
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                      "titulo" => "Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension&#58; a randomised placebo-controlled study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R Channick"
                            1 => "G Simonneau"
                            2 => "O Sitbon"
                            3 => "I Robbins"
                            4 => "A Frost"
                            5 => "V Tapson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(01)06250-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2001"
                        "volumen" => "358"
                        "paginaInicial" => "1119"
                        "paginaFinal" => "1123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11597664"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension&#58; a 1-year follow-up study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O Sitbon"
                            1 => "D Badesch"
                            2 => "R Channick"
                            3 => "A Frost"
                            4 => "I Robbins"
                            5 => "G Simonneau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "247"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12853530"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Galie"
                            1 => "A Hinderliter"
                            2 => "A Torbicki"
                            3 => "T Fourme"
                            4 => "G Simonneau"
                            5 => "T Pulido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "1380"
                        "paginaFinal" => "1386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12706935"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Signaling molecules in nonfamilial pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L Du"
                            1 => "C Sullivan"
                            2 => "D Chu"
                            3 => "A Cho"
                            4 => "M Kido"
                            5 => "P Wolf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa021650"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "348"
                        "paginaInicial" => "500"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12571257"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Induction of pulmonary hypertension by an angiopoietin 1&#47;TIE2&#47;serotonin pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C Sullivan"
                            1 => "L Du"
                            2 => "D Chu"
                            3 => "A Cho"
                            4 => "M Kido"
                            5 => "P Wolf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.1933740100"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "2003"
                        "volumen" => "100"
                        "paginaInicial" => "12331"
                        "paginaFinal" => "12336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14512515"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A Dinh-Xuan"
                            1 => "T Higenbottam"
                            2 => "C Clelland"
                            3 => "J Pepke-Zaba"
                            4 => "G Cremona"
                            5 => "A Butt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199105303242203"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1991"
                        "volumen" => "324"
                        "paginaInicial" => "1539"
                        "paginaFinal" => "1547"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2027358"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sildenafilo como sustituto de la prostaciclina subcut&#225;nea en la hipertensi&#243;n pulmonar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L Cea-Calvo"
                            1 => "P Escribano"
                            2 => "R Tello"
                            3 => "M G&#243;mez"
                            4 => "J Delgado"
                            5 => "C S&#225;enz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "paginaInicial" => "476"
                        "paginaFinal" => "477"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14533998"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Giaid"
                            1 => "D Saleh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199507273330403"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1995"
                        "volumen" => "333"
                        "paginaInicial" => "214"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7540722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Altered arterial expression patterns of inducible and endothelial nitric oxide synthase in pulmonary plexogenic arteriopathy caused by congenital heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R Berger"
                            1 => "R Geiger"
                            2 => "J Hess"
                            3 => "A Bogers"
                            4 => "W Mooi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.163.6.9908137"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "163"
                        "paginaInicial" => "1493"
                        "paginaFinal" => "1499"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11371423"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R Tuder"
                            1 => "C Cool"
                            2 => "M Geraci"
                            3 => "J Wang"
                            4 => "S Abman"
                            5 => "L Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.159.6.9804054"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "1925"
                        "paginaFinal" => "1932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10351941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iloprost en la hipertensi&#243;n pulmonar tromboemb&#243;lica cr&#243;nica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V Roig"
                            1 => "A Herrero"
                            2 => "N de la Torre"
                            3 => "E Hern&#225;ndez"
                            4 => "J Aller"
                            5 => "J Cabello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "326"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15225519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysfunctional voltage-gated K<span class="elsevierStyleSup">&#43;</span> channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Yuan"
                            1 => "A Aldinger"
                            2 => "M Juhaszova"
                            3 => "J Wang"
                            4 => "J Conte"
                            5 => "S Gaine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "1400"
                        "paginaFinal" => "1406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9760294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of human herpesvirus 8 in primary pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C Cool"
                            1 => "P Rai"
                            2 => "M Yeager"
                            3 => "D Hern&#225;ndez-Saavedra"
                            4 => "A Serls"
                            5 => "T Bull"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa035115"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "349"
                        "paginaInicial" => "1113"
                        "paginaFinal" => "1122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13679525"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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