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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Vascular endothelial growth factor &#40;VEGF&#41; is a potent inducer of capillary permeability and its role as a crucial mediator in pleural fluid formation has been established&#46; This study was conducted to assess the usefulness of VEGF for diagnosing malignant and non-malignant pleural effusions of various causes&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">VEGF levels in pleural effusions collected from 52 patients &#40;20 with malignant effusion&#44; 12 with tuberculous effusion&#44; 10 with transudative effusion&#44; and 10 with parapneumonic effusion&#41; were assessed by enzyme-linked immunosorbent assay&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The median level of VEGF was significantly higher &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;001&#41; in exudative effusions &#40;10&#46;16 pg&#47;mL&#41; than in the transudative effusions &#40;3&#46;82 pg&#47;mL&#41;&#46; Although malignant pleural fluids tended to have higher median and mean levels of VEGF compared to tuberculous effusions&#44; the difference was not statistically significant&#46; Pleural VEGF levels in subtypes of lung cancer and in malignant effusions of different origins were not significantly different&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In conclusion&#44; although VEGF levels in pleural effusions of different origins vary&#44; they were only able to discriminate exudates from transudates significantly in this study&#46; Further studies in larger groups of patients are needed to establish the role of VEGF in diagnosing malignant and&#47;or tuberculous effusions&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El factor de crecimiento endotelial vascular &#40;VEGF&#41; es un potente inductor de la permeabilidad capilar y desempe&#241;a un papel clave como mediador en la formaci&#243;n del derrame pleural&#46; Este estudio se ha realizado para evaluar la utilidad del VEGF en el diagn&#243;stico de los derrames pleurales malignos y no malignos de diversas causas&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Mediante la t&#201;cnica de inmunoabsorci&#243;n ligada a enzimas se determinaron las concentraciones de VEGF en los derrames pleurales correspondientes a 52 pacientes &#40;20 con derrame pleural maligno&#44; 12 con derrame de origen tuberculoso&#44; 10 con derrame de tipo trasudado y 10 con derrame paraneum&#243;nico&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La concentraci&#243;n media del VEGF fue signi-ficativamente mayor &#40;p &#61; 0&#44;001&#41; en los derrames pleurales &#40;10&#44;16 pg&#47;ml&#41; de tipo exudado que en los derrames de tipo trasudado &#40;3&#44;82 pg&#47;ml&#41;&#46; Aunque los derrames pleurales malignos mostraron una tendencia a las concentraciones medianas y medias mayores de VEGF&#44; en comparaci&#243;n con los derrames de origen tuberculoso&#44; la diferencia no fue estad&#237;sticamente significativa&#46; Tampoco fueron significativamente diferentes las concentraciones pleurales de VEGF en los distintos subtipos de c&#225;ncer pulmonar&#44; y tampoco en los derrames malignos de distintos or&#237;genes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque las concentraciones de VEGF son distintas en los derrames pleurales de or&#237;genes diferentes&#44; en nuestro estudio no han permitido discriminar los exudados de los trasudados&#46; Son necesarios nuevos estudios de investigaci&#243;n sobre grupos m&#225;s numerosos de pacientes con objeto de establecer el papel que puede desempe&#241;ar la concentraci&#243;n de VEGF en el diagn&#243;stico de los derrames malignos&#44; tuberculosos o ambos&#46;</p>"
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