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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO describe the response to exercise of normal subjects and patients with chronic obstructive pulmonary disease &#40;COPD&#41; in Bogota&#44; Colombia &#40;altitude&#58; 2640 m&#59; atmospheric pressure&#58; 560 mm Hg&#41; and compare it with data published on COPD patients at sea level&#46; Healthy people increase their minute ventilation to attenuate hypoxemia &#40;PaCO<span class="elsevierStyleInf">2</span>&#58; 30 mm Hg&#59; PaO<span class="elsevierStyleInf">2</span>&#58; 63 mm Hg&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Material and method</span><p class="elsevierStyleSimplePara elsevierViewall">A descriptive study was carried out on healthy subjects and COPD patients&#46; Exercise limitation was determined by an incremental test on a cycle ergometer&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The study enrolled 16 healthy subjects and 25 COPD patients &#40;forced expiratory volume in 1 second&#58; 43&#46;3&#37; &#91;SD 13&#37;&#93;&#41;&#46; Minute ventilation at rest was greater in COPD patients compared with healthy subjects&#44; it was not adequately sustained during exercise&#44; and there was a reduction in peak oxygen uptake &#40;53&#46;0&#37; &#91;15&#37;&#93;&#41;&#46; At peak exercise&#44; inspiratory capacity decreased &#40;-0&#46;62 &#91;0&#46;34&#93; L&#41;&#44; the ratio of minute ventilation to maximal voluntary ventilation increased&#44; and severe hypoxemia occurred &#40;PaO<span class="elsevierStyleInf">2</span>&#58; 49&#46;9 &#91;9&#46;9&#93; mm Hg&#41;&#46; There was significant correlation between hypoxemia and the percentage of predicted peak oxygen uptake &#40;r&#61;0&#46;60&#41;&#44; leg fatigue &#40;r&#61;-0&#46;62&#41;&#44; percentage of predicted peak inspiratory capacity &#40;r&#61;0&#46;61&#41;&#44; and the percentage of predicted peak tidal volume &#40;r&#61;0&#46;49&#41;&#46; Minute ventilation at rest was shown to be higher&#44; there was a greater reduction in the inspiratory capacity during exercise&#44; and hypoxemia was more severe at rest and during exercise for patients with COPD in Bogota&#44; compared with those at sea level&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Patients with COPD living in Bogota were shown to have lower tolerance to exercise evidenced by ventilatory limitation and severe hypoxemia&#46; Increased minute ventilation at rest&#44; greater reduction in inspiratory capacity&#44; and severity of hypoxemia during exercise were the main differences between COPD in Bogota and at sea level&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir la respuesta al ejercicio en sujetos normales y en pacientes con enfermedad pulmonar obstruc-tiva cr&#243;nica &#40;EPOC&#41; en Bogot&#225; &#40;altura&#58; 2&#46;640 m&#59; presi&#243;n at-mosf&#233;rica&#58; 560 mmHg&#41; y establecer diferencias con los datos publicados de pacientes con dicha enfermedad a nivel del mar&#46; Las personas sanas a esta altura aumentan la ventilaci&#243;n alveolar para atenuar la hipoxemia &#40;presi&#243;n arterial de CO<span class="elsevierStyleInf">2</span>&#58; 30 mmHg&#59; presi&#243;n arterial de O<span class="elsevierStyleInf">2</span>&#58; 63 mmHg&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio descriptivo en pacientes con EPOC y en sujetos sanos&#46; La capacidad de ejercicio se determin&#243; con una prueba incremental en un cicloerg&#243;metro&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; en el estudio a 16 sujetos sanos y 25 pacientes con EPOC &#40;volumen espiratorio forzado en el primer segundo del 43&#44;3 &#177; 13&#37;&#41;&#46; En comparaci&#243;n con los sujetos sanos&#44; en los pacientes con EPOC se observ&#243; un au-mento de la ventilaci&#243;n minuto en reposo que no se mantuvo adecuadamente en el ejercicio&#44; as&#237; como disminuci&#243;n del con-sumo de ox&#237;geno pico &#40;53&#44;0 &#177; 15&#37;&#41;&#46; En ejercicio pico la capacidad inspiratoria disminuy&#243; &#40;-0&#44;62 &#177; 0&#44;34 1&#41;&#44; la relaci&#243;n ventilaci&#243;n minuto&#47;ventilaci&#243;n voluntaria m&#225;xima aument&#243; y hubo una intensa hipoxemia &#40;presi&#243;n arterial de O<span class="elsevierStyleInf">2</span> de 49&#44;9 &#177; 9&#44;9 mmHg&#41;&#46; Esta hipoxemia se correlacion&#243; significativa-mente con el porcentaje del valor predicho del consumo de ox&#237;geno pico &#40;r &#61; 0&#44;60&#41;&#44; la fatiga de los miembros inferiores &#40;r &#61; -0&#44;62&#41;&#44; el porcentaje predicho de la capacidad inspiratoria pico &#40;r &#61; 0&#44;61&#41; y el porcentaje predicho del volumen corriente pico &#40;r &#61; 0&#44;49&#41;&#46; En comparaci&#243;n con los datos publicados a nivel del mar&#44; en los pacientes con EPOC la ventilaci&#243;n minuto en reposo fue mayor&#44; hubo una mayor disminuci&#243;n de la capacidad inspiratoria durante el ejercicio y la hipoxemia fue m&#225;s grave tan to en reposo como en ejercicio&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">En los pacientes con EPOC residentes en Bogot&#225; demostramos intolerancia al ejercicio determinada por limitaci&#243;n ventilatoria e hipoxemia severa&#46; El aumento de la ventilaci&#243;n minuto en reposo&#44; la mayor disminuci&#243;n de la capacidad inspiratoria y la gravedad de la hipoxemia durante el ejercicio fueron las principales diferencias con la EPOC a nivel del mar&#46;</p>"
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Exercise Limitation in Patients With Chronic Obstructive Pulmonary Disease at the Altitude of Bogota (2640 m): Breathing Pattern and Arterial Gases at Rest and Peak Exercise
M. González-García
Corresponding author
mgonzalez@neumologica.org

Correspondence: Dr. M. González-García. Calle 163 A, 28-60. Bogota. Colombia
, M. Barrero, D. Maldonado
Laboratorio de Fisiología y Función Pulmonar, Fundación Neumológica Colombiana, Bogota, Colombia
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            0 => "Chronic obstructive pulmonary disease"
            1 => "Exercise"
            2 => "Dynamic hyperinflation"
            3 => "Breathing pattern"
            4 => "Arterial blood gases"
            5 => "Altitude"
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            0 => "Enfermedad pulmonar obstructiva cr&#243;nica"
            1 => "Ejercicio"
            2 => "Hiperinflaci&#243;n pulmonary"
            3 => "Patr&#243;n respiratorio"
            4 => "Gases arteriales"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO describe the response to exercise of normal subjects and patients with chronic obstructive pulmonary disease &#40;COPD&#41; in Bogota&#44; Colombia &#40;altitude&#58; 2640 m&#59; atmospheric pressure&#58; 560 mm Hg&#41; and compare it with data published on COPD patients at sea level&#46; Healthy people increase their minute ventilation to attenuate hypoxemia &#40;PaCO<span class="elsevierStyleInf">2</span>&#58; 30 mm Hg&#59; PaO<span class="elsevierStyleInf">2</span>&#58; 63 mm Hg&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Material and method</span><p class="elsevierStyleSimplePara elsevierViewall">A descriptive study was carried out on healthy subjects and COPD patients&#46; Exercise limitation was determined by an incremental test on a cycle ergometer&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The study enrolled 16 healthy subjects and 25 COPD patients &#40;forced expiratory volume in 1 second&#58; 43&#46;3&#37; &#91;SD 13&#37;&#93;&#41;&#46; Minute ventilation at rest was greater in COPD patients compared with healthy subjects&#44; it was not adequately sustained during exercise&#44; and there was a reduction in peak oxygen uptake &#40;53&#46;0&#37; &#91;15&#37;&#93;&#41;&#46; At peak exercise&#44; inspiratory capacity decreased &#40;-0&#46;62 &#91;0&#46;34&#93; L&#41;&#44; the ratio of minute ventilation to maximal voluntary ventilation increased&#44; and severe hypoxemia occurred &#40;PaO<span class="elsevierStyleInf">2</span>&#58; 49&#46;9 &#91;9&#46;9&#93; mm Hg&#41;&#46; There was significant correlation between hypoxemia and the percentage of predicted peak oxygen uptake &#40;r&#61;0&#46;60&#41;&#44; leg fatigue &#40;r&#61;-0&#46;62&#41;&#44; percentage of predicted peak inspiratory capacity &#40;r&#61;0&#46;61&#41;&#44; and the percentage of predicted peak tidal volume &#40;r&#61;0&#46;49&#41;&#46; Minute ventilation at rest was shown to be higher&#44; there was a greater reduction in the inspiratory capacity during exercise&#44; and hypoxemia was more severe at rest and during exercise for patients with COPD in Bogota&#44; compared with those at sea level&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Patients with COPD living in Bogota were shown to have lower tolerance to exercise evidenced by ventilatory limitation and severe hypoxemia&#46; Increased minute ventilation at rest&#44; greater reduction in inspiratory capacity&#44; and severity of hypoxemia during exercise were the main differences between COPD in Bogota and at sea level&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir la respuesta al ejercicio en sujetos normales y en pacientes con enfermedad pulmonar obstruc-tiva cr&#243;nica &#40;EPOC&#41; en Bogot&#225; &#40;altura&#58; 2&#46;640 m&#59; presi&#243;n at-mosf&#233;rica&#58; 560 mmHg&#41; y establecer diferencias con los datos publicados de pacientes con dicha enfermedad a nivel del mar&#46; Las personas sanas a esta altura aumentan la ventilaci&#243;n alveolar para atenuar la hipoxemia &#40;presi&#243;n arterial de CO<span class="elsevierStyleInf">2</span>&#58; 30 mmHg&#59; presi&#243;n arterial de O<span class="elsevierStyleInf">2</span>&#58; 63 mmHg&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio descriptivo en pacientes con EPOC y en sujetos sanos&#46; La capacidad de ejercicio se determin&#243; con una prueba incremental en un cicloerg&#243;metro&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; en el estudio a 16 sujetos sanos y 25 pacientes con EPOC &#40;volumen espiratorio forzado en el primer segundo del 43&#44;3 &#177; 13&#37;&#41;&#46; En comparaci&#243;n con los sujetos sanos&#44; en los pacientes con EPOC se observ&#243; un au-mento de la ventilaci&#243;n minuto en reposo que no se mantuvo adecuadamente en el ejercicio&#44; as&#237; como disminuci&#243;n del con-sumo de ox&#237;geno pico &#40;53&#44;0 &#177; 15&#37;&#41;&#46; En ejercicio pico la capacidad inspiratoria disminuy&#243; &#40;-0&#44;62 &#177; 0&#44;34 1&#41;&#44; la relaci&#243;n ventilaci&#243;n minuto&#47;ventilaci&#243;n voluntaria m&#225;xima aument&#243; y hubo una intensa hipoxemia &#40;presi&#243;n arterial de O<span class="elsevierStyleInf">2</span> de 49&#44;9 &#177; 9&#44;9 mmHg&#41;&#46; Esta hipoxemia se correlacion&#243; significativa-mente con el porcentaje del valor predicho del consumo de ox&#237;geno pico &#40;r &#61; 0&#44;60&#41;&#44; la fatiga de los miembros inferiores &#40;r &#61; -0&#44;62&#41;&#44; el porcentaje predicho de la capacidad inspiratoria pico &#40;r &#61; 0&#44;61&#41; y el porcentaje predicho del volumen corriente pico &#40;r &#61; 0&#44;49&#41;&#46; En comparaci&#243;n con los datos publicados a nivel del mar&#44; en los pacientes con EPOC la ventilaci&#243;n minuto en reposo fue mayor&#44; hubo una mayor disminuci&#243;n de la capacidad inspiratoria durante el ejercicio y la hipoxemia fue m&#225;s grave tan to en reposo como en ejercicio&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">En los pacientes con EPOC residentes en Bogot&#225; demostramos intolerancia al ejercicio determinada por limitaci&#243;n ventilatoria e hipoxemia severa&#46; El aumento de la ventilaci&#243;n minuto en reposo&#44; la mayor disminuci&#243;n de la capacidad inspiratoria y la gravedad de la hipoxemia durante el ejercicio fueron las principales diferencias con la EPOC a nivel del mar&#46;</p>"
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ISSN: 15792129
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