α1-Antitrypsin Deficiency: Situation in Spain and Development of a Screening Program

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Servicio de Neumología. Hospital Clínic. Villarroel, 170. 08036 Barcelona. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-07-27" "fechaAceptado" => "2005-09-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154402" "palabras" => array:4 [ 0 => "α1-Antitrypsin deficiency" 1 => "Diagnosis" 2 => "Prevalence" 3 => "COPD" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154403" "palabras" => array:4 [ 0 => "Déficit de alfa-1-antitripsina" 1 => "Diagnóstico" 2 => "Prevalencia" 3 => "EPOC" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Studies undertaken in Spain indicate that 9% of the general population aged between 40 and 70 years is affected by chronic obstructive pulmonary disease (COPD). Although tobacco smoke is the causative factor in more than 90% of cases, it is estimated that only 10% to 20% of smokers develop COPD. This may be explained by the existence of genetic or environmental factors that modulate the toxic effects of tobacco. The best known genetic factor is α1-antitrypsin deficiency, which is associated with an increased risk of developing pulmonary emphysema in smokers. The most recent guidelines from both the World Health Organization and the American Thoracic Society/European Respiratory Society recommend the establishment of screening programs for the detection of α1-antitrypsin deficiency in patients with COPD. This strategy is crucial in Spain, where the disease is under diagnosed, mainly due to a low index of suspicion among doctors." ] "es" => array:1 [ "resumen" => "Estudios realizados en España señalan que un 9% de la población general de entre 40 y 70 años està afectada de enfermedad pulmonar obstructiva crónica (EPOC). El humo del tabaco es el factor causal en màs del 90% de los casos; sin embargo, se ha estimado que sólo un 10–20% de los fumadores desarrollan EPOC. La causa se puede encontrar en la existencia de factores genéticos o ambientales que modu-lan el efecto tóxico del tabaco. El factor genético màs conocido es el déficit de alfa-1-antitripsina, que comporta un riesgo aumentado de desarrollar enfisema pulmonar en fumadores. Tanto la Organización Mundial de la Salud como la American Thoracic Society/European Respiratory Society en sus recientes normativas recomiendan establecer programas de detección del déficit de alfa-1-antitripsina en pacientes con EPOC. Esta estrategia es crucial en España, donde la enfermedad està infradiagnosticada, sobre todo de-bido a un bajo índice de sospecha entre los médicos." ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "This work was funded by Red Respira grant RTIC 03/111SCII." ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:88 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographic variations in prevalence and underdiagnosis of COPD: results of the IBERPOC multicentre epidemiological study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "V Sobradillo" 1 => "M Miravitlles" 2 => "R Gabriel" 3 => "C Jiménez-Ruiz" 4 => "C Villasante" 5 => "JF Masa" 6 => "JL Viejo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "981" "paginaFinal" => "989" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11035667" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for the development of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "EK Silverman" 1 => "FE Speizer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Clin North Am" "fecha" => "1996" "volumen" => "80" "paginaInicial" => "501" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8637301" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C Fletcher" 1 => "R Peto" 2 => "C Tinker" 3 => "FE Speizer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "The natural history of chronic bronchitis. 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Review Article

α1-Antitrypsin Deficiency: Situation in Spain and Development of a Screening Program

Cristian de la Roza

Corresponding author

croza@clinic.ub.es

Dr. C. de la Roza. Servicio de Neumología. Hospital Clínic. Villarroel, 170. 08036 Barcelona. España

, Beatriz Lara, Sara Vilá, Marc Miravitlles

Servicio de Neumología, Institut Clínic del Tórax, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Red Respira RTIC 03/11 ISCIII, Hospital Clínic, Barcelona, Spain

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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Studies undertaken in Spain indicate that 9&#37; of the general population aged between 40 and 70 years is affected by chronic obstructive pulmonary disease &#40;COPD&#41;&#46; Although tobacco smoke is the causative factor in more than 90&#37; of cases&#44; it is estimated that only 10&#37; to 20&#37; of smokers develop COPD&#46; This may be explained by the existence of genetic or environmental factors that modulate the toxic effects of tobacco&#46; The best known genetic factor is &#945;<span class="elsevierStyleInf">1</span>-antitrypsin deficiency&#44; which is associated with an increased risk of developing pulmonary emphysema in smokers&#46; The most recent guidelines from both the World Health Organization and the American Thoracic Society&#47;European Respiratory Society recommend the establishment of screening programs for the detection of &#945;<span class="elsevierStyleInf">1</span>-antitrypsin deficiency in patients with COPD&#46; This strategy is crucial in Spain&#44; where the disease is under diagnosed&#44; mainly due to a low index of suspicion among doctors&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Estudios realizados en Espa&#241;a se&#241;alan que un 9&#37; de la poblaci&#243;n general de entre 40 y 70 a&#241;os est&#224; afectada de enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41;&#46; El humo del tabaco es el factor causal en m&#224;s del 90&#37; de los casos&#59; sin embargo&#44; se ha estimado que s&#243;lo un 10&#8211;20&#37; de los fumadores desarrollan EPOC&#46; La causa se puede encontrar en la existencia de factores gen&#233;ticos o ambientales que modu-lan el efecto t&#243;xico del tabaco&#46; El factor gen&#233;tico m&#224;s conocido es el d&#233;ficit de alfa-1-antitripsina&#44; que comporta un riesgo aumentado de desarrollar enfisema pulmonar en fumadores&#46; Tanto la Organizaci&#243;n Mundial de la Salud como la American Thoracic Society&#47;European Respiratory Society en sus recientes normativas recomiendan establecer programas de detecci&#243;n del d&#233;ficit de alfa-1-antitripsina en pacientes con EPOC&#46; Esta estrategia es crucial en Espa&#241;a&#44; donde la enfermedad est&#224; infradiagnosticada&#44; sobre todo de-bido a un bajo &#237;ndice de sospecha entre los m&#233;dicos&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">This work was funded by Red Respira grant RTIC 03&#47;111SCII&#46;</p>"
      ]
    ]
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Article information

ISSN: 15792129
Original language: English

DOI:10.1016/S1579-2129(06)60145-6

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Year/Month	Html	Pdf	Total

2024 November	7	4	11
2024 October	36	13	49
2024 September	35	19	54
2024 August	63	55	118
2024 July	30	21	51
2024 June	46	22	68
2024 May	45	25	70
2024 April	32	22	54
2024 March	31	19	50
2024 February	21	10	31
2023 March	6	4	10
2023 February	18	22	40
2023 January	25	24	49
2022 December	29	25	54
2022 November	28	32	60
2022 October	42	31	73
2022 September	29	28	57
2022 August	22	37	59
2022 July	29	38	67
2022 June	31	38	69
2022 May	31	33	64
2022 April	25	28	53
2022 March	22	44	66
2022 February	28	42	70
2022 January	16	21	37
2021 December	17	52	69
2021 November	17	48	65
2021 October	28	60	88
2021 September	23	47	70
2021 August	15	35	50
2021 July	11	27	38
2021 June	18	39	57
2021 May	11	30	41
2021 April	39	60	99
2021 March	24	21	45
2021 February	12	20	32
2021 January	11	12	23
2020 December	6	12	18
2020 November	11	30	41
2020 October	11	9	20
2020 September	6	6	12
2020 August	15	10	25
2020 July	9	17	26
2020 June	12	2	14
2020 May	16	15	31
2020 April	17	23	40
2020 March	25	13	38
2020 February	18	14	32
2020 January	20	15	35
2019 December	17	15	32
2019 November	11	18	29
2019 October	8	10	18
2019 September	6	11	17
2019 August	18	13	31
2019 July	9	17	26
2019 June	7	13	20
2019 May	15	13	28
2019 April	11	21	32
2019 March	14	21	35
2019 February	17	18	35
2019 January	17	15	32
2018 December	12	15	27
2018 November	19	10	29
2018 October	21	13	34
2018 September	11	12	23
2018 May	4	1	5
2018 April	6	6	12
2018 March	5	2	7
2018 February	12	10	22
2018 January	10	4	14
2017 December	11	6	17
2017 November	6	6	12
2017 October	3	11	14
2017 September	2	3	5
2017 August	7	11	18
2017 July	7	4	11
2017 June	9	11	20
2017 May	6	10	16
2017 April	6	3	9
2017 March	2	3	5
2017 February	1	1	2
2017 January	1	3	4
2016 December	11	8	19
2016 November	11	7	18
2016 October	14	8	22
2016 September	7	6	13
2016 August	7	2	9
2016 July	10	2	12
2016 March	2	0	2
2015 December	2	0	2
2015 October	67	10	77
2015 September	69	8	77
2015 August	52	6	58
2015 July	57	8	65
2015 June	47	7	54
2015 May	48	5	53
2015 April	40	10	50
2015 March	31	5	36
2015 February	31	3	34
2015 January	26	7	33
2014 December	28	3	31
2014 November	33	4	37
2014 October	55	6	61
2014 September	44	12	56
2014 August	29	7	36
2014 July	49	8	57
2014 June	56	5	61
2014 May	54	8	62
2014 April	61	11	72
2014 March	69	7	76
2014 February	65	8	73
2014 January	49	7	56
2013 December	53	9	62
2013 November	36	3	39
2013 October	52	10	62
2013 September	44	9	53
2013 August	66	8	74
2013 July	54	10	64
2013 June	38	8	46
2013 May	40	4	44
2013 April	22	4	26
2013 March	6	3	9

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