Original Articles
Effects of Nasal Positive Airway Pressure Treatment on Oxidative Stress in Patients With Sleep Apnea-Hypopnea Syndrome
C. Hernándeza,b,
, J. Abreua,b, P. Abreuc, R. Colinod, A. Jiménezb
Corresponding author
chernandezg@teleline.es
Correspondence: Dra. C. Hernández. Servicio de Neumología. Hospital Universitario de Canarias. La Cuesta, s/n. 38320 La Laguna. Santa Cruz de Tenerife. España
Correspondence: Dra. C. Hernández. Servicio de Neumología. Hospital Universitario de Canarias. La Cuesta, s/n. 38320 La Laguna. Santa Cruz de Tenerife. España
a Servicio de Neumología, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
b Unidad Mixta de Investigación, Hospital Universitario de Canarias, Universidad de la Laguna, La Laguna, Santa Cruz de Tenerife, Spain
c Departamento de Fisiología, Facultad de Medicina, Universidad de La Laguna, Santa Cruz de Tenerife, Spain
d Laboratorio Central, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain
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"apellidos" => "Hernández" "email" => array:1 [ 0 => "chernandezg@teleline.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Abreu" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "Abreu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "R." 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C. Hernández. Servicio de Neumología. Hospital Universitario de Canarias. La Cuesta, s/n. 38320 La Laguna. Santa Cruz de Tenerife. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-04-29" "fechaAceptado" => "2005-09-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec154269" "palabras" => array:3 [ 0 => "Oxidative stress" 1 => "Sleep apnea-hypopnea syndrome" 2 => "Nasal positive airway pressure" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154268" "palabras" => array:3 [ 0 => "Estrés oxidativo" 1 => "Síndrome de apneas-hipopneas durante el sueño (SAHS)" 2 => "Tratamiento con CPAPn" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To analyze whether nasal continuous positive airway pressure (CPAP) reduces oxidative stress in patients with sleep apnea-hypopnea syndrome (SAHS).</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Thirty-six patients with SAHS requiring nasal CPAP treatment and 10 controls in whom SAHS was ruled out were enrolled. Oxidative stress was evaluated by measuring plasma malondialdehyde (MDA) concentrations to assess lipid peroxidation at the beginning of the study and then again after a mean (SD) of 2.9 (0.6) months of nasal CPAP. Plasma MDA concentrations were determined by measuring thiobarbituric acid reactive substances. We controlled for the following factors known to influence oxidative stress: age, sex, use of vitamin supplements, smoking habit, body mass index (kg/m<span class="elsevierStyleSup">2</span>), ischemic cardiopathy, hypertension, diabetes, and hypercholesterolemia.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The mean age of patients with SAHS was 51.4 (9.9) years and the mean body mass index was 32.9 (5.3) kg/m<span class="elsevierStyleSup">2</span>. Nasal CPAP was titrated to a mean pressure of 8.9 (3.4) cm H<span class="elsevierStyleInf">2</span>O. The mean score on the Epworth sleepiness scale was 10.2 (4.3) before treatment and 4.2 (2.8) after treatment (<span class="elsevierStyleItalic">P</span> <.001). The apnea-hypopnea index decreased from 43.7 (22.6) before treatment to 4 (3.5) after treatment (<span class="elsevierStyleItalic">P</span> <.001). Mean MDA concentrations in patients with SAHS were 2.0 (1.1) μmol/mL before treatment and decreased significantly to 1.6 (0.07) μmol/mL after treatment, whereas MDA concentrations remained unchanged in control subjects.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Nasal CPAP treatment significantly reduced oxidative stress in patients with SAHS in our study.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Analizar si el tratamiento con presión positiva continua de la vía aérea nasal (CPAPn) reduce el estrés oxidativo (EO) en pacientes con síndrome de apneas-hipopneas durante el sueño (SAHS).</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyó en el estudio a 36 pacientes con SAHS que requirieron tratamiento con CPAPn y a 10 controles en quienes se excluyó dicho síndrome. Se realizó una primera determinación del EO mediante las concentraciones de malondialdehído (MDA) en sangre para conocer la peroxidación lipídica, y una segunda tras una media ± des-viación estándar de 2,9 ± 0,6 meses de seguimiento con CPAPn. Las concentraciones plasmáticas de MDA se midieron como sustancia reactiva al ácido tiobarbitúrico. Se controló para los siguientes factores, que se sabe que influyen en el EO: edad, sexo, suplementos vitamínicos, consumo de ta-baco, índice de masa corporal (kg/m<span class="elsevierStyleSup">2</span>), cardiopatía isquémi-ca, hipertensión, diabetes e hipercolesterolemia.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes con SAHS fue de 51,4 ± 9,9 años y el índice de masa corporal, de 32,9 ± 5.3 kg/m<span class="elsevierStyleSup">2</span>. La CPAPn se reguló a una presión media de 8,9 ± 3.4 cmH<span class="elsevierStyleInf">2</span>O. La puntuación en la escala de Epworth antes del tratamiento fue de 10,2 ± 4,3, frente a 4,1 ± 2,8 después del tratamiento (p < 0,001). El índice de apneas-hipopneas/h descendió de 43,7 ± 22,6 antes del tratamiento a 4 ± 3,5 después de la CPAPn (p < 0,001). En los pacientes con SAHS las concentraciones de MDA antes del tratamiento con CPAPn fueron de 2,0 ±1,1 μM y descendieron significativa -mente a 1,6 ± 0,7 μM después del tratamiento, mientras que no se modificaron en los sujetos controles.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El tratamiento con CPAPn reduce de forma significativa el EO en los pacientes SAHS de nuestro estudio.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free radicals and the heart" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N Kaul" 1 => "N Siveski-Iliskovic" 2 => "M Hill" 3 => "J Slezak" 4 => "PK Singal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pharmacol Toxicol Methods" "fecha" => "1993" "volumen" => "30" "paginaInicial" => "55" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8298182" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of desferrioxamine on stored erythrocytes: lipid peroxidation, deformability, and morphology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "JA Knight" 1 => "DA Searles" 2 => "FC Clayton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Clin Lab Sci" "fecha" => "1996" "volumen" => "26" "paginaInicial" => "283" "paginaFinal" => "290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8800428" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D Steinberg" 1 => "SS Parthasarathy" 2 => "TE Carew" 3 => "JC Khoo" 4 => "JL Witztum" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "1989" "volumen" => "32" "paginaInicial" => "915" "paginaFinal" => "924" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of hypertension in sleep apnea patients independent of obesity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "JT Carlson" 1 => "JA Hedner" 2 => "H Ejnell" 3 => "LE Peterson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.150.1.8025776" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1994" "volumen" => "150" "paginaInicial" => "72" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8025776" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estrés oxidativo y síndrome de apneahipopnea del sueño" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A Barceló" 1 => "F Barbé" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "393" "paginaFinal" => "399" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16029734" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antioxidant capacity in obstructive sleep apnea patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K Christou" 1 => "AN Moulas" 2 => "C Pastaka" 3 => "KI Gorgoulianis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep Med" "fecha" => "2003" "volumen" => "4" "paginaInicial" => "225" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14592326" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipid peroxidation and osmotic fragility of red blood cells in sleep-apnea patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L Ozturk" 1 => "B Mansour" 2 => "M Yuksel" 3 => "AS Yalcin" 4 => "F Celikoglu" 5 => "N Gokhan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chim Acta" "fecha" => "2003" "volumen" => "332" "paginaInicial" => "83" "paginaFinal" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12763284" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phagocytosis and oxidative burst of granulocytes in the upper respiratory tract in chronic and acute inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G Müns" 1 => "I Rubinstein" 2 => "P Singer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Otolaryngol" "fecha" => "1995" "volumen" => "24" "paginaInicial" => "105" "paginaFinal" => "110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7602670" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M Kato" 1 => "P Roberts-Thomson" 2 => "BG Phillips" 3 => "WG Haynes" 4 => "M Winnick" 5 => "V Accurso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2000" "volumen" => "102" "paginaInicial" => "2607" "paginaFinal" => "2610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11085964" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benefits of obstructive sleep apnoea treatment in coronary artery disease: a long-term follow-up study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O Milleron" 1 => "R Pilliere" 2 => "A Foucher" 3 => "F de Roquefeuil" 4 => "P Aegerter" 5 => "G Jondeau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ehj.2004.03.008" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2004" "volumen" => "25" "paginaInicial" => "709" "paginaFinal" => "711" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15120876" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento del síndrome de apneahipopnea durante el sueño" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JM Montserrat" 1 => "J Amilibia" 2 => "F Barbé" 3 => "F Capote" 4 => "J Durán" 5 => "NG Mangado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1998" "volumen" => "34" "paginaInicial" => "171" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9611649" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validación de la versión española del test de somnolencia Epworth en pacientes con síndrome de apnea de sueño" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E Chiner" 1 => "J Arriero" 2 => "J Signes-Costa" 3 => "J Marco" 4 => "I Fuentes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1999" "volumen" => "35" "paginaInicial" => "422" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10596338" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Grupo de trabajo de la Sociedad Española de Patología Respiratoria (SEPAR) para la práctica de la espirometría clínica" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Normativa para la espirometría forzada" "fecha" => "1985" "editorial" => "Doyma" "editorialLocalizacion" => "Barcelona" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A Rechtshaffen" 1 => "A Kales" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Bethesda: National Institute of Neurological Disease and Blindness" "fecha" => "1986" "editorial" => "US Government Printing Office" "editorialLocalizacion" => "Washington DC" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EEG arousals: scoring rules and examples" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Sleep Disorders Association" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep" "fecha" => "1992" "volumen" => "15" "paginaInicial" => "173" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11032543" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interpretation of the thiobarbituric acid reactivity of rat liver and brain homogenates in the presence of ferric ion and ethylenediaminetetraacetic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K Kikugawa" 1 => "T Kojima" 2 => "S Yamaki" 3 => "H Kosugi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anal Biochem" "fecha" => "1992" "volumen" => "202" "paginaInicial" => "249" "paginaFinal" => "255" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1519749" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "SC Veasey" 1 => "CW Davis" 2 => "P Fenik" 3 => "G Zhan" 4 => "YJ Hsu" 5 => "D Pratico" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep" "fecha" => "2004" "volumen" => "27" "paginaInicial" => "194" "paginaFinal" => "201" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15124711" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep deprivation decreases superoxide dismutase activity in hippocampus and brainstem" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L Ramanathan" 1 => "S Gulyani" 2 => "R Nienhuis" 3 => "JM Siegel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuroreport" "fecha" => "2002" "volumen" => "13" "paginaInicial" => "1387" "paginaFinal" => "1390" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12167758" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep deprivation and cellular responses to oxidative stress" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A Gopalakrishnan" 1 => "LL Ji" 2 => "C Cirelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep" "fecha" => "2004" "volumen" => "27" "paginaInicial" => "27" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998234" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "GE Carpagnano" 1 => "SA Kharitonov" 2 => "O Resta" 3 => "MP Foschino-Barbaro" 4 => "E Gramiccioni" 5 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "1386" "paginaFinal" => "1392" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14555570" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep structure correlates of continuous positive airway pressure variations during application of an autotitrating continuous positive airway pressure machine in patients with obstructive sleep apnea syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "O Marrone" 1 => "G Insalaco" 2 => "MR Bonsignore" 3 => "S Romano" 4 => "A Salvaggio" 5 => "G Bonsignore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "paginaInicial" => "759" "paginaFinal" => "767" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11888957" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sympathetic activity is reduced by nCPAP in hypertensive obstructive sleep apnoea patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Heitmann" 1 => "K Ehlenz" 2 => "T Penzel" 3 => "HF Becker" 4 => "L Grote" 5 => "KH Voigt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2004" "volumen" => "23" "paginaInicial" => "255" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14979500" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "GE Carpagnano" 1 => "SA Kharitonov" 2 => "O Resta" 3 => "MP Foschino-Barbaro" 4 => "E Gramiccioni" 5 => "PJ Barnes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "122" "paginaInicial" => "1162" "paginaFinal" => "1167" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12377837" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The oxidative stress in the development of diabetes chronic complications in the elderly" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I Suciu" 1 => "V Negrean" 2 => "D Sampelean" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rom J Intern Med" "fecha" => "2004" "volumen" => "42" "paginaInicial" => "395" "paginaFinal" => "406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15529629" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute effects of cigarette smoke on inflammation and oxidative stress: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H van der Vaart" 1 => "DS Postman" 2 => "W Timens" 3 => "NH Ten Hacken" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2003.012468" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "713" "paginaFinal" => "721" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15282395" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma homocysteine and malondialdehyde are correlated in an age-and gender-specific manner" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "RW Powers" 1 => "AK Majors" 2 => "DL Lykins" 3 => "CJ Sims" 4 => "KY Lain" 5 => "JM Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Metabolism" "fecha" => "2002" "volumen" => "51" "paginaInicial" => "1433" "paginaFinal" => "1438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12404194" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipid peroxidation and 5–lipoxygenase activity in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P Santus" 1 => "A Sola" 2 => "P Carlucci" 3 => "F Fumagalli" 4 => "A Di Gennaro" 5 => "M Mondoni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200404-558OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "171" "paginaInicial" => "838" "paginaFinal" => "843" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15579728" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abnormal lipid peroxidation in patients with sleep apnoea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A Barceló" 1 => "C Miralles" 2 => "F Barbé" 3 => "M Vila" 4 => "S Pons" 5 => "AGN Agustí" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "644" "paginaFinal" => "647" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11106206" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Susceptibility of LDL to oxidative stress in obstructive sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "SO Wali" 1 => "AS Bahammam" 2 => "H Massaeli" 3 => "GN Pierce" 4 => "N Lliskovic" 5 => "PK Singal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "290" "paginaFinal" => "296" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9595608" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for lipid peroxidation in obstructive sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L Lavie" 1 => "A Vishnevsky" 2 => "P Lavie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sleep" "fecha" => "2004" "volumen" => "27" "paginaInicial" => "123" "paginaFinal" => "128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998248" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R Schulz" 1 => "S Mahmoudi" 2 => "K Hattar" 3 => "U Sibelius" 4 => "O Horst" 5 => "K Mayer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "162" "paginaInicial" => "556" "paginaFinal" => "570" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortality and apnea index in obstructive sleep apnea (experience in 385 male patients)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J He" 1 => "MH Kryger" 2 => "FJ Zorick" 3 => "W Conway" 4 => "T Roth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1988" "volumen" => "94" "paginaInicial" => "9" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3289839" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004200000003/v1_201305150239/S1579212906601304/v1_201305150239/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004200000003/v1_201305150239/S1579212906601304/v1_201305150239/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906601304?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 1 | 5 |
| 2024 October | 33 | 15 | 48 |
| 2024 September | 27 | 12 | 39 |
| 2024 August | 40 | 30 | 70 |
| 2024 July | 20 | 20 | 40 |
| 2024 June | 29 | 19 | 48 |
| 2024 May | 30 | 31 | 61 |
| 2024 April | 16 | 18 | 34 |
| 2024 March | 21 | 13 | 34 |
| 2024 February | 18 | 18 | 36 |
| 2023 March | 0 | 1 | 1 |
| 2023 February | 16 | 20 | 36 |
| 2023 January | 20 | 21 | 41 |
| 2022 December | 22 | 22 | 44 |
| 2022 November | 19 | 16 | 35 |
| 2022 October | 23 | 27 | 50 |
| 2022 September | 16 | 20 | 36 |
| 2022 August | 19 | 34 | 53 |
| 2022 July | 15 | 35 | 50 |
| 2022 June | 13 | 30 | 43 |
| 2022 May | 18 | 28 | 46 |
| 2022 April | 18 | 21 | 39 |
| 2022 March | 19 | 37 | 56 |
| 2022 February | 19 | 36 | 55 |
| 2022 January | 11 | 30 | 41 |
| 2021 December | 17 | 47 | 64 |
| 2021 November | 13 | 44 | 57 |
| 2021 October | 19 | 42 | 61 |
| 2021 September | 18 | 41 | 59 |
| 2021 August | 9 | 27 | 36 |
| 2021 July | 10 | 27 | 37 |
| 2021 June | 11 | 22 | 33 |
| 2021 May | 11 | 24 | 35 |
| 2021 April | 30 | 57 | 87 |
| 2021 March | 23 | 13 | 36 |
| 2021 February | 8 | 16 | 24 |
| 2021 January | 10 | 7 | 17 |
| 2020 December | 11 | 8 | 19 |
| 2020 November | 6 | 6 | 12 |
| 2020 October | 17 | 6 | 23 |
| 2020 September | 4 | 5 | 9 |
| 2020 August | 10 | 11 | 21 |
| 2020 July | 7 | 14 | 21 |
| 2020 June | 4 | 4 | 8 |
| 2020 May | 12 | 17 | 29 |
| 2020 April | 12 | 15 | 27 |
| 2020 March | 10 | 8 | 18 |
| 2020 February | 12 | 15 | 27 |
| 2020 January | 11 | 12 | 23 |
| 2019 December | 12 | 18 | 30 |
| 2019 November | 11 | 10 | 21 |
| 2019 October | 12 | 8 | 20 |
| 2019 September | 34 | 9 | 43 |
| 2019 August | 9 | 4 | 13 |
| 2019 July | 11 | 14 | 25 |
| 2019 June | 8 | 5 | 13 |
| 2019 May | 10 | 12 | 22 |
| 2019 April | 11 | 9 | 20 |
| 2019 March | 12 | 17 | 29 |
| 2019 February | 4 | 7 | 11 |
| 2019 January | 4 | 10 | 14 |
| 2018 December | 9 | 16 | 25 |
| 2018 November | 14 | 11 | 25 |
| 2018 October | 28 | 23 | 51 |
| 2018 September | 8 | 8 | 16 |
| 2018 May | 3 | 1 | 4 |
| 2018 April | 9 | 5 | 14 |
| 2018 March | 0 | 6 | 6 |
| 2018 February | 8 | 9 | 17 |
| 2018 January | 4 | 5 | 9 |
| 2017 December | 2 | 8 | 10 |
| 2017 November | 3 | 8 | 11 |
| 2017 October | 4 | 7 | 11 |
| 2017 September | 4 | 8 | 12 |
| 2017 August | 8 | 10 | 18 |
| 2017 July | 5 | 5 | 10 |
| 2017 June | 4 | 12 | 16 |
| 2017 May | 8 | 11 | 19 |
| 2017 April | 1 | 8 | 9 |
| 2017 March | 3 | 4 | 7 |
| 2017 February | 1 | 2 | 3 |
| 2017 January | 1 | 1 | 2 |
| 2016 December | 13 | 6 | 19 |
| 2016 November | 14 | 5 | 19 |
| 2016 October | 16 | 12 | 28 |
| 2016 September | 4 | 2 | 6 |
| 2016 August | 5 | 2 | 7 |
| 2016 July | 6 | 0 | 6 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 34 | 12 | 46 |
| 2015 September | 42 | 10 | 52 |
| 2015 August | 31 | 9 | 40 |
| 2015 July | 31 | 7 | 38 |
| 2015 June | 31 | 6 | 37 |
| 2015 May | 48 | 16 | 64 |
| 2015 April | 33 | 14 | 47 |
| 2015 March | 42 | 18 | 60 |
| 2015 February | 31 | 7 | 38 |
| 2015 January | 33 | 14 | 47 |
| 2014 December | 36 | 5 | 41 |
| 2014 November | 30 | 7 | 37 |
| 2014 October | 35 | 14 | 49 |
| 2014 September | 37 | 10 | 47 |
| 2014 August | 32 | 7 | 39 |
| 2014 July | 36 | 14 | 50 |
| 2014 June | 56 | 7 | 63 |
| 2014 May | 45 | 7 | 52 |
| 2014 April | 51 | 4 | 55 |
| 2014 March | 62 | 9 | 71 |
| 2014 February | 40 | 8 | 48 |
| 2014 January | 29 | 5 | 34 |
| 2013 December | 36 | 7 | 43 |
| 2013 November | 26 | 4 | 30 |
| 2013 October | 39 | 11 | 50 |
| 2013 September | 20 | 9 | 29 |
| 2013 August | 45 | 11 | 56 |
| 2013 July | 36 | 13 | 49 |
| 2013 June | 29 | 7 | 36 |
| 2013 May | 27 | 4 | 31 |
| 2013 April | 19 | 5 | 24 |
| 2013 March | 7 | 2 | 9 |
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